LIM Kinase
LIM kinase inhibitors target LIM kinases, a family of enzymes involved in the regulation of the actin cytoskeleton and cell cycle progression. LIM kinases phosphorylate and inactivate cofilin, a protein that disassembles actin filaments, thus controlling cell shape, motility, and division. Inhibiting LIM kinases can affect these processes, leading to altered cell cycle dynamics and potential apoptosis. LIM kinase inhibitors are important tools in cancer research and the study of cell motility and invasion. At CymitQuimica, we provide a selection of high-quality LIM kinase inhibitors to support your research in cell signaling, cytoskeletal dynamics, and oncology.
Found 19 products of "LIM Kinase"
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R-10015
CAS:<p>R-10015, potent LIMK inhibitor with 38 nM IC50 for LIMK1, targets ATP pocket, and serves as a broad-spectrum HIV antiviral.</p>Formula:C20H19ClN6O2Purity:98.68%Color and Shape:SolidMolecular weight:410.86S3 Fragment
<p>S3 Fragment is a biologically active peptide featuring the amino-terminal phosphorylation site unique to Xenopus ADF/cofilin, which is the target of LIM kinase</p>Formula:C73H120N18O24S2Color and Shape:SolidMolecular weight:1697.978β,9α-Dihydroxylindan-4(5),7(11)-dien-8α,12-olide
CAS:<p>8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide (compound 3), a sesquiterpene, exhibits anti-LIMK1 activity and inhibits cell motility [1].</p>Formula:C15H18O4Color and Shape:SolidMolecular weight:262.3BMS-3
CAS:<p>BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.</p>Formula:C17H12Cl2F2N4OSPurity:99.31% - 99.81%Color and Shape:SolidMolecular weight:429.27T56-LIMKi
CAS:<p>T56-LIMKi (T5601640) is a selective inhibitor of LIMK2.</p>Formula:C19H14F3N3O3Purity:98.39% - 99.57%Color and Shape:SolidMolecular weight:389.33BMS-5
CAS:<p>BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.</p>Formula:C17H14Cl2F2N4OSPurity:98.01% - 99.88%Color and Shape:SolidMolecular weight:431.29LIMK-IN-22j
CAS:<p>LIMK-IN-22j (LIMK inhibitor 22j) is an effective and selective inhibitor of LIMK.</p>Formula:C20H21BrN8Purity:99.165%Color and Shape:SolidMolecular weight:453.34TH-263
CAS:<p>TH-263 is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257, and is a diaryl sulfonamide derivative.</p>Formula:C21H20N2O3SPurity:99.54%Color and Shape:SolidMolecular weight:380.46TH-257
CAS:<p>TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).</p>Formula:C24H26N2O3SPurity:98.23%Color and Shape:SolidMolecular weight:422.54TH470
CAS:<p>TH470, a potent and highly selective inhibitor of LIM kinase 1/2 (LIMK1/2), demonstrates specificity with IC50 values of 9.8 nM for LIMK1 and 13 nM for LIMK2,</p>Formula:C30H31N5O5S2Color and Shape:SolidMolecular weight:605.73LIMK1 inhibitor BMS-4
CAS:<p>BMS-4 is a LIMK inhibitor targeting LIMK1/2, reduces cofilin phosphorylation, noncytotoxic to A549 cells.</p>Formula:C23H23N7O2SColor and Shape:SolidMolecular weight:461.54CRT-0105446
CAS:<p>CRT-0105446 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.</p>Formula:C20H18F3N3O2SPurity:98%Color and Shape:SolidMolecular weight:421.44SR7826
CAS:<p>SR7826 is a selective LIMK inhibitor.</p>Formula:C22H21N5O2Purity:98%Color and Shape:SolidMolecular weight:387.43LIMK-IN-14
CAS:<p>LIMK-IN-14 is an effective and selective inhibitor of LIMK.</p>Formula:C22H27N7O3Purity:98%Color and Shape:SolidMolecular weight:437.49CRT-0105950
CAS:<p>CRT-0105950 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.</p>Formula:C21H16ClN3OSPurity:99.78% - 99.86%Color and Shape:SolidMolecular weight:393.89LX7101 hydrochloride
CAS:<p>LX7101 is a potent inhibitor of both LIM kinase (LIMK) 1 and 2, and Rho-associated kinase 1 (ROCK1) and ROCK2, with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, demonstrated by its lack of cross-reactivity in a panel of binding assays involving 78 receptors, transporters, and an additional 430 kinases, at a concentration of 10 μM. The topical administration of LX7101 (3 μl of a 1 mg/ml solution) to the eye has been shown to reduce intraocular pressure in a dexamethasone-induced mouse model of glaucoma.</p>Formula:C23H29N7O3HClColor and Shape:SolidMolecular weight:488LIMK-IN-2
CAS:<p>LIMK-IN-2 (Compound 52), an LIMK inhibitor, has demonstrated potential anti-angiogenic activity by suppressing the cell migration of osteosarcoma and cervical cancer cells [1].</p>Formula:C28H27N5O2Color and Shape:SolidMolecular weight:465.55LIMK1 inhibitor 1
CAS:<p>LIMK1 inhibitor1 (compound 24) is a LIMK1 inhibitor, potentially useful for cancer research.</p>Formula:C12H15N3S2Color and Shape:SolidMolecular weight:265.398LIMK1 inhibitor 2
CAS:<p>LIMK1 inhibitor 2 (compound 41) is a LIMK1 inhibitor with an IC50 value of 9 μM.</p>Formula:C10H11N3OSColor and Shape:SolidMolecular weight:221.279
