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Ferroptosis

Ferroptosis

Ferroptosis is a form of regulated cell death characterized by the accumulation of lipid peroxides and iron-dependent oxidative stress. Unlike apoptosis, ferroptosis is not driven by caspases but rather by the failure of cellular antioxidant defenses, leading to cell death. Ferroptosis inhibitors and inducers are critical for studying this unique cell death pathway, which is implicated in various diseases, including cancer, neurodegeneration, and ischemia-reperfusion injury. At CymitQuimica, we offer a wide range of high-quality ferroptosis modulators to support your research in cell death mechanisms, oxidative stress, and disease pathology.

Found 225 products of "Ferroptosis"

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  • CAR-2

    CAS:
    <p>CAR-2 is a BODIPY-based photosensitizer that induces ferroptosis in photodynamic therapy (PDT) by targeting the endoplasmic reticulum (ER) and lipid droplets (LD). It exhibits phototoxicity against breast cancer cells with an IC50 of 0.01-0.02 μM and demonstrates antitumor efficacy in a 4T1 xenograft mouse model.</p>
    Formula:C27H23BF2I2N4O2
    Color and Shape:Solid
    Molecular weight:738.114
  • Microtubule inhibitor 2


    <p>Microtubule inhibitor 2: potent, selective, oral, induces ferroptosis, strong antitumor effect.</p>
    Formula:C20H23NO7
    Color and Shape:Solid
    Molecular weight:389.4
  • Cetzole

    CAS:
    Cetzole (Compound 1) acts as an inducer of ferroptosis (iron-dependent cell death) through the accumulation of ROS, leading to cell death. The compound exhibits varying half-maximal cytotoxic concentrations (CC50) against several cell lines: 2.56 μM in NCI-H522, 10.31 μM in NCI-H522 GFP-SCL7A11 #8, 2.71 μM in NCI-H522 RV-GFP, 3.07 μM in HT-1080, 14.9 μM in NARF2, and 6.28 μM in MDA-MB-231. This highlights Cetzole's potential for research in cancer therapeutics.
    Formula:C11H11NOS
    Color and Shape:Solid
    Molecular weight:205.28
  • PRGL493

    CAS:
    PRGL493 blocks ACSL4, halts PC3/MDA-MB-231 cancer cell spread, and inhibits MA-10 tumor progesterone. Effective in mouse PC3 tumor model at 0.25 mg/kg.
    Formula:C25H21N7O2
    Purity:98.80% - 99.11%
    Color and Shape:Solid
    Molecular weight:451.48

    Ref: TM-T35666

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  • Vatiquinone

    CAS:
    Vatiquinone, also known as EPI 743, is an orally bioavailable para-benzoquinone being developed for inherited mitochondrial diseases. The mechanism of action of EPI-743 involves augmenting the synthesis of glutathione, optimizing metabolic control, enhanc
    Formula:C29H44O3
    Color and Shape:Solid
    Molecular weight:440.66

    Ref: TM-T35040

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