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CDK

CDK

CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.

Found 500 products of "CDK"

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  • Cdc7-IN-1
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    Cdc7-IN-1

    CAS:
    <p>Cdc7-IN-1: selective ATP-competitive Cdc7 kinase inhibitor; IC50 0.6 nM at 1mM ATP; induces cancer cell death.</p>
    Formula:C21H16ClN3O4
    Color and Shape:Solid
    Molecular weight:409.82

    Ref: TM-T10724

  • CDK9-IN-14
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    CDK9-IN-14

    CAS:
    <p>CDK9-IN-14: Potent CDK9 inhibitor, IC50=6.92 nM, effective on MV-4-11 cells and in vivo tumors, low toxicity, minimal side effects.</p>
    Formula:C21H23F2N3O4
    Color and Shape:Solid
    Molecular weight:419.42

    Ref: TM-T62203

  • CLK1/2-IN-3
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    CLK1/2-IN-3

    CAS:
    <p>CLK1/2-IN-3 (Cpd-3) is a CLK1 and CLK2 inhibitor with antiproliferative activity that inhibits the activity of CLK and SRPK.</p>
    Formula:C21H21N5O2
    Purity:99.04%
    Color and Shape:Solid
    Molecular weight:375.42

    Ref: TM-T23897

  • THZ1-R
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    THZ1-R

    CAS:
    <p>THZ1-R is a non-covalent active analogue of THZ1, with the acrylamide group removed from THZ1, not covalently bind to the C312 cysteine residue of CDK7.</p>
    Formula:C31H30ClN7O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:568.07

    Ref: TM-T13153

  • CLK1-IN-1
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    CLK1-IN-1

    CAS:
    <p>CLK1-IN-1 is a potent and selective inhibitor of the Cdc2-like kinase 1 (CLK1; IC50: 2 nM).</p>
    Formula:C24H16FN5O
    Color and Shape:Solid
    Molecular weight:409.42

    Ref: TM-T10836

  • CDK12-IN-E9
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    CDK12-IN-E9

    CAS:
    <p>CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux.</p>
    Formula:C24H30N6O2
    Color and Shape:Solid
    Molecular weight:434.53

    Ref: TM-T14915

  • Cdc7-IN-17
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    Cdc7-IN-17

    CAS:
    <p>Cdc7-IN-17 is a potent inhibitor of CDC7 with an IC 50 of &lt;10 μM that can be used in cancer research [1].</p>
    Formula:C13H15N5OS
    Color and Shape:Solid
    Molecular weight:289.36

    Ref: TM-T60589

  • AS2863619 free base
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    AS2863619 free base

    CAS:
    <p>AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells.</p>
    Formula:C16H12N8O
    Color and Shape:Solid
    Molecular weight:332.32

    Ref: TM-T10382

  • Cdc7-IN-4
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    Cdc7-IN-4

    CAS:
    <p>Cdc7-IN-4 is a potent inhibitor of Cdc7 kinase.</p>
    Formula:C22H24F3N5O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:479.45

    Ref: TM-T10726

  • K 00546
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    K 00546

    CAS:
    <p>K00546 inhibits CDK1/cyclin B (IC50: 0.6 nM), CDK2/cyclin A (IC50: 0.5 nM), CLK1 (IC50: 8.9 nM), and CLK3 (IC50: 29.2 nM).</p>
    Formula:C15H13F2N7O2S2
    Purity:99.12%
    Color and Shape:Solid
    Molecular weight:425.44

    Ref: TM-T21950

  • CDK8-IN-7
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    CDK8-IN-7

    CAS:
    <p>CDK8-IN-7 is a potent CDK8 inhibitor with a Kd of 3.5 nM, showing promise for AML research.</p>
    Formula:C30H40N2
    Color and Shape:Solid
    Molecular weight:428.65

    Ref: TM-T62354

  • Cdc7-IN-15
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    Cdc7-IN-15

    CAS:
    <p>Cdc7-IN-15 (Example 108) is an inhibitor of cdc7 kinase that has potential to be used for cancer research [1].</p>
    Formula:C12H14N4OS
    Color and Shape:Solid
    Molecular weight:262.33

    Ref: TM-T60427

  • CP681301
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    CP681301

    CAS:
    <p>CP681301 is a potent CDK5 inhibitor with anti-tumor effects in Drosophila and reduces Glioma stem cells' growth and renewal.</p>
    Formula:C17H22N4O
    Color and Shape:Solid
    Molecular weight:298.38

    Ref: TM-T60661

  • MDK6204
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    MDK6204

    CAS:
    <p>MDK6204 is a selective inhibitor of CLK1 and CLK2.</p>
    Formula:C20H20N6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:360.41

    Ref: TM-T24439

  • BSJ-01-175
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    BSJ-01-175

    CAS:
    <p>BSJ-01-175: Selective, potent covalent inhibitor of CDK12/13, targets cancer cells, inhibits phosphorylated RNA polymerase II, downregulates CDK12 genes.</p>
    Formula:C30H33ClN6O2
    Color and Shape:Solid
    Molecular weight:545.08

    Ref: TM-T63841

  • Indirubin-3'-monoxime-5-sulphonic acid
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    Indirubin-3'-monoxime-5-sulphonic acid

    CAS:
    <p>Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of GSK-3β, CDK5, and CDK1 with IC50s of 80nM,5 nM, and 7 nM, respectively.</p>
    Formula:C16H11N3O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:357.34

    Ref: TM-T11652

  • CDK7-IN-13
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    CDK7-IN-13

    CAS:
    <p>CDK7-IN-13: A potent pyrimidine-based CDK7 inhibitor, potential for various cancers. See CN114249712A.</p>
    Formula:C20H23F3N6OS
    Purity:99.22%
    Color and Shape:Solid
    Molecular weight:452.5

    Ref: TM-T62759

  • P18IN003
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    P18IN003

    CAS:
    <p>P18IN003 is a selective and effective p18(INK4C) inhibitor that inhibits the activity of p18 protein and can be used to study in vitro expansion of</p>
    Formula:C17H16N2O3
    Purity:98.77%
    Color and Shape:Solid
    Molecular weight:296.32

    Ref: TM-T24580

  • CDK7-IN-20
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    CDK7-IN-20

    <p>CDK7-IN-20: potent, irreversible CDK7 inhibitor, IC50 of 4nM, 206x selectivity vs. other CDKs, potential for ADPKD study.</p>
    Formula:C30H26N6O3
    Color and Shape:Solid
    Molecular weight:518.57

    Ref: TM-T73163

  • FLT3/CDK4-IN-1
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    FLT3/CDK4-IN-1

    CAS:
    <p>FLT3/CDK4-IN-1: Oral FLT3 (7 nM IC50) &amp; CDK4 (11 nM IC50) inhibitor with strong in vivo anti-cancer properties.</p>
    Formula:C25H28F2N8
    Color and Shape:Solid
    Molecular weight:478.54

    Ref: TM-T63135