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CDK

CDK

CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.

Found 500 products of "CDK"

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  • FDA-Approved Kinase Inhibitor Library
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    FDA-Approved Kinase Inhibitor Library

    <p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>
    Color and Shape:Liquid

    Ref: TM-L1610

  • Kinase Inhibitor Library
    Targetmol
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    Kinase Inhibitor Library

    <p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>
    Color and Shape:Odour Solid

    Ref: TM-L1600

  • Cdk2/Cyclin Inhibitory Peptide II
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    Cdk2/Cyclin Inhibitory Peptide II

    CAS:
    <p>Cdk2/Cyclin Inhibitory Peptide II (Tat-LDL), a CDK2 inhibitor, demonstrates dose-dependent cytotoxic effects on U2OS osteosarcoma cells [1].</p>
    Formula:C110H200N48O25
    Color and Shape:Solid
    Molecular weight:2595.07

    Ref: TM-T76377

  • CDK8-IN-12
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    CDK8-IN-12

    CAS:
    <p>CDK8-IN-12: selective CDK8 inhibitor (Ki 14 nM), oral anticancer, blocks GSK-3α/β, PCK-θ, halts MV4-11 cell growth.</p>
    Formula:C21H20ClN3O2
    Purity:99.46% - 99.83%
    Color and Shape:Soild
    Molecular weight:381.86

    Ref: TM-T72048

  • CymitQuimica logo
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    CDK2/PIM1-IN-1

    <p>CDK2/PIM1-IN-1 is an inhibitor of the kinases CDK2 (IC50: 0.27 μM) and PIM1 (IC50: 0.67 μM). It can induce apoptosis (cell death) and reduce the expression of TNF-α, which promotes tumors. CDK2/PIM1-IN-1 exhibits antitumor activity.</p>
    Color and Shape:Odour Solid

    Ref: TM-T206369

  • PROTAC CDK9 degrader-7
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    PROTAC CDK9 degrader-7

    CAS:
    <p>PROTAC CDK9 degrader-7 is a proteolysis-targeting chimera (PROTAC) specifically designed to target and mediate the degradation of Cyclin-Dependent Kinase 9 (</p>
    Formula:C43H50Cl2N8O9
    Color and Shape:Soild
    Molecular weight:893.81

    Ref: TM-T74853

  • Roccellic Acid
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    Roccellic Acid

    CAS:
    <p>Roccellic acid from R. montagnei lichen has antibacterial, anticancer properties; MIC 46.9 μg/ml; inhibits cancer cells by up to 87.9%.</p>
    Formula:C17H32O4
    Color and Shape:Solid
    Molecular weight:300.43

    Ref: TM-T36409

  • CymitQuimica logo
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    PP-C8

    <p>PP-C8: PROTAC CDK12-Cyclin K degrader with DC50s 416/412 nM; synergizes with PARP inhibitor against TNBC.</p>
    Formula:C43H51FN12O7
    Color and Shape:Solid
    Molecular weight:866.94

    Ref: TM-T74359

  • CDK12-IN-6
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    CDK12-IN-6

    CAS:
    <p>CDK12-IN-6, a pyrazolotriazine, strongly inhibits CDK12 (IC50 1.19 μM at 2 mM ATP), but not CDK2/Cyclin E or CDK9/Cyclin T1 (both IC50 &gt;20 μM).</p>
    Formula:C20H21F2N9
    Color and Shape:Solid
    Molecular weight:425.448

    Ref: TM-T40289

  • Cdk2/Cyclin Inhibitory Peptide I
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    Cdk2/Cyclin Inhibitory Peptide I

    <p>CDK2, a Ser/Thr kinase, is akin to yeast cdc28 and human Cdk1, crucial for cell division.</p>
    Formula:C111H196N48O23
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2571.05

    Ref: TM-TP2192

  • CymitQuimica logo
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    NecroIr1

    <p>NecroIr1, an iridium(III) complex, induces necroptosis in Cisplatin-resistant lung cells, targeting mitochondria and disrupting MMP.</p>
    Formula:C40H29ClIrN5O
    Color and Shape:Solid
    Molecular weight:823.36

    Ref: TM-T74680

  • PROTAC CDK9 degrader-5
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    PROTAC CDK9 degrader-5

    CAS:
    <p>PROTAC CDK9 degrader-5 selectively degrades CDK9 isoforms 42, 55 with DC50 of 0.10μM, 0.14μM via proteasome.</p>
    Formula:C42H48Cl2N8O9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:879.78

    Ref: TM-T74851

  • SNX7
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    SNX7

    CAS:
    <p>SNX7 (WAY-323879) inhibits CDKI pathway; useful for studying aging and related diseases.</p>
    Formula:C15H14N2O
    Purity:99.05%
    Color and Shape:Solid
    Molecular weight:238.28

    Ref: TM-T77613

  • CPS2
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    CPS2

    CAS:
    <p>CPS2: potent, selective PROTAC CDK2 degrader. IC50=24nM, targets acute myeloid leukemia research.</p>
    Formula:C38H42N12O10S2
    Color and Shape:Solid
    Molecular weight:890.94

    Ref: TM-T74181

  • CDK7-IN-5
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    CDK7-IN-5

    CAS:
    <p>CDK7-IN-5, a CDK7 inhibitor with an IC 50 value of less than 100 nM, exhibits potent anticancer properties (WO2015154022A1, Compound 104).</p>
    Formula:C34H45N9O2
    Color and Shape:Solid
    Molecular weight:611.795

    Ref: TM-T39247

  • PROTAC CDK9 degrader-2
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    PROTAC CDK9 degrader-2

    CAS:
    <p>PROTAC CDK9 degrader-2, potent, selective, IC50 17 μM in MCF-7, wogonin-derived, targets CRBN.</p>
    Formula:C39H36N6O10
    Purity:98%
    Color and Shape:Solid
    Molecular weight:748.74

    Ref: TM-T17728

  • BSJ-03-204
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    BSJ-03-204

    CAS:
    <p>BSJ-03-204 is a selective Cdk4/6 degrader.</p>
    Formula:C43H48N10O8
    Color and Shape:Solid
    Molecular weight:832.9

    Ref: TM-T30600

  • TMX-2138
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    TMX-2138

    CAS:
    <p>TMX-2138 is a CDKs PROTAC degrader, with IC50 values of 8.7 nM for CDK1/cyclinB, 10.9 nM for CDK2/cyclinA, 7.0 nM for CDK5/p25, and 25.7 nM for CDK9/cyclinT1. It enhances the ubiquitination and degradation of CDKs and is utilized for ovarian cancer research.</p>
    Formula:C40H43BrFN9O11S
    Color and Shape:Solid
    Molecular weight:956.791

    Ref: TM-T204343

  • CymitQuimica logo
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    EGFR/CDK2-IN-4

    <p>EGFR/CDK2-IN-4 (compound 4c) is a dual inhibitor targeting EGFR and CDK-2, demonstrating IC50 values of 89.6 nM for EGFR and 165.4 nM for CDK-2.</p>
    Formula:C24H16N6OS2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:468.55

    Ref: TM-T79729

  • JH-XI-10-02
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    JH-XI-10-02

    CAS:
    <p>JH-XI-10-02 selectively degrades CDK8 (IC50: 159 nM) through proteasome, sparing CDK8 mRNA and CDK19.</p>
    Formula:C53H69N5O9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:920.161

    Ref: TM-T13743