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CDK

CDK

CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.

Found 500 products of "CDK"

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  • Cdc7-IN-1
    Targetmol
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    Cdc7-IN-1

    CAS:
    <p>Cdc7-IN-1: selective ATP-competitive Cdc7 kinase inhibitor; IC50 0.6 nM at 1mM ATP; induces cancer cell death.</p>
    Formula:C21H16ClN3O4
    Color and Shape:Solid
    Molecular weight:409.82

    Ref: TM-T10724

  • CDK9-IN-14
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    CDK9-IN-14

    CAS:
    <p>CDK9-IN-14: Potent CDK9 inhibitor, IC50=6.92 nM, effective on MV-4-11 cells and in vivo tumors, low toxicity, minimal side effects.</p>
    Formula:C21H23F2N3O4
    Color and Shape:Solid
    Molecular weight:419.42

    Ref: TM-T62203

  • CLK1/2-IN-3
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    CLK1/2-IN-3

    CAS:
    <p>CLK1/2-IN-3 (Cpd-3) is a CLK1 and CLK2 inhibitor with antiproliferative activity that inhibits the activity of CLK and SRPK.</p>
    Formula:C21H21N5O2
    Purity:99.04%
    Color and Shape:Solid
    Molecular weight:375.42

    Ref: TM-T23897

  • THZ1-R
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    THZ1-R

    CAS:
    <p>THZ1-R is a non-covalent active analogue of THZ1, with the acrylamide group removed from THZ1, not covalently bind to the C312 cysteine residue of CDK7.</p>
    Formula:C31H30ClN7O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:568.07

    Ref: TM-T13153

  • CLK1-IN-1
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    CLK1-IN-1

    CAS:
    <p>CLK1-IN-1 is a potent and selective inhibitor of the Cdc2-like kinase 1 (CLK1; IC50: 2 nM).</p>
    Formula:C24H16FN5O
    Color and Shape:Solid
    Molecular weight:409.42

    Ref: TM-T10836

  • CDK12-IN-E9
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    CDK12-IN-E9

    CAS:
    <p>CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux.</p>
    Formula:C24H30N6O2
    Color and Shape:Solid
    Molecular weight:434.53

    Ref: TM-T14915

  • Cdc7-IN-17
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    Cdc7-IN-17

    CAS:
    <p>Cdc7-IN-17 is a potent inhibitor of CDC7 with an IC 50 of &lt;10 μM that can be used in cancer research [1].</p>
    Formula:C13H15N5OS
    Color and Shape:Solid
    Molecular weight:289.36

    Ref: TM-T60589

  • AS2863619 free base
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    AS2863619 free base

    CAS:
    <p>AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells.</p>
    Formula:C16H12N8O
    Color and Shape:Solid
    Molecular weight:332.32

    Ref: TM-T10382

  • Cdc7-IN-4
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    Cdc7-IN-4

    CAS:
    <p>Cdc7-IN-4 is a potent inhibitor of Cdc7 kinase.</p>
    Formula:C22H24F3N5O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:479.45

    Ref: TM-T10726

  • K 00546
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    K 00546

    CAS:
    <p>K00546 inhibits CDK1/cyclin B (IC50: 0.6 nM), CDK2/cyclin A (IC50: 0.5 nM), CLK1 (IC50: 8.9 nM), and CLK3 (IC50: 29.2 nM).</p>
    Formula:C15H13F2N7O2S2
    Purity:99.12%
    Color and Shape:Solid
    Molecular weight:425.44

    Ref: TM-T21950

  • CDK8-IN-7
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    CDK8-IN-7

    CAS:
    <p>CDK8-IN-7 is a potent CDK8 inhibitor with a Kd of 3.5 nM, showing promise for AML research.</p>
    Formula:C30H40N2
    Color and Shape:Solid
    Molecular weight:428.65

    Ref: TM-T62354

  • Cdc7-IN-15
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    Cdc7-IN-15

    CAS:
    <p>Cdc7-IN-15 (Example 108) is an inhibitor of cdc7 kinase that has potential to be used for cancer research [1].</p>
    Formula:C12H14N4OS
    Color and Shape:Solid
    Molecular weight:262.33

    Ref: TM-T60427

  • CP681301
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    CP681301

    CAS:
    <p>CP681301 is a potent CDK5 inhibitor with anti-tumor effects in Drosophila and reduces Glioma stem cells' growth and renewal.</p>
    Formula:C17H22N4O
    Color and Shape:Solid
    Molecular weight:298.38

    Ref: TM-T60661

  • MDK6204
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    MDK6204

    CAS:
    <p>MDK6204 is a selective inhibitor of CLK1 and CLK2.</p>
    Formula:C20H20N6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:360.41

    Ref: TM-T24439

  • BSJ-01-175
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    BSJ-01-175

    CAS:
    <p>BSJ-01-175: Selective, potent covalent inhibitor of CDK12/13, targets cancer cells, inhibits phosphorylated RNA polymerase II, downregulates CDK12 genes.</p>
    Formula:C30H33ClN6O2
    Color and Shape:Solid
    Molecular weight:545.08

    Ref: TM-T63841

  • Indirubin-3'-monoxime-5-sulphonic acid
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    Indirubin-3'-monoxime-5-sulphonic acid

    CAS:
    <p>Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of GSK-3β, CDK5, and CDK1 with IC50s of 80nM,5 nM, and 7 nM, respectively.</p>
    Formula:C16H11N3O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:357.34

    Ref: TM-T11652

  • CDK7-IN-13
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    CDK7-IN-13

    CAS:
    <p>CDK7-IN-13: A potent pyrimidine-based CDK7 inhibitor, potential for various cancers. See CN114249712A.</p>
    Formula:C20H23F3N6OS
    Purity:99.22%
    Color and Shape:Solid
    Molecular weight:452.5

    Ref: TM-T62759

  • P18IN003
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    P18IN003

    CAS:
    <p>P18IN003 is a selective and effective p18(INK4C) inhibitor that inhibits the activity of p18 protein and can be used to study in vitro expansion of</p>
    Formula:C17H16N2O3
    Purity:98.77%
    Color and Shape:Solid
    Molecular weight:296.32

    Ref: TM-T24580

  • CDK7-IN-20
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    CDK7-IN-20

    <p>CDK7-IN-20: potent, irreversible CDK7 inhibitor, IC50 of 4nM, 206x selectivity vs. other CDKs, potential for ADPKD study.</p>
    Formula:C30H26N6O3
    Color and Shape:Solid
    Molecular weight:518.57

    Ref: TM-T73163

  • FLT3/CDK4-IN-1
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    FLT3/CDK4-IN-1

    CAS:
    <p>FLT3/CDK4-IN-1: Oral FLT3 (7 nM IC50) &amp; CDK4 (11 nM IC50) inhibitor with strong in vivo anti-cancer properties.</p>
    Formula:C25H28F2N8
    Color and Shape:Solid
    Molecular weight:478.54

    Ref: TM-T63135

  • BS-181
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    BS-181

    CAS:
    <p>BS-181 is a highly selective CDK7 inhibitor (IC50: 21 nM); &gt;40-fold selective for CDK7 than CDK1/2/4/5/6/9.</p>
    Formula:C22H32N6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:380.53

    Ref: TM-T1947

  • CDK4/6-IN-12
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    CDK4/6-IN-12

    CAS:
    <p>CDK4/6-IN-12 inhibits CDK4/6 with IC50s of 592.3 nM &amp; 3090 nM, useful in cancer research.</p>
    Formula:C12H10N6
    Color and Shape:Solid
    Molecular weight:238.25

    Ref: TM-T60328

  • CGP60474
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    CGP60474

    CAS:
    <p>CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC.</p>
    Formula:C18H18ClN5O
    Purity:98.81%
    Color and Shape:Solid
    Molecular weight:355.82

    Ref: TM-T14943

  • CCT068127
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    CCT068127

    CAS:
    <p>CCT068127 is a potent CDK2 and CDK9 inhibitor.</p>
    Formula:C19H27N7O
    Color and Shape:Solid
    Molecular weight:369.46

    Ref: TM-T68913

  • (S)-CR8
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    (S)-CR8

    CAS:
    <p>(S)-CR8 is an effective second-generation cyclin-dependent kinase inhibitor.</p>
    Formula:C24H29N7O
    Color and Shape:Solid
    Molecular weight:431.53

    Ref: TM-T23577

  • CDK7-IN-8
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    CDK7-IN-8

    CAS:
    <p>CDK7-IN-8 is a potent inhibitor of CDK7 (IC50: 54.29 nM) and exhibits inhibitory activity against several cancer cells and in vivo tumor models.</p>
    Formula:C25H38N8O3
    Color and Shape:Solid
    Molecular weight:498.62

    Ref: TM-T63381

  • EGFR/HER2/CDK9-IN-3
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    EGFR/HER2/CDK9-IN-3

    CAS:
    <p>EGFR/HER2/CDK9-IN-3 inhibits EGFR (191.08 nM IC50), HER2 (132.65 nM), CDK9 (113.98 nM); shows anti-tumor effects.</p>
    Formula:C24H21N3O4S2
    Color and Shape:Solid
    Molecular weight:479.57

    Ref: TM-T63161

  • Aloisine A
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    Aloisine A

    CAS:
    <p>Aloisine A, a CDK/GSK-3 inhibitor with IC50: Cdk1/B-150nM, Cdk2/A-120nM, Cdk2/E-400nM, Cdk5/25-200nM, Cdk5/35-160nM, GSK-3α-500nM, GSK-3β-650nM, JNK-3-10μM.</p>
    Formula:C16H17N3O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:267.33

    Ref: TM-T21377

  • TP1287
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    TP1287

    CAS:
    <p>TP-1287 is an oral phosphate prodrug of the CDK9 inhibitor, alvocidib.</p>
    Formula:C21H21ClNO8P
    Color and Shape:Solid
    Molecular weight:481.82

    Ref: TM-T69965

  • Indirubin-5-sulfonate
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    Indirubin-5-sulfonate

    CAS:
    <p>Indirubin-5-sulfonate inhibits GSK-3β &amp; CDKs with IC50: 55/35/150/300/65 nM for CDK1/B, 2/A&amp;E, 4/D1, 5/p35.</p>
    Formula:C16H10N2O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:342.33

    Ref: TM-T11653

  • Crozbaciclib fumarate
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    Crozbaciclib fumarate

    CAS:
    <p>Crozbaciclib fumarate is a CDK4/6 inhibitor with IC 50 s of 3 and 1 nM, respectively.</p>
    Formula:C32H34F2N6O4
    Color and Shape:Solid
    Molecular weight:604.65

    Ref: TM-T72393

  • CDK7-IN-12
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    CDK7-IN-12

    CAS:
    <p>CDK7-IN-12 inhibits CDK7 to control transcription and cell cycle, halting tumor growth in vitro/vivo with cancer research potential.</p>
    Formula:C20H19F3N6
    Color and Shape:Solid
    Molecular weight:400.4

    Ref: TM-T61922

  • CDK1-IN-1
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    CDK1-IN-1

    CAS:
    <p>CDK1-IN-7 inhibits CDK1 at 161.2 nM, triggers p53-dependent apoptosis, and selectively targets tumor growth.</p>
    Formula:C27H23N5O3
    Color and Shape:Solid
    Molecular weight:465.5

    Ref: TM-T62970

  • CDK4/6-IN-9
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    CDK4/6-IN-9

    CAS:
    <p>CDK4/6-IN-9 selectively inhibits CDK4/6 (IC50: 905 nM); potential for MM research.</p>
    Formula:C22H23FN8
    Color and Shape:Solid
    Molecular weight:418.47

    Ref: TM-T62192

  • Cdc7-IN-13
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    Cdc7-IN-13

    CAS:
    <p>Cdc7-IN-13 (compound 84) is a highly potent CDC7 inhibitor, exhibiting an IC50 value of &lt;1 nM. This compound holds promise for cancer research [1].</p>
    Formula:C18H20N4O2S
    Color and Shape:Solid
    Molecular weight:356.44

    Ref: TM-T61288

  • Ulecaciclib
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    Ulecaciclib

    CAS:
    <p>Ulecaciclib: oral, BBB-permeable CDK inhibitor; favorable pharmacokinetics; ki: 0.62 μM (CDK2/A), 3 nM (CDK6/D3), 0.2 nM (CDK4/D1), 0.63 μM (CDK7/H).</p>
    Formula:C25H33FN8S
    Color and Shape:Solid
    Molecular weight:496.65

    Ref: TM-T63362

  • FN-1501
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    FN-1501

    CAS:
    <p>FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively).</p>
    Formula:C22H25N9O
    Purity:97.4%
    Color and Shape:Solid
    Molecular weight:431.49

    Ref: TM-T15335

  • JTK-101
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    JTK-101

    CAS:
    <p>JTK-101 is a potent and selective Tat-dependent HIV-1 replication inhibitor.</p>
    Formula:C25H23N3O3
    Color and Shape:Solid
    Molecular weight:413.47

    Ref: TM-T24221

  • (E/Z)-BIO-acetoxime
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    (E/Z)-BIO-acetoxime

    CAS:
    <p>(E/Z)-BIO-acetoxime: potent GSK-3 α/β inhibitor; IC50: GSK-3α/β 10nM, CDK5/p25 2.4μM, CDK2/A 4.3μM, CDK1/B 63μM.</p>
    Formula:C18H12BrN3O3
    Color and Shape:Solid
    Molecular weight:398.21

    Ref: TM-T61890

  • (S)-LY3177833 hydrate
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    (S)-LY3177833 hydrate

    CAS:
    <p>(S)-LY3177833 ((S)-Example 2) hydrate, an orally active CDC7 kinase inhibitor, exhibits extensive in vitro anticancer efficacy.</p>
    Formula:C16H14FN5O2
    Color and Shape:Solid
    Molecular weight:327.31

    Ref: TM-T72384

  • RP-106
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    RP-106

    CAS:
    <p>RP-106 is an ATP-competitive inhibitor of CDK5/p25, CDK1/cyclin B, and GSK-3.</p>
    Formula:C17H19N3O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:281.35

    Ref: TM-T24734

  • PKC-9
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    PKC-9

    CAS:
    <p>PKC-9 is a PKC-zeta inhibitor 9.</p>
    Formula:C25H25N7
    Color and Shape:Solid
    Molecular weight:423.51

    Ref: TM-T71993

  • CDK4/6-IN-7
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    CDK4/6-IN-7

    CAS:
    <p>CDK4/6-IN-7 is an oral, potent CDK4/6 inhibitor with IC50s of 1.58/4.09 nM, crucial for breast cancer studies.</p>
    Formula:C18H18ClN5O3
    Color and Shape:Solid
    Molecular weight:387.82

    Ref: TM-T61738

  • Cdc7-IN-3
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    Cdc7-IN-3

    CAS:
    <p>Cdc7-IN-3 is a potent inhibitor of Cdc7 kinase.</p>
    Formula:C20H22N4O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:398.41

    Ref: TM-T10725

  • CDK7-IN-2
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    CDK7-IN-2

    CAS:
    <p>CDK7-IN-2 inhibits CDK7, essential for RNA polymerase II activation and cell cycle control, with cancer research potential.</p>
    Formula:C26H39N7O3
    Color and Shape:Solid
    Molecular weight:497.63

    Ref: TM-T63368

  • EGFR/HER2/CDK9-IN-1
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    EGFR/HER2/CDK9-IN-1

    CAS:
    <p>EGFR/HER2/CDK9-IN-1 is a potent inhibitor (IC50: EGFR 90.17 nM, HER2 131.39 nM, CDK9 67.04 nM) with notable anti-tumor activity.</p>
    Formula:C23H21N3O3S2
    Color and Shape:Solid
    Molecular weight:451.56

    Ref: TM-T62746

  • CDK5 inhibitor 20-223
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    CDK5 inhibitor 20-223

    CAS:
    <p>CDK5 inhibitor 20-223 is a potent CDK2/CDK5 inhibitor,anti-Colorectal Cancer (CRC), inhibiting cell migration and inducing cell cycle arrest.</p>
    Formula:C19H19N3O
    Color and Shape:Solid
    Molecular weight:305.37

    Ref: TM-T36742

  • FN-1501-propionic acid
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    FN-1501-propionic acid

    CAS:
    <p>FN-1501-propionic acid, a CDK2/9 ligand, in conjunction with a CRBN ligand, has been utilized in the design of a PROTAC CDK2/9 degrader.</p>
    Formula:C25H27N9O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:517.54

    Ref: TM-T13696

  • EGFR/HER2/CDK9-IN-2
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    EGFR/HER2/CDK9-IN-2

    CAS:
    <p>EGFR/HER2/CDK9-IN-2 inhibits EGFR, HER2, CDK9 with IC50s: 145.35, 129.07, 117.13 nM; strong antitumor effects.</p>
    Formula:C23H20N4O5S2
    Color and Shape:Solid
    Molecular weight:496.56

    Ref: TM-T63357

  • CDK8-IN-10
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    CDK8-IN-10

    CAS:
    <p>CDK8-IN-10 is a selective and potent inhibitor of cell cycle protein-dependent kinase (CDK8) (IC50: 8.25 nM) that can be used to study cancer.</p>
    Formula:C25H15ClF3N5O3
    Color and Shape:Solid
    Molecular weight:525.87

    Ref: TM-T63690