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CDK

CDK

CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.

Found 500 products of "CDK"

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  • CDK4/6-IN-8
    Targetmol
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    CDK4/6-IN-8

    CAS:
    <p>CDK4/6-IN-8 (Compound 7p) is a selective inhibitor of CDK4 (IC50=5.01 nM) and CDK6 (IC50=3.97 nM).</p>
    Formula:C18H18N6O5
    Color and Shape:Solid
    Molecular weight:398.37

    Ref: TM-T61892

  • AS-0141
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    AS-0141

    CAS:
    <p>AS-0141 (Cdc7-IN-6) 是一种有效的 Cdc7 激酶抑制剂 (IC50=4 nM)，具有抗肿瘤活性。Cdc7 是一种丝氨酸苏氨酸蛋白激酶酶，在细胞周期中对 DNA 复制的启动至关重要。</p>
    Formula:C21H22F3N5O4
    Purity:99.97%
    Color and Shape:Solid
    Molecular weight:465.43

    Ref: TM-T10728

  • Ryuvidine
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    Ryuvidine

    CAS:
    <p>Ryuvidine is a dual inhibitor of KDM5A and SETD8, an inducer of the DNA damage response, and can be used to study breast cancer and erythroderma.</p>
    Formula:C15H12N2O2S
    Purity:98.6%
    Color and Shape:Solid
    Molecular weight:284.33

    Ref: TM-T23284

  • (S)-Enitociclib
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    (S)-Enitociclib

    CAS:
    <p>(S)-Enitociclib (VIP152) is a selective CDK9 inhibitor that inhibits the transcription of anti-apoptotic and pro-survival proteins.</p>
    Formula:C19H18F2N4O2S
    Purity:98.98%
    Color and Shape:Solid
    Molecular weight:404.43

    Ref: TM-T70388

  • CLK-IN-T3
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    CLK-IN-T3

    CAS:
    <p>CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.</p>
    Formula:C28H30N6O2
    Purity:99.61%
    Color and Shape:Solid
    Molecular weight:482.58

    Ref: TM-T14980

  • (S)-PF-06873600
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    (S)-PF-06873600

    CAS:
    <p>(S)-PF-06873600 is the S enantiomer of PF-06873600 which is an inhibitor of CDK.</p>
    Formula:C20H27F2N5O4S
    Purity:98.59%
    Color and Shape:Solid
    Molecular weight:471.52

    Ref: TM-T12809

  • CDK9-IN-10
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    CDK9-IN-10

    CAS:
    <p>CDK9-IN-10 is a potent CDK9 inhibitor and the ligand for the PROTAC CDK9 degrader-2.</p>
    Formula:C22H16O5
    Purity:99.8%
    Color and Shape:Solid
    Molecular weight:360.36

    Ref: TM-T10742

  • PS423
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    PS423

    CAS:
    <p>PS423 is a substrate-selective protein kinase PDK1 inhibitor that acts by binding to the PIF-pocket allosteric docking site.</p>
    Formula:C25H23F3O9
    Purity:98.81% - 99.26%
    Color and Shape:Solid
    Molecular weight:524.44

    Ref: TM-T24676

  • HTH-01-091
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    HTH-01-091

    CAS:
    <p>HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3,</p>
    Formula:C26H28Cl2N4O2
    Purity:98.4%
    Color and Shape:Solid
    Molecular weight:499.43

    Ref: TM-T24152

  • hSMG-1 inhibitor 11e
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    hSMG-1 inhibitor 11e

    CAS:
    <p>hSMG-1 inhibitor 11e is an effective and selective inhibitor of hSMG-1 (IC50 &lt;0.05 nM) and can be used in studies about cancer treatment.</p>
    Formula:C26H27N7O3S
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:517.6

    Ref: TM-T35529

  • CDK-IN-2
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    CDK-IN-2

    CAS:
    <p>CDK-IN-2 (CDK inhibitor II) is a potent and specific CDK9 inhibitor (IC50: &lt;8 nM).</p>
    Formula:C18H19ClFN3O2
    Purity:99.67%
    Color and Shape:Solid
    Molecular weight:363.81

    Ref: TM-TQ0078

  • 9-Isopropylolomoucine
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    9-Isopropylolomoucine

    CAS:
    <p>9-Isopropylolomoucine (N9-Isopropylolomoucine), a cell cycle protein-dependent kinase inhibitor, is a thiopurine.</p>
    Formula:C17H22N6O
    Purity:99.82%
    Color and Shape:Solid
    Molecular weight:326.4

    Ref: TM-T23589

  • CDK8-IN-1
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    CDK8-IN-1

    CAS:
    <p>CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).</p>
    Formula:C11H8F3N3O
    Purity:98.48%
    Color and Shape:Solid
    Molecular weight:255.2

    Ref: TM-T10740

  • Cdc7-IN-7c
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    Cdc7-IN-7c

    CAS:
    <p>Cdc7-IN-7c (Cdc7 inhibitor-7c) has antitumor activity and has inhibitory effect on liver cancer, lung cancer, kidney cancer, brain cancer and cervical cancer.</p>
    Formula:C15H17N5OS
    Purity:98.19% - 99.22%
    Color and Shape:Solid
    Molecular weight:315.39

    Ref: TM-T23867

  • SEL120-34A
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    SEL120-34A

    CAS:
    <p>SEL120-34A inhibits CDK8 (IC50: 4.4 nM) &amp; CDK19 (10.4 nM), less on CDK9 (1070 nM), has antitumor properties.</p>
    Formula:C15H18Br2N4
    Purity:99.764% - 99.84%
    Color and Shape:Solid
    Molecular weight:414.14

    Ref: TM-T10744

  • CDK4/6/1 Inhibitor
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    CDK4/6/1 Inhibitor

    CAS:
    <p>CDK4/6/1 Inhibitor (Crozbaciclib) is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM).</p>
    Formula:C28H30F2N6
    Purity:99.26% - 99.72%
    Color and Shape:Solid
    Molecular weight:488.57

    Ref: TM-T10735

  • BML-259
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    BML-259

    CAS:
    <p>BML-259 inhibits CDK5/CDK2 (IC50: 64/98 nM) for cancer and neurodegeneration research.</p>
    Formula:C14H16N2OS
    Purity:99.84%
    Color and Shape:Solid
    Molecular weight:260.35

    Ref: TM-T36964

  • dCeMM2
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    dCeMM2

    CAS:
    <p>dCeMM2 degrades glue by promoting CDK12-cyclin K ubiquitination and degradation via CRL4B ligase interaction.</p>
    Formula:C16H11ClN6OS
    Purity:99.68%
    Color and Shape:Solid
    Molecular weight:370.82

    Ref: TM-T61477

  • Cdk2 Inhibitor II
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    Cdk2 Inhibitor II

    CAS:
    <p>Cdk2 Inhibitor II is a selective and potent CDK2 inhibitor50 at 60 nM.</p>
    Formula:C14H11BrN4O3S
    Purity:97.07%
    Color and Shape:Solid
    Molecular weight:395.23

    Ref: TM-T36933

  • Abemaciclib metabolite M20
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    Abemaciclib metabolite M20

    CAS:
    <p>Abemaciclib metabolite M20 (CDK4/6-IN-4) 是 Abemaciclib 的活性代谢物。 Abemaciclib metabolite M20 是一种特异性 CDK4/6 抑制剂，可用于癌症治疗的相关研究。</p>
    Formula:C27H32F2N8O
    Purity:98.1% - 99.08%
    Color and Shape:Solid
    Molecular weight:522.59

    Ref: TM-T10738

  • SHP2/CDK4-IN-1
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    SHP2/CDK4-IN-1

    CAS:
    <p>SHP2/CDK4-IN-1: dual inhibitor, oral, potent (IC50: SHP2 4.3 nM, CDK4 18.2 nM), hinders TNBC growth, strong antitumor effects in mice.</p>
    Formula:C33H35ClF2N10OS
    Color and Shape:Solid
    Molecular weight:693.21

    Ref: TM-T72836

  • CDK-IN-11
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    CDK-IN-11

    CAS:
    <p>CDK-IN-11, a heterocyclic compound, promotes cardiomyocyte maturation [1].</p>
    Formula:C25H21BrN4O2
    Color and Shape:Solid
    Molecular weight:489.36

    Ref: TM-T84917

  • CDK/HDAC-IN-3
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    CDK/HDAC-IN-3

    CAS:
    <p>CDK/HDAC-IN-3 is an orally active dual inhibitor of HDACs and CDKs, offering potent and selective inhibition of CDK9, CDK12, CDK13, HDAC1, HDAC2, and HDAC3,</p>
    Formula:C24H18Cl2N6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:509.34

    Ref: TM-T78906

  • Cdk4 Inhibitor
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    Cdk4 Inhibitor

    CAS:
    <p>PD 0332991, an unsymmetrical indolocarbazole compound, is cell-permeable and exhibits antiproliferative effects by functioning as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk4/D1 (IC 50 = 76 nM). Although it can inhibit other Cdks, such as Cdk2/E and Cdk1/B, effectiveness requires higher concentrations (IC 50 = 520 nM and 2.1 µM, respectively) and demonstrates minimal activity against CaMKII, PKA, or GSK-3β (IC 50 ≥ 12.4 µM). PD 0332991 efficiently inhibits tumor cell growth in HCT-116 and NCI-H460 cell lines with an IC 50 &lt; 3.0 µM, primarily through blocking Rb phosphorylation and inducing G1 cell cycle arrest.</p>
    Formula:C20H10BrN3O2
    Color and Shape:Solid
    Molecular weight:404.2

    Ref: TM-T84413

  • EHT 5372
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    EHT 5372

    CAS:
    <p>EHT 5372 inhibits DYRK kinases; IC50: 0.22-221 nM for DYRK1A/B, DYRK2/3, CLK1/2/4, GSK-3α/β.</p>
    Formula:C17H11Cl2N5OS
    Color and Shape:Solid
    Molecular weight:404.27

    Ref: TM-T61985

  • Nε-(1-Carboxyethyl)-L-lysine
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    Nε-(1-Carboxyethyl)-L-lysine

    CAS:
    <p>Nε-(1-Carboxyethyl)-L-lysine (CEL) is an advanced glycation end-product (AGE). Exposure to CEL reduces glutamate uptake and S100B secretion in the hippocampus.</p>
    Formula:C9H18N2O4
    Color and Shape:Solid
    Molecular weight:218.25

    Ref: TM-T85157

  • Lerociclib
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    Lerociclib

    CAS:
    <p>Lerociclib (G1T38) is a CDK4/6 inhibitor with anticancer and antitumor activities, inhibiting CDK4/CyclinD1 and CDK6/CyclinD3.</p>
    Formula:C26H34N8O
    Purity:99%
    Color and Shape:Solid
    Molecular weight:474.6

    Ref: TM-T11345

  • CDK8-IN-3
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    CDK8-IN-3

    CAS:
    <p>CDK8-IN-3 is an inhibitor of CDK8.</p>
    Formula:C22H23N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:389.45

    Ref: TM-T14917

  • CDK9-IN-29
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    CDK9-IN-29

    CAS:
    <p>CDK9-IN-29 (compound Z11) is a potent inhibitor of CDK9, exhibiting high kinase selectivity and an IC50 value of 3.20 nM.</p>
    Formula:C29H33F2N5O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:553.6

    Ref: TM-T82757

  • IIIM-290
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    IIIM-290

    CAS:
    <p>IIIM-290 is an oral CDK inhibitor (IC50s: 90 and 94 nM for CDK2/A and CDK9/T1).</p>
    Formula:C23H21Cl2NO5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:462.32

    Ref: TM-T11632

  • CCT-251921
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    CCT-251921

    CAS:
    <p>CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).</p>
    Formula:C21H23ClN6O
    Purity:99.07%
    Color and Shape:Solid
    Molecular weight:410.9

    Ref: TM-T14901

  • CDK9-IN-8
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    CDK9-IN-8

    CAS:
    <p>CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).</p>
    Formula:C31H32FN7O3
    Purity:99.54%
    Color and Shape:Solid
    Molecular weight:569.63

    Ref: TM-T10746

  • QR-6401
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    QR-6401

    CAS:
    <p>QR-6401, a selective macrocyclic CDK2 inhibitor, is orally active with IC50 values of 0.37 nM for CDK2/E1, 10 nM for CDK9/T1, 22 nM for CDK1/A2, 34 nM for CDK6/</p>
    Formula:C19H23N5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:369.42

    Ref: TM-T79014

  • Tacaciclib
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    Tacaciclib

    CAS:
    <p>Tacaciclib is a cyclin-dependent kinase (CDK) inhibitor with observed antineoplastic activity [1].</p>
    Formula:C30H36N6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:528.65

    Ref: TM-T79862

  • Mevociclib
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    Mevociclib

    CAS:
    <p>Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.</p>
    Formula:C31H35ClN8O2
    Purity:98.02% - 98.02%
    Color and Shape:Solid
    Molecular weight:587.11

    Ref: TM-T13044

  • CymitQuimica logo
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    Palbociclib orotate

    CAS:
    <p>Palbociclib (PD 0332991) orotate, an orally active selective inhibitor of CDK4 and CDK6, exhibits IC50 values of 11 and 16 nM, respectively.</p>
    Formula:C29H33N9O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:603.63

    Ref: TM-T72507

  • KM05382
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    KM05382

    CAS:
    <p>KM05382 inhibits CDK9 and the transcription of GAPDH.</p>
    Formula:C20H19ClN2O3S2
    Color and Shape:Solid
    Molecular weight:434.96

    Ref: TM-T27735

  • CDK4-IN-2
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    CDK4-IN-2

    CAS:
    <p>CDK4-IN-2 (A17) is a potent inhibitor of CDK4, exhibiting K i and IC 50 values of less than 10 nM and is utilized in cancer research [1].</p>
    Formula:C22H26F2N6O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:508.54

    Ref: TM-T79046

  • DCB-3503
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    DCB-3503

    CAS:
    <p>DCB-3503, a tylophorine analog, may fight cancer and aid immunosuppression by hindering protein synthesis and modulating HSC70 ATPase function.</p>
    Formula:C24H27NO5
    Color and Shape:Solid
    Molecular weight:409.47

    Ref: TM-T27128

  • LDC3140
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    LDC3140

    CAS:
    <p>LDC3140 is a potent inhibitor of Cyclin-dependent kinase 7 (CDK7).</p>
    Formula:C23H33N7O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:423.55

    Ref: TM-T27805

  • Leucettinib-92
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    Leucettinib-92

    CAS:
    <p>Leucettinib-92 (compound 92) is a kinase inhibitor selective for DYRK/CLK families, displaying IC50 values of 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μM</p>
    Formula:C21H22N4OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:378.49

    Ref: TM-T79562

  • CDK9-IN-9
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    CDK9-IN-9

    CAS:
    <p>CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).</p>
    Formula:C22H23F2N5O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:459.51

    Ref: TM-T10747

  • (2S,3R)-Voruciclib
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    (2S,3R)-Voruciclib

    CAS:
    <p>(2S,3R)-Voruciclib is the (2S,3R)-enantiomer of Voruciclib. It is an orally active CDK inhibitor.</p>
    Formula:C22H19ClF3NO5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:469.84

    Ref: TM-T10096

  • CDK9-IN-2
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    CDK9-IN-2

    CAS:
    <p>CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.</p>
    Formula:C23H25ClFN5
    Purity:99%
    Color and Shape:Solid
    Molecular weight:425.93

    Ref: TM-T14918

  • CDK7-IN-14
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    CDK7-IN-14

    CAS:
    <p>CDK7-IN-14, a potent CDK7 inhibitor from pyrimidines, may treat transcriptionally dysregulated cancers (CN114249712A).</p>
    Formula:C22H24F3N6OP
    Color and Shape:Solid
    Molecular weight:476.43

    Ref: TM-T63108

  • 5-Iodo-indirubin-3'-monoxime
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    5-Iodo-indirubin-3'-monoxime

    CAS:
    <p>5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s</p>
    Formula:C16H10IN3O2
    Color and Shape:Solid
    Molecular weight:403.17

    Ref: TM-T10172

  • NU6300
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    NU6300

    CAS:
    <p>NU6300 is a covalent CDK2 inhibitor exhibiting irreversible and ATP-competitive properties and also functions as a GSDMD (Gasdermin D) inhibitor.</p>
    Formula:C20H23N5O3S
    Purity:96.08%
    Color and Shape:Solid
    Molecular weight:413.49

    Ref: TM-T16360

  • Voruciclib hydrochloride
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    Voruciclib hydrochloride

    CAS:
    <p>Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).</p>
    Formula:C22H20Cl2F3NO5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:506.3

    Ref: TM-T13309

  • PF-6808472
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    PF-6808472

    CAS:
    <p>PF-6808472 is a cell-permeable covalent kinase probe, reacts with conserved lysine residues within the ATP-binding site of kinases.</p>
    Formula:C25H27FN8O3S
    Purity:99.02%
    Color and Shape:Solid
    Molecular weight:538.6

    Ref: TM-T33955

  • CDK7-IN-22
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    CDK7-IN-22

    CAS:
    <p>CDK7-IN-22 (compound 101) is a selective CDK7 inhibitor that exhibits antitumor activity, demonstrating specificity for CDK7 [1].</p>
    Formula:C22H25F3N6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:430.47

    Ref: TM-T79169