CDK
CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.
Found 546 products of "CDK"
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EGFR/HER2/CDK9-IN-3
CAS:EGFR/HER2/CDK9-IN-3 inhibits EGFR (191.08 nM IC50), HER2 (132.65 nM), CDK9 (113.98 nM); shows anti-tumor effects.Formula:C24H21N3O4S2Color and Shape:SolidMolecular weight:479.57PKC-9
CAS:PKC-9 is a PKC-zeta inhibitor 9.Formula:C25H25N7Color and Shape:SolidMolecular weight:423.51CDK7-IN-15
CAS:CDK7-IN-15 (Compound 8) is an effective CDK7 inhibitor for studying cancers associated with transcriptional dysregulation.Formula:C21H24F4N6OSPurity:99.27%Color and Shape:SolidMolecular weight:484.51CDK7-IN-10
CAS:CDK7-IN-10: CDK7 inhibitor, IC50<100 nM, may hinder cell growth, induce apoptosis. (Patent WO2021016388A1, I-1)Formula:C29H35N7O3Color and Shape:SolidMolecular weight:529.63CDK7-IN-16
CAS:CDK7-IN-16, a potent CDK7 inhibitor (IC50: 1-10 nM), is used in cancer research with transcription defects.Formula:C19H21F3N6O2SColor and Shape:SolidMolecular weight:454.47CDK9-IN-14
CAS:CDK9-IN-14: Potent CDK9 inhibitor, IC50=6.92 nM, effective on MV-4-11 cells and in vivo tumors, low toxicity, minimal side effects.Formula:C21H23F2N3O4Color and Shape:SolidMolecular weight:419.42Cdc7-IN-17
CAS:Cdc7-IN-17 is a potent inhibitor of CDC7 with an IC 50 of <10 μM that can be used in cancer research [1].Formula:C13H15N5OSColor and Shape:SolidMolecular weight:289.36K 00546
CAS:K00546 inhibits CDK1/cyclin B (IC50: 0.6 nM), CDK2/cyclin A (IC50: 0.5 nM), CLK1 (IC50: 8.9 nM), and CLK3 (IC50: 29.2 nM).Formula:C15H13F2N7O2S2Purity:99.12%Color and Shape:SolidMolecular weight:425.44CDK8-IN-7
CAS:CDK8-IN-7 is a potent CDK8 inhibitor with a Kd of 3.5 nM, showing promise for AML research.Formula:C30H40N2Color and Shape:SolidMolecular weight:428.65Cdc7-IN-15
CAS:Cdc7-IN-15 (Example 108) is an inhibitor of cdc7 kinase that has potential to be used for cancer research [1].Formula:C12H14N4OSColor and Shape:SolidMolecular weight:262.33CP681301
CAS:CP681301 is a potent CDK5 inhibitor with anti-tumor effects in Drosophila and reduces Glioma stem cells' growth and renewal.Formula:C17H22N4OColor and Shape:SolidMolecular weight:298.38P18IN003
CAS:P18IN003 is a selective and effective p18(INK4C) inhibitor that inhibits the activity of p18 protein and can be used to study in vitro expansion ofFormula:C17H16N2O3Purity:99%Color and Shape:SolidMolecular weight:296.32CDK5 inhibitor 20-223
CAS:CDK5 inhibitor 20-223 is a potent CDK2/CDK5 inhibitor,anti-Colorectal Cancer (CRC), inhibiting cell migration and inducing cell cycle arrest.Formula:C19H19N3OColor and Shape:SolidMolecular weight:305.37Metralindole HCl
CAS:Metralindole is a reversible monoamine oxidase A (RIMA) inhibitor, it was investigated as a potential antidepressant.Formula:C15H18ClN3OPurity:98%Color and Shape:SolidMolecular weight:291.78Metralindole
CAS:Metralindole is a reversible inhibitor of monoamine oxidase A (RIMA).Formula:C15H17N3OColor and Shape:SolidMolecular weight:255.32Olomoucine II
CAS:Olomoucine II, a CDK inhibitor effective on Cdk1/2/4/7/9, also inhibits ERK2, ABCB1, and various virus replications, not effective on measles/influenza.Formula:C19H26N6O2Purity:99.94%Color and Shape:SolidMolecular weight:370.45SLM6
CAS:SLM6, an inhibitor of cyclin-dependent kinase-9 (CDK9), exhibits potent anti-multiple myeloma activity.Formula:C12H17N7O4Color and Shape:SolidMolecular weight:323.31CDK9/10/GSK3β-IN-1
CAS:CDK9/10/GSK3β-IN-1 is a kinase inhibitor (Flavopiridol analogue) that effectively inhibits HsGSK3β, HsCDK9/CyclinT, HsCDK5/p25 and HsCDK2/CyclinA with IC50Formula:C29H24ClN3O4SColor and Shape:SolidMolecular weight:546.04SMAPP1
CAS:SMAPP1 is an activator of protein phosphatase 1 (PP1). SMAPP1 induces PP1 activity in vitro and activates latent HIV-1 provirus in cultured and primary T cells.Formula:C27H25N5O5S2Purity:98%Color and Shape:SolidMolecular weight:563.65SLK/STK10-IN-1
CAS:SLK/STK10-IN-1 is a selective and potent inhibitor of SLK and STK10 with potential antitumor activity.Formula:C17H13ClN2O3Purity:99.34%Color and Shape:SolidMolecular weight:328.75GW8510
CAS:GW8510 is a CDK2 and RRM2 inhibitor that affects DNA synthesis and antiproliferation in tumor cells. In mammalian aging models, GW851 prolongs lifespan.Formula:C21H15N5O3S2Purity:99.32%Color and Shape:SolidMolecular weight:449.51β-catenin-IN-3
CAS:β-catenin-IN-3 is a selective and potent β-catenin inhibitor (KD: 54.96 nM) that targets a cryptic regulatory site of β-catenin and significantly reduces theFormula:C19H20Br2N2OSColor and Shape:SolidMolecular weight:484.25Alsterpaullone, 2-Cyanoethyl
CAS:Alsterpaullone, 2-Cyanoethyl is a selective dual inhibitor of Cdk1/cyclin B and GSK-3β.Formula:C19H14N4O3Color and Shape:SolidMolecular weight:346.34CDK-IN-10
CAS:CDK-IN-10 is a cell cycle protein-dependent kinase (CDK) inhibitor with potential anticancer activity for cancer research.Formula:C18H18N4O2Purity:97.07%Color and Shape:SolidMolecular weight:322.36Zotiraciclib HCl
CAS:Zotiraciclib (TG02/SB1317) is a CDK/JAK2/FLT3 inhibitor potentially treating Myc-overexpressing cancers, including glioblastoma.Formula:C23H26Cl2N4OColor and Shape:SolidMolecular weight:445.388AG-012986
CAS:AG-012986: a selective CDK inhibitor with in vitro and in vivo antitumor effects; low IC50 in 14/18 cancer cell types; CAS# 486414-35-1.Formula:C22H23F2N5O2SColor and Shape:SolidMolecular weight:459.51Aloisine B
CAS:Aloisine B (AloisineB) inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively.Formula:C15H14ClN3Purity:95.15%Color and Shape:SolidMolecular weight:271.74Cdc7-IN-5
CAS:Cdc7-IN-5: potent Cdc7 serine-threonine kinase inhibitor, critical for starting DNA replication.Formula:C25H23N3O5Purity:98.4%Color and Shape:SolidMolecular weight:445.47Ref: TM-T10727
1mg96.00€5mg227.00€10mg376.00€25mg620.00€50mg847.00€100mg1,169.00€1mL*10mM (DMSO)250.00€BS-181
CAS:BS-181 is a highly selective CDK7 inhibitor (IC50: 21 nM); >40-fold selective for CDK7 than CDK1/2/4/5/6/9.Formula:C22H32N6Purity:98%Color and Shape:SolidMolecular weight:380.53FN-1501
CAS:FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively).Formula:C22H25N9OPurity:97.4%Color and Shape:SolidMolecular weight:431.49Ref: TM-T15335
1mg87.00€5mg177.00€10mg295.00€25mg537.00€50mg807.00€100mg1,099.00€1mL*10mM (DMSO)203.00€CDK8-IN-4
CAS:CDK8-IN-4 is an inhibitor of CDK8 (IC50: 0.2 nM).Formula:C20H18N4OColor and Shape:SolidMolecular weight:330.38CDK12-IN-3
CAS:CDK12-IN-3 is a CDK12 inhibitor with anti-tumor activity and can be used for the study of malignant tumors.Formula:C23H28F2N8OPurity:99.85%Color and Shape:SolidMolecular weight:470.52Ref: TM-T14990
1mg101.00€5mg245.00€10mg401.00€25mg842.00€50mg1,701.00€100mg2,250.00€1mL*10mM (DMSO)254.00€Cdc7-IN-1
CAS:Cdc7-IN-1: selective ATP-competitive Cdc7 kinase inhibitor; IC50 0.6 nM at 1mM ATP; induces cancer cell death.Formula:C21H16ClN3O4Color and Shape:SolidMolecular weight:409.82CLK1/2-IN-3
CAS:CLK1/2-IN-3 (Cpd-3) is a CLK1 and CLK2 inhibitor with antiproliferative activity that inhibits the activity of CLK and SRPK.Formula:C21H21N5O2Purity:99.04%Color and Shape:SolidMolecular weight:375.42CDK12-IN-E9
CAS:CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux.Formula:C24H30N6O2Color and Shape:SolidMolecular weight:434.53AS2863619 free base
CAS:AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells.Formula:C16H12N8OColor and Shape:SolidMolecular weight:332.32CLK1-IN-1
CAS:CLK1-IN-1 is a potent and selective inhibitor of the Cdc2-like kinase 1 (CLK1; IC50: 2 nM).Formula:C24H16FN5OColor and Shape:SolidMolecular weight:409.42THZ1-R
CAS:THZ1-R is a non-covalent active analogue of THZ1, with the acrylamide group removed from THZ1, not covalently bind to the C312 cysteine residue of CDK7.Formula:C31H30ClN7O2Purity:98%Color and Shape:SolidMolecular weight:568.07CDK8/19-IN-51
CAS:CDK8/19-IN-51 is a CDK8 and CDK19 inhibitor with anticancer activity, used in research on colorectal and gastric cancers.Formula:C23H22N6O2Purity:98.65% - 99.62%Color and Shape:SoildMolecular weight:414.46HTH-01-091
CAS:HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3,Formula:C26H28Cl2N4O2Purity:98.82%Color and Shape:SolidMolecular weight:499.43Ref: TM-T24152
1mg281.00€5mg692.00€10mg938.00€25mg1,454.00€50mg1,882.00€100mg2,375.00€1mL*10mM (DMSO)775.00€BRD7389
CAS:BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.Formula:C24H18N2O2Purity:99.51%Color and Shape:SolidMolecular weight:366.41ML 315
CAS:ML 315 is a selective Clk and DYRK inhibitor with potential anticancer activity for the study of neurological disorders.Formula:C18H13Cl2N3O2Purity:99.08%Color and Shape:SolidMolecular weight:374.22CDK-IN-2
CAS:CDK-IN-2 (CDK inhibitor II) is a potent and specific CDK9 inhibitor (IC50: <8 nM).Formula:C18H19ClFN3O2Purity:99.67%Color and Shape:SolidMolecular weight:363.81Ref: TM-TQ0078
1mg38.00€2mg51.00€5mg96.00€10mg138.00€25mg258.00€50mg376.00€100mg532.00€500mg1,063.00€1mL*10mM (DMSO)92.00€CDK4/6/1 Inhibitor
CAS:CDK4/6/1 Inhibitor (Crozbaciclib) is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM).Formula:C28H30F2N6Purity:97.25% - 99.72%Color and Shape:SolidMolecular weight:488.57Abemaciclib metabolite M20
CAS:Abemaciclib metabolite M20 (CDK4/6-IN-4) 是 Abemaciclib 的活性代谢物。 Abemaciclib metabolite M20 是一种特异性 CDK4/6 抑制剂，可用于癌症治疗的相关研究。Formula:C27H32F2N8OPurity:98.1% - 99.08%Color and Shape:SolidMolecular weight:522.59Cdc7-IN-7c
CAS:Cdc7-IN-7c (Cdc7 inhibitor-7c) has antitumor activity and has inhibitory effect on liver cancer, lung cancer, kidney cancer, brain cancer and cervical cancer.Formula:C15H17N5OSPurity:98.19% - 99.22%Color and Shape:SolidMolecular weight:315.39Ref: TM-T23867
1mg315.00€5mg745.00€10mg1,018.00€25mg1,431.00€50mg1,783.00€100mg2,250.00€500mg4,410.00€1mL*10mM (DMSO)600.00€AS-0141
CAS:AS-0141 (Cdc7-IN-6) 是一种有效的 Cdc7 激酶抑制剂 (IC50=4 nM)，具有抗肿瘤活性。Cdc7 是一种丝氨酸苏氨酸蛋白激酶酶，在细胞周期中对 DNA 复制的启动至关重要。Formula:C21H22F3N5O4Purity:99.97%Color and Shape:SolidMolecular weight:465.43SJ572403
CAS:SJ572403 inhibits p27 protein, Kd 2.2 mM at D2 subdomain of p27-KID; useful in disordered protein disease research.Formula:C13H17N5O2Purity:99.93%Color and Shape:SolidMolecular weight:275.31Ref: TM-T16889
1mg39.00€5mg86.00€10mg119.00€25mg231.00€50mg371.00€100mg537.00€200mg710.00€1mL*10mM (DMSO)95.00€Cdk2 Inhibitor II
CAS:Cdk2 Inhibitor II is a selective and potent CDK2 inhibitor50 at 60 nM.Formula:C14H11BrN4O3SPurity:97.27%Color and Shape:SolidMolecular weight:395.23Ref: TM-T36933
1mg98.00€2mg133.00€5mg192.00€10mg289.00€25mg485.00€50mg692.00€100mg945.00€500mg1,873.00€SEL120-34A
CAS:SEL120-34A inhibits CDK8 (IC50: 4.4 nM) & CDK19 (10.4 nM), less on CDK9 (1070 nM), has antitumor properties.Formula:C15H18Br2N4Purity:99.764% - 99.84%Color and Shape:SolidMolecular weight:414.14Ref: TM-T10744
1mg612.00€5mg1,529.00€10mg1,880.00€25mg2,178.00€50mg2,862.00€100mg3,870.00€1mL*10mM (DMSO)1,835.00€
