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CDK

CDK

CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.

Found 526 products of "CDK"

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  • Ulecaciclib
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    Ulecaciclib

    CAS:
    Ulecaciclib: oral, BBB-permeable CDK inhibitor; favorable pharmacokinetics; ki: 0.62 μM (CDK2/A), 3 nM (CDK6/D3), 0.2 nM (CDK4/D1), 0.63 μM (CDK7/H).
    Formula:C25H33FN8S
    Color and Shape:Solid
    Molecular weight:496.65

    Ref: TM-T63362

  • CDK9-IN-15
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    CDK9-IN-15

    CAS:
    CDK9-IN-15: potent CDK9 inhibitor, blocks P-TEFb phosphorylation, inhibits transcription, reduces mRNA, induces tumor cell apoptosis.
    Formula:C16H11N3OS
    Purity:99.32%
    Color and Shape:Solid
    Molecular weight:293.34

    Ref: TM-T60619

  • CDK4/6-IN-7
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    CDK4/6-IN-7

    CAS:
    CDK4/6-IN-7 is an oral, potent CDK4/6 inhibitor with IC50s of 1.58/4.09 nM, crucial for breast cancer studies.
    Formula:C18H18ClN5O3
    Color and Shape:Solid
    Molecular weight:387.82

    Ref: TM-T61738

  • CDK8/19-IN-51
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    CDK8/19-IN-51

    CAS:
    CDK8/19-IN-51 is a CDK8 and CDK19 inhibitor with anticancer activity, used in research on colorectal and gastric cancers.
    Formula:C23H22N6O2
    Purity:98.65% - 99.62%
    Color and Shape:Soild
    Molecular weight:414.46

    Ref: TM-T22633

  • Alsterpaullone, 2-Cyanoethyl
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    Alsterpaullone, 2-Cyanoethyl

    CAS:
    Alsterpaullone, 2-Cyanoethyl is a selective dual inhibitor of Cdk1/cyclin B and GSK-3β.
    Formula:C19H14N4O3
    Color and Shape:Solid
    Molecular weight:346.34

    Ref: TM-T68555

  • FN-1501
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    FN-1501

    CAS:
    <p>FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively).</p>
    Formula:C22H25N9O
    Purity:97.4%
    Color and Shape:Solid
    Molecular weight:431.49

    Ref: TM-T15335

  • CGP60474
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    CGP60474

    CAS:
    CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC.
    Formula:C18H18ClN5O
    Purity:98.81%
    Color and Shape:Solid
    Molecular weight:355.82

    Ref: TM-T14943

  • CDK7-IN-12
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    CDK7-IN-12

    CAS:
    CDK7-IN-12 inhibits CDK7 to control transcription and cell cycle, halting tumor growth in vitro/vivo with cancer research potential.
    Formula:C20H19F3N6
    Color and Shape:Solid
    Molecular weight:400.4

    Ref: TM-T61922

  • Crozbaciclib fumarate
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    Crozbaciclib fumarate

    CAS:
    Crozbaciclib fumarate is a CDK4/6 inhibitor with IC 50 s of 3 and 1 nM, respectively.
    Formula:C32H34F2N6O4
    Color and Shape:Solid
    Molecular weight:604.65

    Ref: TM-T72393

  • JTK-101
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    JTK-101

    CAS:
    JTK-101 is a potent and selective Tat-dependent HIV-1 replication inhibitor.
    Formula:C25H23N3O3
    Color and Shape:Solid
    Molecular weight:413.47

    Ref: TM-T24221

  • EGFR/CDK2-IN-1
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    EGFR/CDK2-IN-1

    CAS:
    EGFR/CDK2-IN-1, an inhibitor of both EGFR and CDK2, demonstrates effective cytotoxicity towards MCF7 and HepG2 cells, suggesting its potential application in
    Formula:C19H12BrClO2
    Color and Shape:Solid
    Molecular weight:387.65

    Ref: TM-T72844

  • Cdc7-IN-3
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    Cdc7-IN-3

    CAS:
    Cdc7-IN-3 is a potent inhibitor of Cdc7 kinase.
    Formula:C20H22N4O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:398.41

    Ref: TM-T10725

  • FN-1501-propionic acid
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    FN-1501-propionic acid

    CAS:
    FN-1501-propionic acid, a CDK2/9 ligand, in conjunction with a CRBN ligand, has been utilized in the design of a PROTAC CDK2/9 degrader.
    Formula:C25H27N9O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:517.54

    Ref: TM-T13696

  • Ipivivint
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    Ipivivint

    CAS:
    <p>Ipivivint: orally active, potent CLK inhibitor; hinders CLK1, CLK2, &amp; CLK3; curbs Wnt signaling &amp; SRSF phosphorylation for cancer research.</p>
    Formula:C26H21FN8
    Color and Shape:Solid
    Molecular weight:464.5

    Ref: TM-T36684

  • CDK-IN-10
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    CDK-IN-10

    CAS:
    CDK-IN-10 is a cell cycle protein-dependent kinase (CDK) inhibitor with potential anticancer activity for cancer research.
    Formula:C18H18N4O2
    Purity:97.07%
    Color and Shape:Solid
    Molecular weight:322.36

    Ref: TM-T60869

  • CDK8-IN-6
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    CDK8-IN-6

    CAS:
    CDK8-IN-6 (compound 9) is a potent inhibitor of cyclin-dependent kinase 8 (CDK8) (Kd: 13 nM), CDK8-IN-6 showed potential research value in AML cancers.
    Formula:C26H37ClN2
    Color and Shape:Solid
    Molecular weight:413.04

    Ref: TM-T62112

  • EGFR/HER2/CDK9-IN-3
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    EGFR/HER2/CDK9-IN-3

    CAS:
    <p>EGFR/HER2/CDK9-IN-3 inhibits EGFR (191.08 nM IC50), HER2 (132.65 nM), CDK9 (113.98 nM); shows anti-tumor effects.</p>
    Formula:C24H21N3O4S2
    Color and Shape:Solid
    Molecular weight:479.57

    Ref: TM-T63161

  • Cdc7-IN-4
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    Cdc7-IN-4

    CAS:
    Cdc7-IN-4 is a potent inhibitor of Cdc7 kinase.
    Formula:C22H24F3N5O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:479.45

    Ref: TM-T10726

  • KH-CB19
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    KH-CB19

    CAS:
    KH-CB19 is an effective and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).
    Formula:C15H13Cl2N3O2
    Color and Shape:Solid
    Molecular weight:338.19

    Ref: TM-T15657

  • PKC-9
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    PKC-9

    CAS:
    PKC-9 is a PKC-zeta inhibitor 9.
    Formula:C25H25N7
    Color and Shape:Solid
    Molecular weight:423.51

    Ref: TM-T71993