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CDK

CDK

CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.

Found 526 products of "CDK"

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  • Cdc7-IN-14
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    Cdc7-IN-14

    CAS:
    Cdc7-IN-14 (compound 82) is a potent CDC7 inhibitor with an IC50 < 1 nM, promising for cancer research.
    Formula:C18H20N4O2S
    Color and Shape:Solid
    Molecular weight:356.44

    Ref: TM-T61289

  • EGFR/HER2/CDK9-IN-2
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    EGFR/HER2/CDK9-IN-2

    CAS:
    EGFR/HER2/CDK9-IN-2 inhibits EGFR, HER2, CDK9 with IC50s: 145.35, 129.07, 117.13 nM; strong antitumor effects.
    Formula:C23H20N4O5S2
    Color and Shape:Solid
    Molecular weight:496.56

    Ref: TM-T63357

  • NSC 625987
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    NSC 625987

    CAS:
    Cyclin-dependent kinase (cdk) 4 inhibitor
    Formula:C15H13NO2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:271.33

    Ref: TM-T23092

  • P18IN003
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    P18IN003

    CAS:
    <p>P18IN003 is a selective and effective p18(INK4C) inhibitor that inhibits the activity of p18 protein and can be used to study in vitro expansion of</p>
    Formula:C17H16N2O3
    Purity:98.77%
    Color and Shape:Solid
    Molecular weight:296.32

    Ref: TM-T24580

  • CDK8-IN-10
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    CDK8-IN-10

    CAS:
    CDK8-IN-10 is a selective and potent inhibitor of cell cycle protein-dependent kinase (CDK8) (IC50: 8.25 nM) that can be used to study cancer.
    Formula:C25H15ClF3N5O3
    Color and Shape:Solid
    Molecular weight:525.87

    Ref: TM-T63690

  • RP-106
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    RP-106

    CAS:
    RP-106 is an ATP-competitive inhibitor of CDK5/p25, CDK1/cyclin B, and GSK-3.
    Formula:C17H19N3O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:281.35

    Ref: TM-T24734

  • CDK2-IN-13
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    CDK2-IN-13

    CAS:
    CDK2-IN-13: Potent CDK2 inhibitor, arrests cell cycle, induces apoptosis, IC50=12 µM, used in cancer research.
    Formula:C13H12ClN5
    Color and Shape:Soild
    Molecular weight:273.72

    Ref: TM-T60154

  • Metralindole
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    Metralindole

    CAS:
    Metralindole is a reversible inhibitor of monoamine oxidase A (RIMA).
    Formula:C15H17N3O
    Color and Shape:Solid
    Molecular weight:255.32

    Ref: TM-T71804

  • AG-012986
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    AG-012986

    CAS:
    AG-012986: a selective CDK inhibitor with in vitro and in vivo antitumor effects; low IC50 in 14/18 cancer cell types; CAS# 486414-35-1.
    Formula:C22H23F2N5O2S
    Color and Shape:Solid
    Molecular weight:459.51

    Ref: TM-T69196

  • Atuveciclib S-Enantiomer
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    Atuveciclib S-Enantiomer

    CAS:
    Atuveciclib S-Enantiomer is a (S)-form of BAY-1143572; a potent, selective CDK9 inhibitor with an IC50 of 16 nM.
    Formula:C18H18FN5O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:387.43

    Ref: TM-T10465

  • MFH290
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    MFH290

    CAS:
    MFH290 is a selective CDK12/13 inhibitor, covalently bonding with CDK12 Cys-1039, blocks Pol II CTD phosphorylation, and enhances olaparib's efficacy.
    Formula:C26H31N5O3S2
    Color and Shape:Solid
    Molecular weight:525.69

    Ref: TM-T69931

  • (E/Z)-BIO-acetoxime
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    (E/Z)-BIO-acetoxime

    CAS:
    (E/Z)-BIO-acetoxime: potent GSK-3 α/β inhibitor; IC50: GSK-3α/β 10nM, CDK5/p25 2.4μM, CDK2/A 4.3μM, CDK1/B 63μM.
    Formula:C18H12BrN3O3
    Color and Shape:Solid
    Molecular weight:398.21

    Ref: TM-T61890

  • NSC 693868
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    NSC 693868

    CAS:
    CDKs and GSK-3 inhibitor
    Formula:C9H7N5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:185.19

    Ref: TM-T23093

  • CDK4/6-IN-8
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    CDK4/6-IN-8

    CAS:
    CDK4/6-IN-8 (Compound 7p) is a selective inhibitor of CDK4 (IC50=5.01 nM) and CDK6 (IC50=3.97 nM).
    Formula:C18H18N6O5
    Color and Shape:Solid
    Molecular weight:398.37

    Ref: TM-T61892

  • CLK1-IN-2
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    CLK1-IN-2

    CLK1-IN-2: Metabolically stable, Clk1-selective inhibitor; IC50=1.7nM; useful in tumor, Duchenne MD, HIV-1, influenza research.
    Formula:C16H12Cl2N2O2S
    Color and Shape:Solid
    Molecular weight:367.25

    Ref: TM-T73321

  • CDK8-IN-4
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    CDK8-IN-4

    CAS:
    CDK8-IN-4 is an inhibitor of CDK8 (IC50: 0.2 nM).
    Formula:C20H18N4O
    Color and Shape:Solid
    Molecular weight:330.38

    Ref: TM-T17305

  • Aloisine A
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    Aloisine A

    CAS:
    Aloisine A, a CDK/GSK-3 inhibitor with IC50: Cdk1/B-150nM, Cdk2/A-120nM, Cdk2/E-400nM, Cdk5/25-200nM, Cdk5/35-160nM, GSK-3α-500nM, GSK-3β-650nM, JNK-3-10μM.
    Formula:C16H17N3O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:267.33

    Ref: TM-T21377

  • TP1287
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    TP1287

    CAS:
    TP-1287 is an oral phosphate prodrug of the CDK9 inhibitor, alvocidib.
    Formula:C21H21ClNO8P
    Color and Shape:Solid
    Molecular weight:481.82

    Ref: TM-T69965

  • CymitQuimica logo
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    Zotiraciclib HCl

    CAS:
    Zotiraciclib (TG02/SB1317) is a CDK/JAK2/FLT3 inhibitor potentially treating Myc-overexpressing cancers, including glioblastoma.
    Formula:C23H26Cl2N4O
    Color and Shape:Solid
    Molecular weight:445.388

    Ref: TM-T70897

  • CDK12-IN-3
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    CDK12-IN-3

    CAS:
    CDK12-IN-3 is a CDK12 inhibitor with anti-tumor activity and can be used for the study of malignant tumors.
    Formula:C23H28F2N8O
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:470.52

    Ref: TM-T14990