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CDK

CDK

CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.

Found 526 products of "CDK"

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  • Indirubin-5-sulfonate
    Targetmol
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    Indirubin-5-sulfonate

    CAS:
    Indirubin-5-sulfonate inhibits GSK-3β & CDKs with IC50: 55/35/150/300/65 nM for CDK1/B, 2/A&E, 4/D1, 5/p35.
    Formula:C16H10N2O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:342.33

    Ref: TM-T11653

  • CDK1-IN-1
    Targetmol
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    CDK1-IN-1

    CAS:
    CDK1-IN-7 inhibits CDK1 at 161.2 nM, triggers p53-dependent apoptosis, and selectively targets tumor growth.
    Formula:C27H23N5O3
    Color and Shape:Solid
    Molecular weight:465.5

    Ref: TM-T62970

  • Metralindole HCl
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    Metralindole HCl

    CAS:
    Metralindole is a reversible monoamine oxidase A (RIMA) inhibitor, it was investigated as a potential antidepressant.
    Formula:C15H18ClN3O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:291.78

    Ref: TM-T28030

  • GW8510
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    GW8510

    CAS:
    GW8510 is a CDK2 and RRM2 inhibitor that affects DNA synthesis and antiproliferation in tumor cells. In mammalian aging models, GW851 prolongs lifespan.
    Formula:C21H15N5O3S2
    Purity:99.32%
    Color and Shape:Solid
    Molecular weight:449.51

    Ref: TM-T24125

  • CLK1-IN-1
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    CLK1-IN-1

    CAS:
    CLK1-IN-1 is a potent and selective inhibitor of the Cdc2-like kinase 1 (CLK1; IC50: 2 nM).
    Formula:C24H16FN5O
    Color and Shape:Solid
    Molecular weight:409.42

    Ref: TM-T10836

  • β-catenin-IN-3
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    β-catenin-IN-3

    CAS:
    β-catenin-IN-3 is a selective and potent β-catenin inhibitor (KD: 54.96 nM) that targets a cryptic regulatory site of β-catenin and significantly reduces the
    Formula:C19H20Br2N2OS
    Color and Shape:Solid
    Molecular weight:484.25

    Ref: TM-T63212

  • XIE18-6
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    XIE18-6

    CAS:
    XIE18-6 is a novel INK4C inhibitor that blocks p18 activity and promotes ex vivo expansion of human and murine hematopoietic stem cells.
    Formula:C18H15NO6S
    Purity:99.712%
    Color and Shape:Solid
    Molecular weight:373.38

    Ref: TM-T29166

  • CDK4/6-IN-14
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    CDK4/6-IN-14

    CAS:
    CDK4/6-IN-14: potent CDK4/6 inhibitor, IC50s 10/16 nM, >60-fold selectivity over CDKs 1/2/7/9, selective across 205 kinases.
    Formula:C24H27ClFN7O
    Color and Shape:Solid
    Molecular weight:483.97

    Ref: TM-T72951

  • CDK4/6-IN-9
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    CDK4/6-IN-9

    CAS:
    CDK4/6-IN-9 selectively inhibits CDK4/6 (IC50: 905 nM); potential for MM research.
    Formula:C22H23FN8
    Color and Shape:Solid
    Molecular weight:418.47

    Ref: TM-T62192

  • Cdc7-IN-13
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    Cdc7-IN-13

    CAS:
    Cdc7-IN-13 (compound 84) is a highly potent CDC7 inhibitor, exhibiting an IC50 value of <1 nM. This compound holds promise for cancer research [1].
    Formula:C18H20N4O2S
    Color and Shape:Solid
    Molecular weight:356.44

    Ref: TM-T61288

  • THZ1-R
    Targetmol
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    THZ1-R

    CAS:
    THZ1-R is a non-covalent active analogue of THZ1, with the acrylamide group removed from THZ1, not covalently bind to the C312 cysteine residue of CDK7.
    Formula:C31H30ClN7O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:568.07

    Ref: TM-T13153

  • EGFR/HER2/CDK9-IN-1
    Targetmol
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    EGFR/HER2/CDK9-IN-1

    CAS:
    EGFR/HER2/CDK9-IN-1 is a potent inhibitor (IC50: EGFR 90.17 nM, HER2 131.39 nM, CDK9 67.04 nM) with notable anti-tumor activity.
    Formula:C23H21N3O3S2
    Color and Shape:Solid
    Molecular weight:451.56

    Ref: TM-T62746

  • CDK7-IN-2
    Targetmol
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    CDK7-IN-2

    CAS:
    CDK7-IN-2 inhibits CDK7, essential for RNA polymerase II activation and cell cycle control, with cancer research potential.
    Formula:C26H39N7O3
    Color and Shape:Solid
    Molecular weight:497.63

    Ref: TM-T63368

  • (S)-PF-06873600
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    (S)-PF-06873600

    CAS:
    (S)-PF-06873600 is the S enantiomer of PF-06873600 which is an inhibitor of CDK.
    Formula:C20H27F2N5O4S
    Purity:98.59%
    Color and Shape:Solid
    Molecular weight:471.52

    Ref: TM-T12809

  • hSMG-1 inhibitor 11e
    Targetmol
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    hSMG-1 inhibitor 11e

    CAS:
    hSMG-1 inhibitor 11e is an effective and selective inhibitor of hSMG-1 (IC50 <0.05 nM) and can be used in studies about cancer treatment.
    Formula:C26H27N7O3S
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:517.6

    Ref: TM-T35529

  • CDK4/6/1 Inhibitor
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    CDK4/6/1 Inhibitor

    CAS:
    CDK4/6/1 Inhibitor (Crozbaciclib) is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM).
    Formula:C28H30F2N6
    Purity:97.25% - 99.72%
    Color and Shape:Solid
    Molecular weight:488.57

    Ref: TM-T10735

  • PS423
    Targetmol
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    PS423

    CAS:
    PS423 is a substrate-selective protein kinase PDK1 inhibitor that acts by binding to the PIF-pocket allosteric docking site.
    Formula:C25H23F3O9
    Purity:98.81% - 99.26%
    Color and Shape:Solid
    Molecular weight:524.44

    Ref: TM-T24676

  • DIF-3
    Targetmol
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    DIF-3

    CAS:
    DIF-3 activates GSK-3β, degrades cyclin D1/c-Myc, and inhibits Wnt/β-catenin in DLD-1 cells, curbing HeLa cell proliferation.
    Formula:C13H17ClO4
    Purity:99.57%
    Color and Shape:Solid
    Molecular weight:272.72

    Ref: TM-T60485

  • Abemaciclib metabolite M20
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    Abemaciclib metabolite M20

    CAS:
    Abemaciclib metabolite M20 (CDK4/6-IN-4) 是 Abemaciclib 的活性代谢物。 Abemaciclib metabolite M20 是一种特异性 CDK4/6 抑制剂，可用于癌症治疗的相关研究。
    Formula:C27H32F2N8O
    Purity:98.1% - 99.08%
    Color and Shape:Solid
    Molecular weight:522.59

    Ref: TM-T10738

  • BML-259
    Targetmol
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    BML-259

    CAS:
    <p>BML-259 inhibits CDK5/CDK2 (IC50: 64/98 nM) for cancer and neurodegeneration research.</p>
    Formula:C14H16N2OS
    Purity:99.84%
    Color and Shape:Solid
    Molecular weight:260.35

    Ref: TM-T36964