HSP
HSP (Heat Shock Protein) inhibitors target HSPs, a family of molecular chaperones that assist in protein folding, stability, and protection against stress-induced damage. HSPs are often upregulated in cancer cells, helping them survive under stressful conditions such as hypoxia and chemotherapy. Inhibiting HSPs can disrupt these protective mechanisms, leading to cell death. HSP inhibitors are therefore valuable in cancer therapy and research into stress responses. At CymitQuimica, we provide a comprehensive range of high-quality HSP inhibitors to support your research in protein homeostasis, stress responses, and oncology.
Found 179 products of "HSP"
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MKT-077
CAS:MKT-077 (FJ-776) is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines.Formula:C21H22ClN3OS2Purity:98.2%Color and Shape:SolidMolecular weight:432ML346
CAS:ML346 is a novel activator of Hsp70.Formula:C14H12N2O4Purity:97.32% - 99.36%Color and Shape:SolidMolecular weight:272.26Ref: TM-T3594
1mg38.00€2mg50.00€5mg80.00€10mg109.00€25mg168.00€50mg259.00€100mg405.00€500mg888.00€1mL*10mM (DMSO)80.00€JG-98
CAS:JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7 μM).Formula:C24H21Cl2N3OS3Purity:99.13%Color and Shape:SolidMolecular weight:534.53Alvespimycin
CAS:Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor with potential anticancer activity, which acts by binding to Hsp90.Formula:C32H48N4O8Purity:99.88%Color and Shape:SolidMolecular weight:616.75Calenduloside E
CAS:Calenduloside E (Silphioside F) exhibits hypoglycemic activities by suppressing the transfer of glucose from the stomach to the small intestine and byFormula:C36H56O9Purity:96.16% - 98.99%Color and Shape:SolidMolecular weight:632.8217-AEP-GA
CAS:17-AEP-GA is an HSP90 antagonist and a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion.Formula:C34H50N4O8Purity:97.77% - 99.56%Color and Shape:SolidMolecular weight:642.78HSP90-IN-22
CAS:HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor exhibiting antiproliferative activity, with IC50 values of 3.65 μM in MCF7 breast cancer cells and 2.71 μM inFormula:C25H30N4O3Purity:98%Color and Shape:SolidMolecular weight:434.53HSP90-IN-14
CAS:HSP90-IN-14 inhibits Hsp90 (Kd=0.26 μM) and fights influenza A/H3N2, A/H1N1, B with EC50 of 2.6, 3.9, 17 μM in MDCK cells.Formula:C14H8Cl2N4O4SColor and Shape:SolidMolecular weight:399.21AMP-PCP
CAS:AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.Formula:C11H18N5O12P3Purity:98%Color and Shape:SolidMolecular weight:505.21JG-48
CAS:JG-48 is an inhibitor of Hsp70. JG-48 suppresses phosphorylated and total Tau in cells, endogenous Tau in neuroblastoma cells.Formula:C20H16F3N3OS2Color and Shape:SolidMolecular weight:435.49CH5164840
CAS:CH5164840: strong HSP90 blocker; excels in NSCLC treatment; boosts erlotinib efficacy on EGFR-mutant tumors.Formula:C19H23N5O2SColor and Shape:SolidMolecular weight:385.48Hsp90-Cdc37-IN-1
CAS:Hsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptor (IC50: 140 nM) that inhibit cell migration and reverse drug resistance.Formula:C43H57FN2O6SPurity:98%Color and Shape:SolidMolecular weight:748.99SEW84
CAS:SEW84, an Aha1-stimulated Hsp90 inhibitor, has an IC50 of 0.3 μM, aiding protein deposition disease research.Formula:C19H14F4N4OSColor and Shape:SolidMolecular weight:422.4CCT251236
CAS:CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen.Formula:C32H32N4O5Purity:98.82% - 99.89%Color and Shape:SolidMolecular weight:552.62Ref: TM-T14905
1mg34.00€5mg105.00€10mg200.00€25mg414.00€50mg662.00€100mg1,054.00€1mL*10mM (DMSO)130.00€BMS-358233
CAS:BMS-358233 is an effective LCK inhibitor with excellent cell activity against T cell proliferation.Formula:C25H25ClN6O2SColor and Shape:SolidMolecular weight:509.02PU3
CAS:PU3 is an inhibitor of Hsp90.Formula:C19H25N5O3Purity:98%Color and Shape:SolidMolecular weight:371.43PU24FCl
CAS:PU24FCl is a specific inhibitor of tumor Hsp90.Formula:C20H21ClFN5O3Color and Shape:SolidMolecular weight:433.866BrCaQ
CAS:6BrCaQ inhibits TRAP1, has antiproliferative effects, and is used in 6BrCaQ-TPP synthesis.Formula:C18H15BrN2O3Color and Shape:SolidMolecular weight:387.23Malonganenone A
CAS:Malonganenone A is a selective plasmodial Hsp70s modulator. It also has antimalarial activity.Formula:C26H38N4O2Color and Shape:SolidMolecular weight:438.61SW02
CAS:SW02 is a potent ATPase activator of Hsp70 (EC50: 150 μM). SW02 is able to accumulate total tau and phosphorylated tau (pTau).Formula:C19H23BrN2O5Color and Shape:SolidMolecular weight:439.3Vibsanin A
CAS:Vibsanin A, an activator of protein kinase C (PKC) and an inhibitor of HSP90, demonstrates anti-proliferative effects on human cancer cell lines.Formula:C25H38O4Color and Shape:SolidMolecular weight:402.57Displurigen
CAS:Displurigen is an inhibitor of ATPase activity of HSP70.Formula:C15H10O4SPurity:98%Color and Shape:SolidMolecular weight:286.3Icapamespib HCl
CAS:Icapamespib (PU-HZ151) is an HSP90 inhibitor; EC50 of 5 nM, logD of 2.37; targets epichaperomes, effective in cells, mice, and humans.Formula:C19H25Cl2IN6O2SColor and Shape:SolidMolecular weight:599.31CH5015765
CAS:CH5015765: potent, selective HSP90 inhibitor with high affinity and antitumor effects in human cancer mouse models.Formula:C16H13ClN4OSColor and Shape:SolidMolecular weight:344.82YM-01 Tosylate
CAS:YM-01 Tosylate, a potent antitumor agent, selectively targets cancer cells and overcoming tamoxifen resistance.
Formula:C27H27N3O4S3Color and Shape:SolidMolecular weight:553.72Grp94-IN-2
CAS:Grp94-IN-2 is a inhibitor of Grp94.Formula:C22H23ClN2O5Color and Shape:SolidMolecular weight:430.88Heat Shock Protein Inhibitor II
CAS:Hsp inhibitor II, an active benzylidene lactam, blocks inducible Hsp synthesis, reduces tumor thermotolerance, and enhances AmB effects on A. fumigatus.Formula:C12H11NO3Color and Shape:SolidMolecular weight:217.22BF844
CAS:BF844 chemical counters USH3-induced hearing loss by transporting mutated CLRN1 to cell membranes, effectively preserving hearing in vivo.Formula:C21H19ClN4OColor and Shape:SolidMolecular weight:378.85Hsp90-IN-17
CAS:Hsp90-IN-17 (Example 5) is an inhibitor of HSP90, applicable in researching proliferative diseases, including cancer and neurodegenerative conditions.Formula:C21H20N4O7Color and Shape:SolidMolecular weight:440.41YM-1
CAS:YM-1, a stable MKT-077 analog, inhibits Hsp70 orally, kills HeLa cells, and boosts p53 and p21 proteins.Formula:C20H20ClN3OS2Color and Shape:SolidMolecular weight:417.98HSP90-IN-12
CAS:VAC, a potent anti-cancer vibsanin A analog, inhibits cell proliferation and affects HSP90 protein levels.Formula:C25H36O4Color and Shape:SolidMolecular weight:400.55CH5138303
CAS:CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.Formula:C19H18ClN5O2SPurity:98%Color and Shape:SolidMolecular weight:415.9HSP90-IN-20
CAS:HSP90-IN-20, a potent inhibitor of HSP90, exhibits an IC50 of ≤10 μM, indicating its potential application in cancer research.Formula:C26H32N4O4Color and Shape:SolidMolecular weight:464.56Hsp90-IN-15
CAS:Hsp90-IN-15: Hsp90 blocker with anticancer properties; halts S phase, triggers apoptosis, cuts Hsp90 in Hela cells.Formula:C23H27F3N4Color and Shape:SolidMolecular weight:416.48KUNB31
CAS:KUNB31 is a potent and selective inhibitor of Hsp90β.Formula:C19H18N2O3Color and Shape:SolidMolecular weight:322.36STA-2842
CAS:STA-2842 is an inhibitor of heat shock protein 90 (HSP90).Formula:C29H38N6O5Color and Shape:SolidMolecular weight:550.65Bimoclomol
CAS:Bimoclomol is a heat shock protein co-inducer used for the research of cardiovascular diseases.Formula:C14H20ClN3O2Color and Shape:SolidMolecular weight:297.78Retaspimycin
CAS:Retaspimycin is a potent and water-soluble Hsp90 inhibitor(EC50s of 119 nM for both Hsp90 and Grp9).Formula:C31H45N3O8Purity:98%Color and Shape:SolidMolecular weight:587.7BIIB028
CAS:BIIB028: Hsp90 inhibitor, may degrade oncogenic proteins, potentially hindering tumor growth.Formula:C19H21ClN5O5PColor and Shape:SolidMolecular weight:465.83MPC-3100
CAS:MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of Hsp90 with significant antitumor activity [1].Formula:C22H25BrN6O4SColor and Shape:SolidMolecular weight:549.44Retaspimycin Hydrochloride
CAS:Retaspimycin Hydrochloride is a potent and water-soluble Hsp90 inhibitor(Hsp90 and Grp9 with EC50s of 119 nM).Formula:C31H46ClN3O8Purity:98%Color and Shape:SolidMolecular weight:624.17EC 144
CAS:EC 144, a second-generation selective inhibitor of Hsp90 , inhibits tumor growth for Hsp90α and degradation of Her-2 in MCF-7 cells.Formula:C21H24ClN5O2Color and Shape:SolidMolecular weight:413.9Arimoclomol
CAS:Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (Formula:C14H20ClN3O3Purity:99.15%Color and Shape:SolidMolecular weight:313.78Iroxanadine
CAS:Iroxanadine (BRX-005) is a Novel small molecule MAPK p38 inhibitor that induces phosphorylation of p38 SAPK and induces concentration-dependent relaxation inFormula:C14H20N4OPurity:98.04% - 99.04%Color and Shape:SolidMolecular weight:260.33JG-231
CAS:JG-231, a JG-98 analog, shows anticancer properties by blocking Hsp70-BAG3 interaction and hindering TNBC in MDA-MB-231 models.
Formula:C22H18BrCl2N3OS4Purity:99.79%Color and Shape:SolidMolecular weight:619.47AMP-PCP disodium
CAS:AMP-PCP disodium is an ATP analogue with binding affinity to the N-terminal domain of Hsp90, with a Kd value of 3.8 μM.Formula:C11H16N5Na2O12P3Purity:99.32% - 99.32%Color and Shape:SolidMolecular weight:549.17SNX0723
CAS:SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity.Formula:C22H26FN3O3Purity:99.85%Color and Shape:SolidMolecular weight:399.46Ref: TM-T28824
1mg85.00€5mg178.00€10mg299.00€25mg485.00€50mg665.00€100mg892.00€500mgTo inquire1mL*10mM (DMSO)195.00€MAO A/HSP90-IN-2
CAS:MAO A/HSP90-IN-2 (compound 4-C), a dual inhibitor of HSP90 and MAO A, exhibits IC50 values of 0.016 μM for MAO A and 4.58 μM for HSP90.Formula:C25H31ClN2O4Purity:98%Color and Shape:SolidMolecular weight:458.98Colletofragarone A2
CAS:Colletofragarone A2 from Colletotrichum sp. blocks mutant p53 and HSP90, aiding cancer treatment.Formula:C22H26O6Color and Shape:SolidMolecular weight:386.44HSP90-IN-29
CAS:HSP90-IN-29 (Compound 13), a benzoxazole derivative, serves as a potent and selective HSP-90 inhibitor, exhibiting a low IC50 value of 30 nM. This compound demonstrates significant antitumor activity [1].Formula:C19H20ClN3O4Color and Shape:SolidMolecular weight:389.83
