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HSP

HSP

HSP (Heat Shock Protein) inhibitors target HSPs, a family of molecular chaperones that assist in protein folding, stability, and protection against stress-induced damage. HSPs are often upregulated in cancer cells, helping them survive under stressful conditions such as hypoxia and chemotherapy. Inhibiting HSPs can disrupt these protective mechanisms, leading to cell death. HSP inhibitors are therefore valuable in cancer therapy and research into stress responses. At CymitQuimica, we provide a comprehensive range of high-quality HSP inhibitors to support your research in protein homeostasis, stress responses, and oncology.

Found 169 products of "HSP"

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  • KW-2478
    Targetmol
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    KW-2478

    CAS:
    <p>KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.</p>
    Formula:C30H42N2O9
    Purity:98.68% - 99.52%
    Color and Shape:Solid
    Molecular weight:574.66

    Ref: TM-T6558

  • Alvespimycin
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    Alvespimycin

    CAS:
    <p>Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor with potential anticancer activity, which acts by binding to Hsp90.</p>
    Formula:C32H48N4O8
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:616.75

    Ref: TM-T20890

  • Calenduloside E
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    Calenduloside E

    CAS:
    <p>Calenduloside E (Silphioside F) exhibits hypoglycemic activities by suppressing the transfer of glucose from the stomach to the small intestine and by</p>
    Formula:C36H56O9
    Purity:96.16% - 98.99%
    Color and Shape:Solid
    Molecular weight:632.82

    Ref: TM-TJS0928

  • 17-AEP-GA
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    17-AEP-GA

    CAS:
    <p>17-AEP-GA is an HSP90 antagonist and a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion.</p>
    Formula:C34H50N4O8
    Purity:97.77% - 99.56%
    Color and Shape:Solid
    Molecular weight:642.78

    Ref: TM-T40872

  • Retaspimycin Hydrochloride
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    Retaspimycin Hydrochloride

    CAS:
    <p>Retaspimycin Hydrochloride is a potent and water-soluble Hsp90 inhibitor(Hsp90 and Grp9 with EC50s of 119 nM).</p>
    Formula:C31H46ClN3O8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:624.17

    Ref: TM-T12726L

  • Bimoclomol
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    Bimoclomol

    CAS:
    <p>Bimoclomol is a heat shock protein co-inducer used for the research of cardiovascular diseases.</p>
    Formula:C14H20ClN3O2
    Color and Shape:Solid
    Molecular weight:297.78

    Ref: TM-T13580

  • CH5138303
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    CH5138303

    CAS:
    <p>CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.</p>
    Formula:C19H18ClN5O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:415.9

    Ref: TM-T6442

  • AMP-PCP
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    AMP-PCP

    CAS:
    <p>AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.</p>
    Formula:C11H18N5O12P3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:505.21

    Ref: TM-T13547

  • JG-48
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    JG-48

    CAS:
    <p>JG-48 is an inhibitor of Hsp70. JG-48 suppresses phosphorylated and total Tau in cells, endogenous Tau in neuroblastoma cells.</p>
    Formula:C20H16F3N3OS2
    Color and Shape:Solid
    Molecular weight:435.49

    Ref: TM-T27655

  • Hsp90-IN-15
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    Hsp90-IN-15

    CAS:
    <p>Hsp90-IN-15: Hsp90 blocker with anticancer properties; halts S phase, triggers apoptosis, cuts Hsp90 in Hela cells.</p>
    Formula:C23H27F3N4
    Color and Shape:Solid
    Molecular weight:416.48

    Ref: TM-T62163

  • CCT251236
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    CCT251236

    CAS:
    <p>CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen.</p>
    Formula:C32H32N4O5
    Purity:98.82% - 99.89%
    Color and Shape:Solid
    Molecular weight:552.62

    Ref: TM-T14905

  • HSP90-IN-12
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    HSP90-IN-12

    CAS:
    <p>VAC, a potent anti-cancer vibsanin A analog, inhibits cell proliferation and affects HSP90 protein levels.</p>
    Formula:C25H36O4
    Color and Shape:Solid
    Molecular weight:400.55

    Ref: TM-T61938

  • YM-01 Tosylate
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    YM-01 Tosylate

    CAS:
    <p>YM-01 Tosylate, a potent antitumor agent, selectively targets cancer cells and overcoming tamoxifen resistance.</p>
    Formula:C27H27N3O4S3
    Color and Shape:Solid
    Molecular weight:553.72

    Ref: TM-T29179

  • Displurigen
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    Displurigen

    CAS:
    <p>Displurigen is an inhibitor of ATPase activity of HSP70.</p>
    Formula:C15H10O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:286.3

    Ref: TM-T27184

  • Malonganenone A
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    Malonganenone A

    CAS:
    <p>Malonganenone A is a selective plasmodial Hsp70s modulator. It also has antimalarial activity.</p>
    Formula:C26H38N4O2
    Color and Shape:Solid
    Molecular weight:438.61

    Ref: TM-T24429

  • 6BrCaQ
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    6BrCaQ

    CAS:
    <p>6BrCaQ inhibits TRAP1, has antiproliferative effects, and is used in 6BrCaQ-TPP synthesis.</p>
    Formula:C18H15BrN2O3
    Color and Shape:Solid
    Molecular weight:387.23

    Ref: TM-T61726

  • HSP90-IN-22
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    HSP90-IN-22

    CAS:
    <p>HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor exhibiting antiproliferative activity, with IC50 values of 3.65 μM in MCF7 breast cancer cells and 2.71 μM in</p>
    Formula:C25H30N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:434.53

    Ref: TM-T79083

  • PU3
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    PU3

    CAS:
    <p>PU3 is an inhibitor of Hsp90.</p>
    Formula:C19H25N5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:371.43

    Ref: TM-T26000

  • SEW84
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    SEW84

    CAS:
    <p>SEW84, an Aha1-stimulated Hsp90 inhibitor, has an IC50 of 0.3 μM, aiding protein deposition disease research.</p>
    Formula:C19H14F4N4OS
    Color and Shape:Solid
    Molecular weight:422.4

    Ref: TM-T69571

  • HSP90-IN-14
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    HSP90-IN-14

    CAS:
    <p>HSP90-IN-14 inhibits Hsp90 (Kd=0.26 μM) and fights influenza A/H3N2, A/H1N1, B with EC50 of 2.6, 3.9, 17 μM in MDCK cells.</p>
    Formula:C14H8Cl2N4O4S
    Color and Shape:Solid
    Molecular weight:399.21

    Ref: TM-T61904

  • CH5164840
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    CH5164840

    CAS:
    <p>CH5164840: strong HSP90 blocker; excels in NSCLC treatment; boosts erlotinib efficacy on EGFR-mutant tumors.</p>
    Formula:C19H23N5O2S
    Color and Shape:Solid
    Molecular weight:385.48

    Ref: TM-T71526

  • Hsp90-Cdc37-IN-1
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    Hsp90-Cdc37-IN-1

    CAS:
    <p>Hsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptor (IC50: 140 nM) that inhibit cell migration and reverse drug resistance.</p>
    Formula:C43H57FN2O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:748.99

    Ref: TM-T13725

  • Vibsanin A
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    Vibsanin A

    CAS:
    <p>Vibsanin A, an activator of protein kinase C (PKC) and an inhibitor of HSP90, demonstrates anti-proliferative effects on human cancer cell lines.</p>
    Formula:C25H38O4
    Color and Shape:Solid
    Molecular weight:402.57

    Ref: TM-T68802

  • YM-1
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    YM-1

    CAS:
    <p>YM-1, a stable MKT-077 analog, inhibits Hsp70 orally, kills HeLa cells, and boosts p53 and p21 proteins.</p>
    Formula:C20H20ClN3OS2
    Color and Shape:Solid
    Molecular weight:417.98

    Ref: TM-T73579

  • BIIB028
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    BIIB028

    CAS:
    <p>BIIB028: Hsp90 inhibitor, may degrade oncogenic proteins, potentially hindering tumor growth.</p>
    Formula:C19H21ClN5O5P
    Color and Shape:Solid
    Molecular weight:465.83

    Ref: TM-T68383

  • Retaspimycin
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    Retaspimycin

    CAS:
    <p>Retaspimycin is a potent and water-soluble Hsp90 inhibitor(EC50s of 119 nM for both Hsp90 and Grp9).</p>
    Formula:C31H45N3O8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:587.7

    Ref: TM-T12726

  • KUNB31
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    KUNB31

    CAS:
    <p>KUNB31 is a potent and selective inhibitor of Hsp90β.</p>
    Formula:C19H18N2O3
    Color and Shape:Solid
    Molecular weight:322.36

    Ref: TM-T69779

  • HSP90-IN-20
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    HSP90-IN-20

    CAS:
    <p>HSP90-IN-20, a potent inhibitor of HSP90, exhibits an IC50 of ≤10 μM, indicating its potential application in cancer research.</p>
    Formula:C26H32N4O4
    Color and Shape:Solid
    Molecular weight:464.56

    Ref: TM-T73011

  • Hsp90-IN-17
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    Hsp90-IN-17

    CAS:
    <p>Hsp90-IN-17 (Example 5) is an inhibitor of HSP90, applicable in researching proliferative diseases, including cancer and neurodegenerative conditions.</p>
    Formula:C21H20N4O7
    Color and Shape:Solid
    Molecular weight:440.41

    Ref: TM-T72996

  • Heat Shock Protein Inhibitor II
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    Heat Shock Protein Inhibitor II

    CAS:
    <p>Hsp inhibitor II, an active benzylidene lactam, blocks inducible Hsp synthesis, reduces tumor thermotolerance, and enhances AmB effects on A. fumigatus.</p>
    Formula:C12H11NO3
    Color and Shape:Solid
    Molecular weight:217.22

    Ref: TM-T36865

  • SW02
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    SW02

    CAS:
    <p>SW02 is a potent ATPase activator of Hsp70 (EC50: 150 μM). SW02 is able to accumulate total tau and phosphorylated tau (pTau).</p>
    Formula:C19H23BrN2O5
    Color and Shape:Solid
    Molecular weight:439.3

    Ref: TM-T62519

  • PU24FCl
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    PU24FCl

    CAS:
    <p>PU24FCl is a specific inhibitor of tumor Hsp90.</p>
    Formula:C20H21ClFN5O3
    Color and Shape:Solid
    Molecular weight:433.86

    Ref: TM-T28473

  • BMS-358233
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    BMS-358233

    CAS:
    <p>BMS-358233 is an effective LCK inhibitor with excellent cell activity against T cell proliferation.</p>
    Formula:C25H25ClN6O2S
    Color and Shape:Solid
    Molecular weight:509.02

    Ref: TM-T30518

  • EC 144
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    EC 144

    CAS:
    <p>EC 144, a second-generation selective inhibitor of Hsp90 , inhibits tumor growth for Hsp90α and degradation of Her-2 in MCF-7 cells.</p>
    Formula:C21H24ClN5O2
    Color and Shape:Solid
    Molecular weight:413.9

    Ref: TM-T22758

  • MPC-3100
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    MPC-3100

    CAS:
    <p>MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of Hsp90 with significant antitumor activity [1].</p>
    Formula:C22H25BrN6O4S
    Color and Shape:Solid
    Molecular weight:549.44

    Ref: TM-T21600

  • Iroxanadine
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    Iroxanadine

    CAS:
    <p>Iroxanadine (BRX-005) is a Novel small molecule MAPK p38 inhibitor that induces phosphorylation of p38 SAPK and induces concentration-dependent relaxation in</p>
    Formula:C14H20N4O
    Purity:98.04% - 99.04%
    Color and Shape:Solid
    Molecular weight:260.33

    Ref: TM-T27627

  • AMP-PCP disodium
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    AMP-PCP disodium

    CAS:
    <p>AMP-PCP disodium is an ATP analogue with binding affinity to the N-terminal domain of Hsp90, with a Kd value of 3.8 μM.</p>
    Formula:C11H16N5Na2O12P3
    Purity:99.32%
    Color and Shape:Solid
    Molecular weight:549.17

    Ref: TM-T13547L

  • SNX0723
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    SNX0723

    CAS:
    <p>SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity.</p>
    Formula:C22H26FN3O3
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:399.46

    Ref: TM-T28824

  • Arimoclomol
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    Arimoclomol

    CAS:
    <p>Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (</p>
    Formula:C14H20ClN3O3
    Purity:99.15%
    Color and Shape:Solid
    Molecular weight:313.78

    Ref: TM-T13553

  • JG-231
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    JG-231

    CAS:
    <p>JG-231, a JG-98 analog, shows anticancer properties by blocking Hsp70-BAG3 interaction and hindering TNBC in MDA-MB-231 models.</p>
    Formula:C22H18BrCl2N3OS4
    Purity:99.79%
    Color and Shape:Solid
    Molecular weight:619.47

    Ref: TM-T70353

  • KU-177
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    KU-177

    CAS:
    <p>KU-177 is an Aha1 inhibitor that disrupts the interaction between Hsp90 and Aha1, eliminating cell proliferation and PI resistance induced by elevated AHSA1.</p>
    Formula:C27H23NO8
    Purity:96.92% - 98.54%
    Color and Shape:Solid
    Molecular weight:489.47

    Ref: TM-T63273

  • HSP90-IN-29
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    HSP90-IN-29

    CAS:
    <p>HSP90-IN-29 (Compound 13), a benzoxazole derivative, serves as a potent and selective HSP-90 inhibitor, exhibiting a low IC50 value of 30 nM. This compound demonstrates significant antitumor activity [1].</p>
    Formula:C19H20ClN3O4
    Color and Shape:Solid
    Molecular weight:389.83

    Ref: TM-T84486

  • GRP78-IN-2
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    GRP78-IN-2

    CAS:
    <p>GRP78-IN-2 inhibits surface GRP78, showing anti-angiogenic and anti-cancer properties, sparing normal cells.</p>
    Formula:C29H29NO6
    Color and Shape:Solid
    Molecular weight:487.54

    Ref: TM-T63243

  • HSP90-IN-27
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    HSP90-IN-27

    CAS:
    <p>HSP90-IN-27, also known as compound 19, is an inhibitor of HSP90 [1].</p>
    Formula:C18H21N3O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:343.44

    Ref: TM-T82166

  • Flavokawain 1i
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    Flavokawain 1i

    CAS:
    <p>Flavokawain 1i, a derivative of chalcones flavokawain A, flavokawain B, and flavokawain C, exhibits anticancer and antiviral properties.</p>
    Formula:C21H18O4
    Color and Shape:Solid
    Molecular weight:334.37

    Ref: TM-T83890

  • MAO A/HSP90-IN-2
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    MAO A/HSP90-IN-2

    CAS:
    <p>MAO A/HSP90-IN-2 (compound 4-C), a dual inhibitor of HSP90 and MAO A, exhibits IC50 values of 0.016 μM for MAO A and 4.58 μM for HSP90.</p>
    Formula:C25H31ClN2O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:458.98

    Ref: TM-T79487

  • HSP70/SIRT2-IN-2
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    HSP70/SIRT2-IN-2

    CAS:
    <p>HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1].</p>
    Formula:C17H13N3S3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:355.5

    Ref: TM-T82167

  • CymitQuimica logo
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    Colletofragarone A2

    CAS:
    <p>Colletofragarone A2 from Colletotrichum sp. blocks mutant p53 and HSP90, aiding cancer treatment.</p>
    Formula:C22H26O6
    Color and Shape:Solid
    Molecular weight:386.44

    Ref: TM-T75517

  • YM-08
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    YM-08

    CAS:
    <p>YM-08 (Compound 7a), a brain-penetrant SIRT2 inhibitor, exhibits an IC50 of 19.9 μM. Additionally, it acts as an inhibitor of Hsp70 [1].</p>
    Formula:C19H17N3OS2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:367.49

    Ref: TM-T80752

  • HSP90-IN-19
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    HSP90-IN-19

    CAS:
    <p>HSP90-IN-19: potent Hsp90 inhibitor, IC50 = 0.27 μM, used in research on viral diseases, neurodegeneration, inflammation.</p>
    Formula:C29H38O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:498.61

    Ref: TM-T73038