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HSP

HSP

HSP (Heat Shock Protein) inhibitors target HSPs, a family of molecular chaperones that assist in protein folding, stability, and protection against stress-induced damage. HSPs are often upregulated in cancer cells, helping them survive under stressful conditions such as hypoxia and chemotherapy. Inhibiting HSPs can disrupt these protective mechanisms, leading to cell death. HSP inhibitors are therefore valuable in cancer therapy and research into stress responses. At CymitQuimica, we provide a comprehensive range of high-quality HSP inhibitors to support your research in protein homeostasis, stress responses, and oncology.

Found 169 products of "HSP"

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  • MAO A/HSP90-IN-1
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    MAO A/HSP90-IN-1

    CAS:
    <p>MAO A/HSP90-IN-1 (4-b) is a dual inhibitor of MAO A and HSP90, exhibiting IC50 values of 1.77 μM in glioblastoma (GBM) GL26 cells and 0.019 μM against HSP90α.</p>
    Formula:C24H29ClN2O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:444.95

    Ref: TM-T79486

  • Iroxanadine sulfate
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    Iroxanadine sulfate

    CAS:
    <p>Iroxanadine sulfate is a MAPK p38 inhibitor potentially for the treatment of atherosclerosis.</p>
    Formula:C14H22N4O5S
    Color and Shape:Solid
    Molecular weight:358.41

    Ref: TM-T69520

  • BX-2819
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    BX-2819

    CAS:
    <p>BX-2819 is an Hsp90 inhibitor that exhibits potent antiproliferative activity with an IC50 of 41 nM .</p>
    Formula:C21H24N4O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:428.51

    Ref: TM-T82802

  • EV206
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    EV206

    CAS:
    <p>EV206 is an effective inhibitor of Hsp70, exhibiting antiproliferative properties. This compound induces cell apoptosis (apoptosis) and enhances the protein expression of cleaved PARP and caspase-3. Additionally, EV206 demonstrates antitumor activity.</p>
    Formula:C21H19N3O
    Color and Shape:Solid
    Molecular weight:329.40

    Ref: TM-T200885

  • DDO-6691
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    DDO-6691

    CAS:
    <p>DDO-6691 is an inhibitor of heat shock protein 90 (HSP90). It exhibits antiproliferative effects against various tumor cells, with the highest sensitivity observed in HCT-116 colon cancer cells (IC50: 1.08 μM). DDO-6691 also demonstrates potent tumor growth inhibition in HCT-116 xenograft mouse models.</p>
    Formula:C22H17N3O2S
    Color and Shape:Solid
    Molecular weight:387.45

    Ref: TM-T207588

  • Onalespib lactate
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    Onalespib lactate

    CAS:
    <p>Onalespib lactate is a second-generation, potent and selective HSP90 Inhibitor with antitumor activity.</p>
    Formula:C27H37N3O6
    Color and Shape:Solid
    Molecular weight:499.6

    Ref: TM-T28236

  • Cemdomespib
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    Cemdomespib

    CAS:
    <p>Cemdomespib (KU-596) is a potent Hsp90 modulator with neuroprotective effects and can improve diabetic neuropathy.</p>
    Formula:C24H30FNO6
    Color and Shape:Solid
    Molecular weight:447.5

    Ref: TM-T62670

  • Hsp90-IN-37
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    Hsp90-IN-37

    CAS:
    <p>Hsp90-IN-37 (Z-2) is an inhibitor of heat shock protein 90 (Hsp90), demonstrating a 69% inhibition rate on Hsp90 enzyme activity. It exhibits antitumor properties.</p>
    Formula:C12H15N3O2
    Color and Shape:Solid
    Molecular weight:233.266

    Ref: TM-T204710

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    ETB

    CAS:
    <p>ETB is a potent inhibitor of Hsp60 chaperone activity. It can impede the chaperone function of both wild-type proteins and the C237A and C447A mutant proteins. ETB binds to Hsp60 at Cys442, and the C442A mutant demonstrates resistance to ETB inhibition.</p>
    Formula:C24H33NO6
    Molecular weight:431.52

    Ref: TM-T210270

  • Hsp110-STAT3 interaction-IN-1
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    Hsp110-STAT3 interaction-IN-1

    CAS:
    <p>Row174336 (compound 29) serves as an efficient inhibitor of the Hsp110-STAT3 interaction, exhibiting antiproliferative activity in the HPAEC cell line with an IC50 of 22.67 μM.</p>
    Formula:C23H31N3O4S
    Color and Shape:Solid
    Molecular weight:445.58

    Ref: TM-T201209

  • DCEM1
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    DCEM1

    CAS:
    <p>DCEM1 binds to heat shock protein 60 (HSP60) and inhibits the interaction between HSP60 and ClpP, thereby blocking the mitochondrial unfolded protein response. Additionally, DCEM1 suppresses the expression of β-catenin and reduces ATP production in PC-3 and TKO cells. It is utilized in research related to prostate cancer.</p>
    Formula:C22H23N3O2S
    Color and Shape:Solid
    Molecular weight:393.50

    Ref: TM-T207450

  • KUNG65
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    KUNG65

    CAS:
    <p>KUNG65 acts as a selective Grp94 inhibitor, demonstrating a target dissociation constant (K_d) of 540 nM. It exhibits a minimum selectivity of 73-fold compared to other Hsp90 isoforms.</p>
    Formula:C23H20ClFO4
    Color and Shape:Solid
    Molecular weight:414.85

    Ref: TM-T200265

  • KU-32
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    KU-32

    CAS:
    <p>KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.</p>
    Formula:C20H25NO8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:407.41

    Ref: TM-T15671

  • Macbecin I
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    Macbecin I

    CAS:
    <p>Hsp90 inhibitor</p>
    Formula:C30H42N2O8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:558.66

    Ref: TM-T22960

  • C086
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    C086

    CAS:
    <p>C086 is a novel and potent Hsp90 inhibitor that suppresses cell cycle progression, induces apoptosis, and exhibits anti-metastatic properties by modulating various mechanisms in different cell types.</p>
    Formula:C29H28O8
    Color and Shape:Solid
    Molecular weight:504.53

    Ref: TM-T200395

  • Hsp90-IN-34
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    Hsp90-IN-34

    CAS:
    <p>Hsp90-IN-34 (compound HAM-1) is a chemical inhibitor that targets the Aha1-Hsp90 chaperone complex with high affinity (KDapp=23.5 µM). It modulates the ATPase activity of Hsp90 by affecting the interaction between Hsp90 and Aha1.</p>
    Formula:C22H14F2N6O
    Color and Shape:Solid
    Molecular weight:416.38

    Ref: TM-T201432

  • CymitQuimica logo
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    HSP90-IN-11

    <p>HSP90-IN-11: potent HSP90 inhibitor, akin to AUY-922; hinders CRC/NSCLC cell proliferation; degrades EGFR, Akt proteins.</p>
    Formula:C27H30FN3O6
    Color and Shape:Solid
    Molecular weight:511.54

    Ref: TM-T63528

  • HSP90-IN-32
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    HSP90-IN-32

    CAS:
    <p>HSP90-IN-32, a carboxy-terminus inhibitor of Hsp90C, exhibits antiproliferative activity in various cell lines including SKMel173, SKMel103, SKMel19, and A375, with IC50 values of 1.01 μM, 0.782 μM, 0.607 μM, and 1.413 μM, respectively. This compound holds potential for research in anticancer agents.</p>
    Formula:C33H40N2O4
    Color and Shape:Solid
    Molecular weight:528.68

    Ref: TM-T200425

  • HSP90α-IN-1
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    HSP90α-IN-1

    CAS:
    <p>HSP90α-IN-1 is an HSP90α inhibitor (IC50= 111 nM) that demonstrates anti-aging activity across various cellular senescence models. Belonging to the xanthine family, HSP90α-IN-1 is involved in research focused on combating age-related inflammation, senescence, and diseases (including cancer), and it may contribute to extending healthy lifespan.</p>
    Formula:C19H16N4O2
    Color and Shape:Solid
    Molecular weight:332.356

    Ref: TM-T206700