HSP
HSP (Heat Shock Protein) inhibitors target HSPs, a family of molecular chaperones that assist in protein folding, stability, and protection against stress-induced damage. HSPs are often upregulated in cancer cells, helping them survive under stressful conditions such as hypoxia and chemotherapy. Inhibiting HSPs can disrupt these protective mechanisms, leading to cell death. HSP inhibitors are therefore valuable in cancer therapy and research into stress responses. At CymitQuimica, we provide a comprehensive range of high-quality HSP inhibitors to support your research in protein homeostasis, stress responses, and oncology.
Found 179 products of "HSP"
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HSP70/SIRT2-IN-2
CAS:HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1].
Formula:C17H13N3S3Purity:98%Color and Shape:SolidMolecular weight:355.5Flavokawain 1i
CAS:Flavokawain 1i, a derivative of chalcones flavokawain A, flavokawain B, and flavokawain C, exhibits anticancer and antiviral properties.Formula:C21H18O4Color and Shape:SolidMolecular weight:334.37HSP90-IN-19
CAS:HSP90-IN-19: potent Hsp90 inhibitor, IC50 = 0.27 μM, used in research on viral diseases, neurodegeneration, inflammation.Formula:C29H38O7Purity:98%Color and Shape:SolidMolecular weight:498.61MAO A/HSP90-IN-1
CAS:MAO A/HSP90-IN-1 (4-b) is a dual inhibitor of MAO A and HSP90, exhibiting IC50 values of 1.77 μM in glioblastoma (GBM) GL26 cells and 0.019 μM against HSP90α.Formula:C24H29ClN2O4Purity:98%Color and Shape:SolidMolecular weight:444.95KU-177
CAS:KU-177 is an Aha1 inhibitor that disrupts the interaction between Hsp90 and Aha1, eliminating cell proliferation and PI resistance induced by elevated AHSA1.Formula:C27H23NO8Purity:96.92% - 98.54%Color and Shape:SolidMolecular weight:489.47Iroxanadine sulfate
CAS:Iroxanadine sulfate is a MAPK p38 inhibitor potentially for the treatment of atherosclerosis.Formula:C14H22N4O5SColor and Shape:SolidMolecular weight:358.41GRP78-IN-2
CAS:GRP78-IN-2 inhibits surface GRP78, showing anti-angiogenic and anti-cancer properties, sparing normal cells.Formula:C29H29NO6Color and Shape:SolidMolecular weight:487.54YM-08
CAS:YM-08 (Compound 7a), a brain-penetrant SIRT2 inhibitor, exhibits an IC50 of 19.9 μM. Additionally, it acts as an inhibitor of Hsp70 [1].Formula:C19H17N3OS2Purity:98%Color and Shape:SolidMolecular weight:367.49BX-2819
CAS:BX-2819 is an Hsp90 inhibitor that exhibits potent antiproliferative activity with an IC50 of 41 nM .Formula:C21H24N4O4SPurity:98%Color and Shape:SolidMolecular weight:428.51HSP90-IN-27
CAS:HSP90-IN-27, also known as compound 19, is an inhibitor of HSP90 [1].Formula:C18H21N3O2SPurity:98%Color and Shape:SolidMolecular weight:343.44Hsp110-STAT3 interaction-IN-1
CAS:Row174336 (compound 29) serves as an efficient inhibitor of the Hsp110-STAT3 interaction, exhibiting antiproliferative activity in the HPAEC cell line with an IC50 of 22.67 μM.Formula:C23H31N3O4SColor and Shape:SolidMolecular weight:445.58ETB
CAS:ETB is a potent inhibitor of Hsp60 chaperone activity. It can impede the chaperone function of both wild-type proteins and the C237A and C447A mutant proteins. ETB binds to Hsp60 at Cys442, and the C442A mutant demonstrates resistance to ETB inhibition.Formula:C24H33NO6Molecular weight:431.52Hsp90-IN-34
CAS:Hsp90-IN-34 (compound HAM-1) is a chemical inhibitor that targets the Aha1-Hsp90 chaperone complex with high affinity (KDapp=23.5 µM). It modulates the ATPase activity of Hsp90 by affecting the interaction between Hsp90 and Aha1.Formula:C22H14F2N6OColor and Shape:SolidMolecular weight:416.38DDO-6691
CAS:DDO-6691 is an inhibitor of heat shock protein 90 (HSP90). It exhibits antiproliferative effects against various tumor cells, with the highest sensitivity observed in HCT-116 colon cancer cells (IC50: 1.08 μM). DDO-6691 also demonstrates potent tumor growth inhibition in HCT-116 xenograft mouse models.Formula:C22H17N3O2SColor and Shape:SolidMolecular weight:387.45KU-32
CAS:KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.Formula:C20H25NO8Purity:98%Color and Shape:SolidMolecular weight:407.41KUNG65
CAS:KUNG65 acts as a selective Grp94 inhibitor, demonstrating a target dissociation constant (K_d) of 540 nM. It exhibits a minimum selectivity of 73-fold compared to other Hsp90 isoforms.Formula:C23H20ClFO4Color and Shape:SolidMolecular weight:414.85HSP90-IN-32
CAS:HSP90-IN-32, a carboxy-terminus inhibitor of Hsp90C, exhibits antiproliferative activity in various cell lines including SKMel173, SKMel103, SKMel19, and A375, with IC50 values of 1.01 μM, 0.782 μM, 0.607 μM, and 1.413 μM, respectively. This compound holds potential for research in anticancer agents.Formula:C33H40N2O4Color and Shape:SolidMolecular weight:528.68HSP90α-IN-1
CAS:HSP90α-IN-1 is an HSP90α inhibitor (IC50= 111 nM) that demonstrates anti-aging activity across various cellular senescence models. Belonging to the xanthine family, HSP90α-IN-1 is involved in research focused on combating age-related inflammation, senescence, and diseases (including cancer), and it may contribute to extending healthy lifespan.Formula:C19H16N4O2Color and Shape:SolidMolecular weight:332.356EV206
CAS:EV206 is an effective inhibitor of Hsp70, exhibiting antiproliferative properties. This compound induces cell apoptosis (apoptosis) and enhances the protein expression of cleaved PARP and caspase-3. Additionally, EV206 demonstrates antitumor activity.Formula:C21H19N3OColor and Shape:SolidMolecular weight:329.40HSP90-IN-11
HSP90-IN-11: potent HSP90 inhibitor, akin to AUY-922; hinders CRC/NSCLC cell proliferation; degrades EGFR, Akt proteins.Formula:C27H30FN3O6Color and Shape:SolidMolecular weight:511.54DCEM1
CAS:DCEM1 binds to heat shock protein 60 (HSP60) and inhibits the interaction between HSP60 and ClpP, thereby blocking the mitochondrial unfolded protein response. Additionally, DCEM1 suppresses the expression of β-catenin and reduces ATP production in PC-3 and TKO cells. It is utilized in research related to prostate cancer.Formula:C22H23N3O2SColor and Shape:SolidMolecular weight:393.50Onalespib lactate
CAS:Onalespib lactate is a second-generation, potent and selective HSP90 Inhibitor with antitumor activity.Formula:C27H37N3O6Color and Shape:SolidMolecular weight:499.6Hsp90-IN-37
CAS:Hsp90-IN-37 (Z-2) is an inhibitor of heat shock protein 90 (Hsp90), demonstrating a 69% inhibition rate on Hsp90 enzyme activity. It exhibits antitumor properties.Formula:C12H15N3O2Color and Shape:SolidMolecular weight:233.266Monorden diacetate
CAS:Monorden diacetate a Hsp90 Inhibitor. Monorden diacetate is a Promising Lead Compound for the Development of Novel Fungicides.Formula:C22H21ClO8Color and Shape:SolidMolecular weight:448.85Macbecin I
CAS:Hsp90 inhibitorFormula:C30H42N2O8Purity:98%Color and Shape:SolidMolecular weight:558.66Cemdomespib
CAS:Cemdomespib (KU-596) is a potent Hsp90 modulator with neuroprotective effects and can improve diabetic neuropathy.Formula:C24H30FNO6Color and Shape:SolidMolecular weight:447.5Iroxanadine hydrobromide
CAS:Iroxanadine hydrobromide is a MAPK p38 inhibitor potentially for the treatment of atherosclerosis.Formula:C14H21BrN4OColor and Shape:SolidMolecular weight:341.25C086
CAS:C086 is a novel and potent Hsp90 inhibitor that suppresses cell cycle progression, induces apoptosis, and exhibits anti-metastatic properties by modulating various mechanisms in different cell types.Formula:C29H28O8Color and Shape:SolidMolecular weight:504.53Zelavespib hydrochloride
Zelavespib (PU-H71) hydrochloride is a potent inhibitor of Hsp90, exhibiting an IC50 value of 51 nM in MDA-MB-468 cells.Purity:98%Color and Shape:Odour Solid
