Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2235 products of "Chromatin/Epigenetics"
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CBB1007 trihydrochloride (1379573-92-8 free base)
CAS:<p>CBB1007 trihydrochloride is a selective, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1).</p>Formula:C27H37Cl3N8O4Purity:98%Color and Shape:SoildMolecular weight:643.99PROTAC EED degrader-1
<p>PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.</p>Formula:C55H60FN11O8SPurity:98%Color and Shape:SolidMolecular weight:1054.2FKBP12 PROTAC dTAG-7
CAS:<p>dTAG-7 selectively degrades BRD4 and FKBP12F36V by linking BET bromodomains to E3 ligase CRBN; it's a heterobifunctional degrader.</p>Formula:C63H79N5O19Purity:98%Color and Shape:SolidMolecular weight:1210.32AUR1545
CAS:<p>AUR1545 is a selective KAT2A/KAT2B degradator exhibiting inhibitory activity against cancer models including AML, SCLC, and NEPC, and suppressing tumour growth in the NCI-H1048 xenograft model.</p>Formula:C41H50BrN9O5Purity:98.84%Color and Shape:SolidMolecular weight:828.8PROTAC BRD4 Degrader-30
<p>PROTACBRD4 degrader-30 is an ISOX-DUAL-based PROTAC degrader, targeting BRD4 with an IC50 value of 65 nM. It is used in research studies related to c-Myc oncoproteins and the pathophysiology of cancer cells.</p>Color and Shape:Odour SolidEXQ-2d
<p>EXQ-2d is an inhibitor of tankyrase, effectively targeting TNKS1 and TNKS2 with IC50 values of 48.8 nM and 13.8 nM (pIC50=7.31 and 7.86), respectively. Additionally, EXQ-2d suppresses the WNT/β-catenin signaling pathway with an IC50 of 515 nM. It demonstrates antiproliferative activity in cancer cells COLO 320DM and RKO, with GI50 values of 4.9 μM and 77 μM, respectively.</p>Formula:C18H17N3O3Color and Shape:SolidMolecular weight:323.35SIRT5 inhibitor 8
CAS:<p>SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.</p>Formula:C22H25ClN8O2SPurity:99.56%Color and Shape:SolidMolecular weight:501PROTAC BET degrader-2
CAS:<p>PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins (IC50 of 9.6 nM ).</p>Formula:C41H42N10O6Purity:98%Color and Shape:SolidMolecular weight:770.84Anemonin (6CI)
CAS:<p>Anemonin, a furanone dimer from Buttercups, may help manage melanocytes and osteoarthritis.</p>Formula:C10H8O4Color and Shape:SolidMolecular weight:192.17SMD-3040 TFA
<p>SMD-3040 TFA is a selective SMARCA2 degrader comprising SMARCA2/4 ligands, a linker, and VHL ligands, utilized in PROTAC drug synthesis.</p>Purity:98%Color and Shape:Odour SolidGNE-987
CAS:<p>GNE-987 is a potent chimeric BET degrader, binding BRD4 BD1/BD2 at IC50: 4.7/4.4 nM & has a DC50: 0.03 nM in EOL-1 AML cells.</p>Formula:C56H67F2N9O8S2Purity:98%Color and Shape:SolidMolecular weight:1096.31(+)-JQ-1-aldehyde
<p>(+)-JQ-1-aldehyde is the aldehyde derivative of (+)-JQ1, commonly used as a precursor for the synthesis of PROTACs targeting the BET bromine domain[1].</p>Color and Shape:SolidMRS2698
CAS:<p>MRS2698: potent P2Y2 agonist, EC50 8 nM, >300x selectivity over P2Y4/P2Y6.</p>Formula:C9H16N3O13P3SPurity:98%Color and Shape:SolidMolecular weight:499.22UNC4976
<p>UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.</p>Formula:C47H70N6O8Purity:98%Color and Shape:SolidMolecular weight:847.09PI3Kα/HDAC6-IN-1
<p>PI3Kα/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kα and HDAC6, exhibiting IC50 values of 2.9 nM and 26 nM, respectively.</p>Formula:C27H30F3N7O6S2Purity:98%Color and Shape:SolidMolecular weight:669.7HDAC/CD13-IN-1
<p>HDAC/CD13-IN-1 (Compound 12) is an inhibitor of both HDAC and CD13, with IC50 values of 0.34 μM for hCD13, 0.53 μM for porcine CD13, and 0.03, 0.06, and 0.02 μM</p>Formula:C27H41Cl2N5O4Purity:98%Color and Shape:SolidMolecular weight:570.55JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222
<p>JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222 incorporates a BRD4 ligand and a PROTAC linker, and is used in the synthesis of PROTAC BRD4 Degrader-29.</p>Formula:C43H51ClN8O3S2Color and Shape:SolidMolecular weight:827.5UNC6864 (Kei)
<p>UNC6864, an ethylisopropyllysine-containing ligand, exhibits binding affinity to wild-type CBX5, demonstrating a dissociation constant (K D) of 3.3 μM.</p>Formula:C42H59N7O11Color and Shape:SolidMolecular weight:837.96WDR5 ligand 2
CAS:<p>WDR5ligand 2 is a ligand for WDR5 and can be utilized in the synthesis of PROTAC WDR5degrader 1.</p>Formula:C29H31F3N4O4Color and Shape:SolidMolecular weight:556.576HDAC11-IN-1
<p>HDAC11-IN-1 (Compound 14-NC6OH) is a macrocyclic inhibitor that selectively targets HDAC11 with a Ki of 40 nM. It demonstrates effective cell permeability and suppresses the expression of YAP1 and SOX2.</p>Formula:C43H63F3N6O6S2Color and Shape:SolidMolecular weight:881.12
