Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2612 products of "Chromatin/Epigenetics"
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PKC β pseudosubstrate TFA
PKC β pseudosubstrate TFA is a selective cell-permeable inhibitor of PKC [1] .Formula:C179H295F3N62O40S3Color and Shape:SolidMolecular weight:4108.84CPI-268456
CAS:CPI-268456 is a compound which has bioactive.Formula:C20H15Cl2N3O2Color and Shape:SolidMolecular weight:400.26LSQ-28
LSQ-28 is an orally active HDAC3 inhibitor with an IC50 of 42 nM, demonstrating significant anticancer, antiproliferative, anti-migration, anti-invasion, and anti-wound healing activities. LSQ-28 is suitable for cancer research.Formula:C31H27N5OColor and Shape:SolidMolecular weight:485.579HDAC6-IN-49
HDAC6-IN-49 (Compound 3) is an inhibitor of HDAC, with IC50 values of 0.012 and 0.735 µM against HDAC6 and HDAC1, respectively. Additionally, it inhibits MAO-B, cholinesterase (ChE), histamine receptor (H3R), and serotonin 6 receptor (5-HT6R). HDAC6-IN-49 exhibits neuroprotective effects in SH-SY5Y cells and enhances cognitive functions and motor abilities in fruit fly models of Parkinson's disease and C. elegans models of Alzheimer's disease.Color and Shape:Odour SolidBRD7-IN-2
BRD7-IN-2 (compound 2-77) is a potent selective inhibitor of bromodomain-containing protein 7 (BRD7), exhibiting significant anti-proliferative activity inFormula:C18H18N2O3Purity:98%Color and Shape:SolidMolecular weight:310.35Pulrodemstat HCl
CAS:Pulrodemstat HCl is an LSD1 inhibitor and a KDM1A inhibitor with anticancer anti, proliferative activity.Formula:C24H24ClF2N5O2Purity:97.87% - 99.16%Color and Shape:SoildMolecular weight:487.93P3FI-63
CAS:P3FI-63 is a selective KDM3B inhibitor (IC50: 7 μM) with antitumor activity for the study of fusion-positive rhabdomyosarcoma and other transcriptionally addictive cancers.Formula:C15H15N3O2Purity:99.16%Color and Shape:SoildMolecular weight:269.3TNKS-2-IN-2
CAS:TNKS-2-IN-2 is a TNKS2 selective inhibitor (IC50: 22 nM) with potential anti-tumour activity for the study of colon cancer lung cancer and breast cancer.Formula:C26H23N3O6Purity:99.45%Color and Shape:SoildMolecular weight:473.48PBRM1-BD2-IN-5
CAS:PBRM1-BD2-IN-5 is a potent inhibitor of the PBRM1 Bromodomain, demonstrating dissociation constant (Kd) values of 1.5 μM and 3.9 μM for PBRM1-BD2 and PBRM1-BD5Formula:C15H13ClN2OPurity:99.51%Color and Shape:SoildMolecular weight:272.73Ref: TM-T60159
1mg84.00€5mg177.00€10mg260.00€25mg429.00€50mg572.00€100mg793.00€200mg1,063.00€1mL*10mM (DMSO)170.00€PCAF-IN-1
CAS:PCAF-IN-1 is a highly selective PCAF inhibitor with potential anti-tumor, anti-inflammatory, and anti-heart disease effects.Formula:C15H11ClN6Color and Shape:SolidMolecular weight:310.74MC4171
MC4171 is a selective KAT8 inhibitor with antiproliferative activity and can be used to study cancer.Formula:C21H15N3O3Purity:99.56%Color and Shape:SolidMolecular weight:357.36AS-85
CAS:AS-85 is an ASH1L inhibitor with anti-leukemic activity that inhibits leukemic cell growth and increases cLogP.Formula:C26H28F3N5O3S2Purity:98.96%Color and Shape:SolidMolecular weight:579.66I-BET567
CAS:I-BET567: potent, oral pan-BET inhibitor; pIC50s: 6.9 (BRD4 BD1), 7.2 (BD2); effective in mouse cancer and inflammation models.Formula:C17H18ClN5O2Purity:99.8%Color and Shape:SolidMolecular weight:359.81Ref: TM-T9619
1mg89.00€5mg187.00€10mg286.00€25mg575.00€50mg863.00€100mg1,269.00€1mL*10mM (DMSO)205.00€DTP3
CAS:DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.Formula:C26H35N7O5Color and Shape:SolidMolecular weight:525.6AZ505 ditrifluoroacetate
CAS:AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).Formula:C33H40Cl2F6N4O8Color and Shape:SolidMolecular weight:805.59GSK778
CAS:GSK778 selectively inhibits BD1 bromodomains (BRD2, BRD3, BRD4, BRDT) and impedes cell growth, causing arrest and apoptosis.Formula:C30H33N5O3Purity:98.42%Color and Shape:SolidMolecular weight:511.61Ref: TM-T9703
1mg152.00€5mg295.00€10mg477.00€25mg954.00€50mg1,513.00€100mg2,097.00€1mL*10mM (DMSO)44.00€SGC-iMLLT
CAS:SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class chemical probe displaying cellular targetFormula:C22H24N6OPurity:99.21% - 99.92%Color and Shape:SolidMolecular weight:388.47TPOP146
CAS:TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor (Kd: 134 nM and 5.02 μM for CBP and BRD4).Formula:C27H35N3O5Purity:98%Color and Shape:SolidMolecular weight:481.58(2R)-Octyl-α-hydroxyglutarate
CAS:(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a D-isomer 2-Hydroxyglutarate modified form.Formula:C13H24O5Color and Shape:SolidMolecular weight:260.33KDM4C-IN-1
CAS:KDM4C-IN-1 is aKDM4C inhibitor withial anticancer activity.KDM4C-IN-1 inhibits the growth of HepG2 and A549 cells, and can be used for the study of leukaemia.Formula:C15H14N4O3Purity:99.33%Color and Shape:SolidMolecular weight:298.3Eicosapentaenoic Acid (Standard)
CAS:Eicosapentaenoic Acid (Standard) is the standard substance of Eicosapentaenoic Acid, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Eicosapentaenoic Acid is an ω-3 fatty acid and an inhibitor of fatty acid synthase (FASN). Eicosapentaenoic Acid promotes DNA demethylation in the reexpression of the tumor suppressor gene CCAAT/ enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates the RAS/ERK/C/EBPβ pathway in U937 leukemia cells through demethylation of the CpG island of H-RAS intron 1. Eicosapentaenoic Acid promotes the relaxation of vascular smooth muscle cells and vasodilation.Formula:C20H30O2Color and Shape:LiquidMolecular weight:302.45EHMT2-IN-1
CAS:EHMT2-IN-1: potent EHMT inhibitor, for blood disorders/cancer research; IC50s <100 nM for EHMT1/2 peptides and cellular EHMT2.Formula:C18H23N7OColor and Shape:SolidMolecular weight:353.42PROTAC EZH2 Degrader-1
CAS:PROTAC EZH2 Degrader-1 suppresses EZH2 methyltransferase activity with IC50 2.7 nM, serving as a potent tool in cancer research and EZH2 inhibition studies.Formula:C54H67N7O8Color and Shape:SolidMolecular weight:942.15PR5-LL-CM01
CAS:PR5-LL-CM01 is a novel protein arginine methyltransferase 5 (PRMT5) inhibitor in colorectal and pancreatic cancers.Formula:C23H27N7Color and Shape:SolidMolecular weight:401.51Itacitinib adipate
CAS:Itacitinib adipate: oral JAK1 inhibitor, tested in phase II myelofibrosis trial.Formula:C32H33F4N9O5Color and Shape:SolidMolecular weight:699.66Ifidancitinib
CAS:Ifidancitinib (ATI-50002) is a JAK kinase 1/3 inhibitor used to study autoimmune diseases.Formula:C20H18FN5O3Purity:98.05%Color and Shape:SolidMolecular weight:395.39GSK9311
CAS:GSK9311 inhibits BRPF bromodomain (pIC50: 6.0 and 4.3 for BRPF1 and BRPF2, respectively).Formula:C24H31N5O3Purity:98%Color and Shape:SolidMolecular weight:437.53GSK2879552
CAS:GSK2879552: oral, irreversible LSD1 inhibitor with potential cancer-fighting properties.Formula:C23H28N2O2Purity:99.22%Color and Shape:SolidMolecular weight:364.48Boc-Lys(Ac)-AMC
CAS:Boc-Lys(Ac)-AMC (Boc-L-Lys(Ac)-AMC) is a synthetic substrate coupled to an HDAC-specific fluorophore (Ex/Em = 355 nm/460 nm).Formula:C23H31N3O6Purity:99.87%Color and Shape:SolidMolecular weight:445.51Ref: TM-T36578
5mg51.00€10mg77.00€25mg129.00€50mg182.00€100mg268.00€200mg387.00€1mL*10mM (DMSO)52.00€ADTL-SA1215
CAS:ADTL-SA1215 is a SIRT3 activator with SIRT3 deacetylase activity for the study of triple negative breast cancer.Formula:C26H29I2NO3Purity:99.23%Color and Shape:SolidMolecular weight:657.32PROTAC PARP1 degrader
CAS:PROTAC PARP1 degrader suppresses MDA-MB-231 cells at 10 μM, IC50: 6.12 μM in 24h.Formula:C58H63Cl2N11O10Purity:98%Color and Shape:SolidMolecular weight:1145.1T-448
CAS:T-448 is a lysine-specific demethylase 1 inhibitor (IC50: 22 nM) that improves learning function in mice.T-448 can be used to study memory deficits.Formula:C19H22N4O3SPurity:97% - 98.63%Color and Shape:SolidMolecular weight:386.47JET-209
JET-209 is a potent proteolysis-targeting chimera (PROTAC) that effectively degrades CBP/p300, exhibiting half-maximal degradation concentration (DC50) valuesFormula:C46H47N9O6Purity:98%Color and Shape:SolidMolecular weight:821.92Atinvicitinib
CAS:Atinvicitinib, a selective JAK1 inhibitor, blocks cytokine signaling, modulating itch, allergy, and inflammatory responses, immune and therapeutic studies.Formula:C16H17FN6O3Purity:99.36%Color and Shape:SolidMolecular weight:360.35Ref: TM-T39646
1mg138.00€5mg334.00€10mg550.00€25mg1,063.00€50mg1,738.00€100mg2,547.00€1mL*10mM (DMSO)264.00€2'-Deoxy-2'-fluoro-β-D-arabinocytidine hydrochloride
CAS:2'-Deoxy-2'-fluoro-beta-D-arabinocytidine HCl inhibits DNA methyltransferase with potential anti-tumor properties.Formula:C9H13ClFN3O4Purity:99.43%Color and Shape:SolidMolecular weight:281.67Pim-1/2 kinase inhibitor 1
CAS:Orally active Pim-1/2 inhibitor blocks kinase phosphorylation; used in prostate cancer research.Formula:C11H9NO3SPurity:99.78%Color and Shape:SolidMolecular weight:235.26PKC-θ inhibitor
CAS:PKC-theta inhibitor is PKC-θinhibitor, with an IC50 of 12 nM.Formula:C20H25F3N6O3Purity:99.46%Color and Shape:SolidMolecular weight:454.45Ref: TM-T5423
1mg101.00€5mg236.00€10mg313.00€25mg442.00€50mg580.00€100mg893.00€200mg1,198.00€1mL*10mM (DMSO)259.00€HDAC-IN-4
CAS:HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor (pIC50s: 7.2 and 6.8 in BRET assay) with antitumoral activity.Formula:C20H21N3O2Color and Shape:SolidMolecular weight:335.4Protein kinase inhibitor H-7 dihydrochloride
CAS:Protein kinase inhibitor H-7 dihydrochloride(H-7 dihydrochloride) is a potent protein kinase C (PKC) inhibitor.Formula:C14H19Cl2N3O2SPurity:99.81%Color and Shape:White Crystalline SolidMolecular weight:364.29SIRT5 inhibitor 3
CAS:SIRT5 inhibitor 3 is potent and competitive by inhibiting SIRT5 deacetylation, with potential in metabolic, cancer, neurodegenerative, cardiovascular .Formula:C22H12FN3O4Purity:98%Color and Shape:SolidMolecular weight:401.35MS8511 hydrochloride
CAS:MS8511 hydrochloride is a selective G9a/GLP inhibitor with IC50 values of 100 nM and 140 nM respectively, exhibiting covalent and irreversible characteristics.Formula:C28H42ClN5O3Color and Shape:SolidMolecular weight:532.12(±)-1,2-Diolein
CAS:(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) (1,2-Dioleoyl-rac-glycerol) is a PKC activator. (±)-1,2-Diolein could increases myotubes Ca 2+ influx.Formula:C39H72O5Color and Shape:SolidMolecular weight:620.99O6BTG-octylglucoside
CAS:O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor (IC50s: 10 nM and 32 nM in HeLa S3 cells and in vitro (cell extracts)).Formula:C24H34BrN5O7SPurity:98%Color and Shape:SolidMolecular weight:616.531,4-DPCA ethyl ester
CAS:1,4-DPCA ethyl ester is a form of 1,4-DPCA modified, which has potential anticancer activity based on growth inhibition assays with the mlh1 rad18 yeast strain.Formula:C15H12N2O3Purity:99.54%Color and Shape:SolidMolecular weight:268.27Ref: TM-T36796
2mg37.00€5mg54.00€10mg90.00€25mg157.00€50mg256.00€100mg434.00€200mg623.00€1mL*10mM (DMSO)59.00€Ilunocitinib
CAS:Ilunocitinib is a non-selective and orally active Janus kinase (JAK) inhibitor for pruritus and atopic dermatitis caused by atopic dermatitis in dogs.Formula:C17H17N7O2SPurity:99.88%Color and Shape:SolidMolecular weight:383.43Ref: TM-T38571
1mg92.00€5mg230.00€10mg356.00€25mg713.00€50mg1,189.00€100mg1,791.00€200mg2,412.00€1mL*10mM (DMSO)251.00€GSK-J2
CAS:GSK-J2 is an inactive enantiomer of GSK-J1 that is lipophilic and serves as an inactive control for GSK-J21.Formula:C22H23N5O2Purity:97.55%Color and Shape:SolidMolecular weight:389.45Ref: TM-T11476
1mg34.00€5mg71.00€10mg92.00€25mg157.00€50mg222.00€100mg329.00€200mg487.00€1mL*10mM (DMSO)101.00€DA-3003-1
CAS:DA-3003-1 (NSC 663284) is a Cdc25 dual specificity phosphatase inhibitor with antitumor activity and inhibits Cdc25B2, Cdc25A, Cdc25B2, and Cdc25C.Formula:C15H16ClN3O3Purity:99.27% - 99.79%Color and Shape:SolidMolecular weight:321.76CHZ868
CAS:CHZ868 is a type II JAK inhibitor with potential antitumor activity that reverses the persistence of type I JAK inhibitors and can be used to study leukemia.Formula:C22H19F2N5O2Purity:99.38%Color and Shape:SolidMolecular weight:423.42BAY-850
CAS:BAY-850 is ainhibitor of adenosine triphosphatase family protein 2 that inhibits ovarian cancer growth and metastasis in in vitro and in vivo models.Formula:C38H44ClN5O3Purity:98% - 98%Color and Shape:SolidMolecular weight:654.24SIRT-IN-3
CAS:SIRT-IN-3: potent SIRT1 inhibitor (IC50=17μM), 4x selective over SIRT2, 14x over SIRT3 (IC50s: 74μM & 235μM).Formula:C13H12N2OColor and Shape:SolidMolecular weight:212.25
