Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2235 products of "Chromatin/Epigenetics"
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SB-284851-BT
CAS:<p>SB-284851-BT: BRD4/p38α/BRDT inhibitor; IC50: BRD4-BD1 1.7µM, BRDT 18µM, BRD4 3.7µM; Kd p38α 0.47nM; reduces IL-8, affects c-Myc/NF-κB.</p>Formula:C26H26FN5OColor and Shape:SolidMolecular weight:443.52BET-BAY 002 (S enantiomer)
CAS:<p>The S-enantiomer of BET-BAY 002, referred to as BET-BAY 002 S enantiomer, is a potent inhibitor of BET (Bromodomain and Extra-Terminal motif proteins).</p>Formula:C22H18ClN5OPurity:98%Color and Shape:SolidMolecular weight:403.86PKC-IN-4
CAS:<p>PKC-IN-4 (compound 7l) is a highly potent and orally active inhibitor of atypical protein kinase C (aPKC), exhibiting an IC 50 value of 0.52 μM.</p>Formula:C21H25N5SColor and Shape:SolidMolecular weight:379.52CD161
CAS:<p>CD161: powerful, selective oral BET inhibitor; IC50: 28.2 nM (BRD4 BD1), 7.2 nM (BRD4 BD2); strong anticancer properties.</p>Formula:C26H21N5O2Purity:98%Color and Shape:SolidMolecular weight:435.48YF479
CAS:<p>YF479 is an inhibitor of histone deacetylase that acts by inhibiting breast tumor growth, metastasis, and recurrence.</p>Formula:C22H27BrN2O5Purity:98%Color and Shape:SolidMolecular weight:479.36TC-E 5001
CAS:<p>dual tankyrase (TNKS) inhibitor</p>Formula:C20H19N5O3SPurity:98%Color and Shape:SolidMolecular weight:409.46DC-CPin7
CAS:<p>DC-CPin7, a powerful inhibitor of the bromodomain of CREB-binding protein (CBP), exhibits an IC50 value of 2.5 μM [1].</p>Formula:C19H22N2O5Color and Shape:SolidMolecular weight:358.39OICR-0547
CAS:<p>OICR-0547 is an inactive derivative of OICR-9429 and is commonly used as a negative control for OICR-9429.</p>Formula:C28H29F3N4O4Purity:98%Color and Shape:SolidMolecular weight:542.55HIF-1α inhibitor-1
CAS:<p>HIF-1α inhibitor-1 is a HIF-1 alpha inhibitor.</p>Formula:C15H11N3O4Color and Shape:SolidMolecular weight:297.27Cercosporamide
CAS:<p>Cercosporamide is a ATP-competitive Pkc1 kinase inhibitor (IC50 <50 nM; Ki <7 nM). It also is a unique Mnk inhibitor.</p>Formula:C16H13NO7Purity:98%Color and Shape:SolidMolecular weight:331.28Bisindolylmaleimide II
CAS:<p>protein kinase C (PKC) inhibitor</p>Formula:C27H26N4O2Purity:98%Color and Shape:SolidMolecular weight:438.52LSD1-IN-12
CAS:<p>LSD1-IN-12 (compound 2) is an effective inhibitor of LSD1, demonstrating inhibitory Ki values of 1.1 μM (LSD1), 61 μM (LSD2), 2.3 μM (MAO-A), and 3.5 μM (MAO-B</p>Formula:C16H16N2OColor and Shape:SolidMolecular weight:252.31OM-137
CAS:<p>OM137 inhibits Aurora kinases, impedes cell growth at high doses, and enhances low-dose paclitaxel effects.</p>Formula:C13H14N4O3SColor and Shape:SolidMolecular weight:306.34SRTCX1002
CAS:<p>SRTCX1002 is a SIRT1 Activator Suppressing Inflammatory Responses through Promotion of p65 Deacetylation and NF-κB Activity inhibitor.</p>Formula:C21H19N5O2SPurity:98%Color and Shape:SolidMolecular weight:405.47AMPK activator 6
CAS:<p>AMPK activator 6 stimulates AMPK, lowers lipids in cells, and reduces serum TC, LDL-C, and TG. Useful for NAFLD and metabolic research.</p>Formula:C25H28O5Color and Shape:SolidMolecular weight:408.49ZLD1039
CAS:<p>ZLD1039, an oral EZH2 inhibitor, shows strong PRC2 inhibition at low nanomolar IC50s, and halts breast cancer growth and spread.</p>Formula:C36H48N6O3Purity:99.5%Color and Shape:SolidMolecular weight:612.8PU141
CAS:<p>PU141 is a novel inhibitor of histone acetyltransferase (HAT).</p>Formula:C14H9F3N2OSPurity:98%Color and Shape:SolidMolecular weight:310.29CHIC35
CAS:<p>CHIC-35 is a selective deacetylase SIRT1 inhibitor.</p>Formula:C14H15ClN2OColor and Shape:SolidMolecular weight:262.73OTS186935 trihydrochloride
CAS:<p>OTS186935 trihydrochloride is a protein methyltransferase inhibitor of SUV39H2(IC50 of 6.49 nM).</p>Formula:C25H29Cl4N5O2Purity:98%Color and Shape:SolidMolecular weight:573.34GNA002
CAS:<p>GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).</p>Formula:C42H55NO8Purity:98%Color and Shape:SolidMolecular weight:701.89ET-JQ1-OH
CAS:<p>ET-JQ1-OH is an allele-specific BET inhibitor.</p>Formula:C21H21ClN4O2SColor and Shape:SolidMolecular weight:428.93SMTIN-T140
CAS:<p>SMTIN-T140: strong TRAP1 inhibitor, IC50=1.646μM, anticancer; disrupts mitochondria, boosts ROS, activates AMPK, shrinks PC3 tumors, no in vivo toxicity.</p>Formula:C36H34BrClFN5OPPurity:98%Color and Shape:SolidMolecular weight:718.02F5446
CAS:<p>F5446 is a selective small molecule SUV39H1 methyltransferase inhibitor, promotes apoptosis in colorectal cancer cells by inhibiting the deposition of H3K9me3.</p>Formula:C26H17ClN2O8SPurity:98.56%Color and Shape:SolidMolecular weight:552.94MicroRNA-21-IN-2
CAS:<p>MicroRNA-21-IN-2 is a potential miR-21 inhibitor with an AC50 value of 3.29 μM. MicroRNA-21-IN-2 can be used to study cancer.</p>Formula:C17H15N3O3SPurity:99.2%Color and Shape:SolidMolecular weight:341.38CX-6258
CAS:<p>CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity.</p>Formula:C26H24ClN3O3Purity:97.46%Color and Shape:SolidMolecular weight:461.94BAY1238097
CAS:<p>BAY1238097 is a BET inhibitor with anticancer activity and antiproliferative activity for the study of advanced refractory malignancies.</p>Formula:C25H33N5O3Purity:98.1% - 98.79%Color and Shape:SolidMolecular weight:451.56EZH2-IN-3
CAS:<p>EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth.</p>Formula:C27H28ClN5O2Purity:98%Color and Shape:SolidMolecular weight:490CSV0C018875
CAS:<p>CSV0C018875 is a quinoline-based EHMT2/G9a inhibitor with lower cytotoxicity than BIX-01294 [1].</p>Formula:C18H17ClN2OColor and Shape:SolidMolecular weight:312.79SPV106
CAS:<p>SPV106 is a ligand of lysine acetyltransferases (KATs).</p>Formula:C22H40O4Purity:98%Color and Shape:SolidMolecular weight:368.55BIX-01338 hydrate
CAS:<p>BIX-01338 hydrate is an inhibitor of histone lysine methyltransferase.</p>Formula:C32H26F3N3O7Purity:98%Color and Shape:SolidMolecular weight:621.56(2R,5S)-Ritlecitinib
CAS:<p>(2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective inhibitor of JAK3 with IC 50 of 144.8 nM[1].</p>Formula:C15H19N5OColor and Shape:SolidMolecular weight:285.34PI3K/Akt/CREB activator 1
CAS:<p>PI3K/Akt/CREB activator 1 (AE-18) is an iNOS inhibitor that can be used to study vascular dementia and Parkinson's.</p>Formula:C19H15F4NO3Color and Shape:SolidMolecular weight:381.32Povorcitinib
CAS:<p>Povorcitinib is a highly potent and selective JAK1 inhibitor with significant potential for the investigation of cutaneous lupus erythematosus (CLE) and Lichen planus (LP).</p>Formula:C23H22F5N7OColor and Shape:SolidMolecular weight:507.469JAK3-IN-1
CAS:<p>JAK3-IN-1 is an orally active, selective and potent JAK3 inhibitor for the study of immune system disorders.</p>Formula:C26H30ClN7O2Color and Shape:SolidMolecular weight:508.02SRTCX1003
CAS:<p>SRTCX1003, a SIRT1 activator, suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity.</p>Formula:C23H23N5O3SColor and Shape:SolidMolecular weight:449.53Aurora Kinases-IN-3
CAS:<p>Aurora Kinases-IN-3 is an oral AURKB inhibitor that disrupts its mitotic localization, not its H3 Ser10 phosphorylation.</p>Formula:C20H16F3N3O4Color and Shape:SolidMolecular weight:419.35PBRM1-BD2-IN-6
CAS:<p>PBRM1-BD2-IN-6: potent PBRM1 inhibitor with 0.22 µM IC50, anti-cancer research potential.</p>Formula:C16H15ClN2OColor and Shape:SolidMolecular weight:286.76CK2/PIM1-IN-1
CAS:<p>CK2/PIM1-IN-1 inhibits CK2 & PIM1 (IC50s: 3.787 & 4.327 μM), aimed for cancer research.</p>Formula:C15H9NO4S2Purity:98%Color and Shape:SolidMolecular weight:331.37HDAC3 Inhibitor
CAS:<p>HDAC3 inhibitor: allosteric, Ki=0.16 nM, favors HDAC3 over HDAC1/2, targets specific leukemia cells, EC50=36.37-151.7 nM.</p>Formula:C20H23N3O2Color and Shape:SolidMolecular weight:337.42AMPK activator 8
CAS:<p>AMPK activator 8 targets rAMPK α1β1γ1/α2β1γ1/α1β2γ1 (EC50: 11/27/4 nM) for type 2 diabetes research.</p>Formula:C25H21ClN2O6Color and Shape:SolidMolecular weight:480.9RET-IN-19
CAS:<p>RET-IN-19, a potent RET inhibitor, anticancer: IC50 6.8 nM (RET-wt), 13.51 nM (RET V804M); for NSCLC research.</p>Formula:C28H28N6O4SColor and Shape:SolidMolecular weight:544.62KCN1
CAS:<p>KCN1: a synthetic sulfonamide, nanomolar HIF inhibitor with preclinical anti-glioma and anti-pancreatic cancer effects.</p>Formula:C26H27NO5SColor and Shape:SolidMolecular weight:465.56SIRT2-IN-10
CAS:<p>SIRT2-IN-10 (Compound 12) is a potent inhibitor of SIRT2 (IC50: 1.3 μM), which can be used in the study of cancer and neurodegenerative diseases.</p>Formula:C28H21N5OSColor and Shape:SolidMolecular weight:475.56SIRT5 inhibitor 4
CAS:<p>SIRT5 inhibitor 4 (compound 11) is a dose-dependent and selective SIRT5 (Sirtuin5) inhibitorand no inhibitory effect on SIRT1/2/3,anticancer.</p>Formula:C18H15N3O4SPurity:99.97%Color and Shape:SolidMolecular weight:369.39KDM5-C49
CAS:<p>KDM5-C49 is a potent and selective inhibitor of KDM5, which regulates cell proliferation and stem cell self-renewal and differentiation.</p>Formula:C15H24N4O3Purity:98%Color and Shape:SolidMolecular weight:308.38Dot1L-IN-2
CAS:<p>Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively</p>Formula:C27H24N8OPurity:98%Color and Shape:SolidMolecular weight:476.53CMP-5 hydrochloride
CAS:<p>CMP-5 hydrochloride: potent, selective PRMT5 inhibitor; inactive against PRMT1/4/7; blocks S2Me-H4R3 on histones.</p>Formula:C21H22ClN3Purity:98%Color and Shape:SolidMolecular weight:351.87UMB-136
CAS:<p>UMB-136 is a bromodomain BRD4 inhibitor that acts by significantly inducing HIV-1 reactivation.</p>Formula:C24H27N5O2Purity:98%Color and Shape:SolidMolecular weight:417.5BRM/BRG1 ATP Inhibitor-3
CAS:<p>BRM/BRG1 ATP Inhibitor-3 targets BRM/BRG1 (IC50: 10.4/19.3 nM) for cancer/BAF disorder research.</p>Formula:C26H25N5O2S2Color and Shape:SolidMolecular weight:503.64OTS186935
CAS:<p>OTS186935 is a inhibitor of protein methyltransferase SUV39H2(IC50 of 6.49 nM).</p>Formula:C25H26ClN5O2Purity:98%Color and Shape:SolidMolecular weight:463.96
