Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2602 products of "Chromatin/Epigenetics"
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CX-6258 hydrochloride
CAS:CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).Formula:C26H24ClN3O3·HClPurity:96.03% - 98.60%Color and Shape:SolidMolecular weight:498.4Ref: TM-T6148
1mg40.00€5mg84.00€10mg120.00€25mg222.00€50mg356.00€100mg537.00€200mg762.00€1mL*10mM (DMSO)93.00€TNG-462
CAS:TNG-462 is a oral, potent and selective PRMT5 inhibitor for the treatment of MTAP-deficient and/or MTA-accumulating cancers (e.g., pancreatic & bladder).Formula:C28H36N6O2SPurity:98.7%Color and Shape:SolidMolecular weight:520.69Ref: TM-T79873
1mg147.00€5mg255.00€10mg383.00€25mg575.00€50mg863.00€100mg1,305.00€200mg1,755.00€1mL*10mM (DMSO)294.00€RGFP966 (E-isomer)
CAS:RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC.Formula:C21H19FN4OPurity:99.93%Color and Shape:SolidMolecular weight:362.4MS023 dihydrochloride
CAS:MS023 dihydrochloride (MS023 2HCl) is a human type I protein arginine methyltransferase inhibitor with antitumour activity for the study of breast cancer.Formula:C17H27Cl2N3OPurity:99.52%Color and Shape:SolidMolecular weight:360.32MDL-800
CAS:MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.Formula:C21H16BrCl2FN2O6S2Purity:99.95% - 99.96%Color and Shape:SolidMolecular weight:626.3R 59-022
CAS:R 59-022 (DKGI-I) is a DGK inhibitor and a 5-HT Receptor antagonist that blocks filovirus internalization in host cells.Formula:C27H26FN3OSPurity:98.55%Color and Shape:SolidMolecular weight:459.58Ref: TM-T16709
1mg35.00€5mg74.00€10mg119.00€25mg269.00€50mg447.00€100mg733.00€200mg973.00€1mL*10mM (DMSO)75.00€PFI-2
CAS:PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over otherFormula:C23H25F4N3O3SPurity:99.38%Color and Shape:SolidMolecular weight:499.52Dehydrocorydaline nitrate
CAS:DHC curbs antibody and cell-mediated allergies, inhibits mitochondrial potential in macrophages, and has antinociceptive, anti-inflammatory effects.Formula:C22H24N2O7Purity:99.79% - 99.92%Color and Shape:SolidMolecular weight:428.44Ref: TM-T2S2362
1mg89.00€5mg205.00€10mg334.00€25mg552.00€50mg782.00€100mg1,054.00€200mg1,414.00€1mL*10mM (DMSO)243.00€SCH-1473759 hydrochloride
CAS:SCH-1473759 hydrochloride is an inhibitor of aurora(aurora A and B with IC50s of 4 and 13 nM, respectively).Formula:C20H27ClN8OSPurity:98.29%Color and Shape:SolidMolecular weight:463GSK2807 Trifluoroacetate
CAS:GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).Formula:C21H33F3N8O7Purity:99.95%Color and Shape:SolidMolecular weight:566.53PF-03814735
CAS:PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.Formula:C23H25F3N6O2Purity:98%Color and Shape:SolidMolecular weight:474.48NVP-BSK805
CAS:NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.Formula:C27H28F2N6OPurity:98%Color and Shape:SolidMolecular weight:490.55MK-5108
CAS:MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.Formula:C22H21ClFN3O3SPurity:99.22%Color and Shape:SolidMolecular weight:461.94Diethyl bipy55'DC
CAS:"Diethyl bipy55'DC blocks CP4H, crucial for collagen stability via hydroxylation in cells."Formula:C16H16N2O4Purity:98%Color and Shape:SolidMolecular weight:300.312-PADQZ
CAS:DPQ is an antiviral compound.Formula:C14H19N5O2Purity:98%Color and Shape:White PowderMolecular weight:289.33Acedapsone
CAS:Acedapsone has antimalarial and antimicrobial action, but is mainly used as a depot leprostatic agent.Formula:C16H16N2O4SPurity:98%Color and Shape:SolidMolecular weight:332.37TETi76
CAS:TETi76 is an orally active inhibitor from the TET family, demonstrating IC50 values of 1.5, 9.4, and 8.8 μM against TET1, TET2, and TET3, respectively. The compound competitively binds to the active sites of TET enzymes, reducing cytosine hydroxymethylation and restricting clonal growth in mutated TET2 in vitro and in vivo, without affecting the growth of normal hematopoietic progenitor cells. TETi76 is utilized in leukemia research.Formula:C10H16O5Color and Shape:SolidMolecular weight:216.23Tazemetostat trihydrochloride
CAS:Tazemetostat trihydrochloride, an EZH2 inhibitor, orally active, IC50: 4nM (rat), Ki: 2.5nM (human), effective in peptide and nucleosome assays.Formula:C34H47Cl3N4O4Purity:98%Color and Shape:SolidMolecular weight:682.12(R)-Dihydrolipoic acid
CAS:(R)-Dihydrolipoic acid, the biochemically significant R-enantiomer, partakes in biochemical transformations.Formula:C8H16O2S2Purity:98%Color and Shape:SolidMolecular weight:208.33193 D7
CAS:193 D7 is an inhibitor of histone demethylase JMJD1C (IC50= 0.59 μM in in vitro demethylation assay). In vivo, 193 D7 suppresses tumors by targeting intratumoral Treg cells in mouse tumor models.Formula:C16H15NO4SColor and Shape:SolidMolecular weight:317.36Nicotinamide-d4
CAS:Nicotinamide-d4 is a deuterium-labelled compound of nicotinamide for isotope tracing. Nicotinamide, a vitamin B3 derivative, inhibits SIRT1 and SIRT2.Formula:C6H2D4N2OPurity:99.746%Color and Shape:SolidMolecular weight:126.15GSK 4027
CAS:GSK 4027 is a PCAF/GCN5 bromodomain chemical probe. In a time-resolved fluorescence resonance energy transfer (TR-FRET) assay, it has a pIC50 of 7.4±0.11 for PCAF.Formula:C17H21BrN4OColor and Shape:SolidMolecular weight:377.28KAT6-IN-1
CAS:KAT6-IN-1 (compound E) is a selective, orally available inhibitor of histone acetyltransferases KAT6A and KAT6B, exhibiting antitumour activity for cancer.Formula:C19H18N4O5SPurity:99.86%Color and Shape:SolidMolecular weight:414.43BG47
CAS:BG47: a COMET probe for precise optical epigenetic control, inhibits histone deacetylases with light.Formula:C25H22N4O2SColor and Shape:SolidMolecular weight:442.54BChE/HDAC6-IN-2
CAS:BChE/HDAC6-IN-2 is an inhibitor of BChE and HDAC6 with neuroprotective and ROS scavenging activity and a metal ion co-agonist and inhibits tau phosphorylation.Formula:C27H30N4O4Purity:98.47%Color and Shape:SoildMolecular weight:474.55(3S,4S)-Tofacitinib
CAS:(3S,4S)-Tofacitinib, a less active enantiomer of tofacitinib, is a Janus kinases inhibitor.Formula:C16H20N6OPurity:98%Color and Shape:SolidMolecular weight:312.37BRD 4354 ditrifluoroacetate
BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9 (IC50s: 0.85 and 1.88 μM).Formula:C25H25ClF6N4O5Purity:98%Color and Shape:SolidMolecular weight:610.93Asteltoxin
CAS:Asteltoxin is a useful organic compound for research related to life sciences. The catalog number is T124203 and the CAS number is 79663-49-3.Formula:C23H30O7Color and Shape:SolidMolecular weight:418.486HDAC6-IN-27
CAS:HDAC6-IN-27 (compound 8C), an HDAC inhibitor, exhibits IC 50 values of 15.9 nM, 136.5 nM, and 6180.2 nM against HDAC6, HDAC8, and HDAC1, respectively. It also demonstrates potent antiparasitic effects [1].Formula:C15H15N3O4Color and Shape:SolidMolecular weight:301.3AdipoR agonist 1
CAS:AdipoR agonist 1 (Compound 112254), acting as an agonist for the adiponectin receptor (AdipoR), stimulates transcriptional regulators including peroxisome proliferator-activated receptors (PPARs), peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), sirtuin 1 (SIRT1), and adenylate-activated protein kinase (AMPK). It is employed in the field of preventive doping research.Formula:C26H35N3O3Color and Shape:SolidMolecular weight:437.57ZM39923
CAS:ZM39923 is a JAK3 inhibitor (pIC50: 7.1). ZM39923 also effectively inhibits tissue transglutaminase (IC50: 10 nM).Formula:C23H25NOPurity:98%Color and Shape:SolidMolecular weight:331.45GSK-J1 lithium salt
CAS:GSK-J1 lithium salt is an effective inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with an IC 50 of 60 nM for KDM6B.Formula:C22H22LiN5O2Purity:98%Color and Shape:SolidMolecular weight:395.38KR-39038
CAS:KR-39038 is an oral GRK5 inhibitor for heart failure research; blocks HDAC5 pathway, IC50: 0.02 μM, fights cardiac hypertrophy.Formula:C24H32ClFN6OColor and Shape:SolidMolecular weight:475.00Guanosine-5'-triphosphate disodium salt
CAS:5'-GTP disodium salt boosts myogenic differentiation and fuels cellular processes.Formula:C10H14N5Na2O14P3Purity:95.69% - 99.96%Color and Shape:Odorless White SolidMolecular weight:567.14BG14
CAS:BG14: High-res optical epigenetic control; photo-inhibits human histone deacetylases with visible light.Formula:C21H21N5OColor and Shape:SolidMolecular weight:359.433CrBKA
CAS:CrBKA is a fluorogenic small-molecule substrate of SIRT6 with weak activity [1] .Formula:C28H31N3O6Color and Shape:SolidMolecular weight:505.56PKCTheta-IN-2
CAS:PKCTheta-IN-2 (compound 14) is a potent and selective PKCθ inhibitor (IC50 = 0.25 nM) that suppresses IL-2 production in mice (IC50 = 682 nM).Formula:C24H23N5O2Purity:99.38%Color and Shape:SolidMolecular weight:413.47BG48
CAS:BG48, a COMET probe, enables precise optical epigenetic control and photochromically blocks human histone deacetylases with visible light.Formula:C25H23N5OSColor and Shape:SolidMolecular weight:441.55HDAC2-IN-2
CAS:HDAC2-IN-2 (compound 124) acts as an HDAC2 inhibitor, exhibiting a Kd value ranging from 0.1-1 μM.Formula:C18H15N3O3SColor and Shape:SolidMolecular weight:353.40I-BET787
CAS:I-BET787, an orally active pan-BET bromodomain inhibitor, has demonstrated efficacy in murine inflammation models.Formula:C16H20ClN3O2Color and Shape:SolidMolecular weight:321.80E3330
CAS:E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.Formula:C21H30O6Purity:99.52%Color and Shape:SolidMolecular weight:378.46GW843682X
CAS:GW843682X (GW843682) is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).Formula:C22H18F3N3O4SPurity:99.92%Color and Shape:SolidMolecular weight:477.46UNC0224
CAS:UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.Formula:C26H43N7O2Purity:99.80%Color and Shape:SolidMolecular weight:485.67GSK-1268997
CAS:GSK-1268997 is a bio-active chemical.Formula:C21H23N7O3SPurity:99.33% - 99.81%Color and Shape:SolidMolecular weight:453.52TAK-285
CAS:TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc.Formula:C26H25ClF3N5O3Purity:99.73%Color and Shape:SolidMolecular weight:547.96Ref: TM-T6039
1mg38.00€5mg80.00€10mg120.00€25mg216.00€50mg354.00€100mg512.00€200mg727.00€1mL*10mM (DMSO)96.00€MY-1B
CAS:MY-1B is a nitrogen-substituted butenamide stereoprobe that blocks stereoselective enrichment of NSUN2, binding selectively to the C271 of NSUN2.Formula:C22H18BrN3O2Purity:99.81% - >99.99%Color and Shape:SoildMolecular weight:436.3TMPA
CAS:TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.Formula:C21H32O6Purity:99.21%Color and Shape:SolidMolecular weight:380.48Ref: TM-T13173
1mg75.00€5mg164.00€10mg260.00€25mg440.00€50mg620.00€100mg964.00€1mL*10mM (DMSO)167.00€Phorbol 12,13-dibutyrate
CAS:Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator that induces contraction of isolated rabbit vascular smooth muscle.Formula:C28H40O8Purity:99.32% - 99.37%Color and Shape:SolidMolecular weight:504.61Ref: TM-T16526
1mg58.00€5mg160.00€10mg268.00€25mg530.00€50mg827.00€100mg1,314.00€200mg1,773.00€1mL*10mM (DMSO)170.00€EPZ032597
CAS:EPZ032597 is a novel selective inhibitor of SMYD2 with an IC50 of 16 nM. EPZ032597 has anticancer activity and prevent and treat pancreatic cancerFormula:C20H23N7OPurity:99.70%Color and Shape:SolidMolecular weight:377.44TM6089
CAS:TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.Formula:C13H14N4O3SPurity:99.70%Color and Shape:SolidMolecular weight:306.34Ref: TM-T17105
1mg52.00€5mg115.00€10mg167.00€25mg301.00€50mg452.00€100mg658.00€200mg884.00€1mL*10mM (DMSO)123.00€
