Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2235 products of "Chromatin/Epigenetics"
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NSC 694623
CAS:<p>NSC 694623: Potent HAT inhibitor, IC50=15.9 μM against PCAF, anti-cancer properties.</p>Formula:C16H16N2OSPurity:99.9%Color and Shape:SolidMolecular weight:284.38Flosequinan
CAS:<p>Flosequinan is an arteriovenous vasodilator, which can effectively treat acute heart failure.</p>Formula:C11H10FNO2SPurity:99.95%Color and Shape:SolidMolecular weight:239.27Chiauranib
CAS:<p>Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.</p>Formula:C27H21N3O3Purity:99.22%Color and Shape:SolidMolecular weight:435.47SK-575
CAS:<p>SK-575 is a potent PARP1-degrading agent effective against BRCA1/2 mutant cancers, even at low doses, and enhances tumor inhibition in mice.</p>Formula:C47H53FN8O8Purity:99.39%Color and Shape:SolidMolecular weight:876.97β-NF-JQ1
CAS:<p>β-NF-JQ1 is a PROTAC that recruits aryl hydrocarbon receptor E3 (AhR E3) ligase to target proteins.</p>Formula:C45H42ClN5O6SPurity:97.58% - 99.15%Color and Shape:SolidMolecular weight:816.36BRD4 Inhibitor-20
CAS:<p>BRD4 Inhibitor-20 is a potent bromodomain protein 4 (BRD4) inhibitor with oral activity.</p>Formula:C18H18N2O4SPurity:99.84%Color and Shape:SolidMolecular weight:358.41GSK-690
CAS:<p>GSK-690 is a potent, reversible and selective inhibitors of Lysine Specific Demethylase 1.</p>Formula:C24H23N3OPurity:98.65%Color and Shape:SolidMolecular weight:369.46CD532
CAS:<p>CD532: Potent Aurora A inhibitor, IC50=45 nM, blocks kinase activity, degrades MYCN, interacts with AURKA, studies cancer.</p>Formula:C26H25F3N8OPurity:99.49%Color and Shape:SolidMolecular weight:522.52JAK-STAT-IN-1
CAS:<p>JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.</p>Formula:C21H21N5O2Purity:99.59%Color and Shape:SolidMolecular weight:375.42ML192
CAS:<p>ML192 (CID1434953) is a selective GPR55 ligand antagonist.</p>Formula:C20H22N4O2SPurity:99.17%Color and Shape:SolidMolecular weight:382.48SRX3177
CAS:<p>SRX3177 is a novel and potent inhibitor of BRD4, PI3K and CDK.SRX3177 has potential anticancer activity.</p>Formula:C31H32N6O4SPurity:99.16%Color and Shape:SolidMolecular weight:584.69KRH102140
CAS:<p>KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.</p>Formula:C25H24FNOPurity:98.31% - 99.61%Color and Shape:SolidMolecular weight:373.46Bisaramil hydrochloride
CAS:<p>Bisaramil hydrochloride (Bisaramil) is an antiarrhythmic compound that inhibits free radical production.</p>Formula:C17H24Cl2N2O2Purity:98.64% - 99.48%Color and Shape:SolidMolecular weight:359.29AGI-24512
CAS:<p>AGI-24512 is a inhibitor of methionine adenosyltransferase 2A (MATA2 ).It is useful for treatment of cancer and blocks growth of MTAP-deleted cancer cells in</p>Formula:C24H24N4O2Purity:98.55%Color and Shape:SolidMolecular weight:400.47MAT2A-IN-9
CAS:<p>MAT2A-IN-9, a 2-oxoquinazoline, inhibits MAT2A with antitumor effects on lymphomas and solid cancers.</p>Formula:C14H8ClF3N4OPurity:99.17%Color and Shape:SolidMolecular weight:340.69R 59-022 hydrochloride
CAS:<p>R 59-022 hydrochloride is a 5-HT antagonist, PKC activator, DGK inhibitor (IC50: 2.8 µM), and modulates lipid production in platelets and neutrophils.</p>Formula:C27H27ClFN3OSPurity:97.7%Color and Shape:SolidMolecular weight:496.04OXF BD 02
CAS:<p>OXF BD 02 is a potent and selective BRD4(1) inhibitor (IC50: 382 nM) with anticancer and anti-inflammatory activity.</p>Formula:C18H17NO3Purity:98.25%Color and Shape:SolidMolecular weight:295.33MS0124
CAS:<p>MS0124 is a potent and selective G9A-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM, respectively.</p>Formula:C20H29N5O3Purity:98.97%Color and Shape:SolidMolecular weight:387.48CARM1-IN-1
CAS:<p>CARM1-IN-1 (CARM1-IN-7G) is a selective inhibitor of CARM1 with IC50 of 8.6 μM. CARM1-IN-1 shows weak activity against PRMT1 and SET7 with IC50 > 600 μM.</p>Formula:C26H21Br2NO3Purity:98.24%Color and Shape:SolidMolecular weight:555.26LSD1-IN-20
CAS:<p>LSD1-IN-20: Dual LSD1/G9a inhibitor, Ki 0.44/0.68 μM; hampers THP-1, MDA-MB-231 cell growth with IC50 0.51/1.60 μM at 72h.</p>Formula:C27H38N6O2Purity:98.44% - 99.57%Color and Shape:SolidMolecular weight:478.63EB-47
CAS:<p>EB-47 imitates NAD+, spans nicotinamide to adenosine sites, inhibits PARP-1 (IC50: 45 nM) and is less effective on ARTD5 (IC50: 410 nM).</p>Formula:C24H27N9O6Purity:99.81%Color and Shape:SolidMolecular weight:537.53Corin
CAS:<p>Corin is an irreversible inhibitor of HDAC1(IC50 = 147 nM) and LSD1(Ki = 110 nM).</p>Formula:C26H28N4O2Purity:99.6%Color and Shape:SolidMolecular weight:428.53JAK1-IN-8
CAS:<p>JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).</p>Formula:C22H23FN4O3SPurity:98.4%Color and Shape:SolidMolecular weight:442.51OXFBD04
CAS:<p>OXFBD04: Potent BRD4 inhibitor, IC50=166nM, acts on BET bromodomains; moderate CREBBP affinity; anti-cancer properties.</p>Formula:C17H16N2O3Purity:99.56%Color and Shape:SolidMolecular weight:296.32ZEN-3862
CAS:<p>ZEN-3862, a BET inhibitor, blocks BRD4(BD1) at 0.16 μM & BRD4(BD2) at 0.13 μM; usable in PROTACs for BRD4 degradation.</p>Formula:C19H17FN2O3Purity:97.1%Color and Shape:SolidMolecular weight:340.35OUL232
CAS:<p>OUL232 is a potent single ARTs PARP7, PARP10, PARP11, PARP12, PARP14 and PARP15 inhibitor for cancer and tumour research.</p>Formula:C10H10N4O2SPurity:99.04%Color and Shape:SolidMolecular weight:250.28Izencitinib
CAS:<p>Izencitinib (JNJ-8398) is a JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.</p>Formula:C22H26N8Purity:99.82%Color and Shape:SolidMolecular weight:402.50PARP10-IN-2
CAS:<p>PARP10-IN-2 is a potent inhibitor of PARP10, a mono-ADP-ribosyltransferase, with an IC50 value of 3.64 μM for human PARP10.PARP10-IN-2 also inhibited PARP2 and</p>Formula:C14H10N2O2Purity:99.27%Color and Shape:SolidMolecular weight:238.24ZEN-3411
CAS:<p>ZEN-3411 is an BET inhibitor that inhibits BRD4(BD1), BRD4(BD2), and BRD4(BD1BD2) and suppresses the growth of tumor cells overproducing BET proteins.</p>Formula:C21H20N4O2Purity:97.51% - 98.84%Color and Shape:SolidMolecular weight:360.41AGI-43192
CAS:<p>AGI-43192: potent MAT2A inhibitor, crosses blood-brain barrier, may help study SAM in CNS and treat cancer.</p>Formula:C23H16ClF3N6OPurity:99.89%Color and Shape:SolidMolecular weight:484.86HDAC6 degrader 9c
CAS:<p>HDAC6 degrader 9c is a small molecule histone deacetylase 6 (HDAC6) degrader that can be used to study cancer or other diseases.</p>Formula:C37H45N9O10Purity:>99.99%Color and Shape:SolidMolecular weight:775.81ZEN-2759
CAS:<p>ZEN-2759 is a potent BET small molecule inhibitor of BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2).</p>Formula:C17H16N2O2Purity:99.36%Color and Shape:SolidMolecular weight:280.32Bobcat339 hydrochloride
CAS:<p>Bobcat339 hydrochloride is a 10 11 translocation (TET) dioxygenase inhibitor that inhibits both TET1 and TET2.</p>Formula:C16H13Cl2N3OPurity:99.22%Color and Shape:SolidMolecular weight:334.2GSK761
<p>GSK761 inhibits SP140 (IC50: 77.79 nM), hinders monocyte-to-macrophage differentiation, and prompts CD206+ regulatory macrophages.</p>Formula:C40H46N4O4Color and Shape:SolidMolecular weight:646.82CBB1007 hydrochloride
CAS:<p>CBB1007 Hcl inhibits LSD1 selectively (IC50=5.27μM), blocks H3K4 demethylation, activates genes; less effect on other cells/tissues.</p>Formula:C27H39Cl5N8O4Color and Shape:SoildMolecular weight:716.91KH-3
CAS:<p>KH-3: HuR inhibitor, IC50 0.35 μM, halts cell growth, blocks HuR-FOXQ1 mRNA, curbs breast cancer invasion, slows lung colony growth.</p>Formula:C21H22N2O4S2Color and Shape:SolidMolecular weight:430.54PARP7-IN-16
CAS:<p>PARP7-IN-16 (compound 36) is a potent, selective, and orally active PARP-1/2/7 inhibitor, exhibiting IC50 values of 0.94, 0.87, and 0.21 nM , respectively.</p>Formula:C25H26FN4NaO4Purity:98%Color and Shape:SolidMolecular weight:488.49PHD-IN-1
CAS:<p>PHD-IN-1 (compound 80) serves as a potent PHD2 inhibitor, exhibiting an IC50 value of ≤5 nM.</p>Formula:C24H23N7O2Purity:98%Color and Shape:SolidMolecular weight:441.49CBP/p300-IN-17
CAS:<p>CBP/p300-IN-17 (compound 7) is a potent inhibitor of EP300/CBP HAT, acting on HAT EP300 (IC50: 0.18 μM) and LK2 H3K27 (IC50: 0.69 μM).</p>Formula:C25H28N4O3Color and Shape:SolidMolecular weight:432.51JAK2-IN-4
CAS:<p>JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.</p>Formula:C23H27N5O4SPurity:98%Color and Shape:SolidMolecular weight:469.56PARP-2-IN-1
CAS:<p>PARP-2-IN-1 is a potent and selective inhibitor of PARP-2(IC50 of 11.5 nM).</p>Formula:C21H19F4N5O3Purity:98%Color and Shape:SolidMolecular weight:465.4FHT-1204
CAS:<p>FHT-1204 is a potent inhibitor of SMARCA4/SMARCA2 ATPase (BRG1 and BRM) (IC50 ≤ 10 nM).</p>Formula:C24H23N5O5S2Color and Shape:SolidMolecular weight:525.6HDAC-IN-38
CAS:<p>HDAC-IN-38: Potent HDAC1-3,5,6,8 inhibitor, boosts H3K14/H4K5 acetylation, elevates CBF, lessens cognitive decline & hippocampal atrophy.</p>Formula:C27H28ClN3O2Color and Shape:SolidMolecular weight:461.98PI3K/HDAC-IN-2
CAS:<p>PI3K/HDAC-IN-2: dual inhibitor with IC50s - PI3Kα: 226nM, β: 279nM, γ: 467nM, δ: 29nM; HDAC1: 1.3nM. Selective to PI3Kδ/class I/IIb HDAC, anticancer.</p>Formula:C23H23N7O4Color and Shape:SolidMolecular weight:461.47FHT-2344
CAS:<p>FHT-2344, a SMARCA4/SMARCA2 ATPase inhibitor, exhibits anticancer activity with half-maximal inhibitory concentrations (IC 50 ) of 0.026 μM for SMARCA4 and 0.013 μM for SMARCA2, respectively [1].</p>Formula:C23H24N6O5S2Color and Shape:SolidMolecular weight:528.6HDAC6-IN-34
CAS:<p>HDAC6-IN-34 (compound 21), an orally active, selective HDAC6 inhibitor, exhibits an IC50 of 18 nM. It enhances tubulin acetylation levels without impacting histone acetylation in cutaneous T-cell lymphoma cells and suppresses TNF-α secretion in LPS-stimulated macrophage cells. Furthermore, HDAC6-IN-34 demonstrates outstanding anti-arthritic efficacy in rats [1].</p>Formula:C18H18F3N3O3Color and Shape:SolidMolecular weight:381.35DNMT-IN-3
CAS:<p>DNMT-IN-3 is a DNA Methyltransferase (DNMT) inhibitor with an IC50 of 60 nM against Plasmodium falciparum (Plasmodium), demonstrating antimalarial activity and suitability for malaria-related research [1].</p>Formula:C37H39N7OColor and Shape:SolidMolecular weight:597.75F-Amidine TFA
CAS:<p>F-amidine is a selective inhibitor of protein arginine deiminases (PADs), specifically targeting PAD1 and PAD4 with in vitro IC50 values of 29.5, 350, and 21.6 µM for PAD1, PAD3, and PAD4, respectively. It irreversibly inactivates all four PAD subtypes by covalently modifying an active site cysteine crucial for enzymatic activity, with kinact/KI values of 2,800, 380, 170, and 3,000 M^-1min^-1. Additionally, F-amidine demonstrates cytotoxicity against HL-60, MCF-7, and HT-29 cancer cell lines, with IC50s of 0.5, 0.5, and 1 μM, respectively.</p>Formula:C14H19FN4O2CF3COOHColor and Shape:SolidMolecular weight:408.4Itacnosertib (hydrocholide)
CAS:<p>Itacnosertib hydrochloride acts as an inhibitor targeting JAK2, ACVR1 (ALK2), and ALK5 [1].</p>Formula:C26H29ClN8OColor and Shape:SolidMolecular weight:505.01CW 008
CAS:<p>CW 008 is an agonist of the cAMP/PKA/CREB pathway, promoting osteogenic differentiation of bone marrow-derived mesenchymal stem cells (MSCs).a PKA activator.</p>Formula:C21H14F2N6O2Purity:97.39%Color and Shape:SolidMolecular weight:420.37
