Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2607 products of "Chromatin/Epigenetics"
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Furamidine dihydrochloride
CAS:Furamidine dihydrochloride is a cell-permeable, selective PRMT1 inhibitor that also binds AT-rich DNA. It blocks proliferation in leukemia cell lines.Formula:C18H18Cl2N4OPurity:98.16%Color and Shape:SolidMolecular weight:377.27INCB16562
CAS:INCB16562: oral JAK1/2 inhibitor, halts IL-6/STAT3 in myeloma cells, boosts drug efficacy, stunts myeloma in mice.Formula:C19H11Cl2N5Color and Shape:SolidMolecular weight:380.23ZL0454
CAS:ZL0454 is an effective and selective Bromodomain-containing protein 4 inhibitors (IC50: 49 and 32 nM for BD1 and BD2).Formula:C18H22N4O3SPurity:98%Color and Shape:SolidMolecular weight:374.46Guadecitabine
CAS:Guadecitabine is a second-generation DNA methyltransferases inhibitor. It is used for research on acute myeloid leukemia and myelodysplastic syndromes.Formula:C18H24N9O10PPurity:98%Color and Shape:SolidMolecular weight:557.41BRD4-BD1/2-IN-1
CAS:BRD4-BD1/2-IN-1 efficiently blocks BRD4 BD-1/2 under 100 nM IC50 (US20150148375A1, cmpd 5).Formula:C21H14F2N4O2Color and Shape:SolidMolecular weight:392.36PIM1-IN-7
CAS:PIM1-IN-7 inhibits PIM-1 (IC50: 0.67μM), toxic to HCT-116/MCF-7 cells (IC50: 42.9/7.68μM).Formula:C23H23N5OColor and Shape:SolidMolecular weight:385.46PB131
CAS:PB131, a selective and brain-permeable HDAC6 inhibitor, exhibits high binding affinity (IC50: 1.8 nM) and potent anti-inflammatory activity, making it suitableFormula:C16H16FN3O2Purity:98%Color and Shape:SolidMolecular weight:301.32MPT0G211
CAS:MPT0G211: oral HDAC6 inhibitor with IC50=0.291 nM, 1000x selectivity, neuroprotective, anti-metastatic, crosses blood-brain barrier for Alzheimer's.Formula:C17H15N3O2Purity:99.93% - 99.98%Color and Shape:SolidMolecular weight:293.32Ref: TM-T60616
1mg92.00€5mg222.00€10mg356.00€25mg560.00€50mg782.00€100mg1,063.00€200mg1,459.00€1mL*10mM (DMSO)245.00€Bromodomain inhibitor-9
CAS:Bromodomain inhibitor-9 selectively targets BRD4-1 (Kd 12 nM), used in metabolic, inflammatory, fibrotic, and autoimmune disease studies.Formula:C24H28N4O5SColor and Shape:SolidMolecular weight:484.57Bromodomain inhibitor-8
CAS:Bromodomain inhibitor-8 is an inhibitor of BET bromodomain used to treat autoimmune and inflammatory diseases.Formula:C26H25ClN2O3Color and Shape:SolidMolecular weight:448.94SIRT5 inhibitor 6
CAS:SIRT5 inhibitor 6 is Sirtuin 5 inhibitor for sepsis-associated acute kidney injury (AKI) modulates protein succinylation and pro-inflammatory cytokine release.Formula:C21H28N6O4SPurity:99.84%Color and Shape:SolidMolecular weight:460.55Exifone
CAS:Exifone (NSC-680919) is a mixed, nonessential activator of HDAC1 that is capable of binding to both free and substrate-bound enzyme, resulting in an increasedFormula:C13H10O7Purity:99.77% - 99.95%Color and Shape:Yellow SolidMolecular weight:278.21Guadecitabine sodium
CAS:Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .Formula:C18H24N9NaO10PPurity:98%Color and Shape:SolidMolecular weight:580.407KDM5B-IN-3
CAS:KDM5B-IN-3 inhibits KDM5B/JARID1B with IC50 of 9.32 μM, useful in gastric cancer studies.Formula:C19H25ClN4O2Color and Shape:SolidMolecular weight:376.88DDP-38003 dihydrochloride
CAS:DDP-38003 dihydrochloride is an orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor (IC50: 84 nM).Formula:C21H28Cl2N4OPurity:99.76%Color and Shape:SolidMolecular weight:423.38HPB
CAS:HPB is a selective HDAC6 deacetylase inhibitorFormula:C18H20N2O4Color and Shape:SolidMolecular weight:328.36M-110
CAS:M-110 selectively targets PIM kinases, best at PIM-3 (IC50=47nM), and inhibits prostate cancer cell growth (IC50=0.6-0.9μM).Formula:C22H28ClN5O3Purity:99.55%Color and Shape:SolidMolecular weight:445.941,2,3,4,5,6-Hexabromocyclohexane
CAS:Inhibits JAK2 autophosphorylation; non-cytotoxic at 100μM; 1μM reduces activity by 50%, 50μM nearly abolishes it.Formula:C6H6Br6Purity:98%Color and Shape:SolidMolecular weight:557.54Tankyrase-IN-2
CAS:Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectivelyFormula:C17H14F2N2O2Purity:98%Color and Shape:SolidMolecular weight:316.36(5H)-Phenanthridinone
CAS:6(5H)-Phenanthridinone suppresses PARP1/2, reduces RDM4 cell growth, downregulates pro-inflammatory genes, and alleviates EAE symptoms in rats.Formula:C13H9NOColor and Shape:SolidMolecular weight:195.22NCC-149
CAS:NCC-149 is a HDAC8 inhibitor.Formula:C16H14N4O2SColor and Shape:SolidMolecular weight:326.37MS-1020
CAS:MS-1020 inhibits JAK3/STAT3, blocks active JAK3, suppresses JAK3/STAT5 signaling, and targets STAT3 in certain cells.Formula:C21H18N2O3Purity:98%Color and Shape:SolidMolecular weight:346.38AC-93253 iodide
CAS:AC-93253 iodide is a selective inhibitor of SIRT2. It significantly enhances the acetylation of tubulin p53 and histone H4.Formula:C23H25IN2SPurity:98%Color and Shape:SolidMolecular weight:488.43Ac-Lys-AMC
CAS:Ac-Lys-AMC (Hexanamide) is a fluorescent substrate for histone deacetylase HDACs.Formula:C18H23N3O4Purity:98%Color and Shape:SolidMolecular weight:345.39AZD-1897
CAS:AZD-1897 is a highly efficient ATP-competitive pan-PIM inhibitor with anti-cancer and anti-leukemia activity, used in multiple myeloma research.Formula:C18H23N3O3SPurity:99.49%Color and Shape:SolidMolecular weight:361.46ZYJ-34v
CAS:ZYJ-34v is an oral histone deacetylase inhibitor (HDACi) with potent antitumor activities.Formula:C27H35N3O6Purity:98%Color and Shape:SolidMolecular weight:497.58GNE-272
CAS:GNE-272 is a selective inhibitor of CBP/EP300 (IC50: 0.02, 0.03, and 13 μM for CBP, EP300, and BRD4, respectively) and a selective in vivo probe for CBP/EP300.Formula:C22H25FN6O2Color and Shape:SolidMolecular weight:424.47SD-1029
CAS:SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling.Formula:C25H32Br2Cl2N2O3Color and Shape:SolidMolecular weight:639.25Jaspamycin
CAS:Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα.Formula:C12H12N4O5Color and Shape:SolidMolecular weight:292.25DC_C66
CAS:DC_C66 selectively inhibits CARM1 with IC50 of 1.8μM; also affects PRMT1, 6, 5. It's cell-permeable.Formula:C28H22NO2Purity:98%Color and Shape:SolidMolecular weight:404.48PS315
CAS:PS315, a PS48 derivative, allosterically inhibits PKCζ/η (IC50: 10/30 μM), targeting aPKC's PIF-pocket, with anti-cancer properties.Formula:C23H19ClO2Purity:98%Color and Shape:SolidMolecular weight:362.85(2R/S)-6-PNG
CAS:(2R/S)-6-PNG (6-Prenylnaringenin) from hops is a natural histone deacetylase inhibitor that blocks T-type calcium channels reducing neurogenicity in mice.Formula:C20H20O5Purity:98%Color and Shape:SolidMolecular weight:340.37(R)-UT-155
CAS:(R)-UT-155 is a selective androgen receptor degrader (SARD) ligand.Formula:C20H15F4N3O2Color and Shape:SolidMolecular weight:405.35ARTD10/PARP10-IN-1
CAS:ARTD10/PARP10-IN-1 is a PARP inhibitor that inhibits ARTD8/PARP14 and has anticancer and antitumour activity for the study of prostate cancer.Formula:C12H12N2O4Purity:99.14%Color and Shape:SolidMolecular weight:248.23EPZ032597
CAS:EPZ032597 is a novel selective inhibitor of SMYD2 with an IC50 of 16 nM. EPZ032597 has anticancer activity and prevent and treat pancreatic cancerFormula:C20H23N7OPurity:99.70%Color and Shape:SolidMolecular weight:377.44TM6089
CAS:TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.Formula:C13H14N4O3SPurity:99.70%Color and Shape:SolidMolecular weight:306.34Ref: TM-T17105
1mg52.00€5mg115.00€10mg167.00€25mg301.00€50mg452.00€100mg658.00€200mg884.00€1mL*10mM (DMSO)123.00€JAK-IN-28
CAS:JAK-IN-28 (Compound 111) is a Janus kinase (JAK) inhibitor potentially applicable in the research of cancer and inflammatory diseases [1].Formula:C20H18ClN7OPurity:98%Color and Shape:SolidMolecular weight:407.86JAK-IN-30
CAS:JAK-IN-30 (compound 31) is a water-soluble inhibitor of Janus kinases (JAKs), demonstrating inhibitory potency with half-maximal inhibitory concentration (IC50Formula:C19H26N8SPurity:98%Color and Shape:SolidMolecular weight:398.53Eleven-Nineteen-Leukemia Protein IN-1
CAS:ENL-IN-1: Potent ENL YEATS domain inhibitor with 14.5 nM IC50, enhances thermal stability in vitro.Formula:C27H33N7O2Purity:98%Color and Shape:SolidMolecular weight:487.6Arazine
CAS:Arazine, a cell-permeable G protein modulator, is an isoprenylcysteine methyltransferase substrate.Formula:C20H33NO3SPurity:90%Color and Shape:SolidMolecular weight:367.55Angiogenesis agent 1
CAS:Compound C-31, a salidroside-based glycoside, activates HIF-1α and may aid in diabetic limb ischemia studies.Formula:C20H24O7Purity:98%Color and Shape:SolidMolecular weight:376.4GS-626510
CAS:GS-626510 is an orally bioavailable inhibitor of BET family bromodomains (Kd: 0.59-3.2 nM for BRD2/3/4; IC50: 83 nM and 78 nM for BD1 and BD2).Formula:C25H22N4OColor and Shape:SolidMolecular weight:394.47AMPK activator
CAS:AMPK activatorFormula:C22H21FO4Purity:98%Color and Shape:SolidMolecular weight:368.43-Deazaneplanocin A
CAS:3-Deazaneplanocin A (DZNep) is an EZH2 and AHCY inhibitor with antipoxigenic activity that inhibits fibrosis in the liver, kidneys, peritoneum, and airways.Formula:C12H14N4O3Purity:99.03% - 99.68%Color and Shape:SolidMolecular weight:262.27HIF-1/2α-IN-2
CAS:HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α, which effectively reduces the levels of HIF-1/2α.Formula:C16H11FN4O2SColor and Shape:SolidMolecular weight:342.35LW479
CAS:LW479 is a novel inhibitor of HDAC and is a promising candidate for the prevention of breast cancer.Formula:C21H23BrN2O4SColor and Shape:SolidMolecular weight:479.39CX-6258
CAS:CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity.Formula:C26H24ClN3O3Purity:97.46%Color and Shape:SolidMolecular weight:461.94Ref: TM-T1834
1mg34.00€5mg75.00€10mg101.00€25mg197.00€50mg295.00€100mg447.00€200mg623.00€1mL*10mM (DMSO)77.00€KDM5A-IN-1
CAS:KDM5A-IN-1 is a pan-histidine lysine demethylase 5 KDM5 inhibitor that inhibits KDM5A, KDM5B, and KDM5C.Can be used in the study of cancer.Formula:C15H22N4O2Purity:>99.99%Color and Shape:SolidMolecular weight:290.36PI3K/HDAC-IN-1
CAS:PI3K/HDAC-IN-1 is a potent PI3K and HDAC dual inhibitor(IC50s of 8.1 nM and 1.4 nM, respectively).
Formula:C22H25FN4O4Purity:98%Color and Shape:SolidMolecular weight:428.46BRD4 Inhibitor-19
CAS:BRD4 inhibitors -19 are BET inhibitors that act on BRD4-BD1 (IC50: 55 nM) and can be used to study multiple myeloma.Formula:C29H25N5O3Color and Shape:SolidMolecular weight:491.54
