Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2235 products of "Chromatin/Epigenetics"
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JBI-589
CAS:<p>JBI-589 is an isoform-selective, non-covalent inhibitor of PAD4 that diminishes CXCR2 expression and impedes neutrophil chemotaxis.</p>Formula:C29H28FN5OColor and Shape:SolidMolecular weight:481.56JAK-IN-26
CAS:<p>JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency in</p>Formula:C22H24N6O3Purity:98%Color and Shape:SolidMolecular weight:420.46JAK-IN-1
CAS:<p>JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively.</p>Formula:C20H24N6O2Purity:98%Color and Shape:SolidMolecular weight:380.44CAY10398
CAS:<p>CAY10398 is a compound that serves as an isoform-selective inhibitor of histone deacetylase (HDAC1).</p>Formula:C15H23N3O3Color and Shape:SolidMolecular weight:293.367MS023 trihydrochloride
CAS:<p>MS023 trihydrochloride (MS023 3HCl) is a PRMT inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer research.</p>Formula:C17H28Cl3N3OPurity:99.81%Color and Shape:SolidMolecular weight:396.78dBRD4-BD1
CAS:<p>dBRD4-BD1 selectively inhibits and degrades BRD4 (DC50=280nM), upregulates BRD2/3, and aids in creating BRD4-specific probes.</p>Formula:C50H53F3N8O9Color and Shape:SolidMolecular weight:967Tubulin/JAK2-IN-1
CAS:<p>Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significant</p>Formula:C22H20N6O3Color and Shape:SolidMolecular weight:416.43KDM5-IN-1
CAS:<p>KDM5-IN-1 is an effective and selective inhibitor of KDM5 with an IC50 of 15.1 nM.</p>Formula:C17H20N6OPurity:99.50%Color and Shape:SolidMolecular weight:324.38HIF-2α-IN-13
CAS:<p>HIF-2α-IN-13 (18) acts as a HIF-2α inhibitor and exhibits an IC 50 value of 2.7 μM.</p>Formula:C15H14ClF4NO2Color and Shape:SolidMolecular weight:351.72KF21213
CAS:<p>KF21213 shows a high affinity for the adenosine A2A receptors (Ki=3.0 nM). KF21213 is a highly selective ligand for mapping CNS adenosine A2A receptors.</p>Formula:C19H22N4O3Purity:98%Color and Shape:SolidMolecular weight:354.4Lepzacitinib
CAS:<p>Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.</p>Formula:C18H21N5O3Purity:99.85%Color and Shape:SolidMolecular weight:355.39KAT modulator-1
CAS:<p>KAT modulator-1 (Compound 3), an epigenetics research tool, selectively interacts with the full-length p300 protein but not its catalytic domain [1].</p>Formula:C20H36O2Purity:98%Color and Shape:SolidMolecular weight:308.5BY27
CAS:<p>BY27 is a BET BD2 inhibitor with anticancer activity that inhibits BRD2, BRD3 and BRD4 and suppresses tumor growth.</p>Formula:C22H21ClN6Purity:99.4% - 99.68%Color and Shape:SolidMolecular weight:404.89Lin281632
CAS:<p>Lin281632 is an inhibitor of RNA binding protein Lin28 and bromodomain. Lin281632 promotes mESC differentiation.</p>Formula:C15H15N5OPurity:99.84%Color and Shape:SolidMolecular weight:281.31BRCA1-IN-2
CAS:<p>BRCA1-IN-2 is a cell membrane-crossing BRCA1 protein-protein interaction (PPI) inhibitor with antitumor activity that acts by disrupting the interaction of BRCA1 (BRCT)2 with proteins.</p>Formula:C26H33N4O7PPurity:98.04%Color and Shape:SolidMolecular weight:544.54ZL0420
CAS:<p>ZL0420: Potent, selective BRD4 inhibitor, IC50 27 nM BD1 & 32 nM BD2.</p>Formula:C16H16N4O2Purity:99.38%Color and Shape:SolidMolecular weight:296.32ZINC08792355
CAS:<p>ZINC08792355 is a novel inhibitor of SIRT1.</p>Formula:C31H24N4O3Color and Shape:SolidMolecular weight:500.55RTS-V5
CAS:<p>RTS-V5 is a dual inhibitor of HDAC/proteasome (IC50s: 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively).</p>Formula:C27H35N5O6Purity:98%Color and Shape:SolidMolecular weight:525.6CBP/p300-IN-5
CAS:<p>P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).</p>Formula:C29H27F5N6O4Purity:98%Color and Shape:SolidMolecular weight:618.55Luteolin 7-sulfate
CAS:<p>Luteolin 7-sulfate from Phyllospadix iwatensis inhibits melanin production by disrupting CREB/MITF signaling.</p>Formula:C15H10O9SPurity:98%Color and Shape:SolidMolecular weight:366.3CLB-016
CAS:<p>CLB-016 is an inhibitor of hypoxia-inducible factor (HIF)-1.</p>Formula:C17H20N6O3Purity:98%Color and Shape:SolidMolecular weight:356.38A1B11
CAS:<p>A1B11 is a selective SIRT2 inhibitor.</p>Formula:C22H25N5OColor and Shape:SolidMolecular weight:375.47PARPYnD
CAS:<p>PARPYnD: Photoaffinity PARP probe; inhibits PARP2, PARP1, PARP6 (IC50: 6, 38, 230 nM); tags PARP1/2 with N3 fluorescent probe.</p>Formula:C34H31N9O3Color and Shape:SolidMolecular weight:613.67I-BET762 carboxylic acid
CAS:<p>I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).</p>Formula:C20H17ClN4O3Purity:98%Color and Shape:SolidMolecular weight:396.83L-Moses
CAS:<p>L-45 is the first potent and cell-active bromodomain (Brd) inhibitor of p300/CBP-associated factor (PCAF) (Kd: 126±15 nM).</p>Formula:C21H24N6Purity:98%Color and Shape:SolidMolecular weight:360.46ZINC08792229
CAS:<p>ZINC08792229 is a novel inhibitor of SIRT1.</p>Formula:C30H22N4O3Purity:98%Color and Shape:SolidMolecular weight:486.52NSC756093
CAS:<p>NSC756093 potentially inhibits GBP1:PIM1 interaction. NSC756093 can be used in ovarian cancer studies.</p>Formula:C20H19NO4Purity:99.92%Color and Shape:SolidMolecular weight:337.37HA-1004 dihydrochloride
CAS:<p>HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel protein</p>Formula:C12H16ClN5O2SPurity:98%Color and Shape:White Crystalline SolidMolecular weight:329.81MS67
CAS:<p>MS67 selectively degrades WDR5 with a 63 nM Kd, has anticancer effects, and is inactive against other protein classes.</p>Formula:C52H59F4N9O7SColor and Shape:SolidMolecular weight:1030.14KP-544
CAS:<p>KP-544 is an agent of neurotrophin potentiator.</p>Formula:C18H19ClN4OPurity:98%Color and Shape:SolidMolecular weight:342.82CBP/p300-IN-19 hydrochloride
CAS:<p>CBP/p300-IN-19 HCl is a p300/CBP HAT inhibitor (IC50: p300 1.4 μM, CBP 2.2 μM) with antitumor properties.</p>Formula:C30H28ClN3O3Color and Shape:SolidMolecular weight:514.02KT-531
CAS:<p>KT-531 (KT531) is a highly potent and selective HDAC6 inhibitor with an IC50 value of 8.5 nM and is 39-fold more selective against other HDAC isoenzymes.</p>Formula:C17H14F4N2O4SColor and Shape:SolidMolecular weight:418.36KDM2A/7A-IN-1
CAS:<p>KDM2A/7A-IN-1 is a KDM2A/7A inhibitor with potential anti-tumour activity for the study of duodenal adenomas and ossifying fibromucoid tumours.</p>Formula:C33H38N4OPurity:99.59%Color and Shape:SolidMolecular weight:506.68Bisegliptin
CAS:<p>Bisegliptin(KRP-104) is a small molecule compound with anti-diabetic activity.</p>Formula:C18H26FN3O3Purity:98%Color and Shape:SolidMolecular weight:351.42UNC8153 TFA
CAS:<p>UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 µM, and demonstrating a</p>Formula:C35H38F3N5O7Purity:96.44%Color and Shape:SolidMolecular weight:697.7GNE-955
CAS:<p>GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).</p>Formula:C22H24N8OPurity:98%Color and Shape:SolidMolecular weight:416.48Nezulcitinib
CAS:<p>Nezulcitinib (TD-0903) is an inhaled pan-JAK inhibitor targeting COVID-19-related acute lung injury.</p>Formula:C30H37N7O2Color and Shape:SolidMolecular weight:527.66SIRT5 inhibitor 7
CAS:<p>SIRT5 inhibitor 7 , a substrate-competitive and selective SIRT5 inhibitor, significantly attenuated renal dysfunction and pathological damage in AKI mice.</p>Formula:C28H32ClN7O3SPurity:99.77%Color and Shape:SolidMolecular weight:582.12GNE-207
CAS:<p>GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM).</p>Formula:C29H30N6O3Purity:98%Color and Shape:SolidMolecular weight:510.59FT895
CAS:<p>FT895 is a selective and potent HDAC11 inhibitor with antifungal and antitumor activity that inhibits HDAC11 expression and limits EV71 replication in vitro.</p>Formula:C16H15F3N4O2Purity:98.95% - >99.99%Color and Shape:SolidMolecular weight:352.31NHWD-870
CAS:<p>NHWD-870 selectively inhibits BET bromodomains BRD2-4, BRDT; potent anti-cancer effect by inducing apoptosis, halting cell growth.</p>Formula:C29H29N7OPurity:98%Color and Shape:SolidMolecular weight:491.59T-448 free base
CAS:<p>T-448 free base is a specific, orally active and irreversible lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) inhibitor(IC50 of 22 nM).</p>Formula:C17H20N4OSPurity:98%Color and Shape:SolidMolecular weight:328.43Ginsenoside Rk1
CAS:<p>Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.</p>Formula:C42H70O12Purity:98.46% - 99.13%Color and Shape:SolidMolecular weight:767(S)-Ro 32-0432
CAS:<p>(S)-Ro 32-0432 is a potent, selective inhibitor of protein kinase C (PKC) and G protein-coupled receptor kinase 5 (GRK5), demonstrating ATP-competitive and oral activity. It presents IC50 values of 9.3 nM for PKCα, 28 nM for PKCβI, 30 nM for PKCβII, 36.5 nM for PKCγ, and 108.3 nM for PKCε, showcasing its effectiveness against multiple PKC isoforms. Additionally, (S)-Ro 32-0432 inhibits T-cell activation, indicating its potential application in the research of chronic inflammatory and autoimmune diseases [1] [2].</p>Formula:C28H29ClN4O2Color and Shape:SolidMolecular weight:489.01HDAC6/HSP90-IN-1
CAS:<p>HDAC6/HSP90-IN-1 is a potent dual inhibitor of HDAC6 and HSP90 with IC50s 4.3 nM & 46.8 nM, respectively; curbs PD-L1 and tumor growth in H1975 mice.</p>Formula:C28H37N3O6Color and Shape:SolidMolecular weight:511.61QC6352
CAS:<p>QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM).</p>Formula:C24H25N3O2Purity:98%Color and Shape:SolidMolecular weight:387.47GNE-049
CAS:<p>GNE-049 is a highly selective CBP inhibitor (IC50=1.1 nM) that blocks prostate cancer cell proliferation.</p>Formula:C27H32F2N6O2Purity:98.67%Color and Shape:SolidMolecular weight:510.58JAK-IN-4
CAS:<p>JAK-IN-4 is a prodrug of a JAK inhibitor, effective in murine collagen induced arthritis model.</p>Formula:C18H21N4Na2O6PPurity:98%Color and Shape:SolidMolecular weight:466.341PIM1-IN-1
CAS:<p>PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.</p>Formula:C25H30N8O2Purity:98%Color and Shape:SolidMolecular weight:474.56CM-579 trihydrochloride (1846570-40-8 free base)
<p>CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide</p>Formula:C29H43Cl3N4O3Purity:98%Color and Shape:SolidMolecular weight:602.04
