Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2612 products of "Chromatin/Epigenetics"
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UNC0379 TFA
CAS:UNC0379 TFA inhibits SETD8 (IC50: 7.3 μM), selective for 15+ methyltransferases.Formula:C25H36F3N5O4Color and Shape:SolidMolecular weight:527.589IACS-9571
CAS:IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).Formula:C32H42N4O8SPurity:98%Color and Shape:SolidMolecular weight:642.76YM-53601
CAS:YM-53601 is an SQS inhibitor that inhibits adipogenic biosynthesis and lipid secretion in rodents.YM-53601 is a cholesterol-lowering agent that inhibits FDFT1.Formula:C21H22ClFN2OPurity:99.65%Color and Shape:SolidMolecular weight:372.86MI-2-2
CAS:MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM.Formula:C17H20F3N5S2Purity:99.65%Color and Shape:SolidMolecular weight:415.5CX-6258
CAS:CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity.Formula:C26H24ClN3O3Purity:97.46%Color and Shape:SolidMolecular weight:461.94Ref: TM-T1834
1mg34.00€5mg75.00€10mg101.00€25mg197.00€50mg295.00€100mg447.00€200mg623.00€1mL*10mM (DMSO)77.00€Furamidine dihydrochloride
CAS:Furamidine dihydrochloride is a cell-permeable, selective PRMT1 inhibitor that also binds AT-rich DNA. It blocks proliferation in leukemia cell lines.Formula:C18H18Cl2N4OPurity:98.16%Color and Shape:SolidMolecular weight:377.27F-amidine
CAS:F-amidine is a bioavailable irreversible PAD4 inactivator.Formula:C14H19FN4O2Color and Shape:SolidMolecular weight:294.32KD 5170
CAS:KD 5170, a pan inhibitor of histone deacetylases (HDACs), demonstrates widespread antitumor activity both in vitro and in vivo [1].Formula:C20H25N3O5S2Color and Shape:SolidMolecular weight:451.56PI3K/Akt/CREB activator 1
CAS:PI3K/Akt/CREB activator 1 (AE-18) is an iNOS inhibitor that can be used to study vascular dementia and Parkinson's.Formula:C19H15F4NO3Color and Shape:SolidMolecular weight:381.32JAK3-IN-1
CAS:JAK3-IN-1 is an orally active, selective and potent JAK3 inhibitor for the study of immune system disorders.Formula:C26H30ClN7O2Color and Shape:SolidMolecular weight:508.02TAK-418
CAS:TAK-418 is an orally active LSD1/KDM1A inhibitor with a 2.9 nM IC50, potential for autism therapy.Formula:C17H25ClN2O2SPurity:99.69%Color and Shape:SolidMolecular weight:356.91Ref: TM-T39252
1mg131.00€5mg313.00€10mg494.00€25mg1,009.00€50mg1,359.00€100mg1,818.00€200mg2,457.00€1mL*10mM (DMSO)366.00€TUL01101
CAS:TUL01101, a selective oral JAK1 inhibitor (IC50: 3 nM), also targets JAK2, JAK3, TYK2; for rheumatoid arthritis research.Formula:C22H25F2N5O2Color and Shape:SolidMolecular weight:429.46LSD1-IN-13
CAS:LSD1-IN-13, an oral LSD1 blocker (IC50: 24.43 nM), boosts CD86 (EC50: 470 nM), and triggers AML cell line differentiation.Formula:C23H29N3O2SColor and Shape:SolidMolecular weight:411.56SIRT5 inhibitor 4
CAS:SIRT5 inhibitor 4 (compound 11) is a dose-dependent and selective SIRT5 (Sirtuin5) inhibitorand no inhibitory effect on SIRT1/2/3,anticancer.Formula:C18H15N3O4SPurity:99.97%Color and Shape:SolidMolecular weight:369.39WD2000-012547
CAS:WD2000-012547 is a selective inhibitor of poly(ADP-ribose)-polymerase (PARP-1) (pKi: 8.221).Formula:C17H14N2OPurity:98%Color and Shape:SolidMolecular weight:262.31BI-9321
CAS:BI-9321: Selective NSD3-PWWP1 antagonist, Kd 166 nM. Inactive against NSD2-PWWP1/NSD3-PWWP2.Formula:C22H21FN4Purity:98%Color and Shape:SolidMolecular weight:360.43SIRT5 inhibitor 6
CAS:SIRT5 inhibitor 6 is Sirtuin 5 inhibitor for sepsis-associated acute kidney injury (AKI) modulates protein succinylation and pro-inflammatory cytokine release.Formula:C21H28N6O4SPurity:99.84%Color and Shape:SolidMolecular weight:460.55SHP2/HDAC-IN-1
CAS:SHP2/HDAC-IN-1: dual SHP2/HDAC inhibitor, IC50: 20.4 nM/25.3 nM, boosts antitumor immunity, aids cancer immunotherapy research.Formula:C34H35Cl2N7O3Color and Shape:SolidMolecular weight:660.59BiBET
CAS:BiBET is a potent, selective, bivalent inhibitor of BET bromodomains.Formula:C26H30N10O3Color and Shape:SolidMolecular weight:530.58NSD3-IN-1
CAS:NSD3-IN-1, a histone methyltransferase NSD3 inhibitor, demonstrates an IC50 of 28.58 μM.Formula:C13H13N5OSColor and Shape:SolidMolecular weight:287.34PF-249
CAS:PF-249 (PF-06685249) is a β1-selective AMPK with an EC50 of 12 nM for AMPK α1β1γ1 and can be used in studies about diabetic nephropathy.Formula:C17H16ClN3O3Purity:97.01%Color and Shape:SolidMolecular weight:345.78Ref: TM-T24626
1mg46.00€5mg92.00€10mg147.00€25mg236.00€50mg344.00€100mg482.00€200mg662.00€1mL*10mM (DMSO)100.00€Izencitinib
CAS:Izencitinib (JNJ-8398) is a JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.Formula:C22H26N8Purity:99.82%Color and Shape:SolidMolecular weight:402.50Ref: TM-T35898
1mg84.00€5mg177.00€10mg281.00€25mg567.00€50mg888.00€100mg1,431.00€200mg1,963.00€1mL*10mM (DMSO)195.00€ACY-957
CAS:ACY-957: Oral HDAC1/2 inhibitor (IC50: HDAC1=7nM, HDAC2=18nM, HDAC3=1300nM); inactive on HDAC4/5/6/7/8/9.Formula:C24H23N5OSPurity:99.79%Color and Shape:SolidMolecular weight:429.54Ref: TM-T10245
1mg90.00€2mg136.00€5mg230.00€10mg281.00€25mg432.00€50mg612.00€100mg802.00€1mL*10mM (DMSO)251.00€β-NF-JQ1
CAS:β-NF-JQ1 is a PROTAC that recruits aryl hydrocarbon receptor E3 (AhR E3) ligase to target proteins.Formula:C45H42ClN5O6SPurity:97.58% - 99.15%Color and Shape:SolidMolecular weight:816.36EB-47
CAS:EB-47 imitates NAD+, spans nicotinamide to adenosine sites, inhibits PARP-1 (IC50: 45 nM) and is less effective on ARTD5 (IC50: 410 nM).Formula:C24H27N9O6Purity:99.81%Color and Shape:SolidMolecular weight:537.53PARP10-IN-2
CAS:PARP10-IN-2 is a potent inhibitor of PARP10, a mono-ADP-ribosyltransferase, with an IC50 value of 3.64 μM for human PARP10.PARP10-IN-2 also inhibited PARP2 and
Formula:C14H10N2O2Purity:99.27%Color and Shape:SolidMolecular weight:238.24JAK-STAT-IN-1
CAS:JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.Formula:C21H21N5O2Purity:99.59%Color and Shape:SolidMolecular weight:375.42CD532
CAS:CD532: Potent Aurora A inhibitor, IC50=45 nM, blocks kinase activity, degrades MYCN, interacts with AURKA, studies cancer.Formula:C26H25F3N8OPurity:99.99%Color and Shape:SolidMolecular weight:522.52LSD1-IN-20
CAS:LSD1-IN-20: Dual LSD1/G9a inhibitor, Ki 0.44/0.68 μM; hampers THP-1, MDA-MB-231 cell growth with IC50 0.51/1.60 μM at 72h.Formula:C27H38N6O2Purity:97.17% - 99.57%Color and Shape:SolidMolecular weight:478.63ZEN-3411
CAS:ZEN-3411 is an BET inhibitor that inhibits BRD4(BD1), BRD4(BD2), and BRD4(BD1BD2) and suppresses the growth of tumor cells overproducing BET proteins.Formula:C21H20N4O2Purity:97.51% - 98.84%Color and Shape:SolidMolecular weight:360.41ZEN-2759
CAS:ZEN-2759 is a potent BET small molecule inhibitor of BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2).Formula:C17H16N2O2Purity:99.36%Color and Shape:SolidMolecular weight:280.32TM2-115
CAS:TM2-115 is a inhibitor of malaria parasite histone methyltransferases that results in rapid and irreversible parasite death [1].Formula:C28H38N6O2Purity:97.67%Color and Shape:SolidMolecular weight:490.64ACY-1083
CAS:ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor (IC50: 3 nM) and effectively reverses chemotherapy-induced peripheral neuropathy.Formula:C17H18F2N4O2Purity:99.19% - 99.43%Color and Shape:SolidMolecular weight:348.35Ref: TM-T10244
1mg144.00€5mg295.00€10mg504.00€25mg795.00€50mg1,108.00€100mg1,494.00€500mg2,997.00€1mL*10mM (DMSO)326.00€R 59-022 hydrochloride
CAS:R 59-022 hydrochloride is a 5-HT antagonist, PKC activator, DGK inhibitor (IC50: 2.8 µM), and modulates lipid production in platelets and neutrophils.
Formula:C27H27ClFN3OSPurity:97.7%Color and Shape:SolidMolecular weight:496.04SIRT5 inhibitor 1
CAS:SIRT5 inhibitor 1 targets human Sirtuin 5 deacylase, with an IC50 of 0.11 μM, linked to aging diseases.Formula:C31H39FN6O6S2Purity:97.8%Color and Shape:SolidMolecular weight:674.81Ref: TM-T12921
1mg138.00€2mg197.00€5mg334.00€10mg502.00€25mg884.00€50mg1,288.00€100mg1,728.00€1mL*10mM (DMSO)442.00€Bobcat339 hydrochloride
CAS:Bobcat339 hydrochloride is a 10 11 translocation (TET) dioxygenase inhibitor that inhibits both TET1 and TET2.Formula:C16H13Cl2N3OPurity:99.22%Color and Shape:SolidMolecular weight:334.2Ref: TM-T61012
2mg34.00€5mg50.00€10mg80.00€25mg152.00€50mg236.00€100mg353.00€200mg517.00€1mL*10mM (DMSO)55.00€SS-208
CAS:SS-208 is a selective inhibitor of HDAC6 (IC50 = 12 nM) with anti-tumor activity. SS-208 shows selectivity over other HDAC subtypes.Formula:C13H11Cl2N3O4Purity:99.69%Color and Shape:SolidMolecular weight:344.15Butyrolactone 3
CAS:Butyrolactone 3 (MB-3) is a Gcn5 inhibitor with weak affinity for CBP.Butyrolactone 3 has antimicrobial activity and can be used in cancer.Formula:C9H12O4Purity:98.99% - 99.5%Color and Shape:SolidMolecular weight:184.19KRH102140
CAS:KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.Formula:C25H24FNOPurity:98.31% - 99.61%Color and Shape:SolidMolecular weight:373.46NSC668394
CAS:NSC668394 is an ezrin phosphorylation inhibitor.NSC668394 has antitumor activity and increases ezrin cleavage.NSC668394 can be used to study tumor metastasis.Formula:C17H12Br2N2O3Purity:99.29% - 99.29%Color and Shape:SolidMolecular weight:452.1ZEN-3862
CAS:ZEN-3862, a BET inhibitor, blocks BRD4(BD1) at 0.16 μM & BRD4(BD2) at 0.13 μM; usable in PROTACs for BRD4 degradation.Formula:C19H17FN2O3Purity:97.1%Color and Shape:SolidMolecular weight:340.35HDAC8-IN-20a
CAS:HDAC8-IN-20a (HDAC8 inhibitor-20a) is a potent and selective HDAC8 inhibitor with an IC50 of 27 nM.Formula:C15H15NO4Purity:98.24% - 99.22%Color and Shape:SolidMolecular weight:273.28Ref: TM-T24133
1mg173.00€5mg424.00€10mg585.00€25mg873.00€50mg1,134.00€100mg1,468.00€200mg1,963.00€1mL*10mM (DMSO)380.00€CARM1-IN-1
CAS:CARM1-IN-1 (CARM1-IN-7G) is a selective inhibitor of CARM1 with IC50 of 8.6 μM. CARM1-IN-1 shows weak activity against PRMT1 and SET7 with IC50 > 600 μM.Formula:C26H21Br2NO3Purity:98.24%Color and Shape:SolidMolecular weight:555.26Ref: TM-T10682L
1mg34.00€5mg84.00€10mg120.00€25mg236.00€50mg385.00€100mg600.00€200mg837.00€1mL*10mM (DMSO)92.00€CPUY074020
CAS:CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.Formula:C25H28N4O2Purity:98.64%Color and Shape:SolidMolecular weight:416.52Ref: TM-T10882
1mg71.00€5mg147.00€10mg205.00€25mg319.00€50mg450.00€100mg587.00€200mg803.00€1mL*10mM (DMSO)159.00€MAT2A-IN-9
CAS:MAT2A-IN-9, a 2-oxoquinazoline, inhibits MAT2A with antitumor effects on lymphomas and solid cancers.Formula:C14H8ClF3N4OPurity:99.17%Color and Shape:SolidMolecular weight:340.69CMP-5
CAS:CMP-5 is a PRMT5 inhibitor with antiviral activity, inhibits PRMT5 methyltransferase activity, and can be used in the study of SARS virus infection.Formula:C21H21N3Purity:98.68%Color and Shape:SolidMolecular weight:315.41Ref: TM-T10850
1mg44.00€5mg92.00€10mg137.00€25mg225.00€50mg334.00€100mg494.00€500mg1,054.00€1mL*10mM (DMSO)101.00€Butyzamide
CAS:Butyzamide: oral Mpl activator, non-peptide, antagonizes TPO receptors, boosts hMpl, Ba/F3 cells, and enhances platelets in mice.Formula:C29H32Cl2N2O5SPurity:99.39% - 99.83%Color and Shape:SoildMolecular weight:591.55Ref: TM-T67894
1mg149.00€5mg253.00€10mg371.00€25mg573.00€50mg862.00€100mg1,305.00€200mg1,755.00€1mL*10mM (DMSO)329.00€BRD4 Inhibitor-20
CAS:BRD4 Inhibitor-20 is a potent bromodomain protein 4 (BRD4) inhibitor with oral activity.
Formula:C18H18N2O4SPurity:99.84%Color and Shape:SolidMolecular weight:358.41Chiauranib
CAS:Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.
Formula:C27H21N3O3Purity:99.22%Color and Shape:SolidMolecular weight:435.47ML192
CAS:ML192 (CID1434953) is a selective GPR55 ligand antagonist.Formula:C20H22N4O2SPurity:99.17%Color and Shape:SolidMolecular weight:382.48Ref: TM-T33452
1mg34.00€5mg71.00€10mg104.00€25mg172.00€50mg249.00€100mg350.00€200mg480.00€1mL*10mM (DMSO)92.00€
