Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2235 products of "Chromatin/Epigenetics"
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NPC26
CAS:<p>NPC26 is a small molecule that disrupts mitochondrial function and exhibits antitumor activity. It shows significant antiproliferative and cytotoxic effects on CRC cell lines (HCT-116, DLD-1, and HT-29). NPC26 induces mitochondrial permeability transition pore (mPTP) opening, generates reactive oxygen species (ROS), and triggers cell death. Additionally, NPC26 kills CRC cells by activating the AMP-activated protein kinase (AMPK) signaling pathway.</p>Formula:C19H23N3O5S2Color and Shape:SolidMolecular weight:437.533Aurora/LIM kinase-IN-1
<p>Aurora/LIM kinase-IN-1 (Compound F114) is a dual inhibitor targeting aurora and lim kinases, potentially useful in GBM cancer treatment efforts.</p>Formula:C16H20N6OColor and Shape:SolidMolecular weight:312.37BRD4 Inhibitor-32
CAS:<p>BRD4 Inhibitor-32 (example 15), a BRD4 inhibitor, is applicable in research pertaining to both acute and chronic kidney disease [1].</p>Formula:C26H25N3O3Color and Shape:SolidMolecular weight:427.5SGC6870N
CAS:<p>SGC6870N is inactive against PRMT6 and can be used as a negative control. It is the inactive enantiomer of SGC6870.</p>Formula:C23H21BrN2O2SMolecular weight:469.39PF-06726304 acetate
CAS:<p>PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.</p>Formula:C24H25Cl2N3O5Purity:98%Color and Shape:SolidMolecular weight:506.38GNE-886
CAS:<p>GNE-886 has a wide range of applications in life science related research.</p>Formula:C28H30N6O3Purity:98%Color and Shape:SolidMolecular weight:498.59HuR degrader 2
CAS:<p>HuRdegrader 2 (Compound 3) is a molecular glue that targets and degrades the RNA-binding protein Hu antigen R (HuR), achieving 30% degradation at 0.1 μM. It inhibits the proliferation of Colo-205 cancer cells with an IC50 of ≤200 nM. HuRdegrader 2 also shows high affinity for cereblon with an HTRF ratio < 0.02.</p>Formula:C20H15N3O3Molecular weight:345.35MAT2A-IN-24
CAS:<p>MAT2A-IN-24 (Compound 9) is an inhibitor of methionine adenosyltransferase 2a (MAT2a), with an IC50 value of 20 nM for MAT2a inhibition and an antiproliferative IC50 value of 10 nM for HAP1MTAP–/– cells. MAT2A-IN-24 is applicable in the research of tumor diseases associated with MTAP deficiency.</p>Formula:C32H33Cl2N7O2Color and Shape:SolidMolecular weight:618.556M-525
CAS:<p>M-525, a potent first-in-class menin-MLL inhibitor, binds at 3 nM IC50 and curbs MLL leukemia cell growth & gene expression.</p>Formula:C39H51FN6O5SPurity:98%Color and Shape:SolidMolecular weight:734.92Glycyl H-1152 hydrochloride
CAS:<p>Glycyl-H-1152 is a potent ROCK-II inhibitor (IC50=11.8 nM) with high selectivity over CaMKII, PKG, Aurora A, PKA, and PKC. Better than Y-27632 and HA-1077.</p>Formula:C18H26Cl2N4O3SColor and Shape:SolidMolecular weight:449.39HDAC6-IN-3
<p>HDAC6-IN-3 (Compound 14) is an oral anti-prostate cancer agent, inhibiting HDACs and MAO-A, with IC50 of 0.02-1.54 μM.</p>Formula:C19H27N3O3Color and Shape:SolidMolecular weight:345.44PARP7-IN-23
CAS:<p>PARP7-IN-23 (compound 56) is a potent PARP7 inhibitor with an EC50 of 0.915 nM for pSTAT1 in NCI-H1373 cells, indicating its potential for cancer research.</p>Formula:C27H22F7N5O3Color and Shape:SolidMolecular weight:597.484JAK-IN-19
<p>JAK-IN-19 inhibits JAK (pIC50: 7.2, 7.7), less so for VEGFR2 (7.0) and Aurora B (5.8).</p>Formula:C26H36FN5O2Color and Shape:SolidMolecular weight:469.59RK-0080552
CAS:<p>RK-0080552 (RK-552) is an inhibitor of the NSD2 histone methyltransferase. It demonstrates significant cytotoxicity against multiple myeloma (MM) cells harboring the t(4;14) translocation. This compound suppresses the IRF4 gene and decreases the dimethylation of histone H3 at lysine 36. RK-0080552 holds promise for research in hematologic malignancies.</p>Formula:C12H6N6O2Color and Shape:SolidMolecular weight:266.215Octyl-α-hydroxyglutarate
CAS:<p>Octyl-α-hydroxyglutarate (octyl-2-HG) enhances histone methylation and boosts the viability of LMP1-negative nasopharyngeal carcinoma (NPC) cells.</p>Formula:C13H24O5Molecular weight:260.33GSK852
<p>GSK852 is a potent, second bromodomain (BD2)-selective, bromo and extra-terminal domain (BET) inhibitor with pIC50 of 7.9.</p>Formula:C24H26N2O4Color and Shape:SolidMolecular weight:406.47iBFAR2
CAS:<p>iBFAR2, an inhibitor of BFAR, restores the CD8+ tumor-resident memory T cell subset against solid tumors. It promotes the binding of JAK2-STAT1 and enhances the phosphorylation of STAT1.</p>Formula:C19H15F3N2O2Color and Shape:SolidMolecular weight:360.33BRD4/NAMPT-IN-1
CAS:<p>BRD4/NAMPT-IN-1 (Compound A2) exhibits strong inhibitory effects on NAMPT and BRD4, with IC50 values of 35 nM (NAMPT) and 58 nM (BRD4). This compound significantly suppresses the growth and migration of liver cancer cells while promoting apoptosis. Additionally, BRD4/NAMPT-IN-1 demonstrates potent anticancer activity in HCCLM3 xenograft mouse models without noticeable toxicity.</p>Formula:C30H30ClN7O2SMolecular weight:588.12RU-0415529
CAS:<p>RU-0415529 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (NSP14), with an IC50 of 356 nM. It inhibits viral RNA methylation and replication by stabilizing the cap-binding pocket through SAH binding. Additionally, RU-0415529 exhibits anti-infective activity in mouse models.</p>Formula:C21H29N3O4SColor and Shape:SolidMolecular weight:419.538PKCiota-IN-1
CAS:<p>PKCiota-IN-1: Strong PKC-ι inhibitor (IC50=2.7 nM); also blocks PKC-α/ε (IC50s=45/450 nM).</p>Formula:C25H22FN5OColor and Shape:SolidMolecular weight:427.47AR/BET protein degrader-1
CAS:<p>AR/BET protein degrader-1 (Compound 149) is a dual-targeting protein degrader of Androgen Receptor and BET (bromodomain and extra-terminal domain), suitable for cancer research.</p>Formula:C43H44N6O5Molecular weight:724.85HIF-1α-IN-5
<p>HIF-1α-IN-5 is an inhibitor of HIF-1α with an IC 50 value of 24 nM in HEK293T cells that also inhibits the activity of MAO-A.</p>Formula:C16H15N3O2Color and Shape:SolidMolecular weight:281.31Hesperadin hydrochloride
<p>Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.</p>Formula:C29H33ClN4O3SColor and Shape:SolidMolecular weight:553.12Triciferol
CAS:<p>Triciferol is a VDR agonist and HDAC antagonist with 1,25D-like potency, affecting gene targets and tubulin, and shows anti-cancer effects in vitro. IC50=87nM.</p>Formula:C26H39NO4Color and Shape:SolidMolecular weight:429.591NSD2-PWWP1-IN-3
CAS:<p>NSD2-PWWP1-IN-3 (compound 36) is an effective inhibitor of NSD2-PWWP1, with an IC50 value of 8.05 µM. It has potential applications in cancer research.</p>Formula:C34H39N5O2Color and Shape:SolidMolecular weight:549.706CRV431
CAS:<p>CRV431 is a novel Pan-Cyclophilin Inhibitor, potently inhibiting all cyclophilin isoforms tested - A, B, D, and G (IC50 values ranged from 1-7 nM).</p>Formula:C67H122N12O13Color and Shape:SolidMolecular weight:1303.76TK-129
<p>TK-129: Oral KDM5B inhibitor, IC50=44 nM, low-toxicity, cardioprotective, aids in heart disease research.</p>Formula:C15H23N5O2Color and Shape:SolidMolecular weight:305.385-Ph-IAA-AM
<p>5-Ph-IAA-AM, eggshell-permeable analog of 5-Ph-IAA, boosts protein degradation in embryos, useful for studying proteins in C. elegans.</p>Formula:C19H17NO4Color and Shape:SolidMolecular weight:323.34(Rac)-Nanatinostat
CAS:<p>(Rac)-Nanatinostat ((Rac)-CHR-3996, example 44) is a potent HDAC inhibitor with an IC50 of less than 330 nM. It exhibits anticancer properties, effectively inhibiting the growth of HeLa, U937, and HUT cells.</p>Formula:C20H19FN6O2Color and Shape:SolidMolecular weight:394.402Sapintoxin D
CAS:<p>Sapintoxin D is a fluorescent phorbol ester and selective activator of protein kinase C.</p>Formula:C30H37NO8Color and Shape:SolidMolecular weight:539.62HDAC6-IN-9
CAS:<p>HDAC6-IN-9 is a γ-secretase modulator that can significantly reduce the level of Aβ42 in mouse brain and can be used to study neurological diseases.</p>Formula:C19H16N2O3Purity:98.84%Color and Shape:SolidMolecular weight:320.34EBET-590
CAS:<p>EBET-590 is a BET inhibitor utilized in cancer research.</p>Formula:C26H26N4O3Molecular weight:442.51AZ-3
CAS:<p>AZ-3 is a potent and selective JAK1 inhibitor (IC50: 34 nM).</p>Formula:C20H28FN7Purity:98%Color and Shape:SolidMolecular weight:385.48AMPTX-1
CAS:<p>AMPTX-1 is a molecular glue functioning as a potent, selective, and reversible covalent degrader of BRD9 by recruiting it to the E3 ligase DCAF16.</p>Formula:C42H53N5O4Color and Shape:SolidMolecular weight:691.901EZH2-IN-12
<p>EZH2-IN-12 (Compound 5) is a potent inhibitor of EZH2, which has potential for studies of CNS malignancies.</p>Formula:C23H23Cl2N3O3Color and Shape:SolidMolecular weight:460.35CEE321
CAS:<p>CEE321 is an effective pan-JAK inhibitor with an IC50 of 54 nM. It effectively inhibits biomarkers associated with atopic dermatitis.</p>Formula:C18H16ClN5OColor and Shape:SolidMolecular weight:353.806PARP1-IN-5
<p>PARP1-IN-5 is a potent, selective, orally active, low-toxicity PARP-1 inhibitor with an IC50 value of 14.7 nM. PARP1-IN-5 can be used in cancer research.</p>Formula:C25H24N2O5SColor and Shape:SolidMolecular weight:464.53Pim-1 kinase inhibitor 3
CAS:<p>Pim-1 kinase inhibitor 3 (Compound H5) is a potent inhibitor of Pim-1 kinase, demonstrating an inhibitory concentration (IC50) of 35.13 nM [1].</p>Formula:C20H25N3O2Color and Shape:SolidMolecular weight:339.43EN884
CAS:<p>EN884 is a BRD4 degrader that functions through an SKP1 and proteasome-dependent degradation pathway. It is utilized in the synthesis of proteolysis-targeting chimeras (PROTAC).</p>Formula:C14H18N2OMolecular weight:230.31BRD4 Inhibitor-17
<p>BRD4 Inhibitor-17: Potent with 0.33 μM IC50; modulates gene expression, may counter arsenic toxicity.</p>Formula:C16H16FN3O3SColor and Shape:SolidMolecular weight:349.38O-Desmethyl Midostaurin
CAS:<p>O-Desmethyl Midostaurin is the active Midostaurin metabolite via cytochrome P450 liver enzyme metabolism.</p>Formula:C34H28N4O4Purity:98%Color and Shape:SolidMolecular weight:556.61SMARCA2-IN-6
CAS:<p>SMARCA2-IN-6 is a potent inhibitor of SMARCA2 (also known as BRM), exhibiting an IC50 of less than 5 nM against both SMARCA2 and SMARCA4. Additionally, this compound suppresses the expression of the KRT80 gene in H1299 cells with an IC50 of 26 nM and inhibits the proliferation of SKMEL5 cells carrying a BRG1 mutation with an IC50 value of 13 nM.</p>Formula:C10H8ClF2N5OSColor and Shape:SolidMolecular weight:319.72MS8511
CAS:<p>MS8511: Selective, irreversible G9a/GLP inhibitor. IC50: 100 nM (G9a), 140 nM (GLP). Lowers H3K9me2, anti-proliferative. Useful in cancer/AD/PWS research.</p>Formula:C28H41N5O3Color and Shape:SolidMolecular weight:495.66PARP7-IN-12
CAS:<p>PARP7-IN-12, a potent inhibitor targeting PARP7, exhibits an IC50 of 7.836 nM. This compound is applicable in cancer research.</p>Formula:C23H27ClF3N5O5Color and Shape:SolidMolecular weight:545.94FNDR-20123
<p>FNDR-20123: First safe, effective anti-malarial HDAC inhibitor for Plasmodium (IC50: 31 nM) & human HDACs, with nanomolar potency across several subtypes.</p>Formula:C21H24ClN5O2Color and Shape:SolidMolecular weight:413.9CBP/p300-IN-16
<p>CBP/p300-IN-16 (compound 1) is a potent inhibitor of EP300/CBP HAT, acting on HAT EP300 (IC50: 0.61 μM) and LK2 H3K27 (IC50: 2.24 μM).</p>Formula:C26H31N3O4Color and Shape:SolidMolecular weight:449.54SIRT1-IN-5
CAS:<p>SIRT1-IN-5 (215) is a modulator of the NAD-dependent protein deacetylase SIRT1.</p>Formula:C21H17N3O3SColor and Shape:SolidMolecular weight:391.443Tyk2-IN-3
CAS:<p>Tyk2-IN-3 is an inhibitor of Tyk2 pseudokinase (IC50: 485 nM).</p>Formula:C25H24N6O3S2Purity:98%Color and Shape:SolidMolecular weight:520.63BET-IN-1
<p>BET-IN-1 is a potent inhibitor of BET, exhibiting good brain permeability and a reasonable metabolic stability.</p>Formula:C23H24ClFN4O3SColor and Shape:SolidMolecular weight:490.98JAK3-IN-11
CAS:<p>JAK3-IN-11: potent oral JAK3 inhibitor (IC50=1.7 nM), noncytotoxic, >588-fold selectivity, blocks T-cell growth; useful in autoimmune research.</p>Formula:C23H23N5O2Color and Shape:SolidMolecular weight:401.46
