Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2622 products of "Chromatin/Epigenetics"
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1,2-Didecanoyl-sn-glycerol
CAS:GNN14490, a substrate for human pancreatic lipase, is utilized to create monomolecular films for enzyme assay studies.Formula:C23H44O5Color and Shape:SolidMolecular weight:400.6SP-2-225
CAS:SP-2-225, a selective inhibitor of HDAC6, augments the production of cancer-associated antigens and enhances macrophage antigen cross-presentation to T cells,Formula:C28H34N2O3Purity:98%Color and Shape:SolidMolecular weight:446.58BY27
CAS:BY27 is a BET BD2 inhibitor with anticancer activity that inhibits BRD2, BRD3 and BRD4 and suppresses tumor growth.Formula:C22H21ClN6Purity:99.4% - 99.68%Color and Shape:SolidMolecular weight:404.89HDAC6/HSP90-IN-1
CAS:HDAC6/HSP90-IN-1 is a potent dual inhibitor of HDAC6 and HSP90 with IC50s 4.3 nM & 46.8 nM, respectively; curbs PD-L1 and tumor growth in H1975 mice.Formula:C28H37N3O6Color and Shape:SolidMolecular weight:511.61Bocodepsin
CAS:Bocodepsin (OKI-179) is a selective, orally active inhibitor of histone deacetylases (HDAC) with demonstrated antitumor efficacy.Formula:C26H39N5O6S2Purity:98%Color and Shape:SolidMolecular weight:581.75TCS 21311
CAS:TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.Formula:C27H25F3N4O4Purity:99.39% - ≥98%Color and Shape:SolidMolecular weight:526.51KDM2B-IN-1
CAS:KDM2B-IN-1: Potent, specific KDM2B histone demethylase inhibitor for hyperproliferative disease research.Formula:C21H30N4O2SColor and Shape:SolidMolecular weight:402.56GSK-A
CAS:GSK-A is a Histone Lysine Methyltransferase EZH2 inhibitor.Formula:C21H25N5O2Color and Shape:SolidMolecular weight:379.46PIM-IN-2
CAS:PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM .Formula:C19H22N4O2Purity:98%Color and Shape:SolidMolecular weight:338.4WAY-354574
CAS:WAY-354574 is an active compound that targets the deacetylase Sirtuin, utilized in research focused on Huntington's disease (HD) [1].Formula:C20H23ClN2O3SPurity:98%Color and Shape:SolidMolecular weight:406.93KPZ560
CAS:KPZ560, a potent HDAC 1 and HDAC 2 inhibitor, exhibits IC50 values of 12 nM and 68 nM, respectively.Formula:C26H21N5O3S2Purity:98%Color and Shape:SolidMolecular weight:515.61FD1024
CAS:FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively.Formula:C21H20F2N4O2SPurity:98%Color and Shape:SolidMolecular weight:430.47GW814408X
CAS:GW814408X, a kinase chemical genome group (KCGS) compound, inhibits the AURKC kinase, which is involved in cell cycle progression, checkpoint regulation, and cell division. It exhibits cell line-dependent toxicity, such as cytotoxic effects on HeLa cells, and acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases, potentially impacting Fluc reporter assays [1].Formula:C19H16N6OMolecular weight:344.37PIM1-IN-1
CAS:PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.Formula:C25H30N8O2Purity:98.59%Color and Shape:SolidMolecular weight:474.56Ref: TM-T12474
10mgTo inquire1mL*10mM (DMSO)To inquire1mg117.00€5mg281.00€25mg858.00€50mg1,341.00€100mg2,125.00€JAK-IN-4
CAS:JAK-IN-4 is a prodrug of a JAK inhibitor, effective in murine collagen induced arthritis model.Formula:C18H21N4Na2O6PPurity:98%Color and Shape:SolidMolecular weight:466.341HDAC6-IN-8
CAS:Compound 12C, with altered cap groups, shows wide-range enzyme inhibition; 9m and 9q target HDAC6 specifically.Formula:C23H17BrFN5O3Purity:98%Color and Shape:SolidMolecular weight:510.32Tubulin/JAK2-IN-1
CAS:Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significantFormula:C22H20N6O3Color and Shape:SolidMolecular weight:416.43CM-579 trihydrochloride (1846570-40-8 free base)
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wideFormula:C29H43Cl3N4O3Purity:98%Color and Shape:SolidMolecular weight:602.04dBRD4-BD1
CAS:dBRD4-BD1 selectively inhibits and degrades BRD4 (DC50=280nM), upregulates BRD2/3, and aids in creating BRD4-specific probes.Formula:C50H53F3N8O9Color and Shape:SolidMolecular weight:967CAY10398
CAS:CAY10398 is a compound that serves as an isoform-selective inhibitor of histone deacetylase (HDAC1).Formula:C15H23N3O3Color and Shape:SolidMolecular weight:293.367WM-586
CAS:WM-586 is a covalent inhibitor of WDR5 that impedes the WDR5-MYC binding.Formula:C20H20F3N5O3SPurity:98%Color and Shape:SolidMolecular weight:467.47JAK-IN-1
CAS:JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively.Formula:C20H24N6O2Purity:98%Color and Shape:SolidMolecular weight:380.44JG-2016
CAS:JG-2016, as a histone acetyltransferase 1 inhibitor, inhibits growth of human cancer cell lines and inhibits enzymatic activity in cellulose.Formula:C18H21ClN4O3Purity:99.00% - 99.37%Color and Shape:SolidMolecular weight:376.84Ref: TM-T82008
1mg110.00€5mg268.00€1mL*10mM (DMSO)294.00€10mg432.00€25mg858.00€50mg1,378.00€100mg1,783.00€Ro 32-0432 hydrochloride
CAS:Ro 32-0432 is a selective, ATP-competitive, oral pan-PKC inhibitor exhibiting inhibitory effects on PKCα, PKCβI, PKCβII, PKCγ, and PKCε.Formula:C28H28N4O2Purity:98%Color and Shape:SolidMolecular weight:452.55JAK-IN-17
"JAK-IN-17: Potent JAK inhibitor for studying ocular, skin, and respiratory diseases."Formula:C33H38F2N6O8Color and Shape:SolidMolecular weight:684.69TC-A 2317 hydrochloride
CAS:TC-A 2317 HCl inhibits Aurora A kinase (Ki 1.2 nM) over Aurora B (Ki 101 nM), displaying antitumor effects.Formula:C19H29ClN6OPurity:98%Color and Shape:SolidMolecular weight:392.93JBI-589
CAS:JBI-589 is an isoform-selective, non-covalent inhibitor of PAD4 that diminishes CXCR2 expression and impedes neutrophil chemotaxis.Formula:C29H28FN5OColor and Shape:SolidMolecular weight:481.56Vafidemstat
CAS:Vafidemstat (ORY-2001) is a lysine-histone demethylase (LSD1)/MAO-B inhibitor for the study of neurological disorders.Formula:C19H20N4O2Purity:99.53%Color and Shape:SolidMolecular weight:336.39NMS-P953
CAS:NMS-P953: JAK2 inhibitor, reduces tumor growth in SET-2 model, confirmed in vivo action, good pharmacokinetics and safety.Formula:C16H11ClF3N5OColor and Shape:SolidMolecular weight:381.74CW 008
CAS:CW 008 is an agonist of the cAMP/PKA/CREB pathway, promoting osteogenic differentiation of bone marrow-derived mesenchymal stem cells (MSCs).a PKA activator.Formula:C21H14F2N6O2Purity:97.39%Color and Shape:SolidMolecular weight:420.37KP-544
CAS:KP-544 is an agent of neurotrophin potentiator.Formula:C18H19ClN4OPurity:98%Color and Shape:SolidMolecular weight:342.82Ampkinone
CAS:Ampkinone is an indirect AMPK activator.Formula:C31H23NO6Purity:98%Color and Shape:SolidMolecular weight:505.52NSC756093
CAS:NSC756093 potentially inhibits GBP1:PIM1 interaction. NSC756093 can be used in ovarian cancer studies.Formula:C20H19NO4Purity:99.92%Color and Shape:SolidMolecular weight:337.37Ref: TM-T24557
1mg44.00€5mg96.00€1mL*10mM (DMSO)111.00€10mg148.00€25mg313.00€50mg465.00€100mg662.00€500mg1,333.00€CD235
CAS:CD235 is a structurally similar analog of CD161. CD161 is an orally bioavailable inhibitor of BET bromodomain.Formula:C26H20FN5O2Purity:98%Color and Shape:SolidMolecular weight:453.47BChE/HDAC6-IN-1
CAS:BChE/HDAC6-IN-1 is a dual BChE/HDAC6 inhibitor that exhibits potent and selective inhibition with IC50 values of 4 nM for BChE and 8.9 nM for HDAC6.Formula:C34H43N5O5Purity:98%Color and Shape:SolidMolecular weight:601.74YM-08
CAS:YM-08 (Compound 7a), a brain-penetrant SIRT2 inhibitor, exhibits an IC50 of 19.9 μM. Additionally, it acts as an inhibitor of Hsp70 [1].Formula:C19H17N3OS2Purity:98%Color and Shape:SolidMolecular weight:367.49Ginsenoside Rk1
CAS:Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.Formula:C42H70O12Purity:98.46% - 99.13%Color and Shape:SolidMolecular weight:767.00F-Amidine TFA
CAS:F-amidine is a selective inhibitor of protein arginine deiminases (PADs), specifically targeting PAD1 and PAD4 with in vitro IC50 values of 29.5, 350, and 21.6 µM for PAD1, PAD3, and PAD4, respectively. It irreversibly inactivates all four PAD subtypes by covalently modifying an active site cysteine crucial for enzymatic activity, with kinact/KI values of 2,800, 380, 170, and 3,000 M^-1min^-1. Additionally, F-amidine demonstrates cytotoxicity against HL-60, MCF-7, and HT-29 cancer cell lines, with IC50s of 0.5, 0.5, and 1 μM, respectively.Formula:C14H19FN4O2CF3COOHColor and Shape:SolidMolecular weight:408.4MTDH-SND1 blocker 1
CAS:MTDH-SND1 Blocker 1 (Compound C26-A6) serves as an inhibitor targeting the MTDH-SND1 protein, effectively suppressing cancer metastasis [1].Formula:C14H13ClN4O3SColor and Shape:SolidMolecular weight:352.8MAK683-CH2CH2COOH
CAS:MAK683-CH2CH2COOH, an EED-targeting chemical, serves as a foundation for EED degrader-1 and PROTAC EED degrader-2 design.Formula:C23H21FN6O3Purity:98%Color and Shape:SolidMolecular weight:448.45UNC7145
CAS:UNC6934 Negative Control (Axon 3591) is a chemically related compound that serves as a negative control for UNC6934, a potent and selective chemical probe that specifically targets the N-terminal PWWP (PWWP1) domain of NSD2.Formula:C24H23N5O4Color and Shape:SolidMolecular weight:445.4705GSK217
CAS:GSK217 is a potent and selective inhibitor of the bromo and extraterminal domain (BET) second bromodomain (BD2) with high solubility, utilized in oncology andFormula:C20H20N6OPurity:98%Color and Shape:SolidMolecular weight:360.41EZH2-IN-14
CAS:EZH2-IN-14 selectively inhibits EZH2 at 12 nM IC50, has >200-fold specificity over EZH1, reducing H3K27me3 levels.Formula:C31H39N7O2Color and Shape:SolidMolecular weight:541.69TRC160334 sodium
CAS:TRC160334 is a HIF hydroxylases inhibitor.Formula:C14H15N3O5SColor and Shape:SolidMolecular weight:337.35GSK-3484862
CAS:Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.Formula:C19H19N5OSPurity:99.87% - 99.963%Color and Shape:SolidMolecular weight:365.45Ref: TM-T11469
1mg48.00€5mg113.00€10mg177.00€1mL*10mM (DMSO)203.00€25mg318.00€50mg485.00€100mg692.00€500mg1,395.00€GRK2 Inhibitor 2
CAS:GRK2 Inhibitor 2 (Compound 8h), with an IC50 of 19 nM for GRK2 and 137 nM for Aurora-A, enhances β-AR-mediated cAMP accumulation in GRK2-overexpressing HEK293Formula:C19H16N4O2Color and Shape:SolidMolecular weight:332.36PHD-IN-1
CAS:PHD-IN-1 (compound 80) serves as a potent PHD2 inhibitor, exhibiting an IC50 value of ≤5 nM.Formula:C24H23N7O2Purity:98%Color and Shape:SolidMolecular weight:441.49ARTD3/PARP3-IN-1
CAS:ARTD3/PARP3-IN-1 is a non-selective inhibitor targeting diphtheria toxin-like ADP-ribosyltransferase 3 (ARTD3)/PARP3 [1].Formula:C17H16N4O2Color and Shape:SolidMolecular weight:308.33PI3K/HDAC-IN-2
CAS:PI3K/HDAC-IN-2: dual inhibitor with IC50s - PI3Kα: 226nM, β: 279nM, γ: 467nM, δ: 29nM; HDAC1: 1.3nM. Selective to PI3Kδ/class I/IIb HDAC, anticancer.Formula:C23H23N7O4Color and Shape:SolidMolecular weight:461.47TCJL37
CAS:TCJL37: potent, selective TYK2 inhibitor (K i 1.6 nM), oral, for IBD research.Formula:C17H11ClF2N4O2Color and Shape:SolidMolecular weight:376.74
