Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2235 products of "Chromatin/Epigenetics"
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HIF1-IN-3
CAS:<p>HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used in</p>Formula:C26H24N2O3Purity:99.59%Color and Shape:SolidMolecular weight:412.48SW2_110A acetate
<p>SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD).</p>Formula:C44H64N6O9Purity:98%Color and Shape:SoildMolecular weight:821.01Nicotinamide riboside tartrate
CAS:<p>NRT is an oral NAD+ precursor, boosts NAD+, activates SIRT1/3, provides vitamin B3, enhances metabolism, and may mitigate Alzheimer's.</p>Formula:C15H20N2O11Color and Shape:SolidMolecular weight:404.33PROTAC HDAC6 degrader 4
<p>PROTAC HDAC6 degrader4 (Compound 17c) is a PROTAC that targets and degrades HDAC6, with a DC50 of 14 nM. It exhibits inhibitory activity against HDAC1, HDAC2, HDAC3, and HDAC6, with IC50 values of 2.2, 2.37, 0.61, and 0.295 μM, respectively. [Pink: ligand for target protein HDAC6 ligand-3; Black: linker; Blue: ligand for cereblon E3 ligase]</p>Formula:C39H42FN9O7Color and Shape:SolidMolecular weight:767.81PROTAC BET Degrader-1
CAS:<p>PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC.</p>Formula:C44H45N11O9Purity:98%Color and Shape:SolidMolecular weight:871.9HDAC11-IN-1
<p>HDAC11-IN-1 (Compound 14-NC6OH) is a macrocyclic inhibitor that selectively targets HDAC11 with a Ki of 40 nM. It demonstrates effective cell permeability and suppresses the expression of YAP1 and SOX2.</p>Formula:C43H63F3N6O6S2Color and Shape:SolidMolecular weight:881.12GSK040
CAS:<p>GSK040: Potent BET BD2 inhibitor, pIC50 8.3, 5000x selectivity over BD1, for oncology & immunology research.</p>Formula:C29H34N4O4Color and Shape:SolidMolecular weight:502.6HDAC6-IN-53
<p>HDAC6-IN-53 (Compound W28) is an inhibitor targeting histone deacetylase 6 (HDAC6) with an IC50 of 19.65 nM. It reduces the idiopathic pulmonary fibrosis (IPF) phenotype by inhibiting TGF-β1-induced collagen expression and demonstrates therapeutic efficacy in a bleomycin-induced mouse model of pulmonary fibrosis. HDAC6-IN-53 is applicable for research in idiopathic pulmonary fibrosis and related pulmonary fibrotic diseases.</p>Color and Shape:Odour SolidCDD-1102 HCl
<p>CDD-1102 HCl is a novel BRDT-BD4 / BRD2-BD1302 selective inhibitor that shows non-hormonal contraceptive potential in ex vivo experiments.</p>Formula:C32H31ClN6O3Purity:98.30%Color and Shape:SoildMolecular weight:583.08HDAC6-IN-56
<p>HDAC6-IN-56 (compound 18d) is an inhibitor of HDAC6, with an IC50 of 1.3 nM. This compound can inhibit the S phase and induce apoptosis in HCT-116 colon cancer cells.</p>Formula:C25H27ClN4O4SColor and Shape:SolidMolecular weight:514.14415MZP-54
CAS:<p>MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)</p>Formula:C55H66ClN7O9SPurity:98%Color and Shape:SolidMolecular weight:1036.67PROTAC BRD4-DCAF1 degrader-1
CAS:<p>PROTACBRD4-DCAF1 degrader-1 (I-907) is a PROTAC degrader targeting BRD4-DCAF1, exhibiting a DC50 range of 10~100 nM.</p>Formula:C60H64Cl2F2N8O9SColor and Shape:SolidMolecular weight:1182.17Thalidomide-NH-CBP/p300 ligand 2
CAS:<p>Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based compound designed to degrade CBP and p300, acting as a functional antagonist (WO2020173440).</p>Formula:C48H57F2N11O6Color and Shape:SolidMolecular weight:922.052SIRT1-IN-1
CAS:<p>SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.</p>Formula:C14H16N2OPurity:99.58%Color and Shape:SolidMolecular weight:228.29N-Desmethyltamoxifen
CAS:<p>N-Desmethyltamoxifen, tamoxifen's main human metabolite, regulates AML cell ceramide metabolism and is a more potent PKC inhibitor than tamoxifen.</p>Formula:C25H27NOPurity:98%Color and Shape:SolidMolecular weight:357.49Pim-1 kinase inhibitor 11
<p>Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.</p>Color and Shape:Odour SolidPROTAC SMARCA2/4-degrader-25
<p>PROTAC SMARCA2/4-degrader-25 is a PROTAC that targets SMARCA2/4. It consists of the E3 ligase ligand (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, a PROTAC Linker (S)-2-Amino-3,3-dimethylbutanoic acid, and the target protein ligand SMARCA2/4-ligand-3. The conjugate of the E3 ubiquitin ligase ligand and Linker is (S,R,S)-AHPC.</p>Formula:C44H50N10O9S2Color and Shape:SolidMolecular weight:927.06BRD3067
CAS:<p>BRD3067, a Tubacin derivative, inhibits HDAC6 (IC50 15 nM) and acts as a negative control for Tubacin A, showing anticancer and anti-inflammatory effects.</p>Formula:C21H23N3O2Purity:98%Color and Shape:SolidMolecular weight:349.43KB02-JQ1
CAS:<p>KB02-JQ1: potent BRD4-degrading PROTAC, stable, specific; doesn't affect BRD2/3, modifies DCAF16 for action.</p>Formula:C38H43Cl2N7O6SPurity:98%Color and Shape:SoildMolecular weight:796.76PRMT3-IN-4
<p>PRMT3-IN-4 (intermediate 15) is an inhibitor of Protein arginine methyltransferase 3 (PRMT3) and serves as the active control for SGC707. It can be utilized in the synthesis of PROTACs targeting PRMT3 and is applicable in research related to leukemia.</p>Color and Shape:Odour SolidPROTAC BRD4 Degrader-10
CAS:<p>Compound 8b, a dual-ligand PROTAC, targets VHL & BRD4, degrades BRD4 in PC3 cells; conjugates with STEAP1/CLL1, DC50: 1.3/18 nM.</p>Formula:C59H71F2N9O15S4Color and Shape:SolidMolecular weight:1312.5Uzansertib
CAS:<p>Uzansertib (INCB053914) is a potent pan-PIM kinase inhibitor with low IC50s: 0.24, 30, 0.12 nM for PIM1, 2, 3; hinders hematologic tumor growth.</p>Formula:C26H26F3N5O3Color and Shape:SolidMolecular weight:513.51PROTAC BRD4 Degrader-27
CAS:<p>PROTAC BRD4 Degrader-27 is a selective PROTAC targeting BRD4, distinguished from BRD2/BRD3. This compound is composed of the E3 ubiquitinase ligand Thalidomide-4-OH, the PROTAC Linker γ-Aminobutyric acid, and the PROTAC target protein ligand PROTAC BRD4 ligand-3. The active control for this target protein ligand is Mivebresib, while the conjugate of the E3 ubiquitin ligase ligand and Linker is identified as Pomalidomide 4'-alkylC3-acid.</p>Formula:C37H30F2N6O7Color and Shape:SolidMolecular weight:708.67SIRT5 inhibitor 8
CAS:<p>SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.</p>Formula:C22H25ClN8O2SPurity:99.56%Color and Shape:SolidMolecular weight:501(S,R,S)-AHPC-C5-COOH
CAS:<p>E3 ligase ligand-linker '(S,R,S)-AHPC-C5-COOH' for PROTACs, VH032 inhibits VHL/HIF-1α with 185 nM Kd, may aid anemia and ischemic disease research.</p>Formula:C29H42N4O5SPurity:98%Color and Shape:SolidMolecular weight:558.73DNA Damage & Repair Compound Library
<p>A unique collection of xnum DNA Damage &amp; Repair related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Color and Shape:Odour SolidTyrosine Kinase Inhibitor Library
<p>A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related</p>Color and Shape:Odour SolidPOI ligand 1
<p>POI ligand 1 serves as a template for the non-selective HDAC inhibitor Vorinostat. It functions as a target protein ligand (PROTAC target protein ligand) in the creation of PROTAC HDAC degraders with anti-tumor properties. Additionally, POI ligand 1 is utilized in the synthesis of FF2049.</p>Formula:C14H21N3O3Color and Shape:SolidMolecular weight:279.335MS9024
<p>MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.</p>Color and Shape:Odour SolidPumecitinib
CAS:<p>Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.</p>Formula:C17H20N8O2SPurity:99.94%Color and Shape:SoildMolecular weight:400.46JB300
CAS:<p>JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.</p>Formula:C43H45ClFN7O10SColor and Shape:SolidMolecular weight:906.375(S)-GNE-987
<p>(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).</p>Formula:C56H67F2N9O8S2Purity:98%Color and Shape:SolidMolecular weight:1096.31SIRT5 inhibitor 9
CAS:<p>SIRT5 inhibitor 9 (compound 14) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=4.07 μM and has potential anticancer effects.</p>Formula:C24H29ClN8O4SPurity:98.68%Color and Shape:SolidMolecular weight:561.06NSC 370284
CAS:<p>NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.</p>Formula:C21H25NO6Purity:99.74%Color and Shape:SolidMolecular weight:387.43KDM1A-IN-29
CAS:<p>KDM1A-IN-29 is a histone demethylase inhibitor.</p>Formula:C16H16ClN3O4SColor and Shape:SoildMolecular weight:381.83PROTAC SMARCA2/4-degrader-28
CAS:<p>PROTAC SMARCA2/4-degrader-28 (PROTAC 1) functions as a partial degrader of SMARCA2 and SMARCA4 through the PROTAC-based mechanism.</p>Formula:C54H68ClN9O11S2Color and Shape:SolidMolecular weight:1118.75PROTAC CBP/P300 Degrader-1
CAS:<p>PROTAC CBP/P300 Degrader-1 effectively reduces cancer cell viability by degrading CBP/P300.</p>Formula:C46H53F2N11O6Color and Shape:SolidMolecular weight:893.998(+)-JQ-1-aldehyde
<p>(+)-JQ-1-aldehyde is the aldehyde derivative of (+)-JQ1, commonly used as a precursor for the synthesis of PROTACs targeting the BET bromine domain[1].</p>Color and Shape:SolidTB22
<p>TB22 is a non-nucleoside inhibitor of DOT1LR231Q with anticancer activity. It inhibits the malignant phenotype of lung cancer cells harboring the R231Q mutation via the MAPK/ERK signaling pathway, making it useful for lung cancer research.</p>Color and Shape:Odour SolidZL0590
CAS:<p>ZL0590 is an effective and selective inhibitor of BD1-BRD4 (IC50 = 90 nM) with anti-inflammatory activities.</p>Formula:C23H27F3N4O4SPurity:99.77%Color and Shape:SoildMolecular weight:512.55Methylation Compound Library
<p>xnum methylation-related compounds that can be used for high-throughput and high-content screening.</p>Color and Shape:Odour SolidSW2_110A
CAS:<p>SW2_110A: Cell-permeable, CBX8 ChD inhibitor, Kd 800 nM; 5x selective over other CBXs in vitro.</p>Formula:C42H60N6O7Purity:98%Color and Shape:SolidMolecular weight:760.96XF067-68
CAS:<p>XF067-68 is a PROTAC for targeted degradation of WD40 repeat domain protein 5 ( WDR5 )[1] .</p>Formula:C52H59F4N9O7SColor and Shape:SolidMolecular weight:1030.14SMARCA2 degrader-17
CAS:<p>SMARCA2 degrader-17 is a degrader of SMARCA2, exhibiting synergistic antiproliferative effects with Adagrasib in cancer cells and capable of inhibiting tumor growth.</p>Formula:C47H58N10O6SColor and Shape:SolidMolecular weight:891.09PROTAC HDAC6 degrader 3
<p>PROTACHDAC6 degrader 3 (Compound 4) is a selective inhibitor and degrader of HDAC6, with an IC50 of 686 nM and a DC50 of 171 nM. It enhances the acetylation of α-tubulin. [Pink: ligand for target protein; Blue: ligand for E3ligaseVHL.]</p>Formula:C46H56F2N10O9SColor and Shape:SolidMolecular weight:963.06JAK1/TYK2-IN-1
CAS:<p>JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 ( IC 50 = 29 and 41 nM respectively).</p>Formula:C18H20F3N7OColor and Shape:SolidMolecular weight:407.401SIRT1/2/3-IN-1
CAS:<p>Potent SIRT1/2/3-IN-1 inhibits SIRT1/2/3 with IC50: 0.54, 0.25, 0.72 μM; used in cancer research.</p>Formula:C46H63N9O8S2Color and Shape:SolidMolecular weight:934.18MS33
CAS:<p>MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.</p>Formula:C64H84F3N11O7SColor and Shape:SolidMolecular weight:1208.5PRO-HD3
<p>PRO-HD3 is a cell-specific, PROTAC-based degrader targeting HDAC6 [1].</p>Purity:98%Color and Shape:Odour SolidAxl-IN-16
<p>Axl-IN-16, a dual Axl/HIF inhibitor, promotes Flammulina velutipes fruiting body formation and suppresses hypoxia-inducible factor activity along with receptor</p>Formula:C14H19ClO8Purity:98%Color and Shape:SolidMolecular weight:350.75
