Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2613 products of "Chromatin/Epigenetics"
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XP-524
CAS:XP-524: BET & EP300 inhibitor, suppresses KRAS tumors in vivo, targets PDAC, boosts immune response.Formula:C30H28N6O3SColor and Shape:SolidMolecular weight:552.65LSD1-IN-22
LSD1-IN-22: potent LSD1 inhibitor, K_i 98 nM, curbs cancer cell growth.Formula:C9H8BrF2NColor and Shape:SolidMolecular weight:248.07DDO-3055
CAS:DDO-3055 is an orally active PHD2 inhibitor utilized in studies related to anemia associated with chronic kidney disease.Formula:C17H13ClN2O5Color and Shape:SolidMolecular weight:360.749JTZ-951 HCl
CAS:JTZ-951 is a potent and orally active inhibitor of hypoxia inducible factor prolyl hydroxylase (PHD).Formula:C17H17ClN4O4Purity:98%Color and Shape:SolidMolecular weight:376.79iBFAR2
CAS:iBFAR2, an inhibitor of BFAR, restores the CD8+ tumor-resident memory T cell subset against solid tumors. It promotes the binding of JAK2-STAT1 and enhances the phosphorylation of STAT1.
Formula:C19H15F3N2O2Color and Shape:SolidMolecular weight:360.33PF-06726304 acetate
CAS:PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.Formula:C24H25Cl2N3O5Purity:98%Color and Shape:SolidMolecular weight:506.38LSD1-IN-39
CAS:LSD1-IN-39 (Compound 14) is a reversible inhibitor of LSD1 with an IC50 of 0.18 μM, showing broad-spectrum antiproliferative activity against cancer cells, inhibiting HepG2 cell migration, and suppressing epithelial-mesenchymal transition. Additionally, LSD1-IN-39 exhibits antitumor activity in mouse models.Formula:C25H30N2O7Color and Shape:SolidMolecular weight:470.515PARP7-IN-12
CAS:PARP7-IN-12, a potent inhibitor targeting PARP7, exhibits an IC50 of 7.836 nM. This compound is applicable in cancer research.Formula:C23H27ClF3N5O5Color and Shape:SolidMolecular weight:545.94HIF-1α-IN-4
HIF-1α-IN-4 is an inhibitor of HIF-1α with IC50 of 24 nM in HEK293T cells which has potential antitumor effects.Formula:C16H12N2O3Color and Shape:SolidMolecular weight:280.28Tyk2-IN-20
CAS:Tyk2-IN-20 (Example 289) is an effective inhibitor of Tyk2 with an IC50 value below 5 nM. Additionally, it inhibits JAK1, JAK2, and JAK3 with IC50 values under 100 nM. This compound is utilized for the research of inflammatory diseases.Formula:C24H25N7O2Color and Shape:SolidMolecular weight:443.50JAK-IN-19
JAK-IN-19 inhibits JAK (pIC50: 7.2, 7.7), less so for VEGFR2 (7.0) and Aurora B (5.8).Formula:C26H36FN5O2Color and Shape:SolidMolecular weight:469.59HDAC6-IN-3
HDAC6-IN-3 (Compound 14) is an oral anti-prostate cancer agent, inhibiting HDACs and MAO-A, with IC50 of 0.02-1.54 μM.Formula:C19H27N3O3Color and Shape:SolidMolecular weight:345.44MAT2A-IN-24
CAS:MAT2A-IN-24 (Compound 9) is an inhibitor of methionine adenosyltransferase 2a (MAT2a), with an IC50 value of 20 nM for MAT2a inhibition and an antiproliferative IC50 value of 10 nM for HAP1MTAP–/– cells. MAT2A-IN-24 is applicable in the research of tumor diseases associated with MTAP deficiency.Formula:C32H33Cl2N7O2Color and Shape:SolidMolecular weight:618.556GDC-9918
CAS:GDC-9918 (compound GDC-9918) is an inhibitor of Janus kinases.Formula:C20H18F2N6O5SColor and Shape:SolidMolecular weight:492.46AMPK activator 16
CAS:AMPK activator16 (compound 6) functions as an AMP-activated protein kinase (AMPK) inhibitor. It interacts effectively with crucial AMPK residues, significantly activating the enzyme. In N2a cells, AMPK activator16 enhances the expression of phosphorylated AMPK (p-AMPK) and its downstream signaling proteins, such as phosphorylated ACC (Acetyl-CoA Carboxylase) and phosphorylated raptor (p-raptor).Formula:C23H20ClNO5SColor and Shape:SolidMolecular weight:457.927LSD1-IN-19
LSD1-IN-19 is a potent, selective LSD1 inhibitor with Ki of 0.108 μM and 72h IC50 values of 0.17-0.40 μM.Formula:C33H42N6O2Color and Shape:SolidMolecular weight:554.73Pocenbrodib
CAS:Pocenbrodib (FT-7051) is a potent inhibitor of the bromodomain of the CBP/p300 family with potential antitumour activity and is palatable for cancer research.Formula:C28H32FN3O6Purity:98.48% - 99.54%Color and Shape:SolidMolecular weight:525.57ORIC-944
CAS:ORIC-944 is an orally available, selective variant of PRC2 with anticancer activity for the study of prostate cancer.Formula:C26H25FN6OPurity:98.08%Color and Shape:SolidMolecular weight:456.52Ref: TM-T87073
1mg75.00€5mg148.00€10mg214.00€25mg361.00€50mg471.00€100mg697.00€1mL*10mM (DMSO)172.00€INCB054329
CAS:INCB054329 is a BET inhibitor targeting BRD2/3/4 and BRDT with IC50s ranging from 1-119 nM.Formula:C19H16N4O3Purity:99.52%Color and Shape:SolidMolecular weight:348.36EZM0414
CAS:EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 with IC50 of 18 nM in SETD2 biochemical assay and IC50 of 34 nM in a cellular assay.Formula:C22H29FN4O2Purity:99.58%Color and Shape:SolidMolecular weight:400.49GSK3368715 dihydrochloride
CAS:GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is a PRMTs inhibitor , with anticancer activity, for the study of advanced solid tumors.Formula:C20H40Cl2N4O2Purity:99.66% - 99.66%Color and Shape:SolidMolecular weight:439.46YTH-IN-1
CAS:YTH-IN-1 is an inhibitor of the five YTH structural domains in the human.The YTH family of proteins is an N 6-methyladenosine (m6A) reader in gene expression.Formula:C18H24N6O3Purity:98.46% - 99.94%Color and Shape:SolidMolecular weight:372.42BAY-3827
CAS:BAY-3827 is an AMPK inhibitor with antiproliferative activity and antitumor activity. BAY-3827 inhibits the phosphorylation of acetyl CoA carboxylase 1.Formula:C27H25FN6OPurity:99.90%Color and Shape:SolidMolecular weight:468.53Ref: TM-T73350
1mg52.00€5mg113.00€10mg177.00€25mg334.00€50mg560.00€100mg792.00€500mg1,575.00€1mL*10mM (DMSO)117.00€LLY-283
CAS:LLY-283, PRMT5 inhibitor, IC50 22 nM, Kd 6 nM, oral, selective, with antitumor effects.Formula:C17H18N4O4Purity:99.49%Color and Shape:SolidMolecular weight:342.35Aldometanib
CAS:Aldometanib (LXY-05-029) is an oral aldolase inhibitor that maintains metabolic balance by blocking FBP and activating lysosomal AMPK.Formula:C27H43Cl2IN2Purity:99.32% - 99.55%Color and Shape:SolidMolecular weight:593.46AMG-193
CAS:AMG-193 is an inhibitor of the MTA-PRMT5 complex and is used in the study of cancer, respiratory diseases and digestive disorders.Formula:C22H19F3N4O3Purity:99.52%Color and Shape:SolidMolecular weight:444.41DN02
DN02: a potent, selective BRD8(1) bromodomain probe; Ki=32 nM; 30x more affine than BRD8(2).Formula:C22H24FN3O3Purity:98.22% - 99.74%Color and Shape:SolidMolecular weight:397.44Sinefungin
CAS:Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viralFormula:C15H23N7O5Purity:98% - 98.12%Color and Shape:SolidMolecular weight:381.39JDTic
CAS:JDTic, a 4-phenylpiperidine derivative distantly related to analgesics like meperidine and ketobemidone and more closely to the mu opioid antagonist alvimopan, exhibits a notably long duration of action, maintaining effects in animals for weeks following a single dose. This duration is not due to irreversible binding to the kappa opioid receptor but rather to altered activity of c-Jun N-terminal kinases. As a highly selective antagonist for the κ-opioid receptor, without influencing the μ- or δ-opioid receptors, JDTic has shown potential in animal studies for producing antidepressant and anxiolytic effects. It also demonstrates promise in treating addiction to substances such as cocaine and morphine, distinguishing itself structurally from other kappa antagonists like norbinaltorphimine.Formula:C28H39N3O3Color and Shape:SolidMolecular weight:465.63BRD0639
CAS:BRD0639 is a first-in-class PRMT5-substrate interaction inhibitor for PBM-dependent PRMT5 activity studies.Formula:C21H22ClN5O4SPurity:99.85%Color and Shape:SolidMolecular weight:475.95(8R,9S)-Talazoparib
CAS:(8R,9S)-Talazoparib is Talazoparib enantiomer , less active than Talazoparib on the inhibition of PARP1 (IC50: 144 nM).Formula:C19H14F2N6OColor and Shape:SolidMolecular weight:380.35EHMT2-IN-2
CAS:EHMT2-IN-2 Used in the research of blood disease or cancer. EHMT2-IN-2 is a potent EHMT inhibitor, with IC50s of all <100 nM for EHMT1 peptide, EHMT2 peptide and cellular EHMT2.Formula:C21H22N6OColor and Shape:SolidMolecular weight:374.44CARM1-IN-1 hydrochloride
CAS:CARM1-IN-1 hydrochloride is a potent and selective inhibitor of CARM1 (IC50: 8.6 μM) with minimal inhibition of PRMT1 and SET7.Formula:C26H22Br2ClNO3Color and Shape:SolidMolecular weight:591.72(3R,4S)-Tofacitinib
CAS:(3R,4S)-Tofacitinib, the less active enantiomer of Tofacitinib, is a JAK3 inhibitor with an IC50 of 1 nM.Formula:C16H20N6OPurity:98%Color and Shape:SolidMolecular weight:312.37Amredobresib
CAS:Amredobresib is a potent BET inhibitor that impedes the interaction between bromodomains and acetylated lysines on histone H3 and H4, thereby serving as crucial regulators of gene transcription. It proves valuable in the investigation of acute myeloid leukemia (AML) and cancer.Formula:C26H29N9Color and Shape:SolidMolecular weight:467.581BD-9136
BD-9136, a highly selective BRD4 degrader, demonstrates the capability to inhibit tumor growth without inducing adverse effects in mice, showing potential forFormula:C44H44N10O5SPurity:98%Color and Shape:SolidMolecular weight:824.95HIF-PHD-IN-1
CAS:HIF-PHD-IN-1 is a pharmacological compound that acts as an orally active inhibitor of the hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD), displaying an IC50 of 54 nM for hHIF-PHD2. Its potential as a therapeutic agent for renal anemia is highly promising.Formula:C17H12Cl2N6O3Color and Shape:SolidMolecular weight:419.22PLK1-IN-6
PLK1-IN-6: potent, selective PLK1 inhibitor, IC50 = 0.45 nM, hinders cancer cell growth.
Formula:C28H37N9O3Color and Shape:SolidMolecular weight:547.65HJB97
CAS:HJB97 is used for the design of potential PROTAC BET degrader. It also has antitumor activity. HJB97 is a high-affinity inhibitor of BET (Kis: 0.9 nM (BRD2 BD1), 0.27 nM (BRD2 BD2), 0.18 nM (BRD3 BD1), 0.21 nM (BRD3 BD2), 0.5 nM (BRD4 BD1), 1.0 nM (BRD4 BD2), respectively).Formula:C26H28N8O3Purity:98%Color and Shape:SolidMolecular weight:500.55Ref: TM-T15484
Discontinued productCercosporin
CAS:Cercosporin, produced by the plant pathogen Cercospora kikuchii and the elsinochromes, is a potent photosensitizer with a short activation wavelength. Cercosporin contains perylene quinone structural features essential for PKC activity (IC50: 0.6-1.3 μM).Formula:C29H26O10Purity:98%Color and Shape:SolidMolecular weight:534.51YF-2 hydrochloride
CAS:YF-2 hydrochloride is a potent histone acetyltransferase activator that exhibits high selectivity and can pass through the blood-brain barrier. It specifically acetylates H3 in the hippocampus, with EC50 values of 2.75 μM, 29.04 μM, and 49.31 μM for CBP, PCAF, and GCN5, respectively. Notably, it does not affect HDAC activity. Moreover, YF-2 hydrochloride demonstrates promising anti-cancer and anti-Alzheimer's disease properties.Formula:C20H23Cl2F3N2O3Color and Shape:SolidMolecular weight:467.31Desidustat
CAS:Desidustat is an inhibitor of HIF hydroxylase.
Formula:C16H16N2O6Purity:98%Color and Shape:SolidMolecular weight:332.31CTB
CAS:CTB (Cholera Toxin B subunit) is an activator of p300 histone acetyltransferase and induces apoptosis in MCF-7 cells.
Formula:C16H13ClF3NO2Purity:99.82%Color and Shape:SolidMolecular weight:343.73BLL5 Maleate
CAS:BLL5 Maleate is a first-in-class selective PRMT5 inhibitor, it blocks EBV-driven B lymphocyte transformation and survival while leaving normal B cells unaffected.Formula:C21H21N3Purity:98%Color and Shape:SolidMolecular weight:315.41BET-IN-15
CAS:BET-IN-15 (compound 1) is a potent, orally active inhibitor of BET, demonstrating inhibitory IC50 values of 0.64 nM for BRD4-BD1 and 0.25 nM for BRD4-BD2.
Formula:C21H18F2N4O3SPurity:98%Color and Shape:SolidMolecular weight:444.45Bisindolylmaleimide I HCl
CAS:Bisindolylmaleimide I HCl is a specific ATP-competitive PKC inhibitor.Formula:C25H25ClN4O2Purity:98%Color and Shape:SolidMolecular weight:448.95JAK2-IN-9
CAS:Compound A8, known as JAK2-IN-9, is a selective JAK2 inhibitor with an IC50 of 5 nM.
Formula:C20H24N6O2SPurity:98%Color and Shape:SolidMolecular weight:412.51AMPK activator C2
CAS:AMPK activator C2 is an AMPK allosteric activator.Formula:C7H6NO6PPurity:98%Color and Shape:SolidMolecular weight:231.1JAK1-IN-11
CAS:JAK1-IN-11 (compound 11) serves as a potent inhibitor of Janus kinases, exhibiting nanomolar inhibitory concentrations with IC50 values of 0.02 nM (JAK1) and 0.
Formula:C26H36N6O4SPurity:98%Color and Shape:SolidMolecular weight:528.67STAT3-IN-18
CAS:STAT3-IN-18 (compound SPP), a platinum (IV) complex featuring an axial ligand from sandalwood, suppresses the JAK2-STAT3 pathway in breast cancer (BC) cells and
Formula:C18H24Cl2N2O6PtPurity:98%Color and Shape:SolidMolecular weight:630.38
