Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2597 products of "Chromatin/Epigenetics"
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CAS:Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.Formula:C22H28ClN3O4Purity:99.95%Color and Shape:SolidMolecular weight:433.93Ref: TM-T64336
5mg43.00€10mg60.00€25mg103.00€50mg166.00€100mg259.00€200mg378.00€1mL*10mM (DMSO)47.00€HDAC-IN-26
CAS:HDAC-IN-26 is a highly selective class I HDAC inhibitor with an EC 50 value of 4.7 nM.Formula:C24H28FN5O3Color and Shape:SolidMolecular weight:453.518BRD4 degrader-6
CAS:BRD4 degrader-6 is a dimeric BDR4PROTAC class degrader with a DC50 of less than 0.1 μM. It effectively induces the ubiquitination and degradation of BDR4, exhibiting anticancer properties.Formula:C61H71BClN9O7S2Color and Shape:SolidMolecular weight:1152.67GSK8573
CAS:GSK8573 is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 (Kd of 1.04 μM).Formula:C20H21NO3Purity:99.97%Color and Shape:SolidMolecular weight:323.39PROTAC BRD4 Degrader-9
CAS:PROTAC BRD4 Degrader-9 degrades BRD4 in PC3 cells; binds VHL and BRD4; DC50: STEAP1-0.86 nM, CLL1-7.6 nM.Formula:C59H71F2N9O15S4Color and Shape:SolidMolecular weight:1312.5SMD-3040 TFA
SMD-3040 TFA is a selective SMARCA2 degrader comprising SMARCA2/4 ligands, a linker, and VHL ligands, utilized in PROTAC drug synthesis.Purity:98%Color and Shape:Odour SolidPRMT5-IN-9
CAS:PRMT5-IN-9 is a novel PRMT5 inhibitor for treating cancer, with an IC 50 of 0.01 μM.Formula:C25H23F3N6OColor and Shape:SolidMolecular weight:480.495PRMT5-IN-12
CAS:PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .Formula:C32H40N4O4Color and Shape:SolidMolecular weight:544.696PROTAC SMARCA2/4 degrader-36
CAS:PROTACSMARCA2/4 degrader-36 (Compound 29) is a potent dual degrader targeting SMARCA2 and SMARCA4, exhibiting DC50 values of 0.22 nM and 0.85 nM, respectively. Additionally, PROTACSMARCA2/4 degrader-36 demonstrates antiproliferative activity.Formula:C53H62ClN9O4SColor and Shape:SolidMolecular weight:956.635Anemonin (6CI)
CAS:Anemonin, a furanone dimer from Buttercups, may help manage melanocytes and osteoarthritis.Formula:C10H8O4Color and Shape:SolidMolecular weight:192.17GSK040
CAS:GSK040: Potent BET BD2 inhibitor, pIC50 8.3, 5000x selectivity over BD1, for oncology & immunology research.Formula:C29H34N4O4Color and Shape:SolidMolecular weight:502.6PROTAC BRD4 Degrader-8
PROTAC BRD4 Degrader-8: BRD4 inhibitor with IC50s of 1.1/1.4 nM for BD1/BD2, degrades BRD4 in PC3 cells.Color and Shape:LiquidGSK9311 hydrochloride
CAS:GSK9311 hydrochloride is a less active GSK6853 analog, serving as a negative control, inhibiting BRPF1/2 (pIC50: 6.0/4.3).Formula:C24H32ClN5O3Purity:98%Color and Shape:SolidMolecular weight:474Eldocasiran
CAS:Eldocasiran, a micro-RNA-193a-3p analogue, exhibits anticancer properties. It is utilized in cancer research [1].Formula:C423H529N161O305P42Color and Shape:SolidMolecular weight:14049.5BRD3067
CAS:BRD3067, a Tubacin derivative, inhibits HDAC6 (IC50 15 nM) and acts as a negative control for Tubacin A, showing anticancer and anti-inflammatory effects.Formula:C21H23N3O2Purity:98%Color and Shape:SolidMolecular weight:349.43MS33
CAS:MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.Formula:C64H84F3N11O7SColor and Shape:SolidMolecular weight:1208.5MAK-683 hydrochloride
CAS:MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED), with IC50 values of 59, 26nM measured in EED Alphascreen, ELISA.Cost-effective and quality-assured.Formula:C20H18ClFN6OPurity:97.02% - >99.99%Color and Shape:SolidMolecular weight:412.85BRD7-IN-1 free base
CAS:BRD7-IN-1, a BI7273 derivative, transforms into PROTAC VZ185 (targets BRD7/9 with 4.5/1.8 nM DC50s) via a VHL linker.Formula:C22H26N4O3Purity:98%Color and Shape:SolidMolecular weight:394.47INCB059872
CAS:INCB059872: potent, oral, selective LSD1 inhibitor for myeloid leukemia research.Formula:C23H34N2O3Color and Shape:SolidMolecular weight:386.536SR-0813
CAS:SR-0813 is a potent and selective inhibitor of the YEATS domain in ENL/AF9.Formula:C25H32N6O3SPurity:98.81%Color and Shape:SolidMolecular weight:496.62Ref: TM-T40229
1mg39.00€5mg86.00€10mg124.00€25mg253.00€50mg384.00€100mg532.00€200mg705.00€1mL*10mM (DMSO)94.00€mUNO
CAS:mUNO is a tumor-homing peptide (mUNO, sequence: "CSPGAK") that specifically binds to murine CD206, targeting tumor-associated macrophages that express CD206/MRC1. Additionally, mUNO can interact with human recombinant CD206.Formula:C22H39N7O8SColor and Shape:SolidMolecular weight:561.652POI ligand 1
POI ligand 1 serves as a template for the non-selective HDAC inhibitor Vorinostat. It functions as a target protein ligand (PROTAC target protein ligand) in the creation of PROTAC HDAC degraders with anti-tumor properties. Additionally, POI ligand 1 is utilized in the synthesis of FF2049.Formula:C14H21N3O3Color and Shape:SolidMolecular weight:279.335CBB1007 trihydrochloride (1379573-92-8 free base)
CAS:CBB1007 trihydrochloride is a selective, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1).Formula:C27H37Cl3N8O4Purity:98%Color and Shape:SoildMolecular weight:643.99Ref: TM-T10699L2
2mg131.00€5mg187.00€10mg283.00€50mg665.00€100mg1,034.00€200mgTo inquire500mgTo inquire1mL*10mM (DMSO)264.00€PROTAC EED degrader-1
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.Formula:C55H60FN11O8SPurity:98%Color and Shape:SolidMolecular weight:1054.2GNE-987
CAS:GNE-987 is a potent chimeric BET degrader, binding BRD4 BD1/BD2 at IC50: 4.7/4.4 nM & has a DC50: 0.03 nM in EOL-1 AML cells.Formula:C56H67F2N9O8S2Purity:98%Color and Shape:SolidMolecular weight:1096.31PRMT5-IN-4
CAS:PRMT5-IN-4 (compound AAA-1) is a PRMT5 inhibitor.Formula:C11H13N3O4SColor and Shape:SolidMolecular weight:283.3FHD-609
CAS:FHD-609 inhibits and degrades BRD9, aims at ncBAF, aids in diverse cancer research, and may help treat ACC with Telomelysin/INO5401.Formula:C47H56N8O6Purity:99.96%Color and Shape:SolidMolecular weight:829Ref: TM-T75135
1mgTo inquire5mg147.00€10mg224.00€25mg358.00€50mg512.00€100mg707.00€1mL*10mM (DMSO)To inquireEXQ-2d
EXQ-2d is an inhibitor of tankyrase, effectively targeting TNKS1 and TNKS2 with IC50 values of 48.8 nM and 13.8 nM (pIC50=7.31 and 7.86), respectively. Additionally, EXQ-2d suppresses the WNT/β-catenin signaling pathway with an IC50 of 515 nM. It demonstrates antiproliferative activity in cancer cells COLO 320DM and RKO, with GI50 values of 4.9 μM and 77 μM, respectively.Formula:C18H17N3O3Color and Shape:SolidMolecular weight:323.35SAH-EZH2
CAS:EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.Formula:C155H256N48O40Purity:98%Color and Shape:SolidMolecular weight:3432.05PROTAC BET degrader-2
CAS:PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins (IC50 of 9.6 nM ).Formula:C41H42N10O6Purity:98%Color and Shape:SolidMolecular weight:770.84PROTAC BRD4 Degrader-19
CAS:PROTAC BRD4 Degrader-19 (compound 176) is a proteolysis-targeting chimera (PROTAC) designed to specifically degrade the BRD4 protein, offering potential utilityFormula:C44H38N8O5S2Color and Shape:SolidMolecular weight:822.95GSK 591 dihydrochloride
CAS:Strong PRMT5 inhibitor with 4 nM IC50, surpassing other PRMTs; halts MCL growth in lab tests.Formula:C22H30Cl2N4O2Color and Shape:SolidMolecular weight:453.41SJ10542
CAS:SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.Formula:C41H46N12O5SColor and Shape:SolidMolecular weight:818.95HDAC6-IN-53
HDAC6-IN-53 (Compound W28) is an inhibitor targeting histone deacetylase 6 (HDAC6) with an IC50 of 19.65 nM. It reduces the idiopathic pulmonary fibrosis (IPF) phenotype by inhibiting TGF-β1-induced collagen expression and demonstrates therapeutic efficacy in a bleomycin-induced mouse model of pulmonary fibrosis. HDAC6-IN-53 is applicable for research in idiopathic pulmonary fibrosis and related pulmonary fibrotic diseases.Color and Shape:Odour SolidMNK/PIM-IN-1
CAS:MNK/PIM-IN-1 is a novel dual inhibitor targeting both MNK and PIM pathways, characterized by its favorable pharmacokinetic profile.Formula:C27H27FN6O2Color and Shape:SolidMolecular weight:486.551UNC4976
UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.Formula:C47H70N6O8Purity:98%Color and Shape:SolidMolecular weight:847.09HDAC/CD13-IN-1
HDAC/CD13-IN-1 (Compound 12) is an inhibitor of both HDAC and CD13, with IC50 values of 0.34 μM for hCD13, 0.53 μM for porcine CD13, and 0.03, 0.06, and 0.02 μMFormula:C27H41Cl2N5O4Purity:98%Color and Shape:SolidMolecular weight:570.55BRD4-IN-2
CAS:BRD4-IN-2 is a bromodomain BRD4 inhibitor with an IC 50 value of 9.9 nM.Formula:C43H48N8O11Color and Shape:SolidMolecular weight:852.902JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222
JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222 incorporates a BRD4 ligand and a PROTAC linker, and is used in the synthesis of PROTAC BRD4 Degrader-29.
Formula:C43H51ClN8O3S2Color and Shape:SolidMolecular weight:827.52-PADQZ hydrochloride
CAS:2-PADQZ hydrochloride shows antiviral activity and targets influenza A virus RNA promoter.Formula:C15H21ClN4O2Purity:99.61%Color and Shape:SolidMolecular weight:324.81WDR5 ligand 2
CAS:WDR5ligand 2 is a ligand for WDR5 and can be utilized in the synthesis of PROTAC WDR5degrader 1.Formula:C29H31F3N4O4Color and Shape:SolidMolecular weight:556.576KDM5-C49 hydrochloride
KDM5-C49 hydrochloride selectively inhibits KDM5A/B/C demethylases (IC50: 40/160/100 nM) for cancer research.Formula:C15H25ClN4O3Color and Shape:SolidMolecular weight:344.84UNC2399
CAS:UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its IC
Formula:C67H104N10O17SColor and Shape:SolidMolecular weight:1353.68HIF1-IN-3
CAS:HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used inFormula:C26H24N2O3Purity:99.59%Color and Shape:SolidMolecular weight:412.48TYK2 activator-1
TYK2activator-1 (16b) is a TYK2 activator with an EC50 value of 1.78 μM. It inhibits JAK2 and JAK3 with IC50 values of 6.8 μM and 6.3 μM, respectively.Formula:C23H21FN4O2Color and Shape:SolidMolecular weight:404.16485Dihydrochlamydocin
CAS:Dihydrochlamydocin, an inhibitor of histone deacetylases (HDAC), exhibits potent cytostatic activity against mastocytoma cells.Formula:C28H40N4O6Color and Shape:SolidMolecular weight:528.65MS9024
MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.Color and Shape:Odour SolidRetreversine
CAS:Retreversine serves as an inactive control counterpart to Reversine, a pioneering class of ATP-competitive Aurora kinase inhibitor.Formula:C21H27N7OColor and Shape:SolidMolecular weight:393.49MNN-02-155
CAS:MNN-02-155 is a bivalent molecular glue that can simultaneously interact with both p300/CBP and BCL6. It effectively induces the activation of BCL6-targeted reporter genes and promotes cell death. This compound is used in the research of diffuse large B-cell lymphoma (DLBCL).Formula:C56H68ClF2N15O7Color and Shape:SolidMolecular weight:1136.69PROTAC EED degrader-2
PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.Formula:C50H58FN11O6SPurity:98%Color and Shape:SolidMolecular weight:960.13
