Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2440 products of "Chromatin/Epigenetics"
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Eleven-Nineteen-Leukemia Protein IN-2
CAS:Eleven-Nineteen-Leukemia Protein IN-2 (compound 23), an ENL inhibitor, exhibits an IC50 of 10.7 nM and is utilized for leukemia research [1].Formula:C22H23N5O2Purity:98%Color and Shape:SolidMolecular weight:389.45MK-0626
CAS:MK-0626 is an orally available dipeptidyl peptidase IV (DPP-4) inhibitor enhancing AMP, restoring the expression of GLP-1R. promoting neoangiogenesis.Formula:C22H24F2N6O2Purity:99.47% - >99.99%Color and Shape:SolidMolecular weight:442.46Compound SA91-0178
CAS:SA91-0178 (3-{[(1-methyl-2-oxo-1'-phenyl-1,2-dihydrospiro[indole-3,4'-piperidine]-5-carbonyl)amino]methyl}benzoic acid) is a specific METTL1 inhibitor and effectively alleviated tissue injury during septic inflammation.Formula:C28H27N3O4Molecular weight:469.54JBI-589
CAS:JBI-589 is an isoform-selective, non-covalent inhibitor of PAD4 that diminishes CXCR2 expression and impedes neutrophil chemotaxis.Formula:C29H28FN5OColor and Shape:SolidMolecular weight:481.56GSK3368715 hydrochloride
CAS:GSK3368715, a first-in-class, orally active, potent, and selective SAM-noncompetitive inhibitor of Type I Protein Arginine Methyltransferases (PRMTs), exhibits anti-tumor efficacy across multiple cancer models and alters exon usage with IC50 values in the lower nM range. It synergizes with GSK3326595 (Type II inhibitor) (Axon 3750) to inhibit tumor growth.Formula:C20H38N4O2·HClColor and Shape:SolidMolecular weight:403dBRD4-BD1
CAS:dBRD4-BD1 selectively inhibits and degrades BRD4 (DC50=280nM), upregulates BRD2/3, and aids in creating BRD4-specific probes.Formula:C50H53F3N8O9Color and Shape:SolidMolecular weight:967PHD-IN-2
CAS:PHD-IN-2 (Compound 91), a potent PHD antagonist with an IC50 of less than 5 nM, effectively stimulates erythropoietin synthesis in HEP3B cells with an EC50 ofFormula:C26H27N7O4Purity:98%Color and Shape:SolidMolecular weight:501.54ZINC08792229
CAS:ZINC08792229 is a novel inhibitor of SIRT1.Formula:C30H22N4O3Purity:98%Color and Shape:SolidMolecular weight:486.52BChE/HDAC6-IN-1
CAS:BChE/HDAC6-IN-1 is a dual BChE/HDAC6 inhibitor that exhibits potent and selective inhibition with IC50 values of 4 nM for BChE and 8.9 nM for HDAC6.Formula:C34H43N5O5Purity:98%Color and Shape:SolidMolecular weight:601.74CBP/p300-IN-17
CAS:CBP/p300-IN-17 (compound 7) is a potent inhibitor of EP300/CBP HAT, acting on HAT EP300 (IC50: 0.18 μM) and LK2 H3K27 (IC50: 0.69 μM).Formula:C25H28N4O3Color and Shape:SolidMolecular weight:432.51CBB1007 hydrochloride
CAS:CBB1007 Hcl inhibits LSD1 selectively (IC50=5.27μM), blocks H3K4 demethylation, activates genes; less effect on other cells/tissues.Formula:C27H39Cl5N8O4Color and Shape:SoildMolecular weight:716.91Ampkinone
CAS:Ampkinone is an indirect AMPK activator.Formula:C31H23NO6Purity:98%Color and Shape:SolidMolecular weight:505.52Amelparib
CAS:Amelparib (JPI-289) is an inhibitor of the poly-ADP-ribose polymerase.Formula:C19H25N3O3Purity:98%Color and Shape:SolidMolecular weight:343.42CM-579 trihydrochloride (1846570-40-8 free base)
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wideFormula:C29H43Cl3N4O3Purity:98%Color and Shape:SolidMolecular weight:602.04CBP/p300-IN-5
CAS:P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).Formula:C29H27F5N6O4Purity:98%Color and Shape:SolidMolecular weight:618.55FHT-1204
CAS:FHT-1204 is a potent inhibitor of SMARCA4/SMARCA2 ATPase (BRG1 and BRM) (IC50 ≤ 10 nM).Formula:C24H23N5O5S2Color and Shape:SolidMolecular weight:525.6Nezulcitinib
CAS:Nezulcitinib (TD-0903) is an inhaled pan-JAK inhibitor targeting COVID-19-related acute lung injury.Formula:C30H37N7O2Color and Shape:SolidMolecular weight:527.66Upadacitinib tartrate
CAS:Upadacitinib: potent, selective JAK1 inhibitor, 74x preferential to JAK2, effective in rat arthritis.Formula:C21H33F3N6O11Purity:98%Color and Shape:SolidMolecular weight:602.521JAK-IN-26
CAS:JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency inFormula:C22H24N6O3Purity:98%Color and Shape:SolidMolecular weight:420.46Pim-1 kinase inhibitor 5
CAS:<p>Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-</p>Formula:C22H13Cl2N3OPurity:98%Color and Shape:SolidMolecular weight:406.26
