Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2548 products of "Chromatin/Epigenetics"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
CBP/p300-IN-21
CAS:CBP/p300-IN-21 (Compound 5d), a selective inhibitor of CBP/p300 with IC50 values of 0.07 μM for p300 and 1.755 μM for CBP, reduces H3K18Ac levels and inhibitsFormula:C19H16ClNO4Purity:98%Color and Shape:SolidMolecular weight:357.79FM-479
CAS:FM-479, a structural analog of FM-381, lacks inhibition of JAK3/kinases within 100-300 nM, serving as FM-381's negative control.
Formula:C25H26N6O2Purity:98%Color and Shape:SolidMolecular weight:442.523WM-586
CAS:WM-586 is a covalent inhibitor of WDR5 that impedes the WDR5-MYC binding.Formula:C20H20F3N5O3SPurity:98%Color and Shape:SolidMolecular weight:467.47JG-2016
CAS:JG-2016, as a histone acetyltransferase 1 inhibitor, inhibits growth of human cancer cell lines and inhibits enzymatic activity in cellulose.Formula:C18H21ClN4O3Purity:99.00% - 99.37%Color and Shape:SolidMolecular weight:376.84Ref: TM-T82008
1mg116.00€5mg283.00€10mg455.00€25mg905.00€50mg1,454.00€100mg1,882.00€1mL*10mM (DMSO)310.00€GSK217
CAS:GSK217 is a potent and selective inhibitor of the bromo and extraterminal domain (BET) second bromodomain (BD2) with high solubility, utilized in oncology andFormula:C20H20N6OPurity:98%Color and Shape:SolidMolecular weight:360.41AGI-25696
CAS:AGI-25696 inhibits MATA2, blocking MTAP-deleted tumor growth, potential for cancer research.Formula:C27H18N4OPurity:98.40% - 99.74%Color and Shape:SolidMolecular weight:414.46JAK-IN-31
CAS:JAK-IN-31 (Example 75), a JAK inhibitor, demonstrates IC50 values of ≤0.01 µM for JAK1, ≤0.01 µM for JAK2, 0.01-0.1 µM for JAK3, and ≤0.01 µM for Tyk2,Formula:C21H19N7O2S2Purity:98%Color and Shape:SolidMolecular weight:465.55ABBV-712
CAS:ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 μM, and is implicated in the regulation of autoimmune diseases
Formula:C24H28N4O5Purity:98%Color and Shape:SolidMolecular weight:452.5GSK737
CAS:GSK737 is a dual inhibitor of BRD4 BD1 and BD2, exhibiting pIC50 values of 5.3 and 7.3, respectively.Formula:C20H21N5O2Purity:98%Color and Shape:SolidMolecular weight:363.41PIN1 inhibitor 2
CAS:PIN1 inhibitor 2, compound 12, impedes PIN1, shows promise in breast cancer study, and has IC50 of 9.55 μM in MCF7 cells.Formula:C16H21N3S2Color and Shape:SolidMolecular weight:319.49CBB1007
CAS:CBB1007 is a potent, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1).Formula:C27H34N8O4Purity:98%Color and Shape:SolidMolecular weight:534.61AMPK activator 7
CAS:AMPK activator 7 (I-3-24, EC50: 8.8 nM) targets AMPK-related disorders like type 2 diabetes and obesity.
Formula:C23H22F3N3O5Color and Shape:SolidMolecular weight:477.43PARP7-probe-1
CAS:PARP7-probe-1: biotinylated, chemiluminescent PARP7 active site probe for research use.Formula:C36H49F3N8O5SColor and Shape:SolidMolecular weight:762.89PRT543
CAS:PRT543 is a potent selective inhibitor of the protein arginine methyltransferase 5 (PRMT5), showing a wide range of antitumor activities in vitro and in vivo. The compound also showed an inhibitory effect on methyltransferase activity of the PRMT5/MEP50 complex with an IC50 value of 10.8 nM.Formula:C17H17ClN4O4Color and Shape:SolidMolecular weight:376.79JAK-IN-24
CAS:JAK-IN-24: JAK inhibitor, IC50: 0.534 nM (4 μM ATP), 24 nM (1mM ATP), STAT5 phosphorylation IC50: 86.171 nM.Formula:C20H25N5O2Color and Shape:SolidMolecular weight:367.44EZH2-IN-14
CAS:EZH2-IN-14 selectively inhibits EZH2 at 12 nM IC50, has >200-fold specificity over EZH1, reducing H3K27me3 levels.Formula:C31H39N7O2Color and Shape:SolidMolecular weight:541.69CBP/p300-IN-15
CAS:CBP/p300-IN-15 inhibits p300 (IC50: 2.5 nM) & CBP (28 nM), affects OVCAR-3 (EC50: 0.865 μM) & A2780 cells (2.71 μM) for ovarian cancer research.Formula:C26H28N4O5Color and Shape:SolidMolecular weight:476.52Upadacitinib tartrate
CAS:Upadacitinib: potent, selective JAK1 inhibitor, 74x preferential to JAK2, effective in rat arthritis.Formula:C21H33F3N6O11Purity:98%Color and Shape:SolidMolecular weight:602.521HL23
CAS:HL23 is a histone deacetylase (HDAC) inhibitor that effectively targets hepatocellular carcinoma (HCC).Formula:C44H44N2O7Purity:98%Color and Shape:SolidMolecular weight:712.83BRD4 Inhibitor-23
CAS:BRD4 Inhibitor-23: potent, oral, IC50: BRD4 BD-1 6.21 nM, BD-2 1.44 nM. See WO2022033542A1 Example 1.Formula:C22H19F2N3O4SColor and Shape:SolidMolecular weight:459.47
