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Chromatin/Epigenetics

Chromatin/Epigenetics

Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.

Subcategories of "Chromatin/Epigenetics"

Found 2235 products of "Chromatin/Epigenetics"

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  • mTOR/HDAC-IN-1
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    mTOR/HDAC-IN-1

    CAS:
    <p>mTOR/HDAC-IN-1, a dual inhibitor for mTOR &amp; HDAC1 with IC50s 0.49 &amp; 0.91 nM, potential anti-cancer agent.</p>
    Formula:C23H23N11O3
    Color and Shape:Solid
    Molecular weight:501.5

    Ref: TM-T63399

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    KAT6-IN-2

    <p>KAT6-IN-2 is a potent inhibitor of KAT6, showing promise for use in cancer research.</p>
    Color and Shape:Odour Solid

    Ref: TM-T200700

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    CD532 hydrochloride

    <p>CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.</p>
    Color and Shape:Solid

    Ref: TM-T36932

  • ZIP
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    ZIP

    CAS:
    <p>Novel inhibitor for PKMζ, halts synaptic potentiation and reverses LTP with IC50 of 1-2.5 μM, erasing spatial memory.</p>
    Formula:C90H154N30O17
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1928.4

    Ref: TM-TP1924

  • MT1
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    MT1

    CAS:
    <p>MT1, a bivalent chemical probe targeting BET bromodomains, demonstrates an IC50 value of 0.789 nM for BRD4(1).</p>
    Formula:C54H66Cl2N10O9S2
    Color and Shape:Solid
    Molecular weight:1134.2

    Ref: TM-T39461

  • XF056-132
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    XF056-132

    CAS:
    <p>XF056-132 is a potent WDR5 (WD40 repeat domain protein 5) PROTAC degrader [1] .</p>
    Formula:C51H57F4N9O7S
    Color and Shape:Solid
    Molecular weight:1016.11

    Ref: TM-T74888

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    PROTAC SMARCA2/4-degrader-26

    <p>PROTAC SMARCA2/4-degrader-26 is a PROTAC targeting the SMARCA2/4 proteins. It is composed of the ligand for PROTAC targeting proteins, 2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetic acid, an E3 ligase component (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, and a PROTAC linker (S)-2-Amino-3,3-dimethylbutanoic acid. The coupled complex of the E3 ubiquitin ligase ligand + Linker is referred to as (S,R,S)-AHPC.</p>
    Formula:C38H47N9O5S
    Color and Shape:Solid
    Molecular weight:741.9

    Ref: TM-T89971

  • PROTAC BRD9-binding moiety 1
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    PROTAC BRD9-binding moiety 1

    CAS:
    <p>PROTAC BRD9-binding moiety 1 that binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.</p>
    Formula:C23H25N3O7S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:519.59

    Ref: TM-T13915

  • (S,R,S)-AHPC-C5-COOH
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    (S,R,S)-AHPC-C5-COOH

    CAS:
    <p>E3 ligase ligand-linker '(S,R,S)-AHPC-C5-COOH' for PROTACs, VH032 inhibits VHL/HIF-1α with 185 nM Kd, may aid anemia and ischemic disease research.</p>
    Formula:C29H42N4O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:558.73

    Ref: TM-T18667

  • EPZ028862
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    EPZ028862

    <p>EPZ028862 is a</p>
    Formula:C20H30N4O4S
    Color and Shape:Solid
    Molecular weight:422.54

    Ref: TM-T31662

  • PROTAC SMARCA2/4-degrader-27
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    PROTAC SMARCA2/4-degrader-27

    CAS:
    <p>PROTAC SMARCA2/4-degrader-27 (PROTAC 2) serves as a targeted degrader, utilizing PROTAC technology to degrade both SMARCA2 and SMARCA4.</p>
    Formula:C49H58FN9O6S
    Color and Shape:Solid
    Molecular weight:920.11

    Ref: TM-T89900

  • Retreversine
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    Retreversine

    CAS:
    <p>Retreversine serves as an inactive control counterpart to Reversine, a pioneering class of ATP-competitive Aurora kinase inhibitor.</p>
    Formula:C21H27N7O
    Color and Shape:Solid
    Molecular weight:393.49

    Ref: TM-T73800

  • CBP/p300-IN-14
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    CBP/p300-IN-14

    CAS:
    <p>CBP/p300-IN-14, patent WO2021213521A1's compound 27, inhibits CBP/EP300 with 3.3 nM IC50.</p>
    Formula:C30H31F2N7O2
    Color and Shape:Solid
    Molecular weight:559.622

    Ref: TM-T40344

  • Ep300/CREBBP-IN-2
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    Ep300/CREBBP-IN-2

    CAS:
    <p>Ep300/CREBBP-IN-2: Potent, oral Ep300 &amp; CREBBP inhibitor; IC50s: 0.052μM &amp; 0.148μM; cancer research.</p>
    Formula:C26H27F3N4O4
    Color and Shape:Solid
    Molecular weight:516.51

    Ref: TM-T73921

  • SIRT1/2/3-IN-1
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    SIRT1/2/3-IN-1

    CAS:
    <p>Potent SIRT1/2/3-IN-1 inhibits SIRT1/2/3 with IC50: 0.54, 0.25, 0.72 μM; used in cancer research.</p>
    Formula:C46H63N9O8S2
    Color and Shape:Solid
    Molecular weight:934.18

    Ref: TM-T74894

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    NF-κB/HIF-1α-IN-1

    <p>NF-κB/HIF-1α-IN-1 (compound 9c) effectively inhibits the NF-κB activation pathway and demonstrates selective antifibrotic activity. This compound exhibits no significant cytotoxicity in NCI tumor cell lines. In rat models, NF-κB/HIF-1α-IN-1 successfully ameliorates liver fibrosis, suppresses the expression levels of NF-κB and HIF-1α, and induces Nrf2.</p>
    Formula:C24H27N7O4
    Color and Shape:Solid
    Molecular weight:477.21245

    Ref: TM-T207236

  • MZP-55
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    MZP-55

    CAS:
    <p>MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)</p>
    Formula:C57H70ClN7O10S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1080.73

    Ref: TM-T13786

  • RJW100
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    RJW100

    CAS:
    <p>RJW100 is a potent LRH-1 &amp; SF-1 agonist with pEC50 of 6.6 &amp; 7.5, also activates miR-200c promoter.</p>
    Formula:C28H34O
    Purity:99.15%
    Color and Shape:Solid
    Molecular weight:386.57

    Ref: TM-T38680

  • SAH-EZH2
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    SAH-EZH2

    CAS:
    <p>EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.</p>
    Formula:C155H256N48O40
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3432.05

    Ref: TM-TP2115

  • E67-2
    Targetmol
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    E67-2

    CAS:
    <p>E67-2: Low-toxic, KIAA1718 inhibitor with IC50 of 3.4μM, targets H3K9/H3K4 demethylases.</p>
    Formula:C21H36N6O2
    Color and Shape:Solid
    Molecular weight:404.559

    Ref: TM-T38774