Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2607 products of "Chromatin/Epigenetics"
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SGC3027
SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.Formula:C41H47ClN6O6SPurity:98%Color and Shape:SolidMolecular weight:787.37BRD4 Inhibitor-38
BRD4 Inhibitor-38 (Compound 25) is an orally active BRD4 inhibitor, exhibiting IC50 values of 3.64 μM for BRD4 BD1 and 0.12 μM for BRD4 BD2. It also demonstrates anti-inflammatory properties, with an IC50 value of 1.98 μM for nitric oxide (NO) production.Formula:C19H18N2O4Color and Shape:SolidMolecular weight:338.357CPI-268456
CAS:CPI-268456 is a compound which has bioactive.Formula:C20H15Cl2N3O2Color and Shape:SolidMolecular weight:400.26Ep300/CREBBP-IN-2
CAS:Ep300/CREBBP-IN-2: Potent, oral Ep300 & CREBBP inhibitor; IC50s: 0.052μM & 0.148μM; cancer research.Formula:C26H27F3N4O4Color and Shape:SolidMolecular weight:516.51(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine
CAS:(S,R,S)-AHPC-C2-amide targets Smad3 degradation and boosts HIF-α; it has anti-fibrotic and renal protective roles.Formula:C41H46N6O6SColor and Shape:SolidMolecular weight:750.91HDAC6 degrader-3
CAS:HDAC6 degrader-3: potent, selective, degrades HDAC6 at 19.4 nM, weakens HDAC1 at 0.647 μM, induces α-tubulin hyperacetylation.Formula:C41H41F4N7O11Color and Shape:SolidMolecular weight:883.8BRD4 degrader-6
CAS:BRD4 degrader-6 is a dimeric BDR4PROTAC class degrader with a DC50 of less than 0.1 μM. It effectively induces the ubiquitination and degradation of BDR4, exhibiting anticancer properties.Formula:C61H71BClN9O7S2Color and Shape:SolidMolecular weight:1152.67SJ10542
CAS:SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.Formula:C41H46N12O5SColor and Shape:SolidMolecular weight:818.95PROTAC BRD4 Degrader-14
PROTAC BRD4 Degrader-14 binds VHL & BRD4, degrades BRD4 in PC3 cells; IC50: 1.8/1.7 nM BD1/BD2.Formula:C57H61F2N9O11S2Color and Shape:SolidMolecular weight:1150.27HSP70/SIRT2-IN-1
HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2.Purity:98%Color and Shape:Odour SolidPRMT5-IN-34
PRMT5-IN-34 (Compound C) is an inhibitor of MTA-cooperative protein arginine methyltransferase 5 (PRMT5/MAT).Formula:C23H19F2N5O2Molecular weight:435.15068PROTAC SMARCA2 degrader-23
CAS:PROTAC SMARCA2 degrader-23 (Example 1) is an effective and selective degrader of PROTAC SMARCA2, with a DC50 value of less than 100 nM. It has potential for use in cancer research.Formula:C47H57N9O6SColor and Shape:SolidMolecular weight:876.08MRK-990
MRK-990 is an inhibitor of PRMT that targets both PRMT5 and PRMT9, with IC50 values of 30 nM and 10 nM, respectively.Color and Shape:Odour SolidMalantide TFA
Malantide TFA: synthetic dodecapeptide, PKA-specific with Km 15 μM, >90% PKI blockage, also PKC substrate, Km 16 μM.Formula:C74H125F3N22O23Color and Shape:SolidMolecular weight:1747.91PRMT5-IN-9
CAS:PRMT5-IN-9 is a novel PRMT5 inhibitor for treating cancer, with an IC 50 of 0.01 μM.Formula:C25H23F3N6OColor and Shape:SolidMolecular weight:480.495Tet1 peptide
CAS:Tet1peptide is a neuron-specific ligand for GT1B ganglioside. It can serve as a ligand for the targeted delivery of functionalized polymers.Formula:C73H114N20O17Color and Shape:SolidMolecular weight:1543.81MARK4 inhibitor 2
MARK4 Inhibitor 2 is a potent inhibitor of Microtubule Affinity-Regulating Kinase 4 (MARK4), exhibiting a Kₘ of 6.3×10⁷ and an IC₅₀ of 0.82 μM.Formula:C34H30N4O3Purity:98%Color and Shape:SolidMolecular weight:542.63PROTAC HDAC6 degrader 6
PROTACHDAC6 degrader 6 (Compound 12) is a selective photochemical targeting chimera (PHOTACs), a subset of PROTACs, designed to target HDAC6. Its activity is specifically activated to its cis-state upon irradiation with 390 nm light, resulting in a degradation maximum (Dmax) of approximately 50%.Color and Shape:Odour SolidFluorescein-NAD+
Fluorescein NAD+ is a non-radioactive PARP assay substrate, enabling direct enzyme measurement by fluorescence. Comes as 81μg in 250μl water.Color and Shape:SolidPROTAC SMARCA2/4-degrader-28
CAS:PROTAC SMARCA2/4-degrader-28 (PROTAC 1) functions as a partial degrader of SMARCA2 and SMARCA4 through the PROTAC-based mechanism.Formula:C54H68ClN9O11S2Color and Shape:SolidMolecular weight:1118.75
