Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2235 products of "Chromatin/Epigenetics"
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Sirt2-IN-7
<p>Sirt2-IN-7, a selective SIRT2 inhibitor, has IC50 and Ki values of 178.2 nM and 154.3 nM, useful in cancer research.</p>Formula:C22H38Cl2K3N3OSColor and Shape:SolidMolecular weight:831.98PROTAC PARP1 degrader-4
<p>PROTAC PARP1 degrader-4 (Compound 180055) is a selective PARP1 PROTAC degrader, demonstrating DC50 values of 180 nM and 240 nM in T47D and MDA-MB-231 cell lines, respectively. It facilitates the ubiquitination and degradation of PARP1 and inhibits its enzymatic activity without causing significant DNA trapping effects. Additionally, PROTAC PARP1 degrader-4 can inhibit tumors with BRCA gene mutations while having minimal impact on the growth of normal cells.</p>Formula:C51H62FN7O6SColor and Shape:SolidMolecular weight:920.145WWL0245
CAS:<p>WWL0245 is a potent and selective BRD4-targeting PROTAC that exhibits sub-nanomolar degradation efficiency (DC50 < 1 nM) for BRD4 over BRD2/3 and PLK1 (DC50 > 1</p>Formula:C45H51N11O8Purity:98%Color and Shape:SolidMolecular weight:873.96PRMT5-IN-11
CAS:<p>PRMT5-IN-11 demonstrates potent structure-dependent inhibition against the protein methyltransferase PRMT5:MEP50 complex at submicromolar concentrations.</p>Formula:C13H17N5O4Color and Shape:SolidMolecular weight:307.31Foenumoside B
CAS:<p>Foenumoside B, a triterpene saponin extracted from Lysimachia foenum-graecum, stimulates AMPK signaling, suppresses PPARγ-induced adipogenesis, and promotes</p>Formula:C60H96O25Purity:98%Color and Shape:SolidMolecular weight:1217.39BBDDL2204
<p>BBDDL2204 (compound 13) is a potent and selective covalent inhibitor of EZH2, demonstrating an IC50 of 2.5 nM against EZH2Y641F.</p>Formula:C37H47N5O5SColor and Shape:SolidMolecular weight:673.32979MAT2A-IN-11
<p>MAT2A Allosteric Inhibitor 1, also known as Compound 5, is a selective inhibitor of methionine adenosyltransferase (MAT) demonstrating potent activity with an</p>Formula:C21H22N6OPurity:98%Color and Shape:SolidMolecular weight:374.44JMJD6 inhibitor WL12
CAS:<p>WL12 (ZINC6733033): First-in-class JMJD6 inhibitor; halts JMJD6-dependent cervical/liver cancer cell growth.</p>Formula:C16H11N3O2Purity:98.57%Color and Shape:SolidMolecular weight:277.28BRD9 Degrader-1
<p>BRD9 Degrader-1 functions as a BRD9 degrader, demonstrating micromolar binding affinity towards BRD9 and nanomolar affinity for the ternary complex involving</p>Purity:98%Color and Shape:Odour SolidIzilendustat
CAS:<p>Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.</p>Formula:C22H28ClN3O4Purity:99.95%Color and Shape:SolidMolecular weight:433.93NPC-15437 dihydrochloride
CAS:<p>NPC-15437 dihydrochloride is a PKC inhibitor blocking enzyme activity and phorbol ester binding, selective over other kinases, in cellular signaling research.</p>Formula:C25H52Cl2N4O2Color and Shape:SolidMolecular weight:511.62TO-1187
<p>TO-1187 is a selective HDAC6 PROTAC degrader with a DC50 of 5.81 nM. It enhances the ubiquitination and subsequent degradation of HDAC6, making it useful for research in hematological malignancies and solid tumors.</p>Color and Shape:Odour SolidBET-IN-17
<p>BET-IN-17, also known as compound 16, serves as a pan-inhibitor for BET, exhibiting inhibitory potencies (pIC50) of 7.8 for BET BD1 and 7.6 for BET BD2 [1].</p>Formula:C30H36N4O2Purity:98%Color and Shape:SolidMolecular weight:484.63CARM1 degrader-2
<p>PROTAC CARM1 degrader-2 (compound 3e), with a DC50 value of 8.8 nM, is a VHL- and proteasome-dependent degrader of co-activator associated</p>Formula:C72H100N12O7SPurity:98%Color and Shape:SolidMolecular weight:1277.71MC4171
<p>MC4171 is a selective KAT8 inhibitor with antiproliferative activity and can be used to study cancer.</p>Formula:C21H15N3O3Purity:99.56%Color and Shape:SolidMolecular weight:357.36TH1834
CAS:<p>TH1834 is a specific inhibitor of Tip60/KAT5 histone acetyltransferase. TH1834 induces apoptosis and DNA damage in MCF.</p>Formula:C33H40N6O3Purity:99.96%Color and Shape:SolidMolecular weight:568.71DTP3
CAS:<p>DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.</p>Formula:C26H35N7O5Color and Shape:SolidMolecular weight:525.6GSK2879552
CAS:<p>GSK2879552: oral, irreversible LSD1 inhibitor with potential cancer-fighting properties.</p>Formula:C23H28N2O2Purity:99.22%Color and Shape:SolidMolecular weight:364.48GSK-J2
CAS:<p>GSK-J2 is an inactive enantiomer of GSK-J1 that is lipophilic and serves as an inactive control for GSK-J21.</p>Formula:C22H23N5O2Purity:97.55%Color and Shape:SolidMolecular weight:389.45AZ505 ditrifluoroacetate
CAS:<p>AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).</p>Formula:C33H40Cl2F6N4O8Color and Shape:SolidMolecular weight:805.59
