Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2595 products of "Chromatin/Epigenetics"
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MS402
CAS:MS402 is a novel BD1-selective BET BrD inhibitor.Formula:C20H19ClN2O3Purity:99.72%Color and Shape:SolidMolecular weight:370.83Uzansertib phosphate
CAS:Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase, inhibiting PIM1, PIM2 and PIM3.Formula:C26H29F3N5O7PPurity:99.75% - 99.79%Color and Shape:SolidMolecular weight:611.51SNDX-5613
CAS:Revumenib (SNDX-5613) is a potent and selective oral inhibitor of menin-KMT2A interaction.Cost-effective and quality-assured.Formula:C32H47FN6O4SPurity:99.12% - 99.74%Color and Shape:SolidMolecular weight:630.82Ref: TM-T12943
1mg73.00€2mg97.00€5mg160.00€10mg274.00€25mg542.00€50mg778.00€100mg1,074.00€1mL*10mM (DMSO)217.00€PROTAC BET degrader-2
CAS:PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins (IC50 of 9.6 nM ).Formula:C41H42N10O6Purity:98%Color and Shape:SolidMolecular weight:770.84(R)-SKBG-1
CAS:(R)-SKBG-1 is an inhibitor of the RNA-binding protein NONO, effectively downregulating androgen receptor expression by targeting both AR-FL mRNA and AR-V7 mRNAFormula:C22H26ClN3O6SPurity:97.25%Color and Shape:SolidMolecular weight:495.98UNC4976
UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.Formula:C47H70N6O8Purity:98%Color and Shape:SolidMolecular weight:847.09PROTAC BRD4 Degrader-30
PROTACBRD4 degrader-30 is an ISOX-DUAL-based PROTAC degrader, targeting BRD4 with an IC50 value of 65 nM. It is used in research studies related to c-Myc oncoproteins and the pathophysiology of cancer cells.Color and Shape:Odour SolidPROTAC EED degrader-1
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.Formula:C55H60FN11O8SPurity:98%Color and Shape:SolidMolecular weight:1054.2EXQ-2d
EXQ-2d is an inhibitor of tankyrase, effectively targeting TNKS1 and TNKS2 with IC50 values of 48.8 nM and 13.8 nM (pIC50=7.31 and 7.86), respectively. Additionally, EXQ-2d suppresses the WNT/β-catenin signaling pathway with an IC50 of 515 nM. It demonstrates antiproliferative activity in cancer cells COLO 320DM and RKO, with GI50 values of 4.9 μM and 77 μM, respectively.Formula:C18H17N3O3Color and Shape:SolidMolecular weight:323.35HDAC/CD13-IN-1
HDAC/CD13-IN-1 (Compound 12) is an inhibitor of both HDAC and CD13, with IC50 values of 0.34 μM for hCD13, 0.53 μM for porcine CD13, and 0.03, 0.06, and 0.02 μMFormula:C27H41Cl2N5O4Purity:98%Color and Shape:SolidMolecular weight:570.55PROTAC BRD4 Degrader-5
CAS:PROTAC BRD4 Degrader-5 is a PROTAC that degrades BRD4 in HER2 positive and negative breast cancer cell lines.Formula:C50H62ClN9O8S2Color and Shape:SolidMolecular weight:1016.67PROTAC SMARCA2/4-degrader-26
PROTAC SMARCA2/4-degrader-26 is a PROTAC targeting the SMARCA2/4 proteins. It is composed of the ligand for PROTAC targeting proteins, 2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetic acid, an E3 ligase component (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, and a PROTAC linker (S)-2-Amino-3,3-dimethylbutanoic acid. The coupled complex of the E3 ubiquitin ligase ligand + Linker is referred to as (S,R,S)-AHPC.Formula:C38H47N9O5SColor and Shape:SolidMolecular weight:741.9JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222
JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222 incorporates a BRD4 ligand and a PROTAC linker, and is used in the synthesis of PROTAC BRD4 Degrader-29.
Formula:C43H51ClN8O3S2Color and Shape:SolidMolecular weight:827.5AURKA against 1
Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.Formula:C28H32FN9O2Color and Shape:SolidMolecular weight:545.61CBB1007 trihydrochloride (1379573-92-8 free base)
CAS:CBB1007 trihydrochloride is a selective, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1).Formula:C27H37Cl3N8O4Purity:98%Color and Shape:SoildMolecular weight:643.99Ref: TM-T10699L2
2mg131.00€5mg187.00€10mg283.00€50mg665.00€100mg1,034.00€200mgTo inquire500mgTo inquire1mL*10mM (DMSO)264.00€WDR5 ligand 2
CAS:WDR5ligand 2 is a ligand for WDR5 and can be utilized in the synthesis of PROTAC WDR5degrader 1.Formula:C29H31F3N4O4Color and Shape:SolidMolecular weight:556.576PI3Kα/HDAC6-IN-1
PI3Kα/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kα and HDAC6, exhibiting IC50 values of 2.9 nM and 26 nM, respectively.Formula:C27H30F3N7O6S2Purity:98%Color and Shape:SolidMolecular weight:669.7PROTAC SMARCA2/4 degrader-36
CAS:PROTACSMARCA2/4 degrader-36 (Compound 29) is a potent dual degrader targeting SMARCA2 and SMARCA4, exhibiting DC50 values of 0.22 nM and 0.85 nM, respectively. Additionally, PROTACSMARCA2/4 degrader-36 demonstrates antiproliferative activity.Formula:C53H62ClN9O4SColor and Shape:SolidMolecular weight:956.635PRMT5-IN-9
CAS:PRMT5-IN-9 is a novel PRMT5 inhibitor for treating cancer, with an IC 50 of 0.01 μM.Formula:C25H23F3N6OColor and Shape:SolidMolecular weight:480.495PROTAC BRD4 Degrader-8
PROTAC BRD4 Degrader-8: BRD4 inhibitor with IC50s of 1.1/1.4 nM for BD1/BD2, degrades BRD4 in PC3 cells.Color and Shape:Liquid
