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Topoisomerase

Topoisomerase

Topoisomerases are enzymes that regulate the topology of DNA during processes such as replication, transcription, and chromosome segregation by introducing transient breaks into the DNA strands to relieve torsional stress. Topoisomerase inhibitors interfere with this process, leading to the accumulation of DNA breaks and the induction of cell death, particularly in rapidly dividing cells. These inhibitors are widely used as chemotherapeutic agents in cancer treatment. At CymitQuimica, we offer a broad range of high-quality topoisomerase inhibitors to support your research in DNA replication, cancer therapy, and cell cycle regulation.

Found 136 products of "Topoisomerase"

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  • ARN-21934
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    ARN-21934

    CAS:
    <p>ARN-21934 inhibits human topoisomerase II α/β; IC50=2μM; stronger than Etoposide (IC50=120μM) in DNA relaxation.</p>
    Formula:C21H24N6
    Purity:99.8%
    Color and Shape:Solid
    Molecular weight:360.46

    Ref: TM-T36968

  • NH2-methylpropanamide-Exatecan TFA
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    NH2-methylpropanamide-Exatecan TFA

    CAS:
    <p>Exatecan TFA, a methylpropanamide-modified derivative of the common ADC cytotoxin Exatecan, serves as a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.</p>
    Formula:C30H30F4N4O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:634.58

    Ref: TM-T77889

  • Trovafloxacin mesylate
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    Trovafloxacin mesylate

    CAS:
    <p>Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).</p>
    Formula:C21H19F3N4O6S
    Purity:99.18%
    Color and Shape:Solid
    Molecular weight:512.46

    Ref: TM-T13231L

  • CymitQuimica logo
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    SDOX

    CAS:
    <p>SDOX, a prodrug, releases Doxorubicin selectively in high-GSH tumor cells, minimizing harm to healthy tissue.</p>
    Formula:C69H97NO20S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1324.63

    Ref: TM-T74364

  • LMP744 hydrochloride
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    LMP744 hydrochloride

    CAS:
    <p>LMP744 hydrochloride (NSC-706744 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. </p>
    Formula:C24H25ClN2O7
    Purity:99.59% - 99.85%
    Color and Shape:Solid
    Molecular weight:488.92

    Ref: TM-T11872L

  • Pradofloxacin
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    Pradofloxacin

    CAS:
    <p>Pradofloxacin is a fluoroquinolone antibioticthat exerts its bactericidal effect by inhibiting bacterial DNA gyrase and topoisomerase IV.</p>
    Formula:C21H21FN4O3
    Purity:98.76%
    Color and Shape:Solid
    Molecular weight:396.41

    Ref: TM-T81412

  • Topoisomerase inhibitor 2
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    Topoisomerase inhibitor 2

    CAS:
    <p>Topoisomerase Inhibitor 2 (18C) is a broad-spectrum bacterial topoisomerase inhibitor effective against multidrug-resistant Gram-negative bacteria [1].</p>
    Formula:C23H23N5O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:433.46

    Ref: TM-T78717

  • Topoisomerase I inhibitor 9
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    Topoisomerase I inhibitor 9

    CAS:
    <p>Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial activity, demonstrating an IC50 value</p>
    Formula:C23H15Br2FN2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:498.19

    Ref: TM-T80967

  • TH1338
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    TH1338

    CAS:
    <p>TH1338 is an orally active camptothecin derivative with significant blood-brain barrier permeability and cytotoxicity, used in cancer research.</p>
    Formula:C22H21N3O4
    Purity:98.77%
    Color and Shape:Solid
    Molecular weight:391.42

    Ref: TM-T28959

  • Topoisomerase II inhibitor 18
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    Topoisomerase II inhibitor 18

    CAS:
    <p>Topoisomerase II inhibitor 18 (Compound IV), a Quinoxaline derivative, exhibits an IC 50 of 7.5 μM in inhibiting topoisomerase II. It impedes PC-3 cell proliferation, arrests the cell cycle at the S phase, and induces apoptosis. Moreover, this compound demonstrates substantial antitumor activity against cancer [1].</p>
    Formula:C20H21N3OS
    Color and Shape:Solid
    Molecular weight:351.47

    Ref: TM-T87552

  • Intoplicine
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    Intoplicine

    CAS:
    Intoplicine is an inhibitor of DNA topoisomerase I and II.
    Formula:C21H24N4O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:348.44

    Ref: TM-T15586

  • Karenitecin
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    Karenitecin

    CAS:
    <p>Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.</p>
    Formula:C25H28N2O4Si
    Purity:98%
    Color and Shape:Solid
    Molecular weight:448.59

    Ref: TM-T14703

  • Topoisomerase I/II inhibitor 7
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    Topoisomerase I/II inhibitor 7

    CAS:
    <p>Compound 5h (Topoisomerase I/II inhibitor 7) is a Topoisomerase I/II inhibitor.</p>
    Formula:C18H13ClN2O3
    Color and Shape:Solid
    Molecular weight:340.76

    Ref: TM-T204827

  • Topotecan acetate
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    Topotecan acetate

    CAS:
    <p>Topotecan acetate is an inhibitor of topoisomerase.</p>
    Formula:C25H27N3O7
    Color and Shape:Solid
    Molecular weight:481.498

    Ref: TM-T204761

  • Edotecarin
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    Edotecarin

    CAS:
    <p>Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).</p>
    Formula:C29H28N4O11
    Purity:98%
    Color and Shape:Solid
    Molecular weight:608.55

    Ref: TM-T15200

  • Gimatecan
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    Gimatecan

    CAS:
    Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.
    Formula:C25H25N3O5
    Purity:98.47%
    Color and Shape:Solid
    Molecular weight:447.48

    Ref: TM-T21319