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DNA Methyltransferase

DNA Methyltransferase

DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.

Found 422 products of "DNA Methyltransferase"

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  • TNG-462
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    TNG-462

    CAS:
    <p>TNG-462 is a oral, potent and selective PRMT5 inhibitor for the treatment of MTAP-deficient and/or MTA-accumulating cancers (e.g., pancreatic &amp; bladder).</p>
    Formula:C28H36N6O2S
    Purity:98.7%
    Color and Shape:Solid
    Molecular weight:520.69

    Ref: TM-T79873

  • BI-9321 trihydrochloride
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    BI-9321 trihydrochloride

    CAS:
    BI-9321 trihydrochloride (BI9321 trihydrochloride) is an NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression.
    Formula:C22H24Cl3FN4
    Purity:99.12% - 99.34%
    Color and Shape:Solid
    Molecular weight:469.81

    Ref: TM-T10538L

  • (S)-HH2853
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    (S)-HH2853

    CAS:
    (S)-HH2853 is a potent EZH1/2 inhibitor, aromatic, <100 nM IC50 for EZH2_Y641F, promising for anti-tumor/autoimmune research.
    Formula:C31H36F3N7O3
    Purity:97.18% - 99.74%
    Color and Shape:Solid
    Molecular weight:611.66

    Ref: TM-T73115

  • MRK-740
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    MRK-740

    CAS:
    <p>MRK-740 is a PRDM9 histone methyltransferase inhibitor that inhibits H3K4 methylation.</p>
    Formula:C25H32N6O3
    Purity:99.66%
    Color and Shape:Solid
    Molecular weight:464.56

    Ref: TM-T62957

  • MS023 dihydrochloride
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    MS023 dihydrochloride

    CAS:
    <p>MS023 dihydrochloride (MS023 2HCl) is a human type I protein arginine methyltransferase inhibitor with antitumour activity for the study of breast cancer.</p>
    Formula:C17H27Cl2N3O
    Purity:99.52%
    Color and Shape:Solid
    Molecular weight:360.32

    Ref: TM-T61338

  • CBHcy
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    CBHcy

    CAS:
    <p>CBHcy, a dual substrate analog, is a specific BHMT inhibitor that may induce cysteinemia.</p>
    Formula:C9H17NO4S
    Purity:>99.99% - >99.99%
    Color and Shape:Solid
    Molecular weight:235.3

    Ref: TM-T25210

  • PFI-2
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    PFI-2

    CAS:
    <p>PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other</p>
    Formula:C23H25F4N3O3S
    Purity:99.38%
    Color and Shape:Solid
    Molecular weight:499.52

    Ref: TM-T1987

  • GSK2807 Trifluoroacetate
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    GSK2807 Trifluoroacetate

    CAS:
    <p>GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).</p>
    Formula:C21H33F3N8O7
    Purity:99.95%
    Color and Shape:Solid
    Molecular weight:566.53

    Ref: TM-T11486

  • Tazemetostat trihydrochloride
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    Tazemetostat trihydrochloride

    CAS:
    <p>Tazemetostat trihydrochloride, an EZH2 inhibitor, orally active, IC50: 4nM (rat), Ki: 2.5nM (human), effective in peptide and nucleosome assays.</p>
    Formula:C34H47Cl3N4O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:682.12

    Ref: TM-T15240

  • Acedapsone
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    Acedapsone

    CAS:
    <p>Acedapsone has antimalarial and antimicrobial action, but is mainly used as a depot leprostatic agent.</p>
    Formula:C16H16N2O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:332.37

    Ref: TM-T26549

  • UNC0224
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    UNC0224

    CAS:
    <p>UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.</p>
    Formula:C26H43N7O2
    Purity:99.80%
    Color and Shape:Solid
    Molecular weight:485.67

    Ref: TM-T17203

  • MY-1B
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    MY-1B

    CAS:
    <p>MY-1B is a nitrogen-substituted butenamide stereoprobe that blocks stereoselective enrichment of NSUN2, binding selectively to the C271 of NSUN2.</p>
    Formula:C22H18BrN3O2
    Purity:99.81% - >99.99%
    Color and Shape:Soild
    Molecular weight:436.3

    Ref: TM-T85335

  • GSK-1268997
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    GSK-1268997

    CAS:
    GSK-1268997 is a bio-active chemical.
    Formula:C21H23N7O3S
    Purity:99.33% - 99.81%
    Color and Shape:Solid
    Molecular weight:453.52

    Ref: TM-T32003

  • G9a-IN-2
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    G9a-IN-2

    CAS:
    <p>G9a-IN-2 (Compound 7i) is an inhibitor of the histone methyltransferase G9a, with an IC50 of 0.024 μM. It can reduce the levels of H3K9me2 and induce the expression of γ-globin mRNA. G9a-IN-2 shows potential for improving Sickle Cell Disease (SCD).</p>
    Formula:C30H42N4O4
    Color and Shape:Solid
    Molecular weight:522.68

    Ref: TM-T88804

  • F5446
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    F5446

    CAS:
    <p>F5446 is a selective small molecule SUV39H1 methyltransferase inhibitor, promotes apoptosis in colorectal cancer cells by inhibiting the deposition of H3K9me3.</p>
    Formula:C26H17ClN2O8S
    Purity:98.56%
    Color and Shape:Solid
    Molecular weight:552.94

    Ref: TM-T71890

  • SW155246
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    SW155246

    CAS:
    <p>SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM).</p>
    Formula:C16H11ClN2O5S
    Purity:98.99%
    Color and Shape:Solid
    Molecular weight:378.79

    Ref: TM-T8967

  • Furamidine dihydrochloride
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    Furamidine dihydrochloride

    CAS:
    <p>Furamidine dihydrochloride is a cell-permeable, selective PRMT1 inhibitor that also binds AT-rich DNA. It blocks proliferation in leukemia cell lines.</p>
    Formula:C18H18Cl2N4O
    Purity:98.16%
    Color and Shape:Solid
    Molecular weight:377.27

    Ref: TM-T27395

  • TFMB-(S)-2-HG
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    TFMB-(S)-2-HG

    CAS:
    <p>TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase.</p>
    Formula:C13H11F3O4
    Purity:98.07%
    Color and Shape:Solid
    Molecular weight:288.22

    Ref: TM-T24871

  • OTS186935
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    OTS186935

    CAS:
    OTS186935 is a inhibitor of protein methyltransferase SUV39H2(IC50 of 6.49 nM).
    Formula:C25H26ClN5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:463.96

    Ref: TM-T12344

  • WDR5-IN-4
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    WDR5-IN-4

    CAS:
    WIN site inhibitor 1 is a WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5) inhibitor (Kd: 0.1 nM), with anti-cancer activity.
    Formula:C25H22Cl2FN5O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:498.38

    Ref: TM-T13342