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DNA Methyltransferase

DNA Methyltransferase

DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.

Found 422 products of "DNA Methyltransferase"

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  • Guadecitabine
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    Guadecitabine

    CAS:
    <p>Guadecitabine is a second-generation DNA methyltransferases inhibitor. It is used for research on acute myeloid leukemia and myelodysplastic syndromes.</p>
    Formula:C18H24N9O10P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:557.41

    Ref: TM-T16876

  • PDAT
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    PDAT

    CAS:
    <p>PDAT is a noncompetitive Indolethylamine N-methyltransferase inhibitor.</p>
    Formula:C15H23N3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:245.36

    Ref: TM-T24604

  • JS1310
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    JS1310

    CAS:
    <p>JS1310 is a selective PRMT7 inhibitor (IC50: 5 μM against human PRMT7). JS1310 has shown anti-cancer effects on different cancer cells.</p>
    Formula:C23H22FN5O3
    Color and Shape:Solid
    Molecular weight:435.45

    Ref: TM-T62474

  • NSD3-IN-3
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    NSD3-IN-3

    CAS:
    <p>"NSD3-IN-3, a potent anticancer agent, inhibits NSD3 (IC50: 1.86 μM) and hampers H460 lung cancer cell growth."</p>
    Formula:C15H17N5O2S
    Color and Shape:Solid
    Molecular weight:331.39

    Ref: TM-T73244

  • NSD3-IN-2
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    NSD3-IN-2

    CAS:
    <p>NSD3-IN-2: Potent NSD3 inhibitor, IC50 17.97μM, halts NSCLC growth (H460, H1299, H1650) with anticancer effects.</p>
    Formula:C17H15N5OS
    Color and Shape:Solid
    Molecular weight:337.4

    Ref: TM-T73243

  • CSV0C018875
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    CSV0C018875

    CAS:
    <p>CSV0C018875 is a quinoline-based EHMT2/G9a inhibitor with lower cytotoxicity than BIX-01294 [1].</p>
    Formula:C18H17ClN2O
    Color and Shape:Solid
    Molecular weight:312.79

    Ref: TM-T60786

  • Dihydro-5-azacytidine acetate
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    Dihydro-5-azacytidine acetate

    CAS:
    <p>Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1</p>
    Formula:C10H18N4O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:306.27

    Ref: TM-T78565

  • PRMT5-IN-17
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    PRMT5-IN-17

    CAS:
    <p>PRMT5-IN-17 is a PRMT5-blocking compound with anticancer properties, linked to epigenetic changes.</p>
    Formula:C26H33N7O2
    Color and Shape:Solid
    Molecular weight:475.59

    Ref: TM-T63103

  • BAY-598 R-isomer
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    BAY-598 R-isomer

    CAS:
    <p>BAY-598 R-isomer, a SMYD2-selective inhibitor, is the R-enantiomer of BAY589, not targeting PAR1.</p>
    Formula:C22H20Cl2F2N6O3
    Color and Shape:Solid
    Molecular weight:525.34

    Ref: TM-T26744

  • CPI-905
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    CPI-905

    CAS:
    <p>CPI-905 is a potent and selective EZH2 inhibitor with IC50 value of 39.5 nM.</p>
    Formula:C18H20N2O5
    Color and Shape:Solid
    Molecular weight:344.36

    Ref: TM-T27074

  • DNMT3A-IN-1
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    DNMT3A-IN-1

    CAS:
    <p>DNMT3A-IN-1 is a potent, selective DNMT3A inhibitor with KI 9.16-18.85 μM (AdoMet) and 11.37-23.34 μM (poly dI-dC).</p>
    Formula:C30H38N6O4
    Color and Shape:Solid
    Molecular weight:546.66

    Ref: TM-T63859

  • CM-579
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    CM-579

    CAS:
    <p>CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.</p>
    Formula:C29H40N4O3
    Purity:99.23%
    Color and Shape:Solid
    Molecular weight:492.65

    Ref: TM-T10840L

  • NSC-311068
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    NSC-311068

    CAS:
    <p>NSC-311068: A selective TET1 inhibitor, reducing 5hmC and AML cell viability with high TET1.</p>
    Formula:C10H6N4O4S
    Color and Shape:Solid
    Molecular weight:278.24

    Ref: TM-T68773

  • EZH2-IN-11
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    EZH2-IN-11

    CAS:
    <p>EZH2-IN-11, a potent E2HZ inhibitor with potential for cancer treatment, is highlighted in patent WO2019204490A1.</p>
    Formula:C28H36ClN3O5S
    Color and Shape:Solid
    Molecular weight:562.12

    Ref: TM-T63970

  • EZH2-IN-9
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    EZH2-IN-9

    CAS:
    <p>EZH2-IN-9 inhibits EZH2, targeting SET mutations linked to cancer by reducing H3K27me3 levels.</p>
    Formula:C28H32ClF2N3O5S
    Color and Shape:Solid
    Molecular weight:596.09

    Ref: TM-T64208

  • AA-CW236
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    AA-CW236

    CAS:
    <p>AA-CW236 is a covalent inhibitor of human O(6)-alkylguanine DNA methyltransferase (MGMT).</p>
    Formula:C17H16ClF3N4O2
    Color and Shape:Solid
    Molecular weight:400.78

    Ref: TM-T26496

  • NSD3-IN-1
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    NSD3-IN-1

    CAS:
    <p>NSD3-IN-1, a histone methyltransferase NSD3 inhibitor, demonstrates an IC50 of 28.58 μM.</p>
    Formula:C13H13N5OS
    Color and Shape:Solid
    Molecular weight:287.34

    Ref: TM-T73242

  • BI-9321
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    BI-9321

    CAS:
    <p>BI-9321: Selective NSD3-PWWP1 antagonist, Kd 166 nM. Inactive against NSD2-PWWP1/NSD3-PWWP2.</p>
    Formula:C22H21FN4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:360.43

    Ref: TM-T10538

  • UNC0379 TFA
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    UNC0379 TFA

    CAS:
    <p>UNC0379 TFA inhibits SETD8 (IC50: 7.3 μM), selective for 15+ methyltransferases.</p>
    Formula:C25H36F3N5O4
    Color and Shape:Solid
    Molecular weight:527.589

    Ref: TM-T63705

  • DDO-2093 dihydrochloride
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    DDO-2093 dihydrochloride

    <p>DDO-2093 dihydrochloride: potent MLL1-WDR5 inhibitor, IC50=8.6 nM, Kd=11.6 nM, antitumor.</p>
    Formula:C29H39Cl3FN9O3
    Color and Shape:Solid
    Molecular weight:687.04

    Ref: TM-T72239