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DNA Methyltransferase

DNA Methyltransferase

DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.

Found 422 products of "DNA Methyltransferase"

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  • FTX-6058
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    FTX-6058

    CAS:
    <p>FTX-6058 is an oral inhibitor of EED that induces HbF and may treat hemoglobinopathies like sickle cell and β-thalassemia.</p>
    Formula:C22H18FN5O2
    Color and Shape:Solid
    Molecular weight:403.417

    Ref: TM-T40154

  • PROTAC EED degrader-1
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    PROTAC EED degrader-1

    <p>PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.</p>
    Formula:C55H60FN11O8S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1054.2

    Ref: TM-T12553

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    TB22

    <p>TB22 is a non-nucleoside inhibitor of DOT1LR231Q with anticancer activity. It inhibits the malignant phenotype of lung cancer cells harboring the R231Q mutation via the MAPK/ERK signaling pathway, making it useful for lung cancer research.</p>
    Color and Shape:Odour Solid

    Ref: TM-T200492

  • A-893
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    A-893

    CAS:
    <p>A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .</p>
    Formula:C29H38Cl2N4O4
    Color and Shape:Solid
    Molecular weight:577.54

    Ref: TM-T5381

  • UNC4976
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    UNC4976

    <p>UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.</p>
    Formula:C47H70N6O8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:847.09

    Ref: TM-T13255

  • PROTAC EED degrader-2
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    PROTAC EED degrader-2

    <p>PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.</p>
    Formula:C50H58FN11O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:960.13

    Ref: TM-T12554

  • MS33
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    MS33

    CAS:
    <p>MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.</p>
    Formula:C64H84F3N11O7S
    Color and Shape:Solid
    Molecular weight:1208.5

    Ref: TM-T39975

  • GSK3735967
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    GSK3735967

    CAS:
    <p>GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.</p>
    Formula:C25H31N7OS
    Color and Shape:Solid
    Molecular weight:477.62

    Ref: TM-T74887

  • CymitQuimica logo
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    CS-VIP 8

    <p>CS-VIP 8 is a selective allosteric inhibitor of the WDR5 protein (Ki= 0.008 μM). It induces conformational changes in the MLL1 complex, causing the dissociation of MLL1 from the complex and inhibiting MLL1 histone methyltransferase activity, thereby regulating HOX gene expression. CS-VIP 8 shows potential for research in hematological diseases such as leukemia.</p>
    Formula:C43H52F4N12O7
    Color and Shape:Solid
    Molecular weight:924.4018

    Ref: TM-T207515

  • PRMT5-IN-12
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    PRMT5-IN-12

    CAS:
    <p>PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .</p>
    Formula:C32H40N4O4
    Color and Shape:Solid
    Molecular weight:544.696

    Ref: TM-T40202

  • PRMT5-IN-4
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    PRMT5-IN-4

    CAS:
    <p>PRMT5-IN-4 (compound AAA-1) is a PRMT5 inhibitor.</p>
    Formula:C11H13N3O4S
    Color and Shape:Solid
    Molecular weight:283.3

    Ref: TM-T39008

  • LLY-284
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    LLY-284

    CAS:
    <p>LLY-284, a less active PRMT5 inhibitor diastereomer of LLY-283, serves as its negative control.</p>
    Formula:C17H18N4O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:342.35

    Ref: TM-T22356

  • ND-L11B free base
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    ND-L11B free base

    <p>ND-L11B is an effective degrader of the nuclear receptor binding SET domain protein 2 (NSD2) and RE-IIBP, with DC50 values of 1.48 μM and 0.8 μM, respectively, and a Dmax close to 80%.</p>
    Formula:C37H51F3N10O2
    Color and Shape:Solid
    Molecular weight:724.862

    Ref: TM-T204108

  • PARP/EZH2-IN-1
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    PARP/EZH2-IN-1

    CAS:
    <p>PARP/EZH2-IN-1: Dual PARP (IC50 6.87 nM) &amp; EZH2 (IC50 36.51 nM) inhibitor, potential for BRCA-wild-type triple-negative breast cancer.</p>
    Formula:C43H41FN8O5
    Color and Shape:Solid
    Molecular weight:768.85

    Ref: TM-T40310

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    MAK683-CH2CH2COOH hydrochloride

    <p>MAK683-CH2CH2COOH, an EED binder, was key in crafting PROTAC EED degrader-1 and -2 targeting VHL-E3 ligase.</p>
    Formula:C23H22ClFN6O3
    Color and Shape:Solid
    Molecular weight:484.91

    Ref: TM-T73945

  • PRMT5-IN-9
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    PRMT5-IN-9

    CAS:
    <p>PRMT5-IN-9 is a novel PRMT5 inhibitor for treating cancer, with an IC 50 of 0.01 μM.</p>
    Formula:C25H23F3N6O
    Color and Shape:Solid
    Molecular weight:480.495

    Ref: TM-T40313

  • UNC2399
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    UNC2399

    CAS:
    <p>UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its IC</p>
    Formula:C67H104N10O17S
    Color and Shape:Solid
    Molecular weight:1353.68

    Ref: TM-T40038

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    MS9024

    <p>MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.</p>
    Color and Shape:Odour Solid

    Ref: TM-T206183

  • CymitQuimica logo
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    Histone H3K9me3 (1-15) TFA

    <p>Histone H3K9me3 (1-15) (H3(1-15)K9me3) TFA is used as a substrate. This post-translational modification (PTM) of histone H3K9me3 is indicative of heterochromatin surrounding the centromere.</p>
    Formula:C66H124N25O21·xC2HF3O2

    Ref: TM-TP3321

  • SAH-EZH2
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    SAH-EZH2

    CAS:
    <p>EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.</p>
    Formula:C155H256N48O40
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3432.05

    Ref: TM-TP2115