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DNA Methyltransferase

DNA Methyltransferase

DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.

Found 422 products of "DNA Methyltransferase"

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  • FTX-6058 hydrochloride
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    FTX-6058 hydrochloride

    CAS:
    <p>FTX-6058 hydrochloride is a potent EED inhibitor, induces HbF, and aids sickle cell and β-thalassemia research.</p>
    Formula:C22H19ClFN5O2
    Color and Shape:Solid
    Molecular weight:439.87

    Ref: TM-T40155

  • MS33
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    MS33

    CAS:
    <p>MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.</p>
    Formula:C64H84F3N11O7S
    Color and Shape:Solid
    Molecular weight:1208.5

    Ref: TM-T39975

  • PRMT5-IN-13
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    PRMT5-IN-13

    CAS:
    <p>PRMT5-IN-13 is a selective inhibitor of protein arginine methyltransferase 5 (prmt5) .</p>
    Formula:C18H17ClN4O4
    Color and Shape:Solid
    Molecular weight:388.81

    Ref: TM-T39934

  • WDR5-47
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    WDR5-47

    CAS:
    <p>WDR5-47 is a potent small molecule to disturb the interaction of MLL1-WDR5 with IC50 value of 0.3μM.</p>
    Formula:C19H20ClFN4O3
    Purity:98.15%
    Color and Shape:Soild
    Molecular weight:406.84

    Ref: TM-T67697

  • XF056-132
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    XF056-132

    CAS:
    <p>XF056-132 is a potent WDR5 (WD40 repeat domain protein 5) PROTAC degrader [1] .</p>
    Formula:C51H57F4N9O7S
    Color and Shape:Solid
    Molecular weight:1016.11

    Ref: TM-T74888

  • AS-254s
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    AS-254s

    <p>AS-254s is an inhibitor of absent, small, or homeotic-like 1 protein (ASH1L), with an IC50 of 94 nM (FP assay). It exhibits antiproliferative activity against leukemia cells with MLL1 rearrangement, with a GI50 of less than 1 μM. Additionally, AS-254s can induce differentiation in MLL1-r leukemia cells.</p>
    Formula:C36H41ClN6O3S2
    Color and Shape:Solid
    Molecular weight:705.332

    Ref: TM-T204900

  • PRMT5-IN-15
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    PRMT5-IN-15

    CAS:
    <p>PRMT5-IN-15 is a PRMT5 inhibitor with an IC 50 value of 0.84 nM.</p>
    Formula:C24H23F3N6O2
    Color and Shape:Solid
    Molecular weight:484.483

    Ref: TM-T39993

  • CymitQuimica logo
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    Histone H3K9me3 (1-15) TFA

    <p>Histone H3K9me3 (1-15) (H3(1-15)K9me3) TFA is used as a substrate. This post-translational modification (PTM) of histone H3K9me3 is indicative of heterochromatin surrounding the centromere.</p>
    Formula:C66H124N25O21·xC2HF3O2

    Ref: TM-TP3321

  • CymitQuimica logo
    Targetmol
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    HDACs/EZH2-IN-1

    <p>HDACs/EZH2-IN-1 (Compound 22a) is a dual inhibitor of HDACs and EZH2, exhibiting potent inhibitory activity, with EZH2 Y641N being suppressed by 98% at 50 nM. It selectively targets HDAC1 and HDAC6, with IC50 values of 0.23 μM and 0.07 μM, respectively. HDACs/EZH2-IN-1 effectively inhibits the proliferation of diffuse large B-cell lymphoma cells harboring EZH2 mutations and various acute myeloid leukemia cells. Additionally, this compound has the capability to induce cellular differentiation and apoptosis (Apoptosis).</p>
    Formula:C29H36BrN7O4
    Color and Shape:Solid
    Molecular weight:626.54

    Ref: TM-T201795

  • CymitQuimica logo
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    MRTX9768 hydrochloride

    <p>MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor.</p>
    Color and Shape:Solid

    Ref: TM-T36630

  • EML734
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    EML734

    CAS:
    <p>EML734 is a potent, selective inhibitor of PRMT7 and PRMT9, demonstrating inhibitory concentration 50 (IC50) values of 315 nM for PRMT7 and 0.89 μM for PRMT9.</p>
    Formula:C27H32N10O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:608.61

    Ref: TM-T79614

  • PRMT1-IN-1
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    PRMT1-IN-1

    CAS:
    <p>PRMT1-IN-1 is a PRMT1 inhibitor.</p>
    Formula:C20H7Br6NO5
    Color and Shape:Solid
    Molecular weight:820.702

    Ref: TM-T38421

  • NSC 370284
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    NSC 370284

    CAS:
    <p>NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.</p>
    Formula:C21H25NO6
    Purity:99.74%
    Color and Shape:Solid
    Molecular weight:387.43

    Ref: TM-T9949

  • CymitQuimica logo
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    CARM1 degrader-1

    <p>PROTAC CARM1 degrader-1 (compound 3b) serves as a highly potent degrader (DC50=8.1 nM) of the co-activator associated arginine methyltransferase (CARM1).</p>
    Formula:C71H98N12O8S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1279.68

    Ref: TM-T79741

  • EEDi-5285
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    EEDi-5285

    CAS:
    <p>EEDi-5285: potent EED inhibitor, orally active, IC50=0.2nM, targets EED protein, anti-cancer properties.</p>
    Formula:C24H22FN5O3S
    Purity:100%
    Color and Shape:Solid
    Molecular weight:479.53

    Ref: TM-T22322

  • EPZ-025654
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    EPZ-025654

    CAS:
    <p>EPZ-025654 is an effective and selective inhibitor of arginine methyltransferase CARM1.</p>
    Formula:C29H33ClN8O3
    Color and Shape:Solid
    Molecular weight:577.08

    Ref: TM-T24037

  • SAH-EZH2
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    SAH-EZH2

    CAS:
    <p>EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.</p>
    Formula:C155H256N48O40
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3432.05

    Ref: TM-TP2115

  • Gintemetostat
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    Gintemetostat

    CAS:
    <p>Gintemetostat (KTX-1001) is a potent NSD2 inhibitor (IC50=0.001-0.01μM) for treating NSD2-dysregulated cancers.</p>
    Formula:C25H26F4N8O2
    Color and Shape:Solid
    Molecular weight:546.52

    Ref: TM-T202312

  • AMI-1 free acid
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    AMI-1 free acid

    CAS:
    <p>AMI-1: Potent reversible PRMT inhibitor; IC50: 8.8 μM (hPRMT1), 3.0 μM (yeast-Hmt1p); blocks substrate binding.</p>
    Formula:C21H16N2O9S2
    Purity:97.8%
    Color and Shape:Solid
    Molecular weight:504.49

    Ref: TM-T22239

  • PROTAC EZH2 Degrader-1
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    PROTAC EZH2 Degrader-1

    CAS:
    <p>PROTAC EZH2 Degrader-1 suppresses EZH2 methyltransferase activity with IC50 2.7 nM, serving as a potent tool in cancer research and EZH2 inhibition studies.</p>
    Formula:C54H67N7O8
    Color and Shape:Solid
    Molecular weight:942.15

    Ref: TM-T74602