DNA Methyltransferase
DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.
Found 422 products of "DNA Methyltransferase"
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ND-L11B free base
<p>ND-L11B is an effective degrader of the nuclear receptor binding SET domain protein 2 (NSD2) and RE-IIBP, with DC50 values of 1.48 μM and 0.8 μM, respectively, and a Dmax close to 80%.</p>Formula:C37H51F3N10O2Color and Shape:SolidMolecular weight:724.862Dot1L-IN-8
<p>Dot1L-IN-8 (Compound 15) is an effective Dot1L inhibitor. It suppresses the viability of HL-60, K562, MV4-11, HH, and KG-1 cells, with IC50 values of 0.45, 1.03, 0.68, 1.66, and 1.12 μM, respectively.</p>Formula:C41H53N7O3SColor and Shape:SolidMolecular weight:723.97MS049 2HCl (1502816-23-0(free base))
<p>MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.</p>Formula:C15H26Cl2N2OPurity:99.9%Color and Shape:SolidMolecular weight:321.28PARP/EZH2-IN-1
CAS:<p>PARP/EZH2-IN-1: Dual PARP (IC50 6.87 nM) & EZH2 (IC50 36.51 nM) inhibitor, potential for BRCA-wild-type triple-negative breast cancer.</p>Formula:C43H41FN8O5Color and Shape:SolidMolecular weight:768.85EPZ-719
CAS:<p>EPZ-719: Potent SETD2 inhibitor, IC50=0.005μM, high selectivity, potential for targeted epigenetic therapy.</p>Formula:C22H31FN4O3SColor and Shape:SolidMolecular weight:450.57MAK683-CH2CH2COOH hydrochloride
<p>MAK683-CH2CH2COOH, an EED binder, was key in crafting PROTAC EED degrader-1 and -2 targeting VHL-E3 ligase.</p>Formula:C23H22ClFN6O3Color and Shape:SolidMolecular weight:484.91CS-VIP 8 TFA
<p>CS-VIP 8 TFA is a selective allosteric inhibitor of the WDR5 protein (Ki= 0.008 μM). It induces a conformational change in the MLL1 complex, leading to the dissociation of MLL1 from the complex, thereby inhibiting the MLL1 histone methyltransferase activity and modulating HOX gene expression. CS-VIP 8 TFA shows potential for research in hematological disorders such as leukemia.</p>Formula:C45H53F7N12O9Color and Shape:SolidMolecular weight:1038.39467MRTX9768 hydrochloride
<p>MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor.</p>Color and Shape:SolidFTX-6058 hydrochloride
CAS:<p>FTX-6058 hydrochloride is a potent EED inhibitor, induces HbF, and aids sickle cell and β-thalassemia research.</p>Formula:C22H19ClFN5O2Color and Shape:SolidMolecular weight:439.87LLY-284
CAS:<p>LLY-284, a less active PRMT5 inhibitor diastereomer of LLY-283, serves as its negative control.</p>Formula:C17H18N4O4Purity:98%Color and Shape:SolidMolecular weight:342.35XF056-132
CAS:<p>XF056-132 is a potent WDR5 (WD40 repeat domain protein 5) PROTAC degrader [1] .</p>Formula:C51H57F4N9O7SColor and Shape:SolidMolecular weight:1016.11Aclantate
CAS:<p>Aclantate is a nonsteroidal anti-inflammatory drug.</p>Formula:C15H14ClNO4SPurity:98%Color and Shape:SolidMolecular weight:339.79PRMT5-IN-41
CAS:PRMT5-IN-41 (compound 130) is an effective orally active inhibitor of PRMT5. It inhibits the hERG ion channel with an IC50 of 1.36 µM.Formula:C22H16F5N5O2Molecular weight:477.39Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH
CAS:<p>Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b), an EZH2 degrader, is employed in lymphoma research [1].</p>Formula:C34H43N3O7Color and Shape:SolidMolecular weight:605.72MS33
CAS:<p>MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.</p>Formula:C64H84F3N11O7SColor and Shape:SolidMolecular weight:1208.5MS8511 HCl
<p>MS8511 HCl is a G9a/GLP inhibitor with anticancer activity that can be used in the study of a variety of cancers including brain cancer.</p>Formula:C28H42ClN5O3Purity:98.9% - 98.96%Color and Shape:SolidMolecular weight:532.12PRMT3-IN-4
<p>PRMT3-IN-4 (intermediate 15) is an inhibitor of Protein arginine methyltransferase 3 (PRMT3) and serves as the active control for SGC707. It can be utilized in the synthesis of PROTACs targeting PRMT3 and is applicable in research related to leukemia.</p>Color and Shape:Odour SolidMethylation Compound Library
<p>xnum methylation-related compounds that can be used for high-throughput and high-content screening.</p>Color and Shape:Odour SolidPROTAC EED degrader-2
<p>PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.</p>Formula:C50H58FN11O6SPurity:98%Color and Shape:SolidMolecular weight:960.13PRMT5-IN-12
CAS:<p>PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .</p>Formula:C32H40N4O4Color and Shape:SolidMolecular weight:544.696MAK-683 hydrochloride
CAS:MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED), with IC50 values of 59, 26nM measured in EED Alphascreen, ELISA.Cost-effective and quality-assured.Formula:C20H18ClFN6OPurity:97.02% - >99.99%Color and Shape:SolidMolecular weight:412.85SW2_110A
CAS:<p>SW2_110A: Cell-permeable, CBX8 ChD inhibitor, Kd 800 nM; 5x selective over other CBXs in vitro.</p>Formula:C42H60N6O7Purity:98%Color and Shape:SolidMolecular weight:760.96MRK-990
MRK-990 is an inhibitor of PRMT that targets both PRMT5 and PRMT9, with IC50 values of 30 nM and 10 nM, respectively.Color and Shape:Odour SolidDot1L-IN-1 TFA
<p>Dot1L-IN-1 TFA: potent inhibitor, K i =2 pM, IC 50 <0.1 nM; reduces H3K79 dimethylation (IC 50 =3 nM) & HoxA9 promoter activity (IC 50 =17 nM).</p>Formula:C34H37ClF3N9O4SColor and Shape:SolidMolecular weight:760.23WDR5-MYC-IN-1
<p>WDR5-MYC-IN-1 (compound 4o) is an effective inhibitor of the WDR5-MYC interaction, demonstrating a Ki value of 1.0 µM and exhibiting antiproliferative activity.</p>Color and Shape:Odour SolidEZH2-IN-15
CAS:<p>A compound inhibits EZH2, overexpressed in cancers, affecting Treg activity and innate immunity.</p>Formula:C32H44N4O4Purity:99.88%Color and Shape:SolidMolecular weight:548.72FTX-6058
CAS:<p>FTX-6058 is an oral inhibitor of EED that induces HbF and may treat hemoglobinopathies like sickle cell and β-thalassemia.</p>Formula:C22H18FN5O2Color and Shape:SolidMolecular weight:403.417EPZ-025654
CAS:<p>EPZ-025654 is an effective and selective inhibitor of arginine methyltransferase CARM1.</p>Formula:C29H33ClN8O3Color and Shape:SolidMolecular weight:577.08DDO-2093
CAS:<p>DDO-2093 inhibits MLL1-WDR5 interaction (IC50: 8.6 nM, Kd: 11.6 nM), with strong antitumor properties and selectivity.</p>Formula:C29H37ClFN9O3Color and Shape:SolidMolecular weight:614.12EZH2-IN-5
CAS:<p>EZH2-IN-5, potent EZH2 inhibitor; IC50: 1.52 nM (wild-type), 4.07 nM (Tyr641 mutant).</p>Formula:C26H37BrN4O2Color and Shape:SolidMolecular weight:517.512E67-2
CAS:<p>E67-2: Low-toxic, KIAA1718 inhibitor with IC50 of 3.4μM, targets H3K9/H3K4 demethylases.</p>Formula:C21H36N6O2Color and Shape:SolidMolecular weight:404.559DNMT1/HDAC-IN-1
<p>DNMT1/HDAC-IN-1 (compound (R)-23a), a potent dual inhibitor targeting both DNMT1 and HDAC, exhibits impressive inhibitory effects specifically on HDAC1 (HDAC1:IC50=0.05 μM), a major HDAC isoform that interacts with DNMT1 across multiple protein complexes involved in the transcriptional silencing of TSGs. This compound has been shown to remodel the tumor immune microenvironment and induce tumor regression, effectively reversing cancer-specific epigenetic abnormalities.</p>Color and Shape:Odour SolidUNC4976
<p>UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.</p>Formula:C47H70N6O8Purity:98%Color and Shape:SolidMolecular weight:847.09A-893
CAS:<p>A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .</p>Formula:C29H38Cl2N4O4Color and Shape:SolidMolecular weight:577.54GSK 591 dihydrochloride
CAS:<p>Strong PRMT5 inhibitor with 4 nM IC50, surpassing other PRMTs; halts MCL growth in lab tests.</p>Formula:C22H30Cl2N4O2Color and Shape:SolidMolecular weight:453.41PROTAC EED degrader-1
<p>PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.</p>Formula:C55H60FN11O8SPurity:98%Color and Shape:SolidMolecular weight:1054.2GSK3735967
CAS:<p>GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.</p>Formula:C25H31N7OSColor and Shape:SolidMolecular weight:477.62CPI-1328
CAS:<p>CPI-1328 is an EZH2 inhibitor with a K i value of 63 fM.</p>Formula:C28H36ClN3O4SColor and Shape:SolidMolecular weight:546.12UNC2399
CAS:<p>UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its IC</p>Formula:C67H104N10O17SColor and Shape:SolidMolecular weight:1353.68MS9024
<p>MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.</p>Color and Shape:Odour SolidCARM1/IKZF3 ligand 1
<p>CARM1/IKZF3 ligand 1 functions as an inhibitor of CARM1 and serves as a target protein ligand for the synthesis of PROTAC CARM1/IKZF3 degrader-1.</p>Formula:C27H35ClN6O3Color and Shape:SolidMolecular weight:527.06PRMT5 ligand 1
CAS:<p>PRMT5ligand 1 is a ligand of PRMT5, used as a target protein ligand in the synthesis of the PROTAC degrader MS4322.</p>Formula:C20H26N6O2Color and Shape:SolidMolecular weight:382.459C 21
CAS:<p>PRMT1 inhibitor, IC50=1.8μM; 5x more selective than PRMT6; >250x over PRMT3, CARM1.</p>Formula:C90H161ClN36O24Purity:98%Color and Shape:SolidMolecular weight:2166.94CM112
<p>CM112 is a selective degrader of protein arginine methyltransferase 1 (PRMT1), which connects a hydrophobic adamantane tag to MS023 via a 5-PEG linker. It induces the degradation of PRMT1 in various solid tumor cell lines. CM112 also targets the non-enzymatic functions of PRMT1 by reducing the stability of the orphan receptor TR3. This compound shows potential for cancer research.</p>Formula:C39H61N5O7Color and Shape:SolidMolecular weight:711.4571MS2133
<p>MS2133 is a DOT1L PROTAC degrader. It facilitates the ubiquitination and degradation of DOT1L in THP-1 and MV4-11 cells, with DC50 values of 56 nM and 25 nM, respectively, and reduces H3K79 methylation. MS2133 also inhibits the growth of MLL-r leukemia cells, demonstrating anticancer activity.</p>Formula:C58H66ClF3N14O11S2Color and Shape:SolidMolecular weight:1290.41175ML234
<p>ML234 is a dual inhibitor targeting EZH2/LSD1, with IC50 values of 0.09 and 0.12 μM, respectively. It demonstrates strong antiproliferative effects on prostate cancer cell lines LNCAP, PC3, and 22RV1. Additionally, ML234 inhibits tumor growth in a 22RV1 xenograft mouse model, showing potential as a research agent in prostate cancer therapeutics.</p>Color and Shape:Odour SolidPRMT5-IN-15
CAS:<p>PRMT5-IN-15 is a PRMT5 inhibitor with an IC 50 value of 0.84 nM.</p>Formula:C24H23F3N6O2Color and Shape:SolidMolecular weight:484.483SW2_152F
<p>SW2_152F: Potent CBX2 ChD inhibitor, Kd 80 nM, 24-1000x selective over other CBXs in vitro.</p>Formula:C45H62Cl3N7O8Color and Shape:SolidMolecular weight:935.37DC-S239
CAS:<p>Ethyl 2-amino-4-methyl-5-thiophene carboxylate is a SETD7 inhibitor (IC50=4.59μM) with anticancer properties.</p>Formula:C15H15N3O5SPurity:99.37%Color and Shape:SolidMolecular weight:349.36
