DNA Methyltransferase
DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.
Found 422 products of "DNA Methyltransferase"
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UNC0224
CAS:<p>UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.</p>Formula:C26H43N7O2Purity:99.80%Color and Shape:SolidMolecular weight:485.67MY-1B
CAS:<p>MY-1B is a nitrogen-substituted butenamide stereoprobe that blocks stereoselective enrichment of NSUN2, binding selectively to the C271 of NSUN2.</p>Formula:C22H18BrN3O2Purity:99.81% - >99.99%Color and Shape:SoildMolecular weight:436.3GSK-1268997
CAS:<p>GSK-1268997 is a bio-active chemical.</p>Formula:C21H23N7O3SPurity:99.33% - 99.81%Color and Shape:SolidMolecular weight:453.52G9a-IN-2
CAS:<p>G9a-IN-2 (Compound 7i) is an inhibitor of the histone methyltransferase G9a, with an IC50 of 0.024 μM. It can reduce the levels of H3K9me2 and induce the expression of γ-globin mRNA. G9a-IN-2 shows potential for improving Sickle Cell Disease (SCD).</p>Formula:C30H42N4O4Color and Shape:SolidMolecular weight:522.68F5446
CAS:<p>F5446 is a selective small molecule SUV39H1 methyltransferase inhibitor, promotes apoptosis in colorectal cancer cells by inhibiting the deposition of H3K9me3.</p>Formula:C26H17ClN2O8SPurity:98.56%Color and Shape:SolidMolecular weight:552.94SW155246
CAS:<p>SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM).</p>Formula:C16H11ClN2O5SPurity:98.99%Color and Shape:SolidMolecular weight:378.79Furamidine dihydrochloride
CAS:<p>Furamidine dihydrochloride is a cell-permeable, selective PRMT1 inhibitor that also binds AT-rich DNA. It blocks proliferation in leukemia cell lines.</p>Formula:C18H18Cl2N4OPurity:98.16%Color and Shape:SolidMolecular weight:377.27TFMB-(S)-2-HG
CAS:<p>TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase.</p>Formula:C13H11F3O4Purity:98.07%Color and Shape:SolidMolecular weight:288.22OTS186935
CAS:OTS186935 is a inhibitor of protein methyltransferase SUV39H2(IC50 of 6.49 nM).Formula:C25H26ClN5O2Purity:98%Color and Shape:SolidMolecular weight:463.96WDR5-IN-4
CAS:<p>WIN site inhibitor 1 is a WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5) inhibitor (Kd: 0.1 nM), with anti-cancer activity.</p>Formula:C25H22Cl2FN5OPurity:98%Color and Shape:SolidMolecular weight:498.385WKS
CAS:<p>5WKS, or ZINC97756584, is a G9a inhibitor targeting H3K9me2 for gene silencing research in autoimmune diseases and tumors.</p>Formula:C24H36ClN5O2Purity:98%Color and Shape:SolidMolecular weight:462.03PRMT5-IN-C17
CAS:<p>PRMT5-IN-C17 is a novel potent, selective, and cell active protein arginine methyltransferase 5 (PRMT5) inhibitor.</p>Formula:C18H17N3O4SColor and Shape:SolidMolecular weight:371.41BIX-01338 hydrate
CAS:<p>BIX-01338 hydrate is an inhibitor of histone lysine methyltransferase.</p>Formula:C32H26F3N3O7Purity:98%Color and Shape:SolidMolecular weight:621.56CMP-5 hydrochloride
CAS:<p>CMP-5 hydrochloride: potent, selective PRMT5 inhibitor; inactive against PRMT1/4/7; blocks S2Me-H4R3 on histones.</p>Formula:C21H22ClN3Purity:98%Color and Shape:SolidMolecular weight:351.87Furamidine
CAS:<p>Furamidine is a PRMT1-selective, cell-permeable inhibitor (IC50: 9.4μM), also targeting TDP-1, and is an antiparasitic bisbenzamidine derivative.</p>Formula:C18H16N4OPurity:98%Color and Shape:SolidMolecular weight:304.356-Methyl-5-azacytidine
CAS:<p>6-Methyl-5-azacytidine is a potent DNMT inhibitor.</p>Formula:C9H14N4O5Purity:98%Color and Shape:SolidMolecular weight:258.23Dot1L-IN-7
CAS:<p>Dot1L-IN-7 (compound 25), a potent DOT1L inhibitor with an IC50 of 1.0 μM, selectively kills MLL-AF9, sparing E2A-HLF cells.</p>Formula:C23H27N9O2Color and Shape:SolidMolecular weight:461.52DS-437
CAS:<p>DS-437 is a dual PRMT5/7 inhibitor (IC50s: 6 μM). DS-437 also inhibits DNMT3A and DNMT3B (IC50s: 52 and 62 μM). DS-437 inhibits the methylation of FOXP3.</p>Formula:C15H23N7O4SPurity:98%Color and Shape:SolidMolecular weight:397.45SGC6870
CAS:<p>SGC6870 is a novel potent, selective, and cell-active inhibitor of PRMT6 with IC50 of 77 ± 6 nM, being selective over all other PRMTs and 23 methyltransferases.</p>Formula:C23H21BrN2O2SColor and Shape:SolidMolecular weight:469.39UNC2327
CAS:<p>UNC2327 is a potent and selective inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50:230 nM).</p>Formula:C14H17N5O2SPurity:98%Color and Shape:SolidMolecular weight:319.38RSC-133
CAS:<p>promotes the reprogramming of human somatic cells to pluripotent stem cells</p>Formula:C18H15N3O2Purity:98%Color and Shape:SolidMolecular weight:305.33DCE_42
CAS:<p>DCE_42 is a novel EZH2 inhibitor, it also displays significant anti-proliferation activity against lymphoma cell lines.</p>Formula:C22H19N9O2SPurity:98%Color and Shape:SolidMolecular weight:473.51EZH2-IN-3
CAS:<p>EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth.</p>Formula:C27H28ClN5O2Purity:98%Color and Shape:SolidMolecular weight:490DC_C66
CAS:<p>DC_C66 selectively inhibits CARM1 with IC50 of 1.8μM; also affects PRMT1, 6, 5. It's cell-permeable.</p>Formula:C28H22NO2Purity:98%Color and Shape:SolidMolecular weight:404.48Dot1L-IN-5
CAS:<p>Dot1L-IN-5 is a potent inhibitor of the disruptor of telomeric silencing 1-like protein ( DOT1L ) with an IC 50 SPA DOT1L of 0.17 nM [1].</p>Formula:C23H19ClF2N8O5SColor and Shape:SolidMolecular weight:592.96OTS186935 trihydrochloride
CAS:<p>OTS186935 trihydrochloride is a protein methyltransferase inhibitor of SUV39H2(IC50 of 6.49 nM).</p>Formula:C25H29Cl4N5O2Purity:98%Color and Shape:SolidMolecular weight:573.34DM-01
CAS:<p>DM-01 is a potent and selective inhibitor of EZH2.</p>Formula:C23H24F3N3O2Color and Shape:SolidMolecular weight:431.452′-Deoxy-5-nitrocytidine
CAS:<p>2′-Deoxy-5-nitrocytidine is a DNA Methyltransferase inhibitor that can be used for cancer research[1].</p>Formula:C9H12N4O6Color and Shape:SolidMolecular weight:272.21RM65
CAS:<p>RM65 is an arginine methyltransferase inhibitor.</p>Formula:C34H32N2O4S2Purity:98%Color and Shape:SolidMolecular weight:596.76SKF 91488 dihydrochloride
CAS:<p>histamine N-methyltransferase inhibitor</p>Formula:C7H19Cl2N3SPurity:98%Color and Shape:SolidMolecular weight:248.22Guadecitabine
CAS:<p>Guadecitabine is a second-generation DNA methyltransferases inhibitor. It is used for research on acute myeloid leukemia and myelodysplastic syndromes.</p>Formula:C18H24N9O10PPurity:98%Color and Shape:SolidMolecular weight:557.41PDAT
CAS:<p>PDAT is a noncompetitive Indolethylamine N-methyltransferase inhibitor.</p>Formula:C15H23N3Purity:98%Color and Shape:SolidMolecular weight:245.36JS1310
CAS:<p>JS1310 is a selective PRMT7 inhibitor (IC50: 5 μM against human PRMT7). JS1310 has shown anti-cancer effects on different cancer cells.</p>Formula:C23H22FN5O3Color and Shape:SolidMolecular weight:435.45NSD3-IN-3
CAS:<p>"NSD3-IN-3, a potent anticancer agent, inhibits NSD3 (IC50: 1.86 μM) and hampers H460 lung cancer cell growth."</p>Formula:C15H17N5O2SColor and Shape:SolidMolecular weight:331.39NSD3-IN-2
CAS:<p>NSD3-IN-2: Potent NSD3 inhibitor, IC50 17.97μM, halts NSCLC growth (H460, H1299, H1650) with anticancer effects.</p>Formula:C17H15N5OSColor and Shape:SolidMolecular weight:337.4CSV0C018875
CAS:<p>CSV0C018875 is a quinoline-based EHMT2/G9a inhibitor with lower cytotoxicity than BIX-01294 [1].</p>Formula:C18H17ClN2OColor and Shape:SolidMolecular weight:312.79Dihydro-5-azacytidine acetate
CAS:<p>Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1</p>Formula:C10H18N4O7Purity:98%Color and Shape:SolidMolecular weight:306.27PRMT5-IN-17
CAS:<p>PRMT5-IN-17 is a PRMT5-blocking compound with anticancer properties, linked to epigenetic changes.</p>Formula:C26H33N7O2Color and Shape:SolidMolecular weight:475.59BAY-598 R-isomer
CAS:<p>BAY-598 R-isomer, a SMYD2-selective inhibitor, is the R-enantiomer of BAY589, not targeting PAR1.</p>Formula:C22H20Cl2F2N6O3Color and Shape:SolidMolecular weight:525.34CPI-905
CAS:<p>CPI-905 is a potent and selective EZH2 inhibitor with IC50 value of 39.5 nM.</p>Formula:C18H20N2O5Color and Shape:SolidMolecular weight:344.36DNMT3A-IN-1
CAS:<p>DNMT3A-IN-1 is a potent, selective DNMT3A inhibitor with KI 9.16-18.85 μM (AdoMet) and 11.37-23.34 μM (poly dI-dC).</p>Formula:C30H38N6O4Color and Shape:SolidMolecular weight:546.66CM-579
CAS:<p>CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.</p>Formula:C29H40N4O3Purity:99.23%Color and Shape:SolidMolecular weight:492.65NSC-311068
CAS:<p>NSC-311068: A selective TET1 inhibitor, reducing 5hmC and AML cell viability with high TET1.</p>Formula:C10H6N4O4SColor and Shape:SolidMolecular weight:278.24EZH2-IN-11
CAS:<p>EZH2-IN-11, a potent E2HZ inhibitor with potential for cancer treatment, is highlighted in patent WO2019204490A1.</p>Formula:C28H36ClN3O5SColor and Shape:SolidMolecular weight:562.12EZH2-IN-9
CAS:<p>EZH2-IN-9 inhibits EZH2, targeting SET mutations linked to cancer by reducing H3K27me3 levels.</p>Formula:C28H32ClF2N3O5SColor and Shape:SolidMolecular weight:596.09AA-CW236
CAS:<p>AA-CW236 is a covalent inhibitor of human O(6)-alkylguanine DNA methyltransferase (MGMT).</p>Formula:C17H16ClF3N4O2Color and Shape:SolidMolecular weight:400.78NSD3-IN-1
CAS:<p>NSD3-IN-1, a histone methyltransferase NSD3 inhibitor, demonstrates an IC50 of 28.58 μM.</p>Formula:C13H13N5OSColor and Shape:SolidMolecular weight:287.34BI-9321
CAS:<p>BI-9321: Selective NSD3-PWWP1 antagonist, Kd 166 nM. Inactive against NSD2-PWWP1/NSD3-PWWP2.</p>Formula:C22H21FN4Purity:98%Color and Shape:SolidMolecular weight:360.43UNC0379 TFA
CAS:<p>UNC0379 TFA inhibits SETD8 (IC50: 7.3 μM), selective for 15+ methyltransferases.</p>Formula:C25H36F3N5O4Color and Shape:SolidMolecular weight:527.589DDO-2093 dihydrochloride
<p>DDO-2093 dihydrochloride: potent MLL1-WDR5 inhibitor, IC50=8.6 nM, Kd=11.6 nM, antitumor.</p>Formula:C29H39Cl3FN9O3Color and Shape:SolidMolecular weight:687.04
