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DNA Methyltransferase

DNA Methyltransferase

DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.

Found 440 products of "DNA Methyltransferase"

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  • DCE_42
    Targetmol
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    DCE_42

    CAS:
    DCE_42 is a novel EZH2 inhibitor, it also displays significant anti-proliferation activity against lymphoma cell lines.
    Formula:C22H19N9O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:473.51

    Ref: TM-T27130

  • EZH2-IN-3
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    EZH2-IN-3

    CAS:
    EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth.
    Formula:C27H28ClN5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:490

    Ref: TM-T25400

  • DC_C66
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    DC_C66

    CAS:
    DC_C66 selectively inhibits CARM1 with IC50 of 1.8μM; also affects PRMT1, 6, 5. It's cell-permeable.
    Formula:C28H22NO2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:404.48

    Ref: TM-T10967

  • Dot1L-IN-5
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    Dot1L-IN-5

    CAS:
    <p>Dot1L-IN-5 is a potent inhibitor of the disruptor of telomeric silencing 1-like protein ( DOT1L ) with an IC 50 SPA DOT1L of 0.17 nM [1].</p>
    Formula:C23H19ClF2N8O5S
    Color and Shape:Solid
    Molecular weight:592.96

    Ref: TM-T11084

  • OTS186935 trihydrochloride
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    OTS186935 trihydrochloride

    CAS:
    OTS186935 trihydrochloride is a protein methyltransferase inhibitor of SUV39H2(IC50 of 6.49 nM).
    Formula:C25H29Cl4N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:573.34

    Ref: TM-T12344L

  • DM-01
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    DM-01

    CAS:
    <p>DM-01 is a potent and selective inhibitor of EZH2.</p>
    Formula:C23H24F3N3O2
    Color and Shape:Solid
    Molecular weight:431.45

    Ref: TM-T62403

  • 2′-Deoxy-5-nitrocytidine
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    2′-Deoxy-5-nitrocytidine

    CAS:
    <p>2′-Deoxy-5-nitrocytidine is a DNA Methyltransferase inhibitor that can be used for cancer research[1].</p>
    Formula:C9H12N4O6
    Color and Shape:Solid
    Molecular weight:272.21

    Ref: TM-T60476

  • RM65
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    RM65

    CAS:
    <p>RM65 is an arginine methyltransferase inhibitor.</p>
    Formula:C34H32N2O4S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:596.76

    Ref: TM-T28545

  • SKF 91488 dihydrochloride
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    SKF 91488 dihydrochloride

    CAS:
    histamine N-methyltransferase inhibitor
    Formula:C7H19Cl2N3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:248.22

    Ref: TM-T23367

  • Guadecitabine
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    Guadecitabine

    CAS:
    Guadecitabine is a second-generation DNA methyltransferases inhibitor. It is used for research on acute myeloid leukemia and myelodysplastic syndromes.
    Formula:C18H24N9O10P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:557.41

    Ref: TM-T16876

  • PDAT
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    PDAT

    CAS:
    PDAT is a noncompetitive Indolethylamine N-methyltransferase inhibitor.
    Formula:C15H23N3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:245.36

    Ref: TM-T24604

  • JS1310
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    JS1310

    CAS:
    JS1310 is a selective PRMT7 inhibitor (IC50: 5 μM against human PRMT7). JS1310 has shown anti-cancer effects on different cancer cells.
    Formula:C23H22FN5O3
    Color and Shape:Solid
    Molecular weight:435.45

    Ref: TM-T62474

  • NSD3-IN-3
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    NSD3-IN-3

    CAS:
    "NSD3-IN-3, a potent anticancer agent, inhibits NSD3 (IC50: 1.86 μM) and hampers H460 lung cancer cell growth."
    Formula:C15H17N5O2S
    Color and Shape:Solid
    Molecular weight:331.39

    Ref: TM-T73244

  • NSD3-IN-2
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    NSD3-IN-2

    CAS:
    NSD3-IN-2: Potent NSD3 inhibitor, IC50 17.97μM, halts NSCLC growth (H460, H1299, H1650) with anticancer effects.
    Formula:C17H15N5OS
    Color and Shape:Solid
    Molecular weight:337.4

    Ref: TM-T73243

  • CSV0C018875
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    CSV0C018875

    CAS:
    CSV0C018875 is a quinoline-based EHMT2/G9a inhibitor with lower cytotoxicity than BIX-01294 [1].
    Formula:C18H17ClN2O
    Color and Shape:Solid
    Molecular weight:312.79

    Ref: TM-T60786

  • Dihydro-5-azacytidine acetate
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    Dihydro-5-azacytidine acetate

    CAS:
    <p>Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1</p>
    Formula:C10H18N4O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:306.27

    Ref: TM-T78565

  • PRMT5-IN-17
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    PRMT5-IN-17

    CAS:
    PRMT5-IN-17 is a PRMT5-blocking compound with anticancer properties, linked to epigenetic changes.
    Formula:C26H33N7O2
    Color and Shape:Solid
    Molecular weight:475.59

    Ref: TM-T63103

  • BAY-598 R-isomer
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    BAY-598 R-isomer

    CAS:
    BAY-598 R-isomer, a SMYD2-selective inhibitor, is the R-enantiomer of BAY589, not targeting PAR1.
    Formula:C22H20Cl2F2N6O3
    Color and Shape:Solid
    Molecular weight:525.34

    Ref: TM-T26744

  • CPI-905
    Targetmol
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    CPI-905

    CAS:
    CPI-905 is a potent and selective EZH2 inhibitor with IC50 value of 39.5 nM.
    Formula:C18H20N2O5
    Color and Shape:Solid
    Molecular weight:344.36

    Ref: TM-T27074

  • CM-579
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    CM-579

    CAS:
    CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.
    Formula:C29H40N4O3
    Purity:99.23%
    Color and Shape:Solid
    Molecular weight:492.65

    Ref: TM-T10840L