MTH1

MTH1 (MutT Homolog 1) is an enzyme that sanitizes the nucleotide pool by hydrolyzing oxidized nucleotides, preventing their incorporation into DNA. Inhibitors of MTH1 induce the accumulation of oxidized nucleotides in DNA, leading to increased DNA damage and cell death. MTH1 inhibitors are of particular interest in cancer research, as cancer cells often rely on MTH1 to avoid oxidative stress-induced DNA damage. At CymitQuimica, we offer a selection of high-quality MTH1 inhibitors to support your research in oxidative stress, DNA damage, and cancer therapy.