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NF-κB

NF-κB

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, cell survival, and proliferation. NF-κB is activated in response to various stimuli, including cytokines, pathogens, and stress signals. Dysregulation of NF-κB signaling is associated with chronic inflammatory diseases, cancer, and autoimmune disorders. At CymitQuimica, we offer a comprehensive selection of NF-κB pathway modulators to support your research in inflammation, oncology, and immune regulation.

Found 445 products of "NF-κB"

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  • Neferine
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    Neferine

    CAS:
    <p>Neferine: anti-tumor, enhances DOX efficacy, prevents diabetic vasculopathy; mediates via CYP3A4, GSH depletion, blocks ROS/Akt/NF-κB.</p>
    Formula:C38H44N2O6
    Purity:98.81% - 99.65%
    Color and Shape:Solid
    Molecular weight:624.77

    Ref: TM-T5S1097

  • Gossypin
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    Gossypin

    CAS:
    <p>Gossypin exhibits multiple medicinal properties and inhibits NF-kappaB, reducing inflammation, cancer growth, and angiogenesis.</p>
    Formula:C21H20O13
    Purity:97.57% - 98.97%
    Color and Shape:Solid
    Molecular weight:480.38

    Ref: TM-TN1712

  • Aconine
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    Aconine

    CAS:
    <p>1. Aconine (Jesaconine) is the febrifuge. 2. Aconine possesses gastric anaesthetic props.</p>
    Formula:C25H41NO9
    Purity:99.61% - 99.93%
    Color and Shape:Solid
    Molecular weight:499.59

    Ref: TM-T4S1881

  • Madecassic acid
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    Madecassic acid

    CAS:
    <p>Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica.</p>
    Formula:C30H48O6
    Purity:98.80% - 99.69%
    Color and Shape:Solid
    Molecular weight:504.7

    Ref: TM-T2758

  • Delanzomib
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    Delanzomib

    CAS:
    <p>Delanzomib (CEP-18770) is an oral proteasome inhibitor with an IC50 of 3.8 nM, targeting chymotrypsin-like activity with minimal effect on other activities.</p>
    Formula:C21H28BN3O5
    Purity:95.52% - 99.46%
    Color and Shape:Solid
    Molecular weight:413.28

    Ref: TM-T6027

  • Deoxyelephantopin
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    Deoxyelephantopin

    CAS:
    <p>Deoxyelephantopin: anti-inflammatory, hepatoprotective, wound healing, antitumor; blocks NF-κB, MAPK, PI3K/Akt, β-catenin pathways.</p>
    Formula:C19H20O6
    Purity:99.6% - 99.71%
    Color and Shape:Solid
    Molecular weight:344.36

    Ref: TM-TN1079

  • JH-X-119-01
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    JH-X-119-01

    CAS:
    <p>JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1.</p>
    Formula:C25H20N6O3
    Purity:98.42%
    Color and Shape:Solid
    Molecular weight:452.46

    Ref: TM-T9203

  • Aristolochic acid A
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    Aristolochic acid A

    CAS:
    <p>Aristolochic acid A (TR 1736) is a compound of mutagenic, carcinogenic, and nephrotoxic compounds commonly found in the Birthwort family of plants.</p>
    Formula:C17H11NO7
    Purity:99.85% - 99.97%
    Color and Shape:Yellow Powder
    Molecular weight:341.27

    Ref: TM-T2801

  • Indole-3-carbinol
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    Indole-3-carbinol

    CAS:
    <p>Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase</p>
    Formula:C9H9NO
    Purity:98.59% - >99.99%
    Color and Shape:Solid
    Molecular weight:147.17

    Ref: TM-T2947

  • GSK-872
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    GSK-872

    CAS:
    <p>GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity and inhibits kinase activity.</p>
    Formula:C19H17N3O2S2
    Purity:99.87% - 99.94%
    Color and Shape:Solid
    Molecular weight:383.49

    Ref: TM-T4074

  • 3'-Sialyllactose sodium
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    3'-Sialyllactose sodium

    CAS:
    <p>3'-Sialyllactose sodium is a prebiotic with anti-inflammatory activity that maintains immune homeostasis and can be used to study inflammation.</p>
    Formula:C23H38NNaO19
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:655.53

    Ref: TM-T35707

  • (S)-(+)-Ibuprofen
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    (S)-(+)-Ibuprofen

    CAS:
    <p>(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).</p>
    Formula:C13H18O2
    Purity:99.51% - 99.86%
    Color and Shape:Colourless Crystalline Solid
    Molecular weight:206.28

    Ref: TM-T0448

  • 1,3-Dibenzyl-5-fluorouracil
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    1,3-Dibenzyl-5-fluorouracil

    CAS:
    <p>1,3-Dibenzyl-5-fluorouracil is a chemical inhibitor that suppresses the formation of osteoclasts, functioning by downregulating the signaling pathways of nuclear factor κB ligand receptor activator (Receptor activator of NF-κB ligand, RANKL) and macrophage colony-stimulating factor (M-CSF). This compound is used in the research of metabolic bone diseases.</p>
    Formula:C18H15FN2O2
    Color and Shape:Solid
    Molecular weight:310.32

    Ref: TM-T88494

  • CymitQuimica logo
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    Gatralimab

    CAS:
    <p>Gatralimab (anti-CD52 mAb) shows successful lymphocyte depletion &amp; repopulation in Phase 1, supporting its study for relapsing MS.</p>
    Purity:95%
    Color and Shape:Liquid

    Ref: TM-T78319

  • Kamebakaurin
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    Kamebakaurin

    CAS:
    <p>Kamebakaurin combats liver toxicity, cancer, inflammation, and neuroinflammation by blocking NF-κB, HIF-1α, and key signaling pathways.</p>
    Formula:C20H30O5
    Purity:98.05%
    Color and Shape:Solid
    Molecular weight:350.45

    Ref: TM-TWS1977

  • E3330
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    E3330

    CAS:
    <p>E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.</p>
    Formula:C21H30O6
    Purity:99.52%
    Color and Shape:Solid
    Molecular weight:378.46

    Ref: TM-T6823

  • BAY32-5915
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    BAY32-5915

    CAS:
    <p>BAY32-5915 is a selective inhibitor of IKKalpha.</p>
    Formula:C10H7NO3
    Purity:96.48% - 97%
    Color and Shape:Yellow Crystalline Powder
    Molecular weight:189.17

    Ref: TM-T20770

  • IMD-biphenylB
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    IMD-biphenylB

    CAS:
    <p>IMD-biphenylB: Potent NF-κB inhibitor, curbs tumor growth with low inflammation and toxicity.</p>
    Formula:C35H33N5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:571.67

    Ref: TM-T72870

  • SZM679
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    SZM679

    <p>SZM679: Oral RIPK1 inhibitor, Kd 8.6 nM, weak RIPK3 affinity (&gt;5000 nM). Reduces inflammation, Tau phosphorylation in AD research.</p>
    Formula:C27H18F5N3O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:591.51

    Ref: TM-T73511

  • NF-κB-IN-3
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    NF-κB-IN-3

    CAS:
    <p>NF-κB-IN-3 (Compound 2) is an NF-κB inhibitor (IC50: 0.70 μM) and can be used as an anti-tumour agent.</p>
    Formula:C24H18ClF3N2O2
    Color and Shape:Solid
    Molecular weight:458.86

    Ref: TM-T62875