NF-κB
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, cell survival, and proliferation. NF-κB is activated in response to various stimuli, including cytokines, pathogens, and stress signals. Dysregulation of NF-κB signaling is associated with chronic inflammatory diseases, cancer, and autoimmune disorders. At CymitQuimica, we offer a comprehensive selection of NF-κB pathway modulators to support your research in inflammation, oncology, and immune regulation.
Found 390 products of "NF-κB"
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ABD-350
CAS:ABD-350 is ligand-induced inhibitor of nuclear factor kappaB phosphorylation.Formula:C19H22F2O2Color and Shape:SolidMolecular weight:320.37NF-κB-IN-3
CAS:NF-κB-IN-3 (Compound 2) is an NF-κB inhibitor (IC50: 0.70 μM) and can be used as an anti-tumour agent.Formula:C24H18ClF3N2O2Color and Shape:SolidMolecular weight:458.86IT-901
CAS:IT-901: Oral NF-κB c-Rel inhibitor, IC50 0.1 µM. Blocks c-Rel/DNA binding, IC50 3 µM. Antitumor naphthalene derivative for lymphoma/myeloma therapy.Formula:C17H14N2O4SPurity:98.06%Color and Shape:SolidMolecular weight:342.37BAY32-5915
CAS:BAY32-5915 is a selective inhibitor of IKKalpha.Formula:C10H7NO3Purity:96.48% - 97%Color and Shape:Yellow Crystalline PowderMolecular weight:189.17TNF-α-IN-18
CAS:TNF-α-IN-18 is a small molecule TNF-α inhibitor that blocks NF-κB translocation, alleviates sepsis in models, and protects against rheumatoid arthritis in mice.Formula:C16H7ClF2O4Purity:99.77%Color and Shape:SolidMolecular weight:336.67Sul-121 HCl
CAS:Sul-121 HCl combats COPD by reducing inflammation and AHR via oxidative stress inhibition.Formula:C18H27ClN2O3Purity:98%Color and Shape:SolidMolecular weight:354.87Bay 65-1942 hydrochloride
CAS:Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.Formula:C22H26ClN3O4Color and Shape:SolidMolecular weight:431.91HSR1304
CAS:HSR1304 (5d) inhibits NFκB, key in diseases like cancer, offering research potential.Formula:C24H21ClN2O3Color and Shape:SolidMolecular weight:420.89Asperbisabolane L
Asperbisabolane L, a sesquiterpenoid, combats inflammation by blocking NF-κB signaling and NO in BV-2 cells.Formula:C12H14O3Color and Shape:SolidMolecular weight:206.24IMD-biphenylA
CAS:IMD-biphenylA, a novel imidazoquinolinone-based dimer, functions as an NF-κB immunomodulator and enhances the adjuvant properties of small molecule immuneFormula:C35H33N5O2Purity:98%Color and Shape:SolidMolecular weight:555.67IKKβ-IN-1
CAS:IKKβ-IN-1 is a potent, orally active inhibitor of IkappaB (IKK-β) (IC50: 0.20 μM).Formula:C31H30N4O4SColor and Shape:SolidMolecular weight:554.66DHMEQ racemate
CAS:DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.Formula:C13H11NO5Purity:98%Color and Shape:SolidMolecular weight:261.23NF-κB-IN-8
CAS:NF-κB-IN-8 is a competitive antagonist of LPS for MD-2 binding, and it impedes the expression of inflammatory factors by engaging MD-2.Formula:C24H21N3O3Purity:98%Color and Shape:SolidMolecular weight:399.44NF-κB-IN-2
CAS:NF-κB-IN-2 inhibits canonical NF-κB signaling induced by TNF-α in PC-3 cells.Formula:C15H18O3Color and Shape:SolidMolecular weight:246.3XT2
CAS:XT2 is a potent, oral NF-κB-inducing kinase (NIK) inhibitor with an IC50 of 9.1 nM, reduces ALT levels, and curbs immune cell liver infiltration.Formula:C19H14FN5OSColor and Shape:SolidMolecular weight:379.41Gue1654
CAS:Gue1654 is an OXE-R inhibitor and cardiomyocyte apoptosis.Gue1654 can be used for the study of cardiovascular diseases.Formula:C23H17N3OS3Purity:98.02% - 98.04%Color and Shape:SolidMolecular weight:447.6DMX-129
CAS:DMX-129 is a chemical compound acting as an inhibitor for both ΙΚΚε and TBK-1, demonstrating efficacy with IC50 values of below 30 nM for each [1].Formula:C19H17FN8Color and Shape:SolidMolecular weight:376.39CAY10575
CAS:CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.Formula:C22H21N3O6S2Color and Shape:SolidMolecular weight:487.55IRAK4-IN-20
CAS:IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM).Formula:C22H25F3N4O3Purity:98.09%Color and Shape:SolidMolecular weight:450.45Zharp2-1
CAS:Zharp2-1 is a RIPK2 inhibitor that alleviates MDP-induced peritonitis symptoms in mice and can be used to study inflammatory bowel disease (IBD).
Formula:C19H18N3O2PSPurity:99.41%Color and Shape:SolidMolecular weight:383.4
