NF-κB
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, cell survival, and proliferation. NF-κB is activated in response to various stimuli, including cytokines, pathogens, and stress signals. Dysregulation of NF-κB signaling is associated with chronic inflammatory diseases, cancer, and autoimmune disorders. At CymitQuimica, we offer a comprehensive selection of NF-κB pathway modulators to support your research in inflammation, oncology, and immune regulation.
Found 390 products of "NF-κB"
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NFATc1-IN-1
CAS:NFATc1-IN-1 (A04) inhibits RANKL-induced osteoclast formation with 1.57 μM IC50, blocking NFATc1 translocation.Formula:C13H8F2INO2Purity:99.98%Color and Shape:SolidMolecular weight:375.11B022
CAS:B022 is an NF-κB-induced kinase (NIK) inhibitor that protects the liver from inflammation and injury caused by oxidative stress and toxins.Formula:C19H16ClN5OSPurity:99.74%Color and Shape:SolidMolecular weight:397.88RIPK1-IN-9
CAS:RIPK1-IN-9, a potent dihydronaphthone, selectively inhibits RIPK1 with IC50 of 2 nM (U937) and 1.3 nM (L929).Formula:C26H25FN6O2Purity:99.74%Color and Shape:SolidMolecular weight:472.51Ref: TM-T63055
1mg148.00€5mg344.00€10mg474.00€25mg705.00€50mg944.00€100mg1,283.00€200mg1,710.00€1mL*10mM (DMSO)399.00€SP-100030
CAS:SP-100030: Strong NF-κB/AP-1 inhibitor, IC50=50 nM. Reduces IL-2, IL-8, TNF-alpha, and murine CIA.Formula:C14H5ClF9N3OPurity:99.79%Color and Shape:SolidMolecular weight:437.65Ref: TM-T24816
1mg34.00€5mg70.00€10mg99.00€25mg230.00€50mg358.00€100mg513.00€500mgTo inquire1mL*10mM (DMSO)78.00€Zabedosertib
CAS:Zabedosertib (BAY 1834845) is an inhibitor of IRAK4 with immunomodulatory potential.
Formula:C20H21F3N4O4SPurity:98.54%Color and Shape:SolidMolecular weight:470.47TBK1-IN-1
CAS:TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.Formula:C27H37N7O2Purity:99.81% - >99.99%Color and Shape:SolidMolecular weight:491.63Trovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Formula:C21H19F3N4O6SPurity:99.18%Color and Shape:SolidMolecular weight:512.46IMD-vanillin
CAS:IMD-vanillin is a novel compound characterized as an imidazoquinolinone-derived dimer with NF-κB immunomodulatory properties.Formula:C37H45N7O4Purity:98%Color and Shape:SolidMolecular weight:651.8ACHP Hydrochloride
CAS:ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.Formula:C21H25ClN4O2Purity:99.83%Color and Shape:SolidMolecular weight:400.9Ref: TM-T10237
1mg66.00€5mg144.00€10mg227.00€25mg375.00€50mg540.00€100mg777.00€500mg1,549.00€1mL*10mM (DMSO)159.00€Glabrescone C
CAS:Glabrescone C exhibits strong anti-inflammatory properties through direct binding to IKKα/β.
Formula:C19H22O7Color and Shape:SolidMolecular weight:362.37Ginsenoside Rk1
CAS:Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.Formula:C42H70O12Purity:98.46% - 99.13%Color and Shape:SolidMolecular weight:767.00IMD-biphenylC
CAS:IMD-biphenylC: New, dual-action imidazoquinolinone dimer; inhibits tumor growth, low inflammation/toxicity.Formula:C35H33N5O3Purity:98%Color and Shape:SolidMolecular weight:571.67GGTI 2147
CAS:GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.Formula:C28H30N4O3Purity:98.24%Color and Shape:SolidMolecular weight:470.56Dimethoxycurcumin
CAS:Dimethoxycurcumin is a stable curcumin analog causing epigenetic shifts in leukemia cells, affecting gene expression.Formula:C23H24O6Purity:99.87%Color and Shape:SolidMolecular weight:396.43Ref: TM-T19853
5mg52.00€10mg77.00€25mg133.00€50mg225.00€100mg330.00€200mg470.00€1mL*10mM (DMSO)52.00€(Rac)-BAY-985
CAS:(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.Formula:C27H30F3N9OPurity:98%Color and Shape:SolidMolecular weight:553.58CGA-JK3
CAS:CGA-JK3 is an IkappaB kinase inhibitor in innate immune process.Formula:C15H19NO3Purity:98%Color and Shape:SolidMolecular weight:261.32PK68
CAS:PK68 selectively inhibits RIPK1 (IC50=90nM), potentially useful in inflammation and cancer metastasis studies.Formula:C22H24N4O3SPurity:98.09% - 99.64%Color and Shape:SolidMolecular weight:424.52Ref: TM-T12493
1mg81.00€5mg170.00€10mg274.00€25mg518.00€50mg747.00€100mg938.00€1mL*10mM (DMSO)188.00€RIPK1-IN-16
CAS:RIPK1-IN-16 is an orally active, potent RIPK1 inhibitor that mitigates excessive inflammation via inhibition of RIPK1-mediated necroptosis in vivo.Formula:C20H19N5O2SPurity:98%Color and Shape:SolidMolecular weight:393.46NF-κB-IN-13
CAS:NF-κB-IN-13 (compound 12) markedly suppresses LPS-induced NF-κB activation and NO synthesis in RAW264.7 macrophages, exhibiting anti-inflammatory properties [1Formula:C20H20O5Purity:98%Color and Shape:SolidMolecular weight:340.37
