CCR
C-C chemokine receptors (CCRs) are a group of GPCRs that respond to chemokines, which are signaling molecules that guide the migration of immune cells to sites of inflammation or infection. CCRs play crucial roles in immune responses, inflammation, and the development of various diseases, including autoimmune disorders and cancer. Modulation of CCR activity is being explored as a therapeutic strategy for conditions such as rheumatoid arthritis, multiple sclerosis, and HIV infection. At CymitQuimica, we provide a range of high-quality CCR modulators to support your research in immunology, inflammation, and therapeutic development.
Found 140 products of "CCR"
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J-113863
CAS:J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM).Formula:C30H37Cl2IN2O2Purity:95.11%Color and Shape:SolidMolecular weight:655.44Ref: TM-T11699
1mg56.00€2mg82.00€5mg119.00€10mg160.00€25mg288.00€50mg500.00€100mg718.00€1mL*10mM (DMSO)170.00€Mogamulizumab
CAS:Mogamulizumab is a monoclonal antibody targeting CC chemokine receptor 4 with anticancer effects, used in ATLL and CTCL studies.Purity:SDS-PAGE:97.3%;SEC-HPLC:99.4%Color and Shape:LiquidMolecular weight:146.43 kDaCCR2-RA-[R]
CAS:CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM).Formula:C18H19ClFNO3Purity:99.7%Color and Shape:SolidMolecular weight:351.8RS102895 hydrochloride
CAS:RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).Formula:C21H22ClF3N2O2Purity:98.95%Color and Shape:SolidMolecular weight:426.86CCX140
CAS:CCX140 (CCX140-B) (CCX140-B) is an antagonist of CCR2.Formula:C20H13ClF3N5O3SPurity:99.66% - 99.95%Color and Shape:SolidMolecular weight:495.86INCB-9471
CAS:INCB-9471 is a CCR5 antagonist with anti-HIV activity and inhibits the interaction between HIV-1 gp120.Formula:C30H40F3N5O2Purity:98.80%Color and Shape:SolidMolecular weight:559.666AZ084
CAS:AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.Formula:C26H34N4O2Purity:97.12%Color and Shape:SolidMolecular weight:434.57Ref: TM-T10425
1mg84.00€5mg161.00€10mg245.00€25mg406.00€50mg572.00€100mg772.00€200mg1,035.00€1mL*10mM (DMSO)172.00€MK-0812 Succinate
CAS:MK-0812 Succinate is an effective and selective CCR2 antagonist.Formula:C28H40F3N3O7Purity:98.62% - 99.93%Color and Shape:SolidMolecular weight:587.63Leronlimab
CAS:Leronlimab (PRO 140), a humanized IgG4 monoclonal antibody, targets CCR5 to combat HIV and cancer.Purity:SDS-PAGE:95.0%;SEC-HPLC:99.6%Color and Shape:LiquidMolecular weight:146.66 kDaML604086
CAS:ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations.Formula:C27H32N4O4SPurity:99.91%Color and Shape:SolidMolecular weight:508.63INCB 3284 dimesylate
CAS:INCB 3284 dimesylate: oral CCR2 antagonist, blocks MCP-1/hCCR2 binding (IC50: 3.7 nM), potential in acute liver failure research.Formula:C28H39F3N4O10S2Purity:98%Color and Shape:SolidMolecular weight:712.76CCR4 antagonist 3 hydrochloride
CAS:Orally active CCR4 antagonist 3 hydrochloride with potent selectivity, IC50s: 22/50 nM; has antitumor properties.Formula:C24H27Cl2N7O·xHClColor and Shape:SolidCHS-114
CHS-114 (SRF-114) is a fully human IgG1 antibody targeting the (CCR8) receptor. It shows potential for research in head and neck squamous cell carcinoma (HNSCC). The isotype control for CHS-114 can be referred to as HumanIgG1kappa, Isotype Control.Color and Shape:Odour LiquidCCR4 antagonist 3
CAS:Orally active CCR4 antagonist with piperidinyl-azetidine; IC50: 22 nM (calcium flux), 50 nM (CTX); antitumor effects.Formula:C24H27Cl2N7OColor and Shape:SolidMolecular weight:500.43HGS101
HGS101 is a fully humanized CCR5 monoclonal antibody that exhibits high affinity for CCR5. It binds to the second extracellular loop (ECL-2) and functions as a signaling antagonist. HGS101 restores the inhibitory effect of Maraviroc in Maraviroc-resistant HIV-1 infected PBMCs. In an uninfected simian immunodeficiency virus model of rhesus monkeys, HGS101 shows anti-HIV activity by inhibiting CCR5 signaling.Color and Shape:Odour LiquidTagmokitug
CAS:Tagmokitug is a humanized IgG1κ monoclonal antibody inhibitor targeting CCR8. It exhibits anti-tumor activity and is applicable in cancer immunotherapy research, including studies on breast cancer, colon cancer, and lung cancer.INCB3344 R-isomer
INCB3344 is a potent CCR2 antagonist. INCB3344 R-isomer is the R-isomer of INCB3344.Formula:C29H34F3N3O6Purity:98%Color and Shape:SolidMolecular weight:577.59NI-0701
NI-0701 is a humanized antibody targeting CCL5/RANTES.Purity:95.4% (SDS-PAGE); 99.4% (SEC-HPLC) - 95.4% (SDS-PAGE); 99.4% (SEC-HPLC)Color and Shape:LiquidMolecular weight:144.83 kDaNebokitug
Nebokitug is a humanized IgG1κ antibody targeting CCL24, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Color and Shape:Odour LiquidCMKLR1 antagonist 1
CMKLR1 antagonist 1 (compound S-26d) is a potent, orally active antagonist of the chemokine-like receptor 1 (CMKLR1), exhibiting a pIC50 of 7.44 in hCMKLR1-Color and Shape:Odour SolidSQA1
CAS:SQA1 is a derivative of a phthalamide (SQA) and acts as a CCR6 antagonist with a Kd of 250 nM, as well as a CXCR2 inhibitor. It occupies an intracellular pocket that overlaps with the G protein binding site, stabilizing the pocket's closed conformation.Formula:C22H26N4O5Color and Shape:SolidMolecular weight:426.47CCR2 antagonist 1
CAS:CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).Formula:C28H32BrF3N2OColor and Shape:SolidMolecular weight:549.47Denikitug
Denikitug is a chimeric antibody of the IgG1κ type that targets CCR8, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.Color and Shape:Odour LiquidCH-0076989
CAS:CH-0076989 is a chemokine receptor CCR3 agonist.Formula:C24H22Br2N2O2Color and Shape:SolidMolecular weight:530.25CCR8 agonist 1
CCR8 agonist1 (Compound 2) is an activator of CCR8 and is applicable in studies related to autoimmune diseases.Formula:C22H29NO3Color and Shape:SolidMolecular weight:355.472-Methoxyhydroquinone
CAS:2-Methoxyhydroquinone inhibits MAO-A and MAO-B and reduces TNF-α-induced CCL2 production, a precursor for synthesising the Hsp90 inhibitor Geldanamycin.Formula:C7H8O3Purity:98.25%Color and Shape:SolidMolecular weight:140.14PF-232798
CAS:PF-232798 is a second generation oral CCR5 antagonist with potent broad-spectrum anti-HIV-1 activity.Formula:C29H40FN5O2Color and Shape:SolidMolecular weight:509.66Met-RANTES,human,acetate
Met-RANTES (human) acetate is the acetate salt form of Met-RANTES (human). It acts as an antagonist for CCR1 and CCR5 receptors. This compound inhibits the human chemokines MIP-1α and MIP-1β, with respective IC50 values of 5 and 2 nM. Additionally, Met-RANTES (human) acetate reduces bone destruction and alleviates adjuvant-induced arthritis (AIA) in rats.Color and Shape:Odour SolidCCR6 antagonist 1
CAS:CCR6 antagonist 1 blocks CCL20/CCR6, aiding autoimmune and IBD research.
Formula:C17H12F3NO2Purity:99.83%Color and Shape:SoildMolecular weight:319.28CCR8 antagonist 1
CAS:CCR8 antagonist 1 is an antagonist of C-C Motif Chemokine Receptor 8 (CCR8) with a Ki value of 1.6 nM.Formula:C26H29N3O5SPurity:99.51%Color and Shape:SolidMolecular weight:495.59Bertilimumab
CAS:Bertilimumab (CAT 213; iCo-008), a human monoclonal antibody that targets eotaxin-1 (CCL11), shows promise in the research of allergic disorders [1].
Color and Shape:LiquidZn-DPA-maytansinoid conjugate 1
Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.Formula:C115H145ClN18O31S2Zn2Color and Shape:SolidMolecular weight:2505.83Cafelkibart
Cafelkibart is a chimeric IgG1κ monoclonal antibody targeting CCR8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Color and Shape:Odour LiquidMaceneolignan H
CAS:Maceneolignan H, a neolignane from Myristica fragrans, selectively blocks CCR3 (EC50=1.4μM) with allergy research potential.Formula:C24H30O7Color and Shape:SolidMolecular weight:430.49Lanerkitug
Lanerkitug is a humanized IgG1λ2 antibody that targets CCR8, with HumanIgG1lambda2, Isotype Control serving as its corresponding isotype control.Color and Shape:Odour LiquidWAY-639418
CAS:WAY-639418 has potential anti-inflammatory and anti-HIV activity and can be used to study CCR5-mediated inflammatory and immunomodulatory diseases.Formula:C17H16ClN5Purity:99.89%Color and Shape:SolidMolecular weight:325.8BMS-753426
CAS:BMS-753426 is a potent and orally bioavailable antagonist of CCR2 .
Formula:C25H33F3N6O2Color and Shape:SolidMolecular weight:506.574Chemokine Inhibitor Library
A unique collection of xnum chemokines or chemokine receptors targeted compounds for high throughput and high content screening;
Color and Shape:Odour SolidMLN-3897 TFA
MLN-3897 TFA is a potent CCR1 antagonist that inhibits the binding of 125I-MIP-1α to THP-1 cell membranes.Formula:C32H32ClF3N2O6Purity:98.62%Color and Shape:SolidMolecular weight:633.05Ref: TM-T28072L
1mg115.00€5mg245.00€10mg363.00€25mg562.00€50mg775.00€100mg1,035.00€200mg1,406.00€1mL*10mM (DMSO)To inquireCCR6 antagonist 2
CCR6 antagonist2 (Compound 20c) acts as a CCR6 antagonist with a Ki of 1.1 nM. It inhibits CCL20-induced calcium influx with an IC50 of 4.9 nM and suppresses the chemotactic migration of CCR6+ T cells with an IC50 of 190 nM.Formula:C19H24N4O4Color and Shape:SolidMolecular weight:372.42CKLF1-C27 TFA
CKLF1-C27 peptide activates ERK1/2 via CCR4, competes with CKLF1, promotes HUVEC growth, and has psoriasis research potential.Formula:C153H244F3N39O39Color and Shape:SolidMolecular weight:3310.8Plozalizumab
CAS:Plozalizumab (MLN-1202) is a humanized selective and potent anti-CCR2 antibody.Plozalizumab has antitumor activity.Plozalizumab is used in the study of
Purity:96.4%Color and Shape:LiquidMolecular weight:146.02 kDaCCR6 inhibitor 1
CAS:CCR6 inhibitor 1 selectively blocks CCR6 (0.45 nM in monkeys, 6 nM in humans), aiding in vitro/vivo disease studies.
Formula:C24H23F3N4O3SPurity:99.89%Color and Shape:SolidMolecular weight:504.52Vercirnon
CAS:Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.Formula:C22H21ClN2O4SPurity:99.23%Color and Shape:SolidMolecular weight:444.93Ref: TM-T17225
1mg105.00€5mg259.00€10mg406.00€25mg680.00€50mg938.00€100mg1,301.00€500mg2,593.00€1mL*10mM (DMSO)363.00€AZD-4818
CAS:AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.Formula:C27H32Cl2N2O7Purity:99.01%Color and Shape:SolidMolecular weight:567.46BX471
CAS:BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist.Formula:C21H24ClFN4O3Purity:98% - 99.98%Color and Shape:SolidMolecular weight:434.89Ref: TM-T2375
1mg35.00€5mg86.00€10mg117.00€25mg200.00€50mg313.00€100mg489.00€200mg740.00€1mL*10mM (DMSO)95.00€Vicriviroc maleate
CAS:Vicriviroc maleate (SCH-417690 (maleate))(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus.
Formula:C32H42F3N5O6Purity:98.16% - 98.37%Color and Shape:SolidMolecular weight:649.7SB297006
CAS:SB297006 is an antagonist of C-C chemokine receptor 3, which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ.Formula:C18H18N2O5Purity:99.59%Color and Shape:SolidMolecular weight:342.35RE-640
CAS:NSC-5844 (RE-640) (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.Formula:C20H16Cl2N4Purity:99.60% - 99.87%Color and Shape:SolidMolecular weight:383.27RS 504393
CAS:RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).Formula:C25H27N3O3Purity:98.64% - 99.62%Color and Shape:SolidMolecular weight:417.5
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