Nrf2
Nrf2 is a transcription factor that regulates the expression of antioxidant proteins and detoxification enzymes, playing a pivotal role in cellular defense against oxidative stress and inflammation. Activation of Nrf2 signaling provides protection against various diseases, including cancer, neurodegeneration, and cardiovascular disorders. Nrf2 modulators are being explored for their potential therapeutic applications in reducing oxidative damage and inflammation. At CymitQuimica, we provide a range of high-quality Nrf2 pathway modulators to support your research in oxidative stress, inflammation, and disease prevention.
Found 79 products of "Nrf2"
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TAT 14
CAS:<p>TAT 14: a 14-mer peptide Nrf2 activator, anti-inflammatory, boosts Nrf2 protein, targets Keap1, no effect on mRNA.</p>Formula:C137H230N48O39Purity:98%Color and Shape:SolidMolecular weight:3173.59S217879
<p>S217879 is a potent and selective activator of NRF2 that disrupts the KEAP1-NRF2 interaction, resulting in significant activation of the NRF2 pathway.</p>Formula:C29H30N4O7SColor and Shape:SolidMolecular weight:578.64Keap1-Nrf2-IN-9
CAS:<p>Keap1-Nrf2-IN-9 inhibits Keap1-Nrf2 PPI with 0.575 µM IC50, boosts Nrf2 genes, non-toxic in ARPE19 cells.</p>Formula:C31H30N2O11S2Color and Shape:SolidMolecular weight:670.71Deacetylgedunin
CAS:<p>Deacetylgedunin is a limonoid that is the 7-deacetyl derivative of gedunin. It has been isolated from Azadirachta indica.</p>Formula:C26H32O6Color and Shape:SolidMolecular weight:440.53Anticonvulsant agent 10
<p>Anticonvulsant agent 10 (Compound 6d) is an inhibitor targeting the Keap1-Nrf2 interaction, with a strong activity showing an ED50 of 0.04 mmol/kg. By inhibiting the Keap1-Nrf2 binding, it activates the Nrf2/ARE pathway, providing anticonvulsant and neuroprotective effects, making it useful for research in epilepsy and neuroprotection.</p>Color and Shape:Odour SolidKeap1-IN-1
<p>Keap1-IN-1 (Compound 27) is an inhibitor of Keap1, functioning by covalently modifying the Cys151 residue on the BTB domain of KEAP1, thereby disrupting the interaction between Keap and Nrf. It enhances the mRNA expression of the antioxidant response element (ARE) dependent gene NQO1, with an EC50 of 160 nM, and exhibits cytotoxicity in U2OS cells, with an EC50 of 527 nM.</p>Formula:C17H21Cl2N2O5PS3Color and Shape:SolidMolecular weight:531.434Keap1-Nrf2-IN-3
CAS:<p>Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein protein interaction inhibitor, and with a K d value of 2.5 nM for KEAP1 protein.</p>Formula:C31H34N6O3Color and Shape:SolidMolecular weight:538.652Keap1-Nrf2-IN-27
<p>Keap1-Nrf2-IN-27 is an inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI) with a KD2 value of 0.119 μM. It suppresses the expression of pro-inflammatory cytokines TNF-α and IL-6 in an LPS-induced RAW264.7 cell model.</p>Color and Shape:Odour SolidMonascin
CAS:<p>Monascin: azaphilonoid in red-mold rice; anti-tumor and anti-inflammatory.</p>Formula:C21H26O5Purity:98%Color and Shape:SolidMolecular weight:358.43CBR-470-2
CAS:<p>CBR-470-2 activates NRF2 signaling, aiding in glycolysis research.</p>Formula:C12H13Cl2NO6S2Color and Shape:SolidMolecular weight:402.26ML334
CAS:<p>ML334 (LH601A) is an NRF2 activator that inhibits cardiac fibroblast activation and proliferation ameliorating myocardial infarction-induced cardiac fibrosis.</p>Formula:C26H26N2O5Purity:98.06% - 98.06%Color and Shape:SolidMolecular weight:446.49I-152
CAS:<p>Bepranemab (UCB 0107) is a humanized IgG monoclonal antibody against tau for the study of Alzheimer's disease (AD) and tau proteinopathies.</p>Formula:C9H16N2O3S2Purity:98.36%Color and Shape:SolidMolecular weight:264.37Anti-NFE2L2 Antibody (9K94)
<p>Anti-NFE2L2 Antibody (9K94) is a Mouse antibody targeting NFE2L2. Anti-NFE2L2 Antibody (9K94) can be used in ELISA, WB, IHC, IF, FCM.</p>Purity:>95%Color and Shape:Odour LiquidAnti-Phospho-NFE2L2 (Ser40) Antibody (6V851)
<p>Anti-Phospho-NFE2L2 (Ser40) Antibody (6V851) is an antibody targeting Phospho-NFE2L2 (Ser40). Anti-Phospho-NFE2L2 (Ser40) Antibody (6V851) can be used in ELISA, WB, IHC, IF.</p>Color and Shape:Odour LiquidAnti-NFE2L2 Antibody (6K859)
<p>Anti-NFE2L2 Antibody (6K859) is an antibody targeting NFE2L2. Anti-NFE2L2 Antibody (6K859) can be used in ELISA, IF.</p>Color and Shape:Odour LiquidDimethyl fumarate-d6
CAS:<p>Dimethyl fumarate D6 is a deuterium labeled Dimethyl fumarate. can induces upregulation of antioxidant gene expression.</p>Formula:C6H8O4Purity:98%Color and Shape:SolidMolecular weight:150.16KI696 isomer
CAS:<p>KI696 isomer is an isomer of KI696, a low affinity probe for the study of immune and metabolic diseases.</p>Formula:C28H30N4O6SPurity:99.8%Color and Shape:SolidMolecular weight:550.63Brusatol
CAS:<p>Brusatol (NSC-172924) is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.</p>Formula:C26H32O11Purity:99.35% - 99.95%Color and Shape:SolidMolecular weight:520.53Trilobatin
CAS:<p>Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially</p>Formula:C21H24O10Purity:97.16%Color and Shape:SolidMolecular weight:436.41AEM1
CAS:<p>AEM1 is an inhibitor of deregulated NRF2 transcriptional activity in cancer.</p>Formula:C20H14FN3O2SPurity:98.37% - 99.88%Color and Shape:SolidMolecular weight:379.41
