CXCR
CXCRs are a subset of GPCRs that bind to chemokines, small signaling proteins that guide the movement of immune cells towards sites of inflammation, infection, or injury. CXCRs play crucial roles in immune responses, cancer metastasis, and inflammatory diseases. Modulators of CXCRs are being investigated for their potential in treating autoimmune diseases, cancer, and chronic inflammatory conditions. At CymitQuimica, we offer a range of high-quality CXCR modulators to support your research in immunology, oncology, and inflammation.
Found 147 products of "CXCR"
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CXCR4 antagonist 7
CAS:<p>Compound PARA-B, a CXCR4 antagonist with IC50 = 9.3 nM, targets HIV, cancer, inflammatory diseases, and WHIM syndrome.</p>Formula:C15H17N5O3Color and Shape:SolidMolecular weight:315.33CXCR2 antagonist 2
CAS:<p>CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC 50 value of 95 nM.</p>Formula:C17H17FN2O4SColor and Shape:SolidMolecular weight:364.39NUCC-390 dihydrochloride (1060524-97-1 free base)
<p>NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.</p>Formula:C23H35Cl2N5OPurity:98%Color and Shape:SolidMolecular weight:468.46CXCR2-IN-2
CAS:<p>CXCR2-IN-2: A selective, brain-penetrant, oral CXCR2 inhibitor (IC50: 5.2 nM/1 nM). ~730x selectivity vs CXCR1, >1900x vs other chemokine receptors.</p>Formula:C18H23ClN2O5SColor and Shape:SolidMolecular weight:414.9E6130
CAS:<p>E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.</p>Formula:C28H37ClF3N3O3Color and Shape:SolidMolecular weight:556.06CXCR2 antagonist 3
CAS:<p>Compound 11h, a CXCR2 antagonist, inhibits neutrophil/MDSCs and boosts CD3+ T cells in Pan02 tumors.</p>Formula:C17H15FN2O4SColor and Shape:SolidMolecular weight:362.38(R,R)-CXCR2-IN-2
CAS:<p>'(R,R)-CXCR2-IN-2 is a brain-penetrating diastereoisomer and CXCR2 antagonist with pIC50 of 9 (Tango) and 6.8 (HWB Gro-α/CD11b).'</p>Formula:C18H23ClN2O5SColor and Shape:SolidMolecular weight:414.9CXCR2-IN-1
CAS:<p>CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.</p>Formula:C19H20Cl2FN3O4SPurity:99.89%Color and Shape:SolidMolecular weight:476.35EMU-116
CAS:<p>EMU-116 is an orally active antagonist of CXCR4, utilized in cancer research.</p>Formula:C25H35N5Color and Shape:SolidMolecular weight:405.58CXCR4 modulator-1
CAS:<p>CXCR4 modulator-1 (ZINC72372983) is potent (EC50=100nM) with uses in anti-inflammatory, anticancer, and anti-HIV research.</p>Formula:C23H27N5O2Color and Shape:SolidMolecular weight:405.49ACT-777991
CAS:<p>ACT-777991: oral CXCR3 blocker, stable in microsomes/hepatocytes, inhibits T-cell migration to CXCL11.</p>Formula:C20H20F6N8O2SColor and Shape:SolidMolecular weight:550.48(R)-SCH 546738
CAS:<p>(R)-SCH 546738, the R-isomer of SCH 546738, is a non-competitive, orally active antagonist targeting the CXCR3 receptor, exhibiting a K_i of 0.4 nM for the human CXCR3 receptor.</p>Formula:C23H31Cl2N7OColor and Shape:SolidMolecular weight:492.45CXCR4 antagonist 10
CAS:<p>CXCR4 antagonist10 (compound 21) is an effective CXCR4 inhibitor with an IC50 value of 7.8 nM. It plays a significant role in cancer research.</p>Formula:C18H18N4O4Color and Shape:SolidMolecular weight:354.36CXCR4 antagonist 3
<p>CXCR4 antagonist 3, aka compound 12a, has 11 nM IC50, shares TIQ15 traits, and is promising in HIV research.</p>Formula:C22H31N5Color and Shape:SolidMolecular weight:365.52CXCR7 modulator 2
CAS:<p>CXCR7 modulator 2 is a 7-type C-X-C chemokine receptor (CXCR7) modulator with a Ki of 13 nM.</p>Formula:C29H42N6O3Color and Shape:SolidMolecular weight:522.68CXCR2 antagonist 4
<p>CXCR2 antagonist 4 inhibits CXCR2 (IC50: 0.13 μM) and CXCL8-induced calcium rise (IC50: 27 μM), promising for cancer research.</p>Formula:C15H14F2N4OS2Color and Shape:SolidMolecular weight:368.42CXCR2 antagonist 6
<p>CXCR2 antagonist 6: strong CXCR2 affinity (IC50=0.044 μM), hinders calcium mobilization (IC50=0.66 μM).</p>Formula:C17H16F2N4OSColor and Shape:SolidMolecular weight:362.4Paeoniflorin-6′-O-benzene sulfonate
CAS:<p>Paeoniflorin-6′-O-benzene sulfonate (CP-25) acts as an inhibitor of G protein-coupled receptor kinase 2 (GRK2), preventing its translocation to the cell membrane and inhibiting the JAK1/STAT3 signaling pathway. It suppresses HaCaT cell proliferation induced by IL-17A/CXCL2. In mouse models, CP-25 reduces the levels of inflammatory cytokines and chemokines such as IL-17A, IL-17F, IFN-γ, TNF-α, IL-22, IL-23, CXCL2, CXCL3, and CXCL9, thereby alleviating psoriasis induced by Imiquimod.</p>Formula:C29H32O13SColor and Shape:SolidMolecular weight:620.622CXCR7 antagonist-1 hydrochloride
CAS:<p>CXCR7 antagonist-1 hydrochloride blocks SDF-1 and I-TAC from CXCR7; may prevent cancer and inflammation.</p>Formula:C21H20ClFN6OColor and Shape:SolidMolecular weight:426.87CXCR2 antagonist 5
<p>CXCR2 antagonist 5 (compound 25) binds strongly (IC50=0.013μM) and mobilizes calcium (IC50=0.1μM).</p>Formula:C15H14F2N4O2SColor and Shape:SolidMolecular weight:352.36
