CXCR
CXCRs are a subset of GPCRs that bind to chemokines, small signaling proteins that guide the movement of immune cells towards sites of inflammation, infection, or injury. CXCRs play crucial roles in immune responses, cancer metastasis, and inflammatory diseases. Modulators of CXCRs are being investigated for their potential in treating autoimmune diseases, cancer, and chronic inflammatory conditions. At CymitQuimica, we offer a range of high-quality CXCR modulators to support your research in immunology, oncology, and inflammation.
Found 147 products of "CXCR"
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Quetmolimab
CAS:<p>Quetmolimab is a humanized monoclonal antibody targeting chemokine ligand 1 (CX3CL1) that can be used to study rheumatoid arthritis.</p>Purity:SDS-PAGE:95% SEC-HPLC:97.59%Color and Shape:LiquidMolecular weight:150 kDaLY2510924 acetate(1088715-84-7 free base)
<p>Ly2510924 acetate is an potent and selective CXCR4 antagonist. It prevents the binding of SDF-1 to CXCR4 with an IC50 of 0.079 nM.</p>Formula:C64H91N13O13Purity:97.32%Color and Shape:SolidMolecular weight:1250.49VUF11207 fumarate
CAS:<p>VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).</p>Formula:C31H39FN2O8Purity:97.98%Color and Shape:SolidMolecular weight:586.65Reparixin L-lysine salt
CAS:<p>Reparixin L-lysine salt (Repertaxin L-lysine salt) is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor.</p>Formula:C20H35N3O5SPurity:99%Color and Shape:SolidMolecular weight:429.57Motixafortide TFA(664334-36-5,Free)
<p>Motixafortide TFA is a CXCR4 antagonist with ~1 nM IC50, promoting AML apoptosis by modulating miR-15a/16-1 and downregulating ERK and BCL-2.</p>Formula:C99H145F4N33O21S2Purity:>99.99%Color and Shape:SolidMolecular weight:2273.54Delmetacin
CAS:<p>Delmetacin: a non-steroidal anti-inflammatory drug with analgesic properties, inhibits CXCR1.</p>Formula:C18H15NO3Purity:98.14%Color and Shape:SolidMolecular weight:293.32AMG 487
CAS:<p>AMG 487: potent CXCR3 antagonist, blocks CXCL10/CXCL11 binding, IC50s: 8.0/8.2 nM.</p>Formula:C32H28F3N5O4Purity:99.82% - 99.89%Color and Shape:SolidMolecular weight:603.59Eldelumab
CAS:<p>Eldelumab (BMS-936557) is an anti-IP-10 IgG 1 monoclonal antibody.Eldelumab has anti-inflammatory activity and is used to study rheumatoid arthritis.</p>Purity:95%Color and Shape:LiquidCTCE-9908
CAS:<p>CXCR4 blocker; triggers cell division failure in ovarian cancer, boosts taxol and docetaxel treatment effects, proven in mice.</p>Formula:C86H147N27O23Purity:98%Color and Shape:SolidMolecular weight:1927.27CXCR4-IN-3
<p>CXCR4-IN-3 (compound XVI) is an orally active inhibitor targeting the inflammation-related receptor CXCR4, with an IC50 of 3.2 nM. It exhibits potent anti-chemotactic effects, with an inhibition rate of 79.19±2.33%. Additionally, CXCR4-IN-3 possesses anti-inflammatory properties and can be utilized in research on IBD (inflammatory bowel disease).</p>RCP168
<p>RCP168 is a highly selective and potent CXCR4 receptor antagonist with an IC50 of 5 nM. It exhibits superior capacity to inhibit HIV-1 (Human Immunodeficiency Virus type 1) from entering host cells via the CXCR4 receptor compared to natural chemokines. RCP168 suppresses HIV-1 infection by blocking viral binding sites or inducing receptor internalization. It can be utilized in research to study interactions between the CXCR4 receptor and other chemokine receptors.</p>Formula:C365H585N105O95S5Molecular weight:8119.27766BVT173187
CAS:<p>BVT173187 is a neutrophil formyl peptide receptors (FPR1) inhibitor.</p>Formula:C14H10Cl3NO2Color and Shape:SolidMolecular weight:330.59CXCL-CXCR1/2-IN-1
CAS:<p>CXCL-CXCR1/2-IN-1 is an ELR+CXCL-CXCR1/2 pathway inhibitor with anticancer activity and can be used in the study of cardiovascular disease.</p>Formula:C14H8Cl2N4O3SPurity:99.4%Color and Shape:SoildMolecular weight:383.21PDE4D inhibitor 1
<p>PDE4-IN-1 is a PDE4 inhibitor characterized by high potency (IC50: 8.6 nM) and superior selectivity over other PDE subtypes. This compound inhibits the release of inflammatory cytokines and chemokines. Additionally, PDE4-IN-1 significantly restores the damaged cAMP-CREB signaling pathway, inhibits proliferation, and promotes differentiation to reverse psoriasis formation.</p>Color and Shape:Odour SolidCX4338
CAS:<p>CX4338 is a CXCL8-mediated chemotaxis inhibitor.</p>Formula:C22H24N2OSColor and Shape:SolidMolecular weight:364.50E70K
<p>E70K, a CXCL8 C-terminal peptide, features a lysine (K) substitution for glutamic acid (E) at position 70 and has demonstrated the ability to attenuate</p>Formula:C108H178N34O28Purity:98%Color and Shape:SolidMolecular weight:2400.78TC14012
CAS:<p>CXCR4 antagonist and ACKR3 (CXCR7) agonist (EC50 = 350 nM for CXCR7).</p>Formula:C90H140N34O19S2Purity:98%Color and Shape:SolidMolecular weight:2066.434-Amino-D-phenylalanine
CAS:<p>4-Amino-D-phenylalanine ([D-Phe(4-NH2)]) is a cyclic pentapeptide that inhibits the binding of CXCL12 to CXCR4 in FC131, with an IC50 value of 0.1 μM.</p>Formula:C9H12N2O2Color and Shape:SolidMolecular weight:180.2CCR7 antagonist 1
<p>CCR7 antagonist1 (30c) functions as a dual antagonist, targeting CXCR2 with an IC50 of 11.02 μM and CCR7 with an IC50 of 0.43 μM.</p>Formula:C13H22N6OSMolecular weight:310.15758Peptide R
CAS:<p>Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.</p>Formula:C39H59N13O8S2Color and Shape:SolidMolecular weight:902.1CXCR7 modulator 1
CAS:<p>CXCR7 modulator 1 is an effective and orally bioavailable peptoid hybrid CXCR7 modulator with Ki of 9 nM.</p>Formula:C48H57F2N7O7SPurity:98%Color and Shape:SolidMolecular weight:914.07SDF-1α (human)
CAS:<p>SDF-1α (human) serves as a chemotactic agent for mononuclear cells through its interaction with the CXCR4 receptor, facilitating critical biological processes</p>Formula:C356H578N106O93S4Purity:98%Color and Shape:SolidMolecular weight:7959.34Balixafortide TFA (1051366-32-5 free base)
<p>Balixafortide TFA is a selective CXCR4 antagonist with IC50 < 10nM, over 1000x preference for CXCR4, and blocks β-arrestin and calcium flux.</p>Formula:C82H113N22F3O23S2Purity:98%Color and Shape:SolidMolecular weight:1896.05CXCL8 (54-72)
<p>CXCL8 (54-72) is a C-terminal peptide segment of the chemokine CXCL8. This peptide features a long, highly positively charged C-terminal region that interacts with the negative charges on glycosaminoglycans (GAG) to facilitate binding. CXCL8 (54-72) inhibits neutrophil adhesion and migration, as well as adhesion to endothelial cells. It is useful in studying the role of chemokines in inflammatory responses.</p>Formula:C107H173N33O30Molecular weight:2400.30261vMIP-II (1-21) TFA
<p>vMIP-II (1-21) (NT21MP) TFA (TFA is a potent inhibitor of CXCR4. This compound interacts broadly with CC and CXC chemokine receptors. Furthermore, vMIP-II (1-21) TFA inhibits CXCR4 by competing for binding sites with 125I-SDF-1R, exhibiting an IC50 value of 190 nM.</p>Color and Shape:Odour SolidDOTA-CXCR4-L
<p>DOTA-CXCR4-L, a peptide targeting the CXCR4 receptor, is utilized in cancer research, notably in the contexts of glioblastoma and triple-negative breast cancer</p>Formula:C58H78N16O14Purity:98%Color and Shape:SolidMolecular weight:1223.34Chemokine Inhibitor Library
<p>A unique collection of xnum chemokines or chemokine receptors targeted compounds for high throughput and high content screening;</p>Color and Shape:Odour SolidVUF-11222
CAS:<p>VUF-11222 is an agonist of high affinity non-peptide CXCR3 agonist (pKi = 7.2).</p>Formula:C25H31BrINPurity:99.82%Color and Shape:SolidMolecular weight:552.33Cyclic MKEY
CAS:<p>MKEY peptide inhibits CXCL4-CCL5, reduces atherosclerosis and aneurysm, neuroinflammatory effects unknown.</p>Formula:C113H174N28O34S2Purity:98%Color and Shape:SolidMolecular weight:2532.89NI-0801
<p>NI-0801 (Anti-CXCL10 / IP-1) is a CHO-expressed humanized monoclonal antibody targeting CXCL10/IP-10 for the study of vitiligo and biliary cirrhosis.</p>Purity:97.9% (SDS-PAGE); 99.4% (SEC-HPLC) - 97.9% (SDS-PAGE); 99.4% (SEC-HPLC)Color and Shape:Odour LiquidAZD4721
CAS:<p>AZD4721, an oral CXCR2 antagonist, may be researched for treating inflammation.</p>Formula:C19H25FN4O5S2Color and Shape:SolidMolecular weight:472.55CXCR2 Probe 1
<p>CXCR2Probe 1 (Compound[18F]16b) is a selective ligand for CXCR2 and serves as a radioactive tracer for PET imaging of neutrophils in inflammatory diseases.</p>Formula:C20H24FN3O4Molecular weight:389.17508VB-85247
<p>VB-85247 is a STING agonist that, by activating the STING pathway, induces the upregulation of inflammatory cytokines IFNα/β, TNFα, IL6, and CXCL10, as well as the maturation and activation of dendritic cells. It can lead to the regression of tumors within the bladder and is applicable in bladder cancer research.</p>Color and Shape:Odour SolidCXCR4 antagonist 1
CAS:<p>CXCR4 antagonist 1 is a potent inhibitor of the CXCR4 receptor, with notable anti-HIV activity.</p>Formula:C27H43N7Color and Shape:SolidMolecular weight:465.69TC14012 TFA
<p>TC14012 TFA is a peptide-mimetic CXCR4 antagonist and CXCR7 agonist that promotes the recruitment of β-arrestin by CXCR7 .</p>Formula:C92H141F3N34O21S2Purity:96.31%Color and Shape:SolidMolecular weight:2180.44PF-06835375
CAS:<p>PF-06835375 is a humanized IgG1 antibody that selectively targets CXCR5 expressed on B cells, Tfh cells, and circulating Tfh-like cells (cTfh). It is applicable for research into systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).</p>Color and Shape:LiquidITIC-4F
CAS:<p>ITIC-4F: a postfullerene IDTT electron acceptor for high-efficiency PSCs, relevant in binary, ternary, and tandem setups.</p>Formula:C94H78F4N4O2S4Purity:98%Color and Shape:SolidMolecular weight:1499.92Bam 12P
CAS:<p>Bam 12P is a Pro-Met-enkephalin precursor that is isolated from the bovine adrenal medulla.</p>Formula:C62H97N21O16SPurity:98%Color and Shape:SolidMolecular weight:1424.64CXCR4 antagonist 2
CAS:<p>CXCR4 antagonist 2 is a CXCR4 antagonist with an IC 50 value of 47 nM.</p>Formula:C25H36N6Color and Shape:SolidMolecular weight:420.605KRH-3955 hydrochloride
CAS:<p>KRH-3955 hydrochloride is an orally available CXCR4 blocker with IC50 of 0.61 nM and EC50 of 0.3-1.0 nM against X4 HIV-1.</p>Formula:C28H48Cl3N7Color and Shape:SolidMolecular weight:589.09ITIC
CAS:<p>"ITIC, a non-fullerene acceptor with high Tg of 180°C, shows excellent thermal stability and a low glass-crystal transition, plus unique crystallization."</p>Formula:C94H82N4O2S4Purity:98%Color and Shape:SolidMolecular weight:1427.96Polyphemusin II-Derived Peptide
CAS:<p>T140, a Polyphemusin II-derived peptide, inhibits HIV-1 entry and blocks anti-CXCR4 antibody (12G5) binding.</p>Formula:C90H141N33O18S2Color and Shape:SolidMolecular weight:2037.42ACT-1004-1239
CAS:<p>ACT-1004-1239 is a CXCR7 antagonist with immunomodulatory and myelination-promoting effects, used for research on inflammatory demyelinating diseases.</p>Formula:C27H28F2N6O3Purity:98.31%Color and Shape:SolidMolecular weight:522.55Peptide R TFA
<p>Peptide R (TFA) is a synthetic and specific CXCR4 antagonist. It demonstrates excellent tumor stroma remodeling capabilities and is applicable in research on solid tumors, such as glioblastoma.</p>Formula:C39H57N13O8S2·xC2HF3O2Color and Shape:SolidMolecular weight:900.08 (free base)PS372424 hydrochloride
CAS:<p>PS372424 hydrochloride,CXCR3 agonist. Anti-inflammatory. Inhibits T-cell migration.</p>Formula:C33H45ClN6O4Purity:95.03%Color and Shape:SolidMolecular weight:625.2ATI-2341
CAS:<p>ATI-2341, pepducin targeting the CXCR4, is an allosteric agonist activating the Gi to promote inhibition of cAMP production and induce calcium mobilization.</p>Formula:C104H178N26O25S2Color and Shape:SolidMolecular weight:2256.82LY2510924
CAS:<p>LY2510924 is an effective and selective CXCR4 antagonist. It blocks SDF-1 binding to CXCR4 (IC50: 0.079 nM).</p>Formula:C62H88N14O10Color and Shape:SolidMolecular weight:1189.45Motixafortide
CAS:<p>Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).</p>Formula:C97H144FN33O19S2Purity:98%Color and Shape:SolidMolecular weight:2159.52CXCR2 antagonist 8
CAS:<p>CXCR2 antagonist 8 is a selective CXCR2 antagonist, which can be used for the treatment and prevention of insulin resistance.</p>Formula:C14H13N3O5Color and Shape:SolidMolecular weight:303.27Navarixin
CAS:<p>Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil</p>Formula:C21H23N3O5Purity:98% - 99.51%Color and Shape:SolidMolecular weight:397.42
