CXCR
CXCRs are a subset of GPCRs that bind to chemokines, small signaling proteins that guide the movement of immune cells towards sites of inflammation, infection, or injury. CXCRs play crucial roles in immune responses, cancer metastasis, and inflammatory diseases. Modulators of CXCRs are being investigated for their potential in treating autoimmune diseases, cancer, and chronic inflammatory conditions. At CymitQuimica, we offer a range of high-quality CXCR modulators to support your research in immunology, oncology, and inflammation.
Found 147 products of "CXCR"
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MSX-122
CAS:<p>MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).</p>Formula:C16H16N6Purity:98.31% - 98.94%Color and Shape:SolidMolecular weight:292.34Plerixafor
CAS:<p>Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.</p>Formula:C28H54N8Purity:99.17% - >99.99%Color and Shape:SolidMolecular weight:502.78UNBS5162
CAS:<p>UNBS5162 (UNBS-5162) is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers.</p>Formula:C17H18N4O3Purity:98.37% - 99.97%Color and Shape:SolidMolecular weight:326.35WZ811
CAS:<p>WZ811 is a novel and effective small molecular CXCR4 antagonist (EC50: 0.3 nM).</p>Formula:C18H18N4Purity:99.42% - ≥95%Color and Shape:SolidMolecular weight:290.36Baohuoside I
CAS:<p>Baohuoside I (Icariside-II) is a component of Epimedium koreanum, exhibits anti-inflammatory activity and anti-osteoporosis activities.</p>Formula:C27H30O10Purity:97.64% - 98.14%Color and Shape:SolidMolecular weight:514.52USL311
CAS:<p>USL311 blocks CXCR4/SDF-1 interaction, inhibits tumor cell growth and migration.</p>Formula:C24H34N6OPurity:98.46% - 99.56%Color and Shape:SolidMolecular weight:422.57SB225002
CAS:<p>SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2.</p>Formula:C13H10BrN3O4Purity:98.16% - 99.85%Color and Shape:SolidMolecular weight:352.14JMS-17-2
CAS:<p>JMS-17-2 is a potent and selective antagonist of CX3CR1( IC50 : 0.32 nM).</p>Formula:C25H26ClN3OPurity:98.7% - 99.44%Color and Shape:SolidMolecular weight:419.95Reparixin
CAS:<p>Reparixin inhibits CXCR1 (IC50=1 nM) strongly, CXCR2 weakly (IC50=100 nM), and it's a CXCL8 receptor blocker.</p>Formula:C14H21NO3SPurity:98% - 99.89%Color and Shape:SolidMolecular weight:283.39Mavorixafor trihydrochloride
CAS:<p>Mavorixafor trihydrochloride blocks CXCR4 (IC50: 13 nM) and suppresses T-tropic HIV-1 replication (IC50: 1-9 nM). It's orally active.</p>Formula:C21H30Cl3N5Purity:98.00%Color and Shape:SolidMolecular weight:458.86Navarixin
CAS:<p>Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil</p>Formula:C21H23N3O5Purity:98% - 99.51%Color and Shape:SolidMolecular weight:397.42MSX-127
CAS:<p>MSX-127 elicites positive response in peptide CXCR4.</p>Formula:C16H24N2O4Purity:98.43%Color and Shape:SolidMolecular weight:308.37MSX-130
CAS:<p>MSX-130 is CXCR4 Antagonist.</p>Formula:C36H26N4Purity:99.19%Color and Shape:SolidMolecular weight:514.62JMS-17-2 hydrochloride
CAS:<p>JMS-17-2 hydrochloride: potent CX3CR1 blocker, IC50 of 0.32 nM, hinders breast cancer metastasis.</p>Formula:C25H27Cl2N3OColor and Shape:SolidMolecular weight:456.41CTCE 9908 acetate
<p>CTCE 9908 acetate is an antagonist of CXCR4 and inhibits migration in CXCR4-expressing ovarian cancer cells.</p>Formula:C88H151N27O25Purity:98.47%Color and Shape:SolidMolecular weight:1987.31ATI-2341 acetate(1337878-62-2 free base)
<p>ATI-2341 acetate is an effective allosteric agonist of CXCR4, it activates Gα1 instead of Gα13.</p>Formula:C106H182N26O27S2Purity:97.14%Color and Shape:SolidMolecular weight:2316.87Elubrixin HCl
CAS:<p>Elubrixin is a interleukin 8 inhibitor and CXCR2 selective antagonist.</p>Formula:C17H18Cl3FN4O4SColor and Shape:SolidMolecular weight:499.77NUCC-390 dihydrochloride
CAS:<p>NUCC-390, a selective CXCR4 agonist, promotes nerve repair by inducing CXCR4 internalization, opposite to AMD3100.</p>Formula:C23H35Cl2N5OColor and Shape:SolidMolecular weight:468.46Decursin
CAS:<p>Decursin: potential antiepileptic, hepatoprotective, anti-cancer, anti-amnesic; affects NOX activation, PKCα/MAPK/NF-κB pathways, AChE.</p>Formula:C19H20O5Purity:97.22% - 99.84%Color and Shape:SolidMolecular weight:328.36FC131 TFA (606968-52-9 free base)
CAS:<p>FC131 TFA (606968-52-9 free base) (FC131 TFA) is an antagonist of CXCR4 that inhibits the binding of [125I] -sdf-1 to CXCR4(IC50 : 4.5 nM ), and has anti-hiv</p>Formula:C38H48F3N11O8Purity:99.39% - 99.67%Color and Shape:SolidMolecular weight:843.85AZD-5069
CAS:<p>AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM).</p>Formula:C18H22F2N4O5S2Purity:98.38% - 98.63%Color and Shape:SolidMolecular weight:476.52ML339
CAS:<p>ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.</p>Formula:C26H32ClN3O5Purity:99.9%Color and Shape:SolidMolecular weight:502AMD 3465 hexahydrobromide
CAS:<p>AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity.</p>Formula:C24H44Br6N6Purity:99.39%Color and Shape:SolidMolecular weight:896.07SB-265610
CAS:<p>SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist.</p>Formula:C14H9BrN6OPurity:99.5%Color and Shape:SolidMolecular weight:357.16Danirixin
CAS:<p>Danirixin (GSK1325756) is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM).</p>Formula:C19H21ClFN3O4SPurity:99.78% - >99.99%Color and Shape:SolidMolecular weight:441.9SX-682
CAS:<p>SX-682 is an orally available allosteric inhibitor of CXCR1 and CXCR2.Cost-effective and quality-assured.</p>Formula:C19H14BF4N3O4SPurity:98.19% - 99.57%Color and Shape:SolidMolecular weight:467.2Nicotinamide N-oxide
CAS:<p>Nicotinamide N-oxide, a metabolite of nicotinamide and precursor to NAD+, is reduced by liver enzyme xanthine oxidase.</p>Formula:C6H6N2O2Purity:99.66% - 99.9%Color and Shape:SolidMolecular weight:138.12Plerixafor octahydrochloride
CAS:<p>Plerixafor octahydrochloride mobilizes HSCs by blocking SDF-1alpha/CXCR4 interaction, facilitating their release into circulation.</p>Formula:C28H62Cl8N8Purity:98.01% - 99.79%Color and Shape:SolidMolecular weight:794.46TAK-779
CAS:<p>TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).</p>Formula:C33H39ClN2O2Purity:99.21%Color and Shape:SolidMolecular weight:531.13AMD-070 hydrochloride
CAS:<p>AMD-070 hydrochloride is a CXCR4 antagonist, is useful for Anti HIV.</p>Formula:C21H28ClN5Purity:98.38% - 98.57%Color and Shape:SolidMolecular weight:385.93ML 145
CAS:<p>ML 145 is a selective antagonist of GPR35/CXCR8 (IC50/EC50 of 20.1 nM)</p>Formula:C24H22N2O5S2Purity:97.74%Color and Shape:SolidMolecular weight:482.57HF51116
CAS:<p>HF51116 blocks XCR4, hinders SDF-1α cell effects & HIV-1; potential for HIV, stem cells, cancer spread.</p>Formula:C29H46N8OColor and Shape:SolidMolecular weight:522.73CXCR3 Antagonist 6c
CAS:<p>CXCR3 antagonist 6c blocks CXCR3 and inhibits Ca2+ movement and T-cell migration (IC50: 0.06 µM & 100 nM) with selectivity over 14 other GPCRs.</p>Formula:C30H32Cl3N5O3Color and Shape:SolidMolecular weight:616.97CXCR4 antagonist 9
CAS:<p>CXCR4 antagonist 9, with IC50s of 15 nM & 1.3 nM against CXCR4 & Ca²⁺ rise by CXCL12 respectively.</p>Formula:C21H27FN6Color and Shape:SolidMolecular weight:382.48VUF10132
CAS:<p>VUF10132 is a full inverse CXCR3 N3.35A agonist.</p>Formula:C19H13BrCl4N2O2Purity:98%Color and Shape:SolidMolecular weight:523.03AMG 487 (S-enantiomer)
CAS:<p>AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an CXCR3 antagonist.</p>Formula:C32H28F3N5O4Purity:98%Color and Shape:SolidMolecular weight:603.59HF50731
CAS:<p>HF50731 is a CXCR4 antagonist with high binding affinity (IC50: 19.8 nM) and inhibits calcium mobilization, cell migration, and HIV-1 (IC50: 1.5 nM).</p>Formula:C26H46N4Color and Shape:SolidMolecular weight:414.67SRT3190
CAS:<p>SRT3190 is an antagonist of CXCR2.</p>Formula:C18H23F2N5O4S2Purity:98%Color and Shape:SolidMolecular weight:475.53CXCR4 modulator-2
CAS:<p>CXCR4 modulator-2 (Z7R) has high potency (IC50: 1.25 nM), stable in mouse serum (t1/2=77.1 min), and anti-inflammatory in mice.</p>Formula:C21H32N8O2Color and Shape:SolidMolecular weight:428.53ICT5040
CAS:<p>ICT5040 is a CXCR4 antagonist.</p>Formula:C10H8F3N3OSColor and Shape:SolidMolecular weight:275.25SB-332235
CAS:<p>SB-332235 is an effective specific CXCR2 antagonist. And it is effectively inhibited CS-induced neutrophilia in a dose-dependent manner.</p>Formula:C13H10Cl3N3O4SColor and Shape:SolidMolecular weight:410.66VUF11211
CAS:<p>VUF11211 is an effective antagonist of CXCR3 that acts by extending from the minor pocket into the major pocket of the transmembrane domains.</p>Formula:C26H35Cl2N5OPurity:98%Color and Shape:SolidMolecular weight:504.49TN-14003
CAS:<p>TN-14003 is a synthetic antagonist 14-mer peptide inhibiting metastasis in an animal model.</p>Formula:C90H141N33O18S2Color and Shape:SolidMolecular weight:2037.42CXCR4 antagonist 8
CAS:<p>CXCR4 antagonist 8 (Compound 3) blocks CXCR4, IC50 of 57 nM; stops CXCL12-induced Ca2+ increase, IC50 of 0.24 nM; hinders cell migration.</p>Formula:C21H26N6Color and Shape:SolidMolecular weight:362.47CXCR4 antagonist 5
CAS:<p>CXCR4 antagonist with IC50 of 8.8 nM, inhibits CXCL12-induced calcium increase and chemotaxis, with good safety and minimal CYP, hERG impact.</p>Formula:C21H30N6Color and Shape:SolidMolecular weight:366.5SX-517
CAS:<p>SX-517 is a non-competitive dual antagonist of CXCR1/2, demonstrating anti-inflammatory effects, inhibits CXCL-1-induced Ca²⁺ flux.</p>Formula:C19H16BFN2O3SColor and Shape:SolidMolecular weight:382.22KRH-1636
CAS:<p>KRH-1636: potent, selective CXCR4 antagonist; orally active; inhibits X4 HIV-1 by blocking viral entry and membrane fusion.</p>Formula:C32H37N7O2Color and Shape:SolidMolecular weight:551.68IT1t
CAS:<p>IT1t inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. is a potent CXCR4 antagonist.</p>Formula:C21H34N4S2Purity:98%Color and Shape:SolidMolecular weight:406.65Burixafor hydrobromide
CAS:<p>Burixafor hydrobromide is an oral CXCR4 blocker with anti-angiogenic properties, potentially treating choroid neovascularization.</p>Formula:C27H52BrN8O3PPurity:98%Color and Shape:SolidMolecular weight:647.644VUF5834
CAS:<p>VUF5834 is a full inverse agonist of CXCR3 N3.35A.</p>Formula:C31H41N5O2Purity:98%Color and Shape:SolidMolecular weight:515.69
