CXCR
CXCRs are a subset of GPCRs that bind to chemokines, small signaling proteins that guide the movement of immune cells towards sites of inflammation, infection, or injury. CXCRs play crucial roles in immune responses, cancer metastasis, and inflammatory diseases. Modulators of CXCRs are being investigated for their potential in treating autoimmune diseases, cancer, and chronic inflammatory conditions. At CymitQuimica, we offer a range of high-quality CXCR modulators to support your research in immunology, oncology, and inflammation.
Found 154 products of "CXCR"
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rac-NBI-74330
CAS:rac-NBI-74330 is an effective and selective CXCR3 antagonist.Formula:C32H27F4N5O3Purity:99.6%Color and Shape:SolidMolecular weight:605.58VUF10132
CAS:VUF10132 is a full inverse CXCR3 N3.35A agonist.Formula:C19H13BrCl4N2O2Purity:98%Color and Shape:SolidMolecular weight:523.03Burixafor hydrobromide
CAS:Burixafor hydrobromide is an oral CXCR4 blocker with anti-angiogenic properties, potentially treating choroid neovascularization.Formula:C27H52BrN8O3PPurity:98%Color and Shape:SolidMolecular weight:647.644VUF11211
CAS:VUF11211 is an effective antagonist of CXCR3 that acts by extending from the minor pocket into the major pocket of the transmembrane domains.Formula:C26H35Cl2N5OPurity:98%Color and Shape:SolidMolecular weight:504.49TN-14003
CAS:TN-14003 is a synthetic antagonist 14-mer peptide inhibiting metastasis in an animal model.Formula:C90H141N33O18S2Color and Shape:SolidMolecular weight:2037.42CXCR4 antagonist 8
CAS:CXCR4 antagonist 8 (Compound 3) blocks CXCR4, IC50 of 57 nM; stops CXCL12-induced Ca2+ increase, IC50 of 0.24 nM; hinders cell migration.Formula:C21H26N6Color and Shape:SolidMolecular weight:362.47HF51116
CAS:HF51116 blocks XCR4, hinders SDF-1α cell effects & HIV-1; potential for HIV, stem cells, cancer spread.Formula:C29H46N8OColor and Shape:SolidMolecular weight:522.73ACT-660602
CAS:ACT-660602: Oral CXCR3 blocker, T-cell migration inhibitor, effective in acute lung injury models, potential for autoimmune research. IC50: 204 nM.Formula:C20H20F6N8OSColor and Shape:SolidMolecular weight:534.48SX-517
CAS:SX-517 is a non-competitive dual antagonist of CXCR1/2, demonstrating anti-inflammatory effects, inhibits CXCL-1-induced Ca²⁺ flux.Formula:C19H16BFN2O3SColor and Shape:SolidMolecular weight:382.22SB02024
CAS:SB02024 inhibits VPS34, boosts cGAS-STING, hinders autophagy, and shrinks breast cancer xenografts; enhances Sunitinib/Erlotinib efficacy.Formula:C16H22F3N3O2Color and Shape:SolidMolecular weight:345.36KRH-1636
CAS:KRH-1636: potent, selective CXCR4 antagonist; orally active; inhibits X4 HIV-1 by blocking viral entry and membrane fusion.Formula:C32H37N7O2Color and Shape:SolidMolecular weight:551.68VUF5834
CAS:VUF5834 is a full inverse agonist of CXCR3 N3.35A.Formula:C31H41N5O2Purity:98%Color and Shape:SolidMolecular weight:515.69GSK812397
CAS:GSK812397 inhibits X4-tropic HIV-1 with high potency, targeting CXCR4 receptor noncompetitively and showing broad efficacy and good pharmacokinetics.Formula:C24H32N6OColor and Shape:SolidMolecular weight:420.55Mavorixafor
CAS:Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding.Formula:C21H27N5Purity:98.56%Color and Shape:SolidMolecular weight:349.47Ref: TM-TQ0174
1mg39.00€2mg50.00€5mg84.00€10mg123.00€25mg215.00€50mg348.00€100mg557.00€1mL*10mM (DMSO)92.00€AZD8797
CAS:AZD8797 (KAND567) is a CX3CR1 antagonist with potential protective effects against neuronal damage and prevents nociceptive hypersensitivity in rats.Formula:C19H25N5OS2Purity:98.73% - 99.68%Color and Shape:SolidMolecular weight:403.56Ref: TM-T14384
1mg80.00€5mg170.00€10mg253.00€25mg442.00€50mg620.00€100mg845.00€1mL*10mM (DMSO)187.00€Elubrixin
CAS:Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM).Formula:C17H17Cl2FN4O4SPurity:98.65% - 99.78%Color and Shape:SolidMolecular weight:463.31Ref: TM-T11179
1mg109.00€5mg235.00€10mg349.00€25mg532.00€50mg745.00€100mg999.00€200mg1,333.00€1mL*10mM (DMSO)253.00€IT1t dihydrochloride
CAS:IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.Formula:C21H36Cl2N4S2Purity:99.91%Color and Shape:SolidMolecular weight:479.57Ref: TM-T11693L
2mg35.00€5mg52.00€10mg96.00€25mg170.00€50mg305.00€100mg444.00€200mg615.00€1mL*10mM (DMSO)59.00€AZD8309
CAS:AZD8309 is an oral CXCR2 antagonist, curbing neutrophil movement, lowering MPO in lungs/pancreas, and trypsin/elastase activity.
Formula:C15H14F2N4O2S2Purity:98.35% - 99.67%Color and Shape:SolidMolecular weight:384.42NUCC-390
CAS:NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100.Formula:C23H33N5OPurity:97.08%Color and Shape:SolidMolecular weight:395.54Ref: TM-T12269
1mg109.00€5mg260.00€10mg409.00€25mg730.00€50mg1,018.00€100mg1,369.00€200mg1,783.00€1mL*10mM (DMSO)268.00€CXCR2 antagonist 2
CAS:CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC 50 value of 95 nM.Formula:C17H17FN2O4SColor and Shape:SolidMolecular weight:364.39CXCR4 antagonist 7
CAS:Compound PARA-B, a CXCR4 antagonist with IC50 = 9.3 nM, targets HIV, cancer, inflammatory diseases, and WHIM syndrome.Formula:C15H17N5O3Color and Shape:SolidMolecular weight:315.33TIQ-15
CAS:TIQ-15 is an effective and selective CXCR4 antagonist. It has good drug-like properties.Formula:C23H32N4Purity:98%Color and Shape:SolidMolecular weight:364.53CXCR2 antagonist 3
CAS:Compound 11h, a CXCR2 antagonist, inhibits neutrophil/MDSCs and boosts CD3+ T cells in Pan02 tumors.Formula:C17H15FN2O4SColor and Shape:SolidMolecular weight:362.38CXCR4 antagonist 6
CAS:CXCR4 antagonist 6 is a potent small-molecule inhibitor of CXCL12/CXCR4 signaling that suppresses cell migration and metastasis in cancer models.Formula:C21H30N6Purity:100%Color and Shape:SolidMolecular weight:366.5Ladarixin Sodium
CAS:Ladarixin Sodium, an Chemokine CXCR antagonist, is used potentially for the treatment of type I diabetes.Formula:C11H12F3NNaO6S2Color and Shape:SolidMolecular weight:398.32E6130
CAS:E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.Formula:C28H37ClF3N3O3Color and Shape:SolidMolecular weight:556.06Pentixafor
CAS:Pentixafor is a peptide that selectively targets the CXCR4 receptor and can be labeled with Gallium-68 (68Ga) for visualization using positron emissionFormula:C60H80N14O14Purity:98%Color and Shape:SolidMolecular weight:1221.36AZD0233
CAS:AZD0233, Oral CX3CR1 antagonist, modulates CX3CR1/CX3CL1 axis, improves cardiac function in DCM models.Formula:C19H29FN6O4SColor and Shape:SolidMolecular weight:456.54AMD-3329 free base
CAS:AMD-3329 is a potent anti-HIV agent that blocks virus replication by targeting CXCR4, a key receptor for X4 viruses' entry.Formula:C34H50N8Color and Shape:SolidMolecular weight:570.81AMD-3329 hydrobromide
CAS:AMD-3329 hydrobromide: strong, selective anti-HIV agent, blocks virus replication by targeting CXCR4 co-receptor.Formula:C34H58Br8N8Color and Shape:SolidMolecular weight:1218.13NUCC-390 dihydrochloride (1060524-97-1 free base)
NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.Formula:C23H35Cl2N5OPurity:98%Color and Shape:SolidMolecular weight:468.46(±)-AMG 487
AMG 487 is an effective and selective antagonist of chemokine receptor 3.Formula:C32H28F3N5O4Purity:98%Color and Shape:SolidMolecular weight:603.59CXCR2-IN-2
CAS:CXCR2-IN-2, Selective CXCR2 antagonist (IC50=5.2 nM), BBB penetration, oral bioavailability, inhibits Gro-α-induced CD11b expression in blood.Formula:C18H23ClN2O5SColor and Shape:SolidMolecular weight:414.9(R,R)-CXCR2-IN-2
CAS:'(R,R)-CXCR2-IN-2 is a brain-penetrating diastereoisomer and CXCR2 antagonist with pIC50 of 9 (Tango) and 6.8 (HWB Gro-α/CD11b).'Formula:C18H23ClN2O5SColor and Shape:SolidMolecular weight:414.9CXCR2-IN-1
CAS:CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.Formula:C19H20Cl2FN3O4SPurity:99.89%Color and Shape:SolidMolecular weight:476.35(R)-SCH 546738
CAS:(R)-SCH 546738, the R-isomer of SCH 546738, is a non-competitive, orally active antagonist targeting the CXCR3 receptor, exhibiting a K_i of 0.4 nM for the human CXCR3 receptor.Formula:C23H31Cl2N7OColor and Shape:SolidMolecular weight:492.45EMU-116
CAS:EMU-116 is an orally active antagonist of CXCR4, utilized in cancer research.Formula:C25H35N5Color and Shape:SolidMolecular weight:405.58Paeoniflorin-6′-O-benzene sulfonate
CAS:Paeoniflorin-6′-O-benzene sulfonate (CP-25) acts as an inhibitor of G protein-coupled receptor kinase 2 (GRK2), preventing its translocation to the cell membrane and inhibiting the JAK1/STAT3 signaling pathway. It suppresses HaCaT cell proliferation induced by IL-17A/CXCL2. In mouse models, CP-25 reduces the levels of inflammatory cytokines and chemokines such as IL-17A, IL-17F, IFN-γ, TNF-α, IL-22, IL-23, CXCL2, CXCL3, and CXCL9, thereby alleviating psoriasis induced by Imiquimod.Formula:C29H32O13SColor and Shape:SolidMolecular weight:620.622CXCR2 antagonist 6
CXCR2 antagonist 6: strong CXCR2 affinity (IC50=0.044 μM), hinders calcium mobilization (IC50=0.66 μM).Formula:C17H16F2N4OSColor and Shape:SolidMolecular weight:362.4CXCR2 antagonist 5
CXCR2 antagonist 5 (compound 25) binds strongly (IC50=0.013μM) and mobilizes calcium (IC50=0.1μM).
Formula:C15H14F2N4O2SColor and Shape:SolidMolecular weight:352.36SCH 563705
CAS:SCH 563705 is a CXCR2 and CXCR1 antagonist used in the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.Formula:C23H27N3O5Purity:98.03%Color and Shape:SolidMolecular weight:425.48SLW131
CAS:SLW131 (Compound 10) is a CCR7 antagonist with strong affinity, showing a Ki of 9.85 nM. It inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM and β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 also suppresses CCL19-induced morphological changes in primary BMDC cells and CCR7-mediated migration of mouse CD4+ T cells.Formula:C21H27N5O5SColor and Shape:SolidMolecular weight:461.535CXCR2 antagonist 4
CXCR2 antagonist 4 inhibits CXCR2 (IC50: 0.13 μM) and CXCL8-induced calcium rise (IC50: 27 μM), promising for cancer research.Formula:C15H14F2N4OS2Color and Shape:SolidMolecular weight:368.42CXCR4 antagonist 10
CAS:CXCR4 antagonist10 (compound 21) is an effective CXCR4 inhibitor with an IC50 value of 7.8 nM. It plays a significant role in cancer research.Formula:C18H18N4O4Color and Shape:SolidMolecular weight:354.36CXCR7 antagonist-1 hydrochloride
CAS:CXCR7 antagonist-1 hydrochloride, Inhibits SDF-1 (CXCL12) or I-TAC binding to CXCR7, used for tumor and inflammation research.Formula:C21H20ClFN6OPurity:99.84%Color and Shape:SolidMolecular weight:426.87CXCR4 antagonist 3
CXCR4 antagonist 3, aka compound 12a, has 11 nM IC50, shares TIQ15 traits, and is promising in HIV research.Formula:C22H31N5Color and Shape:SolidMolecular weight:365.52CCX662
CAS:CCX662 is a CXCR7 antagonist. It inhibits the binding of 125I-CXCL12 to CXCR7 with an IC50 of 9 nM. This compound is suitable for use in cancer research.Formula:C28H37N5O4SColor and Shape:SolidMolecular weight:539.69CXCR2 antagonist 7
CXCR2 antagonist 7 is a powerful blocker with IC50s: 0.044 μM for binding, 0.66 μM for calcium mobilization.Formula:C14H14F2N6OSColor and Shape:SolidMolecular weight:352.36ACT-672125
CAS:ACT-672125: Potent CXCR3 blocker, may treat autoimmunity, safe with dose-dependent efficacy in lung inflammation.Formula:C25H25F3N10O2SColor and Shape:SolidMolecular weight:586.59CXCR4 modulator-1
CAS:CXCR4 modulator-1 (ZINC72372983) is potent (EC50=100nM) with uses in anti-inflammatory, anticancer, and anti-HIV research.Formula:C23H27N5O2Color and Shape:SolidMolecular weight:405.49
