CXCR
CXCRs are a subset of GPCRs that bind to chemokines, small signaling proteins that guide the movement of immune cells towards sites of inflammation, infection, or injury. CXCRs play crucial roles in immune responses, cancer metastasis, and inflammatory diseases. Modulators of CXCRs are being investigated for their potential in treating autoimmune diseases, cancer, and chronic inflammatory conditions. At CymitQuimica, we offer a range of high-quality CXCR modulators to support your research in immunology, oncology, and inflammation.
Found 147 products of "CXCR"
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rac-NBI-74330
CAS:<p>rac-NBI-74330 is an effective and selective CXCR3 antagonist.</p>Formula:C32H27F4N5O3Purity:99.6%Color and Shape:SolidMolecular weight:605.58PS372424
CAS:<p>PS372424 is a specific agonist of human CXCR3, with anti-inflammatory activity.</p>Formula:C33H44N6O4Purity:98%Color and Shape:SolidMolecular weight:588.74AZ10397767
CAS:<p>AZ10397767: Potent CXCR2 blocker (IC50=1nM); lowers neutrophil infiltration in tumors in vitro/in vivo.</p>Formula:C15H14ClFN4O2S2Color and Shape:SolidMolecular weight:400.88AMD 3465
CAS:<p>AMD 3465 (GENZ-644494) blocks CXCR4, hinders X4 HIV replication (IC50: 1-10 nM), ineffective against R5 viruses, IC50: 0.75 nM (12G5 mAb), 18 nM (CXCL12AF647).</p>Formula:C24H38N6Purity:98%Color and Shape:SolidMolecular weight:410.60SCH 546738
CAS:<p>SCH 546738 is an orally available, selective and potent CXCR3 antagonist that attenuates the development of autoimmune diseases and delays graft rejection.</p>Formula:C23H31Cl2N7OPurity:98.67%Color and Shape:SolidMolecular weight:492.45GPR35 agonist 1
CAS:<p>GPR35 agonist 1 is a highly effective and specific GPR35/CXCR8 agonist (EC50: 5.8 nM).</p>Formula:C10H4BrN5O5Purity:98%Color and Shape:SolidMolecular weight:354.07FC131
CAS:<p>CXCR4 antagonist</p>Formula:C36H47N11O6Purity:98%Color and Shape:SolidMolecular weight:729.83SB02024
CAS:<p>SB02024 inhibits VPS34, boosts cGAS-STING, hinders autophagy, and shrinks breast cancer xenografts; enhances Sunitinib/Erlotinib efficacy.</p>Formula:C16H22F3N3O2Color and Shape:SolidMolecular weight:345.36ACT-660602
CAS:<p>ACT-660602: Oral CXCR3 blocker, T-cell migration inhibitor, effective in acute lung injury models, potential for autoimmune research. IC50: 204 nM.</p>Formula:C20H20F6N8OSColor and Shape:SolidMolecular weight:534.48IT1t dihydrochloride
CAS:<p>IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.</p>Formula:C21H36Cl2N4S2Purity:99.91%Color and Shape:SolidMolecular weight:479.57Mavorixafor
CAS:<p>Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding.</p>Formula:C21H27N5Purity:98.56%Color and Shape:SolidMolecular weight:349.47NUCC-390
CAS:<p>NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100.</p>Formula:C23H33N5OPurity:97.08%Color and Shape:SolidMolecular weight:395.54AZD8797
CAS:<p>AZD8797 (KAND567) is a CX3CR1 antagonist with potential protective effects against neuronal damage and prevents nociceptive hypersensitivity in rats.</p>Formula:C19H25N5OS2Purity:98.73% - 99.68%Color and Shape:SolidMolecular weight:403.56Elubrixin
CAS:<p>Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM).</p>Formula:C17H17Cl2FN4O4SPurity:98.65% - 99.78%Color and Shape:SolidMolecular weight:463.31AZD8309
CAS:<p>AZD8309 is an oral CXCR2 antagonist, curbing neutrophil movement, lowering MPO in lungs/pancreas, and trypsin/elastase activity.</p>Formula:C15H14F2N4O2S2Purity:98.35% - 99.67%Color and Shape:SolidMolecular weight:384.42TIQ-15
CAS:<p>TIQ-15 is an effective and selective CXCR4 antagonist. It has good drug-like properties.</p>Formula:C23H32N4Purity:98%Color and Shape:SolidMolecular weight:364.53CXCR4 antagonist 6
CAS:<p>CXCR4 antagonist 6 blocks CXCR4 (IC50: 79 nM), hinders calcium flux (IC50: 0.25 nM), reduces cell migration, and is effective in cancer metastasis mice.</p>Formula:C21H30N6Color and Shape:SolidMolecular weight:366.5Ladarixin Sodium
CAS:<p>Ladarixin Sodium, an Chemokine CXCR antagonist, is used potentially for the treatment of type I diabetes.</p>Formula:C11H12F3NNaO6S2Color and Shape:SolidMolecular weight:398.32(±)-AMG 487
<p>AMG 487 is an effective and selective antagonist of chemokine receptor 3.</p>Formula:C32H28F3N5O4Purity:98%Color and Shape:SolidMolecular weight:603.59Pentixafor
CAS:<p>Pentixafor is a peptide that selectively targets the CXCR4 receptor and can be labeled with Gallium-68 (68Ga) for visualization using positron emission</p>Formula:C60H80N14O14Purity:98%Color and Shape:SolidMolecular weight:1221.36CXCR4 antagonist 7
CAS:<p>Compound PARA-B, a CXCR4 antagonist with IC50 = 9.3 nM, targets HIV, cancer, inflammatory diseases, and WHIM syndrome.</p>Formula:C15H17N5O3Color and Shape:SolidMolecular weight:315.33CXCR2 antagonist 2
CAS:<p>CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC 50 value of 95 nM.</p>Formula:C17H17FN2O4SColor and Shape:SolidMolecular weight:364.39NUCC-390 dihydrochloride (1060524-97-1 free base)
<p>NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.</p>Formula:C23H35Cl2N5OPurity:98%Color and Shape:SolidMolecular weight:468.46CXCR2-IN-2
CAS:<p>CXCR2-IN-2: A selective, brain-penetrant, oral CXCR2 inhibitor (IC50: 5.2 nM/1 nM). ~730x selectivity vs CXCR1, >1900x vs other chemokine receptors.</p>Formula:C18H23ClN2O5SColor and Shape:SolidMolecular weight:414.9E6130
CAS:<p>E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.</p>Formula:C28H37ClF3N3O3Color and Shape:SolidMolecular weight:556.06CXCR2 antagonist 3
CAS:<p>Compound 11h, a CXCR2 antagonist, inhibits neutrophil/MDSCs and boosts CD3+ T cells in Pan02 tumors.</p>Formula:C17H15FN2O4SColor and Shape:SolidMolecular weight:362.38(R,R)-CXCR2-IN-2
CAS:<p>'(R,R)-CXCR2-IN-2 is a brain-penetrating diastereoisomer and CXCR2 antagonist with pIC50 of 9 (Tango) and 6.8 (HWB Gro-α/CD11b).'</p>Formula:C18H23ClN2O5SColor and Shape:SolidMolecular weight:414.9CXCR2-IN-1
CAS:<p>CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.</p>Formula:C19H20Cl2FN3O4SPurity:99.89%Color and Shape:SolidMolecular weight:476.35EMU-116
CAS:<p>EMU-116 is an orally active antagonist of CXCR4, utilized in cancer research.</p>Formula:C25H35N5Color and Shape:SolidMolecular weight:405.58CXCR4 modulator-1
CAS:<p>CXCR4 modulator-1 (ZINC72372983) is potent (EC50=100nM) with uses in anti-inflammatory, anticancer, and anti-HIV research.</p>Formula:C23H27N5O2Color and Shape:SolidMolecular weight:405.49ACT-777991
CAS:<p>ACT-777991: oral CXCR3 blocker, stable in microsomes/hepatocytes, inhibits T-cell migration to CXCL11.</p>Formula:C20H20F6N8O2SColor and Shape:SolidMolecular weight:550.48(R)-SCH 546738
CAS:<p>(R)-SCH 546738, the R-isomer of SCH 546738, is a non-competitive, orally active antagonist targeting the CXCR3 receptor, exhibiting a K_i of 0.4 nM for the human CXCR3 receptor.</p>Formula:C23H31Cl2N7OColor and Shape:SolidMolecular weight:492.45CXCR4 antagonist 10
CAS:<p>CXCR4 antagonist10 (compound 21) is an effective CXCR4 inhibitor with an IC50 value of 7.8 nM. It plays a significant role in cancer research.</p>Formula:C18H18N4O4Color and Shape:SolidMolecular weight:354.36CXCR4 antagonist 3
<p>CXCR4 antagonist 3, aka compound 12a, has 11 nM IC50, shares TIQ15 traits, and is promising in HIV research.</p>Formula:C22H31N5Color and Shape:SolidMolecular weight:365.52CXCR7 modulator 2
CAS:<p>CXCR7 modulator 2 is a 7-type C-X-C chemokine receptor (CXCR7) modulator with a Ki of 13 nM.</p>Formula:C29H42N6O3Color and Shape:SolidMolecular weight:522.68CXCR2 antagonist 4
<p>CXCR2 antagonist 4 inhibits CXCR2 (IC50: 0.13 μM) and CXCL8-induced calcium rise (IC50: 27 μM), promising for cancer research.</p>Formula:C15H14F2N4OS2Color and Shape:SolidMolecular weight:368.42CXCR2 antagonist 6
<p>CXCR2 antagonist 6: strong CXCR2 affinity (IC50=0.044 μM), hinders calcium mobilization (IC50=0.66 μM).</p>Formula:C17H16F2N4OSColor and Shape:SolidMolecular weight:362.4Paeoniflorin-6′-O-benzene sulfonate
CAS:<p>Paeoniflorin-6′-O-benzene sulfonate (CP-25) acts as an inhibitor of G protein-coupled receptor kinase 2 (GRK2), preventing its translocation to the cell membrane and inhibiting the JAK1/STAT3 signaling pathway. It suppresses HaCaT cell proliferation induced by IL-17A/CXCL2. In mouse models, CP-25 reduces the levels of inflammatory cytokines and chemokines such as IL-17A, IL-17F, IFN-γ, TNF-α, IL-22, IL-23, CXCL2, CXCL3, and CXCL9, thereby alleviating psoriasis induced by Imiquimod.</p>Formula:C29H32O13SColor and Shape:SolidMolecular weight:620.622CXCR7 antagonist-1 hydrochloride
CAS:<p>CXCR7 antagonist-1 hydrochloride blocks SDF-1 and I-TAC from CXCR7; may prevent cancer and inflammation.</p>Formula:C21H20ClFN6OColor and Shape:SolidMolecular weight:426.87CXCR2 antagonist 5
<p>CXCR2 antagonist 5 (compound 25) binds strongly (IC50=0.013μM) and mobilizes calcium (IC50=0.1μM).</p>Formula:C15H14F2N4O2SColor and Shape:SolidMolecular weight:352.36SCH 563705
CAS:<p>SCH 563705 is a CXCR2 and CXCR1 antagonist used in the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.</p>Formula:C23H27N3O5Purity:98.03%Color and Shape:SolidMolecular weight:425.48SLW131
CAS:<p>SLW131 (Compound 10) is a CCR7 antagonist with strong affinity, showing a Ki of 9.85 nM. It inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM and β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 also suppresses CCL19-induced morphological changes in primary BMDC cells and CCR7-mediated migration of mouse CD4+ T cells.</p>Formula:C21H27N5O5SColor and Shape:SolidMolecular weight:461.535CCX662
CAS:<p>CCX662 is a CXCR7 antagonist. It inhibits the binding of 125I-CXCL12 to CXCR7 with an IC50 of 9 nM. This compound is suitable for use in cancer research.</p>Formula:C28H37N5O4SColor and Shape:SolidMolecular weight:539.69CXCR2 antagonist 7
<p>CXCR2 antagonist 7 is a powerful blocker with IC50s: 0.044 μM for binding, 0.66 μM for calcium mobilization.</p>Formula:C14H14F2N6OSColor and Shape:SolidMolecular weight:352.36ACT-672125
CAS:<p>ACT-672125: Potent CXCR3 blocker, may treat autoimmunity, safe with dose-dependent efficacy in lung inflammation.</p>Formula:C25H25F3N10O2SColor and Shape:SolidMolecular weight:586.59VUF11207 trifluoroacetate salt
CAS:<p>VUF11207 trifluoroacetate salt is a useful organic compound for research related to life sciences. The catalog number is T66657 and the CAS number is 1378524-41-4.</p>Formula:C29H36F4N2O6Color and Shape:SolidMolecular weight:584.609CXCR4-IN-1
CAS:<p>CXCR4-IN-1 (Example C5), with an IC50 of 20 nM, is a potent inhibitor of CXCR4, applicable for the research of various conditions such as cancer, HIV, diabetic</p>Formula:C23H32N6Purity:98%Color and Shape:SolidMolecular weight:392.54
