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TGF-beta/Smad

TGF-beta/Smad

TGF-beta/Smad inhibitors are compounds that interfere with the TGF-beta (Transforming Growth Factor-beta) signaling pathway, which is mediated by Smad proteins. This pathway is involved in the regulation of cell growth, differentiation, apoptosis, and stem cell function. Dysregulation of TGF-beta/Smad signaling is associated with cancer, fibrosis, and other diseases. Inhibitors of this pathway are important tools for studying these conditions and developing potential therapies. At CymitQuimica, we provide TGF-beta/Smad inhibitors to support your research in cell signaling, oncology, and tissue repair.

Found 58 products of "TGF-beta/Smad"

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  • Myristoyl tetrapeptide-12
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    Myristoyl tetrapeptide-12

    CAS:
    <p>Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair growth [1] [2].</p>
    Formula:C32H63N7O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:625.89

    Ref: TM-T80628

  • TP0427736
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    TP0427736

    CAS:
    <p>TP0427736: ALK5 inhibitor, IC50=2.72 nM, 300x &gt; ALK3 selectivity; counters TGF-β in human cells, extends anagen in mice.</p>
    Formula:C14H10N4S2
    Purity:97.26%
    Color and Shape:Solid
    Molecular weight:298.39

    Ref: TM-T24897

  • (+)-ITD-1
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    (+)-ITD-1

    CAS:
    <p>(+)-ITD-1 is an inhibitor of TGF-β, effectively inhibiting TGF-β2 with an IC50 of 0.46 μM. It promotes the degradation of the TGF-β type II receptor (TGFBR2) and the differentiation of cardiomyocytes. Additionally, it suppresses the formation of the mesoderm during the early differentiation of mouse embryonic stem cells (mESCs).</p>
    Formula:C27H29NO3
    Color and Shape:Solid
    Molecular weight:415.52

    Ref: TM-T201672

  • CDD-1431
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    CDD-1431

    CAS:
    <p>CDD-1431 is a highly selective BMPR2 kinase inhibitor with a Kiapp of 20.6 nM. It inhibits BRE reporter gene activity, exhibiting an IC50 of 4.87 μM. BMPs regulate cellular processes across various tissue types such as the kidneys, skeletal muscle, heart, and reproductive organs, and can induce ectopic bone formation.</p>
    Formula:C33H38N8O5S
    Color and Shape:Solid
    Molecular weight:658.77

    Ref: TM-T205082

  • TGFβ1-IN-1
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    TGFβ1-IN-1

    CAS:
    <p>TGFβ1-IN-1 is a TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrosis markers (α-SMA and fibronectin) and can be used in cancer research.</p>
    Formula:C22H24N2O3
    Purity:99.89% - 99.89%
    Color and Shape:Solid
    Molecular weight:364.438

    Ref: TM-T61389

  • TGFβRI-IN-3
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    TGFβRI-IN-3

    CAS:
    <p>TGFβRI-IN-3 inhibits TGFβR1 with an IC 50 of 0.79 nM with 2000-fold selectivity against MAP4K4.</p>
    Formula:C28H23N3O2S
    Purity:99.85%
    Color and Shape:Soild
    Molecular weight:465.57

    Ref: TM-T9523

  • CymitQuimica logo
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    Luspatercept

    CAS:
    <p>Luspatercept (ACE-536), a recombinant modified ActRIIB fusion protein, selectively binds to transforming growth factor β superfamily ligands, thereby enhancing erythrocyte production and advancing the maturation of erythroid precursors. Moreover, by binding with GDF11, it inhibits Smad2/3 signaling. This compound is instrumental in anemia research [1].</p>
    Color and Shape:Liquid

    Ref: TM-T77076

    ne
    Discontinued
    Discontinued product
  • DCN1-IN-2
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    DCN1-IN-2

    CAS:
    <p>DCN1-IN-2, a DCN1 inhibitor, exhibits potent activity with an IC 50 of 2.96 nM. It effectively mitigates Ang II/TGFβ-induced activation of cardiac fibroblasts and diminishes ISO-induced cardiac fibrosis and remodeling in mice through the selective inhibition of cullin 3.</p>
    Formula:C18H14ClF3N4OS
    Color and Shape:Solid
    Molecular weight:426.84

    Ref: TM-T89956

    10mg
    Discontinued
    50mg
    Discontinued
    Discontinued product