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JAK

JAK

JAK (Janus kinase) inhibitors are compounds that target the JAK-STAT signaling pathway, which is involved in cell growth, immune response, and angiogenesis. By inhibiting JAK, these compounds can reduce the signaling that leads to the formation of new blood vessels in tumors, thereby inhibiting tumor growth. JAK inhibitors are important in the treatment of cancers and inflammatory diseases. At CymitQuimica, we offer a diverse range of high-quality JAK inhibitors to support your research in oncology, immunology, and angiogenesis.

Found 245 products of "JAK"

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  • TK4g
    Targetmol
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    TK4g

    CAS:
    <p>TK4g, a potent JAK inhibitor, has IC50s of 12.61 nM (JAK2) &amp; 15.80 nM (JAK3); promising for lymphoid diseases &amp; leukemia research.</p>
    Formula:C19H19N3O4S
    Color and Shape:Solid
    Molecular weight:385.44

    Ref: TM-T61698

  • JAK-IN-14
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    JAK-IN-14

    CAS:
    <p>JAK-IN-14 (compound 16) is a specific JAK1 inhibitor. It prevents JAK1 phosphorylation by binding to the active site of JAK in immune, inflammation and cancer.</p>
    Formula:C19H15FN4O
    Purity:98.27%
    Color and Shape:Solid
    Molecular weight:334.35

    Ref: TM-T9764

  • TyK2-IN-2
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    TyK2-IN-2

    CAS:
    <p>TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).</p>
    Formula:C16H18N6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:310.35

    Ref: TM-T13232

  • JAK-IN-18
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    JAK-IN-18

    CAS:
    <p>"JAK-IN-18: potent JAK inhibitor for eye, skin, respiratory disease research (WO2018204238A1, comp 1)."</p>
    Formula:C27H28F2N6O3
    Color and Shape:Solid
    Molecular weight:522.55

    Ref: TM-T63658

  • JAK3-IN-12
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    JAK3-IN-12

    CAS:
    <p>JAK3-IN-12 (compound 15k) is a potent inhibitor of JAK3 (IC50: 9.5 nM) and can be used in the study of rheumatoid arthritis.</p>
    Formula:C19H19N5O4S
    Color and Shape:Solid
    Molecular weight:413.45

    Ref: TM-T62114

  • Tyk2-IN-5
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    Tyk2-IN-5

    CAS:
    <p>Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086 nM for Tyk2 JH2; IC50: 25 nM for IFNα).</p>
    Formula:C21H19FN8O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:434.43

    Ref: TM-T13234

  • EP009
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    EP009

    CAS:
    <p>EP009, a novel, selective, and orally active inhibitor of JAK3, induces therapeutic response in T-cell malignancies.</p>
    Formula:C14H24O2
    Color and Shape:Solid
    Molecular weight:224.34

    Ref: TM-T27274

  • Tyk2-IN-7
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    Tyk2-IN-7

    CAS:
    <p>Tyk2-IN-7 is an inhibitor of TYK2 JH2, binds to the TYK2 JH2 domain (IC50: 0.00053 μM; Ki.app: 0.00007 μM).</p>
    Formula:C18H15D3N6O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:401.46

    Ref: TM-T13235

  • MS-1020
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    MS-1020

    CAS:
    <p>MS-1020 inhibits JAK3/STAT3, blocks active JAK3, suppresses JAK3/STAT5 signaling, and targets STAT3 in certain cells.</p>
    Formula:C21H18N2O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:346.38

    Ref: TM-T28113

  • 1,2,3,4,5,6-Hexabromocyclohexane
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    1,2,3,4,5,6-Hexabromocyclohexane

    CAS:
    <p>Inhibits JAK2 autophosphorylation; non-cytotoxic at 100μM; 1μM reduces activity by 50%, 50μM nearly abolishes it.</p>
    Formula:C6H6Br6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:557.54

    Ref: TM-T22462

  • OICR-0547
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    OICR-0547

    CAS:
    <p>OICR-0547 is an inactive derivative of OICR-9429 and is commonly used as a negative control for OICR-9429.</p>
    Formula:C28H29F3N4O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:542.55

    Ref: TM-T12290

  • INCB16562
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    INCB16562

    CAS:
    <p>INCB16562: oral JAK1/2 inhibitor, halts IL-6/STAT3 in myeloma cells, boosts drug efficacy, stunts myeloma in mice.</p>
    Formula:C19H11Cl2N5
    Color and Shape:Solid
    Molecular weight:380.23

    Ref: TM-T68306

  • JAK3-IN-9
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    JAK3-IN-9

    CAS:
    <p>JAK3-IN-9, potent JAK3 inhibitor, IC50 of 1.7 nM, highly selective, low toxicity, orally bioavailable, shows anti-arthritis activity.</p>
    Formula:C17H23N5O4S
    Color and Shape:Solid
    Molecular weight:393.46

    Ref: TM-T61814

  • TUL01101
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    TUL01101

    CAS:
    <p>TUL01101, a selective oral JAK1 inhibitor (IC50: 3 nM), also targets JAK2, JAK3, TYK2; for rheumatoid arthritis research.</p>
    Formula:C22H25F2N5O2
    Color and Shape:Solid
    Molecular weight:429.46

    Ref: TM-T73392

  • CP-690550A
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    CP-690550A

    CAS:
    <p>Cp-690550a is a novel JAK3 inhibitor, which is used to treat rheumatoid arthritis, graft rejection, psoriasis, and other immune-mediated diseases.</p>
    Formula:C15H21N5O2
    Color and Shape:Solid
    Molecular weight:303.36

    Ref: TM-T31074

  • GDC-4379
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    GDC-4379

    CAS:
    <p>GDC-4379 is a JAK1 inhibitor that can be used to study asthma.</p>
    Formula:C21H18ClF2N7O3
    Color and Shape:Solid
    Molecular weight:489.86

    Ref: TM-T63280

  • Peficitinib hydrobromide
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    Peficitinib hydrobromide

    CAS:
    <p>Peficitinib hydrobromide is used in the treatment of Psoriasis and Rheumatoid Arthritis.</p>
    Formula:C18H23BrN4O2
    Color and Shape:Solid
    Molecular weight:407.312

    Ref: TM-T33905

  • Povorcitinib
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    Povorcitinib

    CAS:
    <p>Povorcitinib is a highly potent and selective JAK1 inhibitor with significant potential for the investigation of cutaneous lupus erythematosus (CLE) and Lichen planus (LP).</p>
    Formula:C23H22F5N7O
    Color and Shape:Solid
    Molecular weight:507.469

    Ref: TM-T39113

  • (2R,5S)-Ritlecitinib
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    (2R,5S)-Ritlecitinib

    CAS:
    <p>(2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective inhibitor of JAK3 with IC 50 of 144.8 nM[1].</p>
    Formula:C15H19N5O
    Color and Shape:Solid
    Molecular weight:285.34

    Ref: TM-T60565

  • TYK2-IN-11
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    TYK2-IN-11

    CAS:
    <p>TYK2-IN-11 (5B) selectively inhibits TYK2 (IC50: 0.016 nM) and JAK1 (IC50: 0.31 nM), aiding autoimmune and inflammatory disease research.</p>
    Formula:C18H17N5O3S
    Color and Shape:Solid
    Molecular weight:383.42

    Ref: TM-T61658