JNK
JNKs are a subgroup of the MAPK family that respond to stress stimuli, such as cytokines, ultraviolet irradiation, and heat shock, and are involved in controlling apoptosis, inflammation, and immune responses. JNK signaling is crucial for the regulation of cellular stress responses and has been implicated in various diseases, including neurodegenerative disorders, cancer, and inflammatory conditions. At CymitQuimica, we provide a range of JNK pathway modulators to support your research in stress signaling, apoptosis, and disease pathology.
Found 105 products of "JNK"
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JNK1 Protein, Human, Recombinant (GST)
Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family.Color and Shape:Lyophilized PowderMolecular weight:75 kDa (predicted); 65 kDa (reducing conditions)D-JNKI-1 acetate
D-JNKI-1 acetate (AM-111 acetate) is a highly potent and cell-permeable peptide inhibitor of JNK.Formula:C166H290N66O42Purity:99.48%Color and Shape:SolidMolecular weight:3882.5Ref: TM-T10937L
1mg156.00€5mg296.00€10mg442.00€25mg707.00€50mg1,009.00€1mL*10mM (DMSO)1,089.00€100mg1,333.00€IMM-H007
CAS:IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expressionFormula:C22H23N5O8Purity:97.73%Color and Shape:SolidMolecular weight:485.45Ref: TM-T9010
1mg38.00€5mg92.00€1mL*10mM (DMSO)124.00€10mg128.00€25mg215.00€50mg304.00€100mg411.00€200mg570.00€AS601245
CAS:AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK), with neuroprotective properties.Formula:C20H16N6SPurity:98% - 99.02%Color and Shape:SolidMolecular weight:372.45JNK Inhibitor VIII
CAS:JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2,Formula:C18H20N4O4Purity:98.93%Color and Shape:SolidMolecular weight:356.38Taurochenodeoxycholic Acid
CAS:Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.Formula:C26H45NO6SPurity:99.53% - 99.86%Color and Shape:SolidMolecular weight:499.7DB07268
CAS:DB07268 is a potent and selective JNK1 inhibitor.Formula:C17H15N5O2Purity:98.2% - 98.91%Color and Shape:SolidMolecular weight:321.33SP600125
CAS:SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitiveFormula:C14H8N2OPurity:97.63% - 99.82%Color and Shape:SolidMolecular weight:220.23BI-78D3
CAS:BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.Formula:C13H9N5O5S2Purity:97.89% - >99.99%Color and Shape:SolidMolecular weight:379.37Anisomycin
CAS:Anisomycin (NSC-76712), an antibiotic from Streptomyces, blocks protein/DNA synthesis by targeting peptidyl transferase/80S ribosomes.Formula:C14H19NO4Purity:98.33% - 99.81%Color and Shape:White Crystalline SolidMolecular weight:265.3Loureirin B
CAS:Loureirin B suppresses fibrosis by modulating MMPs/TIMPs, hindering fibroblast growth, and targeting TGF-β1/Smad2/3 pathway.Formula:C18H20O5Purity:99.33% - 99.86%Color and Shape:SolidMolecular weight:316.35TOMATIDINE HYDROCHLORIDE
CAS:Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway.Formula:C27H46ClNO2Purity:99.75% - ≥95%Color and Shape:SolidMolecular weight:452.11Actein
CAS:Actein stimulates bone formation, counters osteoporosis and oxidative damage, and may treat lipid disorders and cancer, inhibiting breast cancer cell growth.Formula:C37H56O11Purity:≥98%Color and Shape:Brown PowderMolecular weight:676.83Polyphyllin I
CAS:Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,Formula:C44H70O16Purity:98% - 99.5%Color and Shape:SolidMolecular weight:855.02Ro 31-8220 Mesylate
CAS:Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor, and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β.Formula:C25H23N5O2S·CH4O3SPurity:98.79% - 99.02%Color and Shape:SolidMolecular weight:553.65Ref: TM-T6643
1mg49.00€2mg64.00€5mg92.00€1mL*10mM (DMSO)133.00€10mg150.00€25mg230.00€50mg319.00€100mg475.00€Guggulsterone
CAS:Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.Formula:C21H28O2Purity:99.4% - 99.8%Color and Shape:Light Yellow PowderMolecular weight:312.45Ref: TM-T5574
1mg34.00€5mg50.00€1mL*10mM (DMSO)55.00€10mg93.00€25mg152.00€50mg205.00€100mg289.00€200mg432.00€JNK-IN-7
CAS:JNK-IN-7 (JNK inhibitor) is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM).Formula:C28H27N7O2Purity:98.02% - 99.53%Color and Shape:SolidMolecular weight:493.56Ref: TM-T3598
1mg93.00€2mg149.00€5mg215.00€1mL*10mM (DMSO)233.00€10mg275.00€25mg495.00€50mg712.00€100mg973.00€CC-401 Hydrochloride
CAS:CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with antineoplastic activity.Formula:C22H25ClN6OPurity:99.71% - ≥95%Color and Shape:SolidMolecular weight:424.93JIP-1 (153-163) acetate(438567-88-5 free base)
JNK peptide inhibitor. Mimics JIP-1 residues 153-163. Micromolar affinity, little effect on p38, ERK.Formula:C63H108N20O16Purity:92.89%Color and Shape:SolidMolecular weight:1401.65Ro 31-8220
CAS:Ro 31-8220: potent PKC inhibitor (IC50: 5-27 nM). Affects MAPKAP-K1b, MSK1, S6K1, GSK3β (IC50: 3-38 nM), not MKK3/4/6/7.Formula:C25H23N5O2SColor and Shape:SolidMolecular weight:457.55
