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JNK

JNK

JNKs are a subgroup of the MAPK family that respond to stress stimuli, such as cytokines, ultraviolet irradiation, and heat shock, and are involved in controlling apoptosis, inflammation, and immune responses. JNK signaling is crucial for the regulation of cellular stress responses and has been implicated in various diseases, including neurodegenerative disorders, cancer, and inflammatory conditions. At CymitQuimica, we provide a range of JNK pathway modulators to support your research in stress signaling, apoptosis, and disease pathology.

Found 96 products of "JNK"

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  • Taurochenodeoxycholic Acid
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    Taurochenodeoxycholic Acid

    CAS:
    <p>Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.</p>
    Formula:C26H45NO6S
    Purity:99.53% - 99.86%
    Color and Shape:Solid
    Molecular weight:499.7

    Ref: TM-T2A2481

  • DB07268
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    DB07268

    CAS:
    <p>DB07268 is a potent and selective JNK1 inhibitor.</p>
    Formula:C17H15N5O2
    Purity:98.2% - 98.91%
    Color and Shape:Solid
    Molecular weight:321.33

    Ref: TM-T3200

  • SP600125
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    SP600125

    CAS:
    <p>SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitive</p>
    Formula:C14H8N2O
    Purity:97.63% - 99.82%
    Color and Shape:Solid
    Molecular weight:220.23

    Ref: TM-T3109

  • BI-78D3
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    BI-78D3

    CAS:
    <p>BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays &gt; 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.</p>
    Formula:C13H9N5O5S2
    Purity:97.89% - >99.99%
    Color and Shape:Solid
    Molecular weight:379.37

    Ref: TM-T6784

  • Anisomycin
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    Anisomycin

    CAS:
    <p>Anisomycin (NSC-76712), an antibiotic from Streptomyces, blocks protein/DNA synthesis by targeting peptidyl transferase/80S ribosomes.</p>
    Formula:C14H19NO4
    Purity:98.33% - 99.81%
    Color and Shape:White Crystalline Solid
    Molecular weight:265.3

    Ref: TM-T6758

  • Loureirin B
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    Loureirin B

    CAS:
    <p>Loureirin B suppresses fibrosis by modulating MMPs/TIMPs, hindering fibroblast growth, and targeting TGF-β1/Smad2/3 pathway.</p>
    Formula:C18H20O5
    Purity:99.33% - 99.86%
    Color and Shape:Solid
    Molecular weight:316.35

    Ref: TM-T3876

  • TOMATIDINE HYDROCHLORIDE
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    TOMATIDINE HYDROCHLORIDE

    CAS:
    <p>Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway.</p>
    Formula:C27H46ClNO2
    Purity:99.75% - ≥95%
    Color and Shape:Solid
    Molecular weight:452.11

    Ref: TM-T4592

  • Actein
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    Actein

    CAS:
    <p>Actein stimulates bone formation, counters osteoporosis and oxidative damage, and may treat lipid disorders and cancer, inhibiting breast cancer cell growth.</p>
    Formula:C37H56O11
    Purity:≥98%
    Color and Shape:Brown Powder
    Molecular weight:676.83

    Ref: TM-T7190

  • Polyphyllin I
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    Polyphyllin I

    CAS:
    <p>Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,</p>
    Formula:C44H70O16
    Purity:98% - 99.5%
    Color and Shape:Solid
    Molecular weight:855.02

    Ref: TM-T3895

  • Ro 31-8220 Mesylate
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    Ro 31-8220 Mesylate

    CAS:
    <p>Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor, and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β.</p>
    Formula:C25H23N5O2S·CH4O3S
    Purity:98.79% - 99.02%
    Color and Shape:Solid
    Molecular weight:553.65

    Ref: TM-T6643

  • Guggulsterone
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    Guggulsterone

    CAS:
    <p>Guggulsterone (Guggulsterone E&amp;Z) E&amp;Z is a 3-hydroxy steroid. It has a role as an androgen.</p>
    Formula:C21H28O2
    Purity:99.4% - 99.8%
    Color and Shape:Light Yellow Powder
    Molecular weight:312.45

    Ref: TM-T5574

  • JNK-IN-7
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    JNK-IN-7

    CAS:
    <p>JNK-IN-7 (JNK inhibitor) is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM).</p>
    Formula:C28H27N7O2
    Purity:98.02% - 99.53%
    Color and Shape:Solid
    Molecular weight:493.56

    Ref: TM-T3598

  • CC-401 Hydrochloride
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    CC-401 Hydrochloride

    CAS:
    <p>CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with antineoplastic activity.</p>
    Formula:C22H25ClN6O
    Purity:99.71% - ≥95%
    Color and Shape:Solid
    Molecular weight:424.93

    Ref: TM-T5833

  • Bentamapimod
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    Bentamapimod

    CAS:
    <p>Bentamapimod (AS 602801) is a novel, orally active inhibitor of JNK.</p>
    Formula:C25H23N5O2S
    Purity:97.04% - 99.92%
    Color and Shape:Solid
    Molecular weight:457.55

    Ref: TM-T2675

  • Astragaloside IV
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    Astragaloside IV

    CAS:
    <p>Astragaloside IV suppresses ERK1/2, JNK, MMP-2/9 in breast cancer; inhibits adenovirus and protects cardiovascular, immune, digestive, nervous systems.</p>
    Formula:C41H68O14
    Purity:99% - 99.84%
    Color and Shape:Hydroscopic Brown Or Yellow Powder
    Molecular weight:784.97

    Ref: TM-T2973

  • JNK-IN-8
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    JNK-IN-8

    CAS:
    <p>JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM).</p>
    Formula:C29H29N7O2
    Purity:99.24% - >99.99%
    Color and Shape:Solid
    Molecular weight:507.59

    Ref: TM-T2668

  • Epieriocalyxin A
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    Epieriocalyxin A

    CAS:
    <p>Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.</p>
    Formula:C20H24O5
    Purity:97.00%
    Color and Shape:Solid
    Molecular weight:344.4

    Ref: TM-TN3967

  • Isovitexin
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    Isovitexin

    CAS:
    <p>1.</p>
    Formula:C21H20O10
    Purity:99.79% - 99.97%
    Color and Shape:Solid
    Molecular weight:432.38

    Ref: TM-T6S1371

  • IQ-3
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    IQ-3

    CAS:
    <p>IQ3 inhibits JNK3 (Kd 66 nM), JNK1/2, NF-κB/AP1 in THP1-Blue cells (IC50 1.4 μM), and reduces TNF-α/IL-6 production.</p>
    Formula:C20H11N3O3
    Purity:≥98%
    Color and Shape:Solid
    Molecular weight:341.32

    Ref: TM-T8477

  • Indirubin-3′-oxime
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    Indirubin-3′-oxime

    CAS:
    <p>Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.</p>
    Formula:C16H11N3O2
    Purity:98.34%
    Color and Shape:Solid
    Molecular weight:277.28

    Ref: TM-T9138