MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Found 885 products of "MAPK"
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KRAS G12D inhibitor 6
CAS:<p>KRAS G12D inhibitor 6 is an efficacious compound that effectively inhibits KRAS G12D.</p>Formula:C32H37ClN8O2Color and Shape:SolidMolecular weight:601.15SOS1-IN-11
CAS:<p>SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).</p>Formula:C22H24F3N5OPurity:99.4%Color and Shape:SolidMolecular weight:431.45PROTAC K-Ras Degrader-6
CAS:<p>Pan-KRAS degrader 5 (compound 102) is a cereblon-based PROTAC KRAS degrader with a DC50 value less than 100 nM, exhibiting anticancer activity.</p>Formula:C57H65F2N11O5Color and Shape:SolidMolecular weight:1022.19Anti-osteoporosis agent-8
<p>Anti-osteoporosis agent-8 (Compound 4aa) is a RANKL inhibitor, capable of preventing RANKL-induced osteoclastogenesis and osteoclast differentiation, with an IC50 of 2.41 μM. Furthermore, Anti-osteoporosis agent-8 has been shown to mitigate bone loss in an ovariectomized (OVX) mouse model.</p>Formula:C18H19F3N2O2SeMolecular weight:432.05638Cobimetinib (R-enantiomer)
CAS:<p>Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.</p>Formula:C21H21F3IN3O2Purity:98%Color and Shape:SolidMolecular weight:531.318PROTAC SOS1 degrader-4
<p>PROTAC SOS1 Degrader-4 (compound 10) is a potent degrader of SOS1 and exhibits antiproliferative activity [1].</p>Formula:C53H65ClN8O7SPurity:98%Color and Shape:SolidMolecular weight:993.65HRX-0233
CAS:<p>HRX-0233 is a small molecule inhibitor targeting MAP2K4. In vivo, HRX-0233 effectively reduces tumors in H358 KRASG12C mutant non-small cell lung cancer (NSCLC) without significant toxicity. This compound also prevents feedback activation of receptor tyrosine kinases (RTKs) when used as a monotherapy with the KRAS inhibitor Sotorasib, leading to more sustained and comprehensive inhibition of the MAPK signaling pathway. HRX-0233 holds potential for research in AR-negative prostate cancer, lung cancer, and colon cancer.</p>Formula:C24H21F2N5O3SColor and Shape:SolidMolecular weight:497.52RTIL 13
CAS:<p>RTIL 13 inhibits dynamin GTPase (IC50: 2.3 μM), targets its lipid binding domain, and suppresses endocytosis (IC50: 9.3 & 7.1 μM).</p>Formula:C30H55BrN2O3Color and Shape:SolidMolecular weight:571.685Enniatin B1
CAS:<p>Enniatin B1, a Fusarium mycotoxin, crosses the blood-brain barrier and modulates ERK, NF-κB, and ACAT with an IC50 of 73 μM.</p>Formula:C34H59N3O9Purity:98%Color and Shape:SolidMolecular weight:653.858JH295
CAS:<p>JH295: potent, selective Nek2 inhibitor (IC50 = 770 nM), irreversibly targets Cys22, no effect on Cdk1, Aurora B, Plk1, or spindle mechanisms.</p>Formula:C18H16N4O2Color and Shape:SolidMolecular weight:320.352LC-2
CAS:<p>LC-2 (PROTAC KRASG12C Degrader-LC-2) is a novel von Hippel-Lindau-based PROTAC degrader of endogenous KRAS G12C with a DC50 between 0.25 and 0.76 μM.LC-2 is a</p>Formula:C59H71ClFN11O7SPurity:98%Color and Shape:SolidMolecular weight:1132.78Tunlametinib
CAS:<p>Tunlametinib is a MEK1/2 inhibitor (IC50=1.9 nM) for treating RAS/RAF-driven cancers.</p>Formula:C16H12F2IN3O3SPurity:98.72%Color and Shape:SolidMolecular weight:491.25Anti-ERK2 Antibody (5V598)
<p>Anti-ERK2 Antibody (5V598) is a Rabbit antibody targeting ERK2. Anti-ERK2 Antibody (5V598) can be used in ELISA.</p>Color and Shape:Odour LiquidAnti-ERK2 Antibody (4F551)
<p>Anti-ERK2 Antibody (4F551) is a Rabbit antibody targeting ERK2. Anti-ERK2 Antibody (4F551) can be used in ELISA,FCM.</p>Color and Shape:Odour LiquidAnti-ERK2 Antibody (9C922)
<p>Anti-ERK2 Antibody (9C922) is a Mouse antibody targeting ERK2. Anti-ERK2 Antibody (9C922) can be used in WB,ELISA.</p>Color and Shape:Odour LiquidTAK1-IN-3
CAS:<p>TAK1-IN-3 is a novel ATP-competitive TAK1 inhibitor for the study of cancer.</p>Formula:C16H19N3O2SPurity:98.88%Color and Shape:SolidMolecular weight:317.41Enniatin B
CAS:<p>Enniatins B decreases the activation of ERK (p44/p42).</p>Formula:C33H57N3O9Purity:98%Color and Shape:SolidMolecular weight:639.831TRPM4 inhibitor 8
CAS:<p>TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.</p>Formula:C11H17BrN2Purity:97%Color and Shape:SolidMolecular weight:257.17RAS GTPase inhibitor 1
CAS:<p>RAS GTPase inhibitor 1 is a RAS GTPase inhibitor with potential antitumor activity.</p>Formula:C27H28ClF4N5O2Purity:98.43%Color and Shape:SolidMolecular weight:565.99EM127
CAS:<p>EM127: covalent SMYD3 inhibitor, KD 13μM, impedes ERK1/2, hinders SMYD3 gene regulation, long-term methyltransferase reduction, potential in cancer study.</p>Formula:C14H18ClN3O3Purity:97.61%Color and Shape:SolidMolecular weight:311.76
